{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:46:23Z","timestamp":1792633583910,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s12325-019-01019-z","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T21:02:37Z","timestamp":1562965357000},"page":"2223-2232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A Comprehensive Update of Current Anesthesia Perspectives on Therapeutic Hypothermia"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-6085","authenticated-orcid":false,"given":"Ivan","family":"Urits","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vwaire","family":"Orhurhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sikorsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Viswanath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,12]]},"reference":[{"issue":"4","key":"1019_CR1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1007\/s00134-003-2152-x","volume":"30","author":"KH Polderman","year":"2004","unstructured":"Polderman KH. Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: indications and evidence. Intensive Care Med. 2004;30(4):556\u201375.","journal-title":"Intensive Care Med"},{"issue":"1","key":"1019_CR2","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2344\/0003-3006-57.1.25","volume":"57","author":"M D\u00edaz","year":"2010","unstructured":"D\u00edaz M, Becker DE. Thermoregulation: physiological and clinical considerations during sedation and general anesthesia. Anesth Prog. 2010;57(1):25\u201332.","journal-title":"Anesth Prog"},{"issue":"3","key":"1019_CR3","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1093\/ejcts\/ezr002","volume":"41","author":"N Ali Aydemir","year":"2012","unstructured":"Ali Aydemir N, et al. Randomized comparison between mild and moderate hypothermic cardiopulmonary bypass for neonatal arterial switch operation. Eur J Cardiothorac Surg. 2012;41(3):581\u20136.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"2","key":"1019_CR4","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.athoracsur.2008.10.078","volume":"87","author":"M Boodhwani","year":"2009","unstructured":"Boodhwani M, Rubens FD, Wozny D, Nathan HJ. Effects of mild hypothermia and rewarming on renal function after coronary artery bypass grafting. Ann Thorac Surg. 2009;87(2):489\u201395.","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"1019_CR5","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/S0741-5214(95)70281-4","volume":"21","author":"HL Bush","year":"1995","unstructured":"Bush HL, et al. Hypothermia during elective abdominal aortic aneurysm repair: the high price of avoidable morbidity. J Vasc Surg. 1995;21(3):392\u2013402.","journal-title":"J Vasc Surg"},{"issue":"5","key":"1019_CR6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1093\/bjaceaccp\/mkq024","volume":"10","author":"S Conolly","year":"2010","unstructured":"Conolly S, Arrowsmith JE, Klein AA. Deep hypothermic circulatory arrest. Contin Educ Anaesth Crit Care Pain. 2010;10(5):138\u201342.","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"issue":"3","key":"1019_CR7","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/j.jtcvs.2012.11.072","volume":"145","author":"RB Griepp","year":"2013","unstructured":"Griepp RB, Di Luozzo G. Hypothermia for aortic surgery. J Thorac Cardiovasc Surg. 2013;145(3):S56\u20138.","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"1019_CR8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/ALN.0b013e3181dfd4f7","volume":"113","author":"HP Nguyen","year":"2010","unstructured":"Nguyen HP, et al. Perioperative hypothermia (33\u00a0\u00b0C) does not increase the occurrence of cardiovascular events in patients undergoing cerebral aneurysm surgery: findings from the intraoperative hypothermia for aneurysm surgery trial. Anesthesiology. 2010;113(2):327\u201342.","journal-title":"Anesthesiology"},{"issue":"2","key":"1019_CR9","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1056\/NEJMoa040975","volume":"352","author":"MM Todd","year":"2005","unstructured":"Todd MM, et al. Mild intraoperative hypothermia during surgery for intracranial aneurysm. N Engl J Med. 2005;352(2):135\u201345.","journal-title":"N Engl J Med"},{"issue":"3","key":"1019_CR10","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4103\/joacp.JOACP_334_16","volume":"33","author":"B Bindu","year":"2017","unstructured":"Bindu B, Bindra A, Rath G. Temperature management under general anesthesia: compulsion or option. J Anaesthesiol Clin Pharmacol. 2017;33(3):306\u201316.","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"1019_CR11","first-page":"57","volume":"12","author":"SF Morrison","year":"2018","unstructured":"Morrison SF, Nakamura K. Central mechanisms for thermoregulation. Annu Rev Physiol. 2018;12:57.","journal-title":"Annu Rev Physiol"},{"key":"1019_CR12","volume-title":"StatPearls physiology, temperature regulation","author":"EV Osilla","year":"2018","unstructured":"Osilla EV, Sharma S. StatPearls physiology, temperature regulation. Treasure Island: StatPearls; 2018."},{"issue":"1","key":"1019_CR13","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1152\/ajpregu.00668.2006","volume":"292","author":"AA Romanovsky","year":"2007","unstructured":"Romanovsky AA. Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R37\u201346.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"1019_CR14","first-page":"227","volume":"138","author":"KC Wong","year":"1983","unstructured":"Wong KC. Physiology and pharmacology of hypothermia. West J Med. 1983;138(2):227\u201332.","journal-title":"West J Med"},{"issue":"2","key":"1019_CR15","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/00000542-199408000-00004","volume":"81","author":"M Ozaki","year":"1994","unstructured":"Ozaki M, et al. Thermoregulatory thresholds during epidural and spinal anesthesia. Anesthesiology. 1994;81(2):282\u20138.","journal-title":"Anesthesiology"},{"key":"1019_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jclinane.2017.01.005","volume":"38","author":"CA Shaw","year":"2017","unstructured":"Shaw CA, Steelman VM, Deberg J, Schweizer ML. Effectiveness of active and passive warming for the prevention of inadvertent hypothermia in patients receiving neuraxial anesthesia: a systematic review and meta-analysis of randomized controlled trials. J Clin Anesth. 2017;38:93\u2013104.","journal-title":"J Clin Anesth"},{"issue":"3","key":"1019_CR17","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1097\/00000542-199509000-00007","volume":"83","author":"A Kurz","year":"1995","unstructured":"Kurz A, Sessler DI, Christensen R, Dechert M. Heat Balance and Distribution during the Core-Temperature Plateau in Anesthetized Humans. Anesthesiology. 1995;83(3):491\u20139.","journal-title":"Anesthesiology"},{"key":"1019_CR18","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/fneur.2011.00004","volume":"2","author":"FP Gonz\u00e1lez-Ibarra","year":"2011","unstructured":"Gonz\u00e1lez-Ibarra FP, Varon J, L\u00f3pez-Meza EG. Therapeutic hypothermia: critical review of the molecular mechanisms of action. Front Neurol. 2011;2:4.","journal-title":"Front Neurol"},{"issue":"Suppl","key":"1019_CR19","doi-asserted-by":"publisher","first-page":"S186","DOI":"10.1097\/CCM.0b013e3181aa5241","volume":"37","author":"KH Polderman","year":"2009","unstructured":"Polderman KH. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med. 2009;37(Suppl):S186\u2013202.","journal-title":"Crit Care Med"},{"issue":"6","key":"1019_CR20","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/vaa.12299","volume":"42","author":"KA Otto","year":"2015","unstructured":"Otto KA. Therapeutic hypothermia applicable to cardiac surgery. Vet Anaesth Analg. 2015;42(6):559\u201369.","journal-title":"Vet Anaesth Analg"},{"issue":"4","key":"1019_CR21","doi-asserted-by":"publisher","first-page":"H2119","DOI":"10.1152\/ajpheart.00123.2007","volume":"293","author":"X-H Ning","year":"2007","unstructured":"Ning X-H, et al. Moderate hypothermia (30\u00b0C) maintains myocardial integrity and modifies response of cell survival proteins after reperfusion. Am J Physiol Heart Circ Physiol. 2007;293(4):H2119\u201328.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"1019_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1055\/s-0038-1642495","volume":"71","author":"AD Michelson","year":"1994","unstructured":"Michelson AD, et al. Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. Thromb Haemost. 1994;71(5):633\u201340.","journal-title":"Thromb Haemost"},{"issue":"1","key":"1019_CR23","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/01.anes.0000296719.73450.52","volume":"108","author":"S Rajagopalan","year":"2008","unstructured":"Rajagopalan S, Mascha E, Na J, Sessler DI. The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology. 2008;108(1):71\u20137.","journal-title":"Anesthesiology"},{"issue":"6","key":"1019_CR24","first-page":"561","volume":"27","author":"CJ van Oss","year":"1980","unstructured":"van Oss CJ, et al. Effect of temperature on the chemotaxis, phagocytic engulfment, digestion and O2 consumption of human polymorphonuclear leukocytes. J Reticuloendothel Sox. 1980;27(6):561\u20135.","journal-title":"J Reticuloendothel Sox"},{"issue":"Suppl 2","key":"1019_CR25","doi-asserted-by":"publisher","first-page":"A8","DOI":"10.1186\/cc11278","volume":"16","author":"KH Polderman","year":"2012","unstructured":"Polderman KH. Is therapeutic hypothermia immunosuppressive? Crit Care. 2012;16(Suppl 2):A8.","journal-title":"Crit Care"},{"issue":"2 Suppl","key":"1019_CR26","first-page":"29","volume":"49","author":"H Rintam\u00e4ki","year":"2007","unstructured":"Rintam\u00e4ki H. Human responses to cold. Alaska Med. 2007;49(2 Suppl):29\u201331.","journal-title":"Alaska Med"},{"issue":"3","key":"1019_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0188-4409(01)00272-7","volume":"32","author":"A Flores-Maldonado","year":"2001","unstructured":"Flores-Maldonado A, Medina-Escobedo CE, R\u00edos-Rodr\u00edguez HM, Fern\u00e1ndez-Dom\u00ednguez R. Mild perioperative hypothermia and the risk of wound infection. Arch Med Res. 2001;32(3):227\u201331.","journal-title":"Arch Med Res"},{"issue":"3","key":"1019_CR28","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.jamcollsurg.2007.04.042","volume":"205","author":"TL Hedrick","year":"2007","unstructured":"Hedrick TL, et al. Efficacy of protocol implementation on incidence of wound infection in colorectal operations. J Am Coll Surg. 2007;205(3):432\u20138.","journal-title":"J Am Coll Surg"},{"issue":"9","key":"1019_CR29","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1007\/s00101-007-1217-6","volume":"56","author":"AP Pietsch","year":"2007","unstructured":"Pietsch AP, Lindenblatt N, Klar E. Perioperative hypothermie. Der Anaesthes. 2007;56(9):936\u20139.","journal-title":"Der Anaesthes"},{"issue":"4","key":"1019_CR30","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1097\/SLA.0b013e31824b7e35","volume":"255","author":"MJ Seamon","year":"2012","unstructured":"Seamon MJ, et al. The effects of intraoperative hypothermia on surgical site infection. Ann Surg. 2012;255(4):789\u201395.","journal-title":"Ann Surg"},{"issue":"5","key":"1019_CR31","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/BF01691254","volume":"9","author":"A Koht","year":"1983","unstructured":"Koht A, Cane R, Cerullo LJ. Serum potassium levels during prolonged hypothermia. Intensive Care Med. 1983;9(5):275\u20137.","journal-title":"Intensive Care Med"},{"issue":"10","key":"1019_CR32","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/milmed\/163.10.719","volume":"163","author":"AW Zydlewski","year":"1998","unstructured":"Zydlewski AW, Hasbargen JA. Hypothermia-induced hypokalemia. Mil Med. 1998;163(10):719\u201321.","journal-title":"Mil Med"},{"issue":"1","key":"1019_CR33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/bjaceaccp\/mki064","volume":"6","author":"M Luscombe","year":"2006","unstructured":"Luscombe M, Andrzejowski JC. Clinical applications of induced hypothermia. Contin Educ Anaesth Crit Care Pain. 2006;6(1):23\u20137.","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"issue":"7","key":"1019_CR34","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1517\/17425255.2011.574127","volume":"7","author":"J Zhou","year":"2011","unstructured":"Zhou J, Poloyac SM. The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function. Expert Opin Drug Metab Toxicol. 2011;7(7):803\u201316.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"5","key":"1019_CR35","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1097\/00000542-199105000-00003","volume":"74","author":"T Heier","year":"1991","unstructured":"Heier T, Caldwell JE, Sessler DI, Miller RD. Mild intraoperative hypothermia increases duration of action and spontaneous recovery of vecuronium blockade during nitrous oxide-isoflurane anesthesia in humans. Anesthesiology. 1991;74(5):815\u20139.","journal-title":"Anesthesiology"},{"issue":"5","key":"1019_CR36","first-page":"1007","volume":"80","author":"K Leslie","year":"1995","unstructured":"Leslie K, Sessler DI, Bjorksten AR, Moayeri A. Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg. 1995;80(5):1007\u201314.","journal-title":"Anesth Analg"},{"issue":"3","key":"1019_CR37","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/00000542-200103000-00011","volume":"94","author":"M Liu","year":"2001","unstructured":"Liu M, Hu X, Liu J. The effect of hypothermia on isoflurane MAC in children. Anesthesiology. 2001;94(3):429\u201332.","journal-title":"Anesthesiology"},{"issue":"9","key":"1019_CR38","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1002\/j.1552-4604.1988.tb03229.x","volume":"28","author":"M Bansinath","year":"1988","unstructured":"Bansinath M, Turndorf H, Puig MM. Influence of hypo and hyperthermia on disposition of morphine. J Clin Pharmacol. 1988;28(9):860\u20134.","journal-title":"J Clin Pharmacol"},{"issue":"11","key":"1019_CR39","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1093\/bja\/59.11.1459","volume":"59","author":"MM Puig","year":"1987","unstructured":"Puig MM, et al. Effects of temperature on the interaction of morphine with opioid receptors. Br J Anaesth. 1987;59(11):1459\u201364.","journal-title":"Br J Anaesth"},{"issue":"3","key":"1019_CR40","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.cryobiol.2008.09.006","volume":"57","author":"Y-S Han","year":"2008","unstructured":"Han Y-S, et al. Changes in cardiovascular \u03b2-adrenoceptor responses during hypothermia. Cryobiology. 2008;57(3):246\u201350.","journal-title":"Cryobiology"},{"issue":"2","key":"1019_CR41","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/europace\/eup376","volume":"12","author":"JN Khan","year":"2010","unstructured":"Khan JN, Prasad N, Glancy JM. QTc prolongation during therapeutic hypothermia: are we giving it the attention it deserves? Europace. 2010;12(2):266\u201370.","journal-title":"Europace"},{"issue":"1","key":"1019_CR42","first-page":"1","volume":"6","author":"H Soleimanpour","year":"2014","unstructured":"Soleimanpour H, Rahmani F, Golzari SE, Safari S. Main complications of mild induced hypothermia after cardiac arrest: a review article. J Cardiovasc Thorac Res. 2014;6(1):1\u20138.","journal-title":"J Cardiovasc Thorac Res"},{"issue":"2","key":"1019_CR43","doi-asserted-by":"publisher","first-page":"e15499","DOI":"10.5812\/aapm.15499","volume":"4","author":"M Eydi","year":"2014","unstructured":"Eydi M, et al. Postoperative management of shivering: a comparison of pethidine vs. ketamine. Anesthesiol Pain Med. 2014;4(2):e15499.","journal-title":"Anesthesiol Pain Med"},{"key":"1019_CR44","first-page":"107","volume":"8","author":"SR Lewis","year":"2015","unstructured":"Lewis SR, Nicholson A, Smith AF, Alderson P. Alpha-2 adrenergic agonists for the prevention of shivering following general anaesthesia. Cochrane Database Syst Rev. 2015;8:107.","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"1019_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1089\/ther.2013.0015","volume":"3","author":"JD Raper","year":"2013","unstructured":"Raper JD, Wang HE. Urine output changes during postcardiac arrest therapeutic hypothermia. Ther Hypoth Temp Manag. 2013;3(4):173\u20137.","journal-title":"Ther Hypoth Temp Manag"},{"key":"1019_CR46","unstructured":"Cheung AT. Anesthesia for aortic surgery requiring deep hypothermia - UpToDate [Internet]. UpToDate. 2019. p. 1."},{"key":"1019_CR47","doi-asserted-by":"crossref","unstructured":"Galvin IM, et al. Cooling for cerebral protection during brain surgery. Cochrane Database of Syste Rev. 2015;(1):CD006638.","DOI":"10.1002\/14651858.CD006638.pub3"},{"issue":"3","key":"1019_CR48","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.bpa.2016.07.005","volume":"30","author":"KK Yeung","year":"2016","unstructured":"Yeung KK, et al. Organ protection during aortic cross-clamping. Best Pract Res Clin Anaesthesiol. 2016;30(3):305\u201315.","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"1","key":"1019_CR49","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s13063-018-2610-y","volume":"19","author":"J Presneill","year":"2018","unstructured":"Presneill J, et al. Statistical analysis plan for the POLAR-RCT: the Prophylactic hypOthermia trial to Lessen trAumatic bRain injury-Randomised Controlled Trial. Trials. 2018;19(1):259.","journal-title":"Trials"},{"key":"1019_CR50","unstructured":"Rittenberger JC, Callaway CW. Post-cardiac arrest management in adults - UpToDate [Internet]. UpToDate. 2019. p. 1."},{"key":"1019_CR51","unstructured":"Rajajee V. Management of acute severe traumatic brain injury - UpToDate [Internet]. UpToDate. 2019. p. 1."},{"key":"1019_CR52","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.wneu.2015.09.079","volume":"86","author":"S Alkabie","year":"2016","unstructured":"Alkabie S, Boileau AJ. The role of therapeutic hypothermia after traumatic spinal cord injury\u2014a systematic review. World Neurosurg. 2016;86:432\u201349.","journal-title":"World Neurosurg"},{"issue":"8","key":"1019_CR53","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1046\/j.1528-1157.2002.03902.x","volume":"43","author":"KM Karkar","year":"2002","unstructured":"Karkar KM, et al. Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. Epilepsia. 2002;43(8):932\u20135.","journal-title":"Epilepsia"},{"issue":"25","key":"1019_CR54","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1056\/NEJMoa1608193","volume":"375","author":"S Legriel","year":"2016","unstructured":"Legriel S, et al. Hypothermia for neuroprotection in convulsive status epilepticus. N Engl J Med. 2016;375(25):2457\u201367.","journal-title":"N Engl J Med"},{"issue":"1","key":"1019_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-015-0804-1","volume":"19","author":"C Vaity","year":"2015","unstructured":"Vaity C, Al-Subaie N, Cecconi M. Cooling techniques for targeted temperature management post-cardiac arrest. Crit Care. 2015;19(1):1\u20136.","journal-title":"Crit Care"},{"issue":"6","key":"1019_CR56","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s11940-012-0201-x","volume":"14","author":"SS Song","year":"2012","unstructured":"Song SS, Lyden PD. Overview of therapeutic hypothermia. Curr Trea Opt Neurol. 2012;14(6):541\u20138.","journal-title":"Curr Trea Opt Neurol"},{"issue":"4","key":"1019_CR57","first-page":"705","volume":"17","author":"A Baraka","year":"2004","unstructured":"Baraka A. Alpha-stat vs. pH-stat strategy during hypothermic cardiopulmonary bypass. Middle East J Anaesthesiol. 2004;17(4):705\u201312.","journal-title":"Middle East J Anaesthesiol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-01019-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-019-01019-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-01019-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T23:24:50Z","timestamp":1594423490000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-019-01019-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,12]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["1019"],"URL":"https:\/\/doi.org\/10.1007\/s12325-019-01019-z","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,12]]},"assertion":[{"value":"1 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}