{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:12:29Z","timestamp":1789726349351,"version":"4.0.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s12325-019-01124-z","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T06:01:16Z","timestamp":1572588076000},"page":"27-40","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Safety and Efficacy of Enoxaparin in Pregnancy: A Systematic Review and Meta-Analysis"],"prefix":"10.1007","volume":"37","author":[{"given":"Barry","family":"Jacobson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Rambiritch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara","family":"Paek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Sayre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poobalan","family":"Naidoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-4771","authenticated-orcid":false,"given":"Rory","family":"Leisegang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"issue":"10","key":"1124_CR1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-143-10-200511150-00006","volume":"143","author":"JA Heit","year":"2005","unstructured":"Heit JA, Kobbervig CE, James AH, Petterson TM, Bailey KR, Melton LJ. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Ann Intern Med. 2005;143(10):697\u2013706.","journal-title":"Ann Intern Med"},{"issue":"4","key":"1124_CR2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2008.02921.x","volume":"6","author":"E Pomp","year":"2008","unstructured":"Pomp E, Lenselink A, Rosendaal F, Doggen CJM. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. J Thromb Haemost. 2008;6(4):632\u20137.","journal-title":"J Thromb Haemost"},{"key":"1124_CR3","unstructured":"Knight M BK, Tuffnell D, Jayakody H, editors on behalf of MBRRACE-UK. Saving Lives, Improving Mothers\u2019 Care: Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2014\u201316. Oxford: National Perinatal Epidemiology Unit, University of Oxford; 2018."},{"issue":"18","key":"1124_CR4","first-page":"423","volume":"68","author":"EE Petersen","year":"2019","unstructured":"Petersen EE, Davis NL, Goodman D, et al. Vital signs: pregnancy-related deaths, United States, 2011\u20132015, and strategies for prevention, 13 States, 2013\u20132017. Morb Mortal Wkly Rep. 2019;68(18):423.","journal-title":"Morb Mortal Wkly Rep"},{"issue":"5","key":"1124_CR5","doi-asserted-by":"crossref","first-page":"489S","DOI":"10.1378\/chest.114.5_Supplement.489S","volume":"114","author":"J Hirsh","year":"1998","unstructured":"Hirsh J, Warkentin TE, Raschke R, Granger C, Ohman EM, Dalen JE. Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. Chest. 1998;114(5):489S\u2013510S.","journal-title":"Chest"},{"issue":"3","key":"1124_CR6","first-page":"539","volume":"51","author":"EM Ostrea","year":"2004","unstructured":"Ostrea EM, Mantaring JB, Silvestre MA. Drugs that affect the fetus and newborn infant via the placenta or breast milk. Pediatr Clin. 2004;51(3):539\u201379.","journal-title":"Pediatr Clin"},{"issue":"1","key":"1124_CR7","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/AOG.0000000000002706","volume":"132","author":"American College of Obstetricians and Gynecologists","year":"2018","unstructured":"American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 196: thromboembolism in Pregnancy. Obstet Gynecol. 2018;132(1):e1\u201317. https:\/\/doi.org\/10.1097\/AOG.0000000000002706 .","journal-title":"Obstet Gynecol"},{"issue":"2","key":"1124_CR8","doi-asserted-by":"crossref","first-page":"e691S","DOI":"10.1378\/chest.11-2300","volume":"141","author":"SM Bates","year":"2012","unstructured":"Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos A-M, Vandvik PO. VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141(2):e691S\u2013736S.","journal-title":"Chest"},{"issue":"22","key":"1124_CR9","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1182\/bloodadvances.2018024802","volume":"2","author":"SM Bates","year":"2018","unstructured":"Bates SM, Rajasekhar A, Middeldorp S, et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. Blood Adv. 2018;2(22):3317\u201359. https:\/\/doi.org\/10.1182\/bloodadvances.2018024802 .","journal-title":"Blood Adv"},{"issue":"6","key":"1124_CR10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1701-2163(15)30569-7","volume":"36","author":"WS Chan","year":"2014","unstructured":"Chan WS, Rey E, Kent NE, et al. Venous thromboembolism and antithrombotic therapy in pregnancy. J Obstet Gynaecol Can. 2014;36(6):527\u201353.","journal-title":"J Obstet Gynaecol Can"},{"key":"1124_CR11","unstructured":"Royal College of Obstetricians and Gynaecologists. Reducing the risk of thrombosis and embolism during pregnancy and the puerperium. Green-top Guideline. 2015(37a). London: College of Obstetricians and Gynaecologists."},{"key":"1124_CR12","unstructured":"Royal College of Obstetricians and Gynaecologists. Thromboembolic disease in pregnancy and the puerperium: acute management. Green-top Guideline. 2015(37b). London: College of Obstetricians and Gynaecologists."},{"issue":"34","key":"1124_CR13","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1093\/eurheartj\/ehy340","volume":"39","author":"V Regitz-Zagrosek","year":"2018","unstructured":"Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018;39(34):3165\u2013241. https:\/\/doi.org\/10.1093\/eurheartj\/ehy340 .","journal-title":"Eur Heart J"},{"issue":"2","key":"1124_CR14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood-2005-02-0626","volume":"106","author":"IA Greer","year":"2005","unstructured":"Greer IA, Nelson-Piercy C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood. 2005;106(2):401\u20137.","journal-title":"Blood"},{"key":"1124_CR15","volume-title":"CRD\u2019s guidance for undertaking reviews in health care","author":"Centre for Reviews and Dissemination","year":"2009","unstructured":"Centre for Reviews and Dissemination. CRD\u2019s guidance for undertaking reviews in health care. Layerthorpe: University of York, Centre for Reviews and Dissemination; 2009."},{"key":"1124_CR16","volume-title":"Guide to the methods of technology appraisal","author":"NICE","year":"2008","unstructured":"NICE. Guide to the methods of technology appraisal. London: National Institute for Health and Clinical Excellence (NICE); 2008."},{"key":"1124_CR17","unstructured":"Higgins J, Green S, editors. Cochrane handbook for systematic reviews of interventions version 5.1. 0. The Cochrane Collaboration. 2011. 2015."},{"issue":"4","key":"1124_CR18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","volume":"151","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264\u20139.","journal-title":"Ann Intern Med"},{"issue":"4","key":"1124_CR19","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.chest.2018.01.016","volume":"153","author":"PJ Mazzone","year":"2018","unstructured":"Mazzone PJ, Silvestri GA, Patel S, et al. Screening for lung cancer: chest guideline and expert panel report. Chest. 2018;153(4):954\u201385.","journal-title":"Chest"},{"key":"1124_CR20","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JP Higgins","year":"2011","unstructured":"Higgins JP, Altman DG, G\u00f8tzsche PC, et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.","journal-title":"BMJ"},{"key":"1124_CR21","unstructured":"Wells G. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis. http:\/\/www.ohrica\/programs\/clinical_epidemiology\/oxfordhtm . 2013. Accessed 30 Aug 2018."},{"issue":"3","key":"1124_CR22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/01443610802042688","volume":"28","author":"A Badawy","year":"2008","unstructured":"Badawy A, Khiary M, Sherif L, Hassan M, Ragab A, Abdelall I. Low-molecular weight heparin in patients with recurrent early miscarriages of unknown aetiology. J Obstet Gynaecol. 2008;28(3):280\u20134.","journal-title":"J Obstet Gynaecol"},{"issue":"21","key":"1124_CR23","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1182\/blood-2010-01-267252","volume":"115","author":"Peter Clark","year":"2010","unstructured":"Clark P, Walker ID, Langhorne P, et al. SPIN: the Scottish Pregnancy Intervention Study: a multicentre randomised controlled trial of low molecular weight heparin and low dose aspirin in women with recurrent miscarriage. Blood. 2010;115(21):4162\u20137.","journal-title":"Blood"},{"issue":"2","key":"1124_CR24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.fertnstert.2005.12.068","volume":"86","author":"M Dolitzky","year":"2006","unstructured":"Dolitzky M, Inbal A, Segal Y, Weiss A, Brenner B, Carp H. A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages. Fertil Steril. 2006;86(2):362\u20136.","journal-title":"Fertil Steril"},{"issue":"1","key":"1124_CR25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1756-0500-7-23","volume":"7","author":"MO Elmahashi","year":"2014","unstructured":"Elmahashi MO, Elbareg AM, Essadi FM, Ashur BM, Adam I. Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage. BMC Res Notes. 2014;7(1):23.","journal-title":"BMC Res Notes"},{"issue":"1","key":"1124_CR26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00404-007-0527-x","volume":"278","author":"M Fawzy","year":"2008","unstructured":"Fawzy M, Shokeir T, El-Tatongy M, Warda O, El-Refaiey A-AA, Mosbah A. Treatment options and pregnancy outcome in women with idiopathic recurrent miscarriage: a randomized placebo-controlled study. Arch Gynecol Obstet. 2008;278(1):33\u20138.","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"1124_CR27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijgo.2010.09.010","volume":"112","author":"UM Fouda","year":"2011","unstructured":"Fouda UM, Sayed AM, Abdou AMA, Ramadan DI, Fouda IM, Zaki MM. Enoxaparin versus unfractionated heparin in the management of recurrent abortion secondary to antiphospholipid syndrome. Int J Gynecol Obstet. 2011;112(3):211\u20135.","journal-title":"Int J Gynecol Obstet"},{"issue":"4","key":"1124_CR28","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.ajog.2004.03.039","volume":"191","author":"S Gates","year":"2004","unstructured":"Gates S, Brocklehurst P, Ayers S, Bowler U. Thromboprophylaxis and pregnancy: two randomized controlled pilot trials that used low-molecular-weight heparin. Am J Obstet Gynecol. 2004;191(4):1296\u2013303.","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"1124_CR29","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3109\/14767058.2011.600366","volume":"25","author":"A Giancotti","year":"2012","unstructured":"Giancotti A, Torre RL, Spagnuolo A, et al. Efficacy of three different antithrombotic regimens on pregnancy outcome in pregnant women affected by recurrent pregnancy loss. J Maternal Fetal Neonatal Med. 2012;25(7):1191\u20134.","journal-title":"J Maternal Fetal Neonatal Med"},{"issue":"04","key":"1124_CR30","first-page":"771","volume":"103","author":"J-C Gris","year":"2010","unstructured":"Gris J-C, Chauleur C, Faillie J-L, et al. Enoxaparin for the secondary prevention of placental vascular complications in women with abruptio placentae. Thromb Haemost. 2010;103(04):771\u20139.","journal-title":"Thromb Haemost"},{"issue":"06","key":"1124_CR31","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1160\/TH10-09-0591","volume":"105","author":"J-C Gris","year":"2011","unstructured":"Gris J-C, Chauleur C, Molinari N, et al. Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. Thromb Haemost. 2011;105(06):1053\u201361.","journal-title":"Thromb Haemost"},{"issue":"10","key":"1124_CR32","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1182\/blood-2003-12-4250","volume":"103","author":"J-C Gris","year":"2004","unstructured":"Gris J-C, Mercier E, Qu\u00e9r\u00e9 I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood. 2004;103(10):3695\u20139.","journal-title":"Blood"},{"issue":"3","key":"1124_CR33","doi-asserted-by":"crossref","first-page":"296.e1","DOI":"10.1016\/j.ajog.2017.01.014","volume":"216","author":"KM Groom","year":"2017","unstructured":"Groom KM, McCowan LM, Mackay LK, et al. Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial. Am J Obstet Gynecol. 2017;216(3):296.e1\u201314.","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"1124_CR34","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/AOG.0000000000001673","volume":"128","author":"B Haddad","year":"2016","unstructured":"Haddad B, Winer N, Chitrit Y, et al. Enoxaparin and aspirin compared with aspirin alone to prevent placenta-mediated pregnancy complications. Obstet Gynecol. 2016;128(5):1053\u201363.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"1124_CR35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7196\/SAJOG.2017.v23i1.1112","volume":"23","author":"E Khan","year":"2017","unstructured":"Khan E, Basharat A, Jamil M, Ayub S, Khan M. Preventive role of low-molecular-weight heparin in unexplained recurrent pregnancy loss. S Afr J Obstet Gynaecol. 2017;23(1):17\u20139.","journal-title":"S Afr J Obstet Gynaecol"},{"issue":"3","key":"1124_CR36","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.mefs.2013.12.004","volume":"19","author":"KAA Mohamed","year":"2014","unstructured":"Mohamed KAA, Saad AS. Enoxaparin and aspirin therapy for recurrent pregnancy loss due to anti-phospholipid syndrome (APS). Middle East Fertil Soc J. 2014;19(3):176\u201382.","journal-title":"Middle East Fertil Soc J"},{"issue":"3","key":"1124_CR37","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.fertnstert.2004.11.002","volume":"83","author":"LS Noble","year":"2005","unstructured":"Noble LS, Kutteh WH, Lashey N, Franklin RD, Herrada J. Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin. Fertil Steril. 2005;83(3):684\u201390.","journal-title":"Fertil Steril"},{"issue":"14","key":"1124_CR38","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1182\/blood-2014-11-610857","volume":"125","author":"Elisabeth Pasquier","year":"2015","unstructured":"Pasquier E, de Saint Martin L, Bohec C, et al. Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood. 2015;125(14):2200\u20135.","journal-title":"Blood"},{"issue":"4","key":"1124_CR39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/14647270801995431","volume":"11","author":"H Qublan","year":"2008","unstructured":"Qublan H, Amarin Z, Dabbas M, et al. Low-molecular-weight heparin in the treatment of recurrent IVF\u2013ET failure and thrombophilia: a prospective randomized placebo-controlled trial. Human Fertil. 2008;11(4):246\u201353.","journal-title":"Human Fertil"},{"issue":"7","key":"1124_CR40","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/humrep\/dep086","volume":"24","author":"B Urman","year":"2009","unstructured":"Urman B, Ata B, Yakin K, et al. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial. Hum Reprod. 2009;24(7):1640\u20137.","journal-title":"Hum Reprod"},{"issue":"02","key":"1124_CR41","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1160\/TH10-05-0334","volume":"105","author":"J Visser","year":"2011","unstructured":"Visser J, Ulander V-M, Helmerhorst FM, et al. Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. Thromb Haemost. 2011;105(02):295\u2013301.","journal-title":"Thromb Haemost"},{"issue":"3","key":"1124_CR42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0020-7292(00)00202-2","volume":"69","author":"J Bar","year":"2000","unstructured":"Bar J, Cohen-Sacher B, Hod M, Blickstein D, Lahav J, Merlob P. Low-molecular-weight heparin for thrombophilia in pregnant women. Int J Gynecol Obstet. 2000;69(3):209\u201313.","journal-title":"Int J Gynecol Obstet"},{"issue":"2","key":"1124_CR43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/10641950600745517","volume":"25","author":"F Sergio","year":"2006","unstructured":"Sergio F, Maria Clara DA, et al. Prophylaxis of recurrent preeclampsia: low-molecular-weight heparin plus low-dose aspirin versus low-dose aspirin alone. Hypertens Pregnancy. 2006;25(2):115\u201327.","journal-title":"Hypertens Pregnancy"},{"issue":"6","key":"1124_CR44","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1177\/0300060516675111","volume":"45","author":"P Merviel","year":"2017","unstructured":"Merviel P, Cabry R, Lourdel E, et al. Comparison of two preventive treatments for patients with recurrent miscarriages carrying a C677T methylenetetrahydrofolate reductase mutation: 5-year experience. J Int Med Res. 2017;45(6):1720\u201330.","journal-title":"J Int Med Res"},{"issue":"6","key":"1124_CR45","first-page":"1232","volume":"30","author":"H Yuksel","year":"2014","unstructured":"Yuksel H, Kayatas S, Boza AT, Api M, Ertekin AA, Cam C. Low molecular weight heparin use in unexplained recurrent miscarriage. Pak J Med Sci. 2014;30(6):1232.","journal-title":"Pak J Med Sci"},{"issue":"11","key":"1124_CR46","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1080\/14767058.2017.1419179","volume":"32","author":"Angelo Sirico","year":"2018","unstructured":"Sirico A, Saccone G, Maruotti GM, et al. Low molecular weight heparin use during pregnancy and risk of postpartum hemorrhage: a systematic review and meta-analysis. J Maternal Fetal Neonatal Med. 2019;32(11):1893\u20131900.","journal-title":"The Journal of Maternal-Fetal & Neonatal Medicine"},{"key":"1124_CR47","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd004734.pub4","author":"PG de Jong","year":"2014","unstructured":"de Jong PG, Kaandorp S, Di Nisio M, Goddijn M, Middeldorp S. Aspirin and\/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. Cochrane Database Syst Rev. 2014. https:\/\/doi.org\/10.1002\/14651858.cd004734.pub4 .","journal-title":"Cochrane Database Syst Rev"},{"issue":"45","key":"1124_CR48","doi-asserted-by":"publisher","first-page":"e1732","DOI":"10.1097\/MD.0000000000001732","volume":"94","author":"T Zhang","year":"2015","unstructured":"Zhang T, Ye X, Zhu T, et al. Antithrombotic treatment for recurrent miscarriage: Bayesian network meta-analysis and systematic review. Medicine (Baltimore). 2015;94(45):e1732. https:\/\/doi.org\/10.1097\/MD.0000000000001732 .","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"1124_CR49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s13063-015-0719-9","volume":"16","author":"PG de Jong","year":"2015","unstructured":"de Jong PG, Quenby S, Bloemenkamp KW, et al. ALIFE2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia-study protocol for a randomized controlled trial. Trials. 2015;16(1):208.","journal-title":"Trials"},{"issue":"11","key":"1124_CR50","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s40264-017-0573-7","volume":"40","author":"M Shlomo","year":"2017","unstructured":"Shlomo M, Gorodischer R, Daniel S, et al. The fetal safety of enoxaparin use during pregnancy: a population-based retrospective cohort study. Drug Saf. 2017;40(11):1147\u201355.","journal-title":"Drug Saf"},{"issue":"6","key":"1124_CR51","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0049-3848(84)90260-3","volume":"34","author":"F Forestier","year":"1984","unstructured":"Forestier F, Daffos F, Capella-Pavlovsky M. Low molecular weight heparin (PK 10169) does not cross the placenta during the second trimester of pregnancy study by direct fetal blood sampling under ultrasound. Thromb Res. 1984;34(6):557\u201360.","journal-title":"Thromb Res"},{"issue":"5","key":"1124_CR52","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000054140","volume":"30","author":"C Dimitrakakis","year":"2000","unstructured":"Dimitrakakis C, Papageorgiou P, Papageorgiou I, Antzaklis A, Sakarelou N, Michalas S. Absence of transplacental passage of the low molecular weight heparin enoxaparin. Pathophysiol Haemost Thromb. 2000;30(5):243\u20138.","journal-title":"Pathophysiol Haemost Thromb"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-01124-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-019-01124-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-01124-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T05:46:08Z","timestamp":1664775968000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-019-01124-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["1124"],"URL":"https:\/\/doi.org\/10.1007\/s12325-019-01124-z","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]},"assertion":[{"value":"23 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}