{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:37:46Z","timestamp":1793529466703,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671752"],"award-info":[{"award-number":["81671752"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s12325-019-00959-w","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T12:03:07Z","timestamp":1556798587000},"page":"1314-1325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparing the Efficacy and Safety of High-Intensity Focused Ultrasound and Uterine Artery Embolization in Caesarean Scar Pregnancy: A Meta-analysis"],"prefix":"10.1007","volume":"36","author":[{"given":"Xiaoyi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengwang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"959_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/uog.56","volume":"21","author":"D Jurkovic","year":"2003","unstructured":"Jurkovic D, Hillaby K, Woelfer B, et al. First-trimester diagnosis and management of pregnancies implanted into the lower uterine segment cesarean section scar. Ultrasound Obstet Gynecol. 2003;21:220\u20137.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"959_CR2","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1097\/01.AOG.0000218690.24494.ce","volume":"107","author":"MA Rotas","year":"2006","unstructured":"Rotas MA, Haberman S, Levgur M. Cesarean scar ectopic pregnancies: etiology, diagnosis, and management. Obstet Gynecol. 2006;107:1373\u201381.","journal-title":"Obstet Gynecol"},{"key":"959_CR3","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/uog.974","volume":"23","author":"KM Seow","year":"2004","unstructured":"Seow KM, Huang LW, Lin YH, et al. Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol. 2004;23:247\u201353.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"959_CR4","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/S0140-6736(09)61870-5","volume":"375","author":"P Lumbiganon","year":"2010","unstructured":"Lumbiganon P, Laopaiboon M, Gulmezoglu AM, et al. Method of delivery and pregnancy outcomes in Asia: the WHO global survey on maternal and perinatal health 2007\u201308. Lancet. 2010;375:490\u20139.","journal-title":"Lancet"},{"key":"959_CR5","doi-asserted-by":"publisher","first-page":"601","DOI":"10.7863\/ultra.34.4.601","volume":"34","author":"IE Timor-Tritsch","year":"2015","unstructured":"Timor-Tritsch IE, Khatib N, Monteagudo A, et al. Cesarean scar pregnancies: the experience of 60 cases. J Ultrasound Med. 2015;34:601\u201310.","journal-title":"J Ultrasound Med"},{"key":"959_CR6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cca.2018.08.012","volume":"486","author":"D Liu","year":"2018","unstructured":"Liu D, Yang M, Wu Q. Application of ultrasonography in the diagnosis and treatment of cesarean scar pregnancy. Clin Chim Acta. 2018;486:291\u20137.","journal-title":"Clin Chim Acta"},{"key":"959_CR7","doi-asserted-by":"publisher","first-page":"147","DOI":"10.5468\/ogs.2018.61.1.147","volume":"61","author":"YR Kim","year":"2018","unstructured":"Kim YR, Moon MJ. Ultrasound-guided local injection of methotrexate and systemic intramuscular methotrexate in the treatment of cesarean scar pregnancy. Obstet Gynecol Sci. 2018;61:147\u201353.","journal-title":"Obstet Gynecol Sci."},{"key":"959_CR8","first-page":"137","volume":"11","author":"P Peng","year":"2015","unstructured":"Peng P, Gui T, Liu X, et al. Comparative efficacy and safety of local and systemic methotrexate injection in cesarean scar pregnancy. Ther Clin Risk Manag. 2015;11:137\u201342.","journal-title":"Ther Clin Risk Manag"},{"key":"959_CR9","first-page":"2570","volume":"8","author":"Y Huang","year":"2015","unstructured":"Huang Y, Li Y, Xi R, et al. An application of uterine artery chemoembolization in treating cesarean scar pregnancy. Int J Clin Exp Med. 2015;8:2570\u20137.","journal-title":"Int J Clin Exp Med."},{"key":"959_CR10","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1472-6874-14-116","volume":"14","author":"Y He","year":"2014","unstructured":"He Y, Wu X, Zhu Q, et al. Combined laparoscopy and hysteroscopy vs. uterine curettage in the uterine artery embolization-based management of cesarean scar pregnancy: a retrospective cohort study. BMC Womens Health. 2014;14:116.","journal-title":"BMC Womens Health."},{"key":"959_CR11","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00404-018-4686-8","volume":"297","author":"L Gao","year":"2018","unstructured":"Gao L, Hou YY, Sun F, et al. A retrospective comparative study evaluating the efficacy of adding intra-arterial methotrexate infusion to uterine artery embolisation followed by curettage for cesarean scar pregnancy. Arch Gynecol Obstet. 2018;297:1205\u201311.","journal-title":"Arch Gynecol Obstet"},{"key":"959_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00404-015-3952-2","volume":"294","author":"W Liu","year":"2016","unstructured":"Liu W, Shen L, Wang Q, et al. Uterine artery embolization combined with curettage vs. methotrexate plus curettage for cesarean scar pregnancy. Arch Gynecol Obstet. 2016;294:71\u20136.","journal-title":"Arch Gynecol Obstet."},{"key":"959_CR13","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S1001-9294(16)30005-0","volume":"30","author":"MH Guo","year":"2015","unstructured":"Guo MH, Wang MF, Liu MM, et al. Management of cesarean scar pregnancy: a case series. Chin Med Sci J. 2015;30:226\u201330.","journal-title":"Chin Med Sci J"},{"key":"959_CR14","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00270-018-1934-z","volume":"41","author":"A Tumenjargal","year":"2018","unstructured":"Tumenjargal A, Tokue H, Kishi H, et al. Uterine artery embolization combined with dilation and curettage for the treatment of cesarean scar pregnancy: efficacy and future fertility. Cardiovasc Interv Radiol. 2018;41:1165\u201373.","journal-title":"Cardiovasc Interv Radiol"},{"key":"959_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/ijgo.12636","volume":"143","author":"Y Li","year":"2018","unstructured":"Li Y, Lu L, Wang W, et al. Retrospective study of patients with cesarean scar pregnancies treated by uterine artery chemoembolization and curettage. Int J Gynaecol Obstet. 2018;143:172\u20137.","journal-title":"Int J Gynaecol Obstet."},{"key":"959_CR16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1051-0443(07)61881-8","volume":"12","author":"JB Spies","year":"2001","unstructured":"Spies JB, Roth AR, Gonsalves SM, et al. Ovarian function after uterine artery embolization for leiomyomata: assessment with the use of serum follicle stimulating hormone assay. J Vasc Interv Radiol. 2001;12:437\u201342.","journal-title":"J Vasc Interv Radiol"},{"key":"959_CR17","first-page":"9621741","volume":"2018","author":"SK Mutiso","year":"2018","unstructured":"Mutiso SK, Oindi FM, Hacking N, et al. Uterine necrosis after uterine artery embolization for symptomatic fibroids. Case Rep Obstet Gynecol. 2018;2018:9621741.","journal-title":"Case Rep Obstet Gynecol."},{"key":"959_CR18","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1177\/0300060517723257","volume":"46","author":"Y Wang","year":"2018","unstructured":"Wang Y, Huang X. Sepsis after uterine artery embolization-assisted termination of pregnancy with complete placenta previa: a case report. J Int Med Res. 2018;46:546\u201350.","journal-title":"J Int Med Res"},{"key":"959_CR19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.zemedi.2012.07.001","volume":"22","author":"JW Jenne","year":"2012","unstructured":"Jenne JW, Preusser T, Gunther M. High-intensity focused ultrasound: principles, therapy guidance, simulations, and applications. Z Med Phys. 2012;22:311\u201322.","journal-title":"Z Med Phys"},{"key":"959_CR20","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.1001\/jama.292.23.2826","volume":"292","author":"S Ringold","year":"2004","unstructured":"Ringold S. FDA approves ultrasound fibroid therapy. JAMA. 2004;292:2826.","journal-title":"JAMA"},{"key":"959_CR21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/uog.12557","volume":"43","author":"L Huang","year":"2014","unstructured":"Huang L, Du Y, Zhao C. High-intensity focused ultrasound combined with dilatation and curettage for cesarean scar pregnancy. Ultrasound Obstet Gynecol. 2014;43:98\u2013101.","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"356","key":"959_CR22","first-page":"e1","volume":"211","author":"J Xiao","year":"2014","unstructured":"Xiao J, Zhang S, Wang F, et al. Cesarean scar pregnancy: noninvasive and effective treatment with high-intensity focused ultrasound. Am J Obstet Gynecol. 2014;211(356):e1\u20137.","journal-title":"Am J Obstet Gynecol"},{"key":"959_CR23","doi-asserted-by":"publisher","first-page":"e7687","DOI":"10.1097\/MD.0000000000007687","volume":"96","author":"Y Hong","year":"2017","unstructured":"Hong Y, Guo Q, Pu Y, et al. Outcome of high-intensity focused ultrasound and uterine artery embolization in the treatment and management of cesarean scar pregnancy: a retrospective study. Medicine (Baltimore). 2017;96:e7687.","journal-title":"Medicine (Baltimore)."},{"key":"959_CR24","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3109\/02656736.2015.1104733","volume":"32","author":"X Zhu","year":"2016","unstructured":"Zhu X, Deng X, Xiao S, et al. A comparison of high-intensity focused ultrasound and uterine artery embolisation for the management of caesarean scar pregnancy. Int J Hyperth. 2016;32:144\u201350.","journal-title":"Int J Hyperth."},{"issue":"3","key":"959_CR25","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ultrasmedbio.2016.11.001","volume":"43","author":"J Xiao","year":"2016","unstructured":"Xiao J, Shi Z, Zhou J, et al. Cesarean scar pregnancy: comparing the efficacy and tolerability of treatment with high-intensity focused ultrasound and uterine artery embolization. Ultrasound Med Biol. 2016;43(3):640\u20137.","journal-title":"Ultrasound Med Biol"},{"key":"959_CR26","doi-asserted-by":"publisher","first-page":"b2535","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.","journal-title":"BMJ"},{"key":"959_CR27","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1245\/ASO.2006.05.045","volume":"13","author":"O Aziz","year":"2006","unstructured":"Aziz O, Constantinides V, Tekkis PP, et al. Laparoscopic versus open surgery for rectal cancer: a meta-analysis. Ann Surg Oncol. 2006;13:413\u201324.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"959_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177\u201388.","journal-title":"Control Clin Trials"},{"issue":"4","key":"959_CR29","first-page":"719","volume":"22","author":"N Mantel","year":"1959","unstructured":"Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22(4):719\u201348.","journal-title":"J Natl Cancer Inst"},{"issue":"02","key":"959_CR30","first-page":"124","volume":"16","author":"Y Zhou","year":"2017","unstructured":"Zhou Y. Clinical comparative analysis of interventional embolization and high intensity focused ultrasound in the treatment of uterine incision pregnancy after cesarean section. Health Way. 2017;16(02):124.","journal-title":"Health Way."},{"issue":"02","key":"959_CR31","first-page":"146","volume":"11","author":"T Zhang","year":"2018","unstructured":"Zhang T. Diagnosis and treatment of recurrent cesarean section scar pregnancy. Chin J Ration Drug Use. 2018;11(02):146\u20137.","journal-title":"Chin J Ration Drug Use."},{"key":"959_CR32","first-page":"52","volume":"31","author":"J Huang","year":"2015","unstructured":"Huang J, Xu D. Diagnosis and treatment of uterine scar pregnancy after cesarean section. Chin Commun Doc. 2015;31:52\u20133.","journal-title":"Chin Commun Doc."},{"issue":"11","key":"959_CR33","first-page":"1040","volume":"38","author":"X Wei","year":"2017","unstructured":"Wei X, Gao Y, Dong W, et al. High-intensity focused ultrasound ablation for the treatment of cesarean section scar pregnancy. Acad J Pla Postgrad Med Sch. 2017;38(11):1040\u20132.","journal-title":"Acad J Pla Postgrad Med Sch."},{"key":"959_CR34","first-page":"723","volume":"32","author":"Q Dai","year":"2017","unstructured":"Dai Q, Zhen A, Wang W, et al. Prospective cohort study of high-intensity focused ultrasound and uterine artery embolization for the treatment of cesarean scar pregnancy. West China Med J. 2017;32:723\u20136.","journal-title":"West China Med J"},{"issue":"3","key":"959_CR35","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.ultrasmedbio.2016.11.001","volume":"43","author":"J Xiao","year":"2017","unstructured":"Xiao J, Shi Z, Zhou J, et al. Cesarean scar pregnancy: comparing the efficacy and tolerability of treatment with high-intensity focused ultrasound and uterine artery embolization. Ultrasound Med Biol. 2017;43(3):640\u20137.","journal-title":"Ultrasound Med Biol"},{"key":"959_CR36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1159\/000381263","volume":"80","author":"YJ Du","year":"2015","unstructured":"Du YJ, Zhang XH, Wang LQ. Risk factors for haemorrhage during suction curettage after uterine artery embolization for treating caesarean scar pregnancy: a case\u2013control study. Gynecol Obstet Investig. 2015;80:259\u201364.","journal-title":"Gynecol Obstet Investig"},{"key":"959_CR37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.ejogrb.2014.03.040","volume":"179","author":"A Mollo","year":"2014","unstructured":"Mollo A, Conforti A, Alviggi C, et al. Successful direct bipolar resection of 6th week cesarean scar pregnancy: case report and literature review. Eur J Obstet Gynecol Reprod Biol. 2014;179:229\u201331.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"959_CR38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.gyobfe.2015.01.015","volume":"43","author":"J Le Gall","year":"2015","unstructured":"Le Gall J, Fichez A, Lamblin G, et al. Cesarean scar ectopic pregnancies: combined modality therapies with uterine artery embolization before surgical procedure. Gynecol Obstet Fertil. 2015;43:191\u20139.","journal-title":"Gynecol Obstet Fertil."},{"key":"959_CR39","doi-asserted-by":"crossref","first-page":"128","DOI":"10.12891\/ceog16962014","volume":"41","author":"QY Wu","year":"2014","unstructured":"Wu QY, Ling J, Xue Q, et al. Clinical analysis of diagnosis and treatment of 13 cases with cesarean scar pregnancy. Clin Exp Obstet Gynecol. 2014;41:128\u201331.","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"7","key":"959_CR40","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.jmig.2016.08.819","volume":"23","author":"B Qiao","year":"2016","unstructured":"Qiao B, Zhang Z, Li Y. Uterine artery embolization versus methotrexate for cesarean scar pregnancy in a chinese population: a meta-analysis. J Minim Invasive Gynecol. 2016;23(7):1040\u20138.","journal-title":"J Minim Invasive Gynecol."},{"key":"959_CR41","first-page":"914","volume":"49","author":"Y Chong","year":"2014","unstructured":"Chong Y, Zhang K, Zhou Y, et al. Clinical value of MRI in cesarean scar pregnancy. Zhonghua Fu Chan Ke Za Zhi. 2014;49:914\u20138.","journal-title":"Zhonghua Fu Chan Ke Za Zhi."},{"key":"959_CR42","first-page":"9536869","volume":"2017","author":"C Ndubizu","year":"2017","unstructured":"Ndubizu C, McLaren RA Jr, McCalla S, et al. Recurrent cesarean scar ectopic pregnancy treated with systemic methotrexate. Case Rep Obstet Gynecol. 2017;2017:9536869.","journal-title":"Case Rep Obstet Gynecol."},{"key":"959_CR43","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s11596-017-1769-x","volume":"37","author":"Z Zeng","year":"2017","unstructured":"Zeng Z, Ding SP, Zeng X, et al. The value of transvaginal ultrasound in the clinical surgical treatment of cesarean scar pregnancy. J Huazhong Univ Sci Technol Med Sci. 2017;37:536\u201340.","journal-title":"J Huazhong Univ Sci Technol Med Sci."},{"key":"959_CR44","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ijgo.2014.05.005","volume":"127","author":"L Gao","year":"2014","unstructured":"Gao L, Huang Z, Gao J, et al. Uterine artery embolization followed by dilation and curettage within 24 hours compared with systemic methotrexate for cesarean scar pregnancy. Int J Gynaecol Obstet. 2014;127:147\u201351.","journal-title":"Int J Gynaecol Obstet"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-00959-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-019-00959-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-00959-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T08:32:08Z","timestamp":1663403528000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-019-00959-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,2]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["959"],"URL":"https:\/\/doi.org\/10.1007\/s12325-019-00959-w","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,2]]},"assertion":[{"value":"29 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}