{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:31:43Z","timestamp":1788496303584,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Kyowa Kirin"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s12325-019-01178-z","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T16:03:47Z","timestamp":1585670627000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["X-Linked Hypophosphataemic Rickets and Growth"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-8252","authenticated-orcid":false,"given":"Fernando","family":"Santos Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"1178_CR1","first-page":"1743","volume-title":"The metabolic basis of inherit disease","author":"H Ramussen","year":"1983","unstructured":"Ramussen H, Anast C. Familial hypophosphatemic rickets and vitamin D-dependent rickets. In: Wyngaarden JB, Fredericson DS, Goldstain JL, Brrown MS, editors. The metabolic basis of inherit disease. New York: McGraw-Hill; 1983. p. 1743\u201373."},{"issue":"10","key":"1178_CR2","first-page":"3615","volume":"83","author":"PH Dixon","year":"1998","unstructured":"Dixon PH, Christie PT, Wooding C, et al. Mutational analysis of PHEX gene in X-linked hypophosphatemia. J Clin Endocrinol Metab. 1998;83(10):3615\u201323.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1178_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/ndt\/14.2.333","volume":"14","author":"HS Tenenhouse","year":"1999","unstructured":"Tenenhouse HS. X-linked hypophosphataemia: a homologous disorder in humans and mice. Nephrol Dial Transplant. 1999;14(2):333\u201341.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"1178_CR4","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11154-008-9075-3","volume":"9","author":"M Bastepe","year":"2008","unstructured":"Bastepe M, Juppner H. Inherited hypophosphatemic disorders in children and the evolving mechanisms of phosphate regulation. Rev Endocr Metab Disord. 2008;9(2):171\u201380.","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"1178_CR5","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1615\/CritRevEukarGeneExpr.v22.i1.50","volume":"22","author":"PS Rowe","year":"2012","unstructured":"Rowe PS. Regulation of bone-renal mineral and energy metabolism: the PHEX, FGF23, DMP1, MEPE ASARM pathway. Crit Rev Eukaryot Gene Expr. 2012;22(1):61\u201386.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"1","key":"1178_CR6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11154-017-9408-1","volume":"18","author":"R Fuente","year":"2017","unstructured":"Fuente R, Gil-Pe\u00f1a H, Claramunt-Taberner D, et al. X-linked hypophosphatemia and growth. Rev Endocr Metab Disord. 2017;18(1):107\u201315.","journal-title":"Rev Endocr Metab Disord"},{"issue":"Suppl 1","key":"1178_CR7","first-page":"119","volume":"15","author":"M Cagnoli","year":"2017","unstructured":"Cagnoli M, Richter R, Bohm P, Knye K, Empting S, Mohnike K. Spontaneous growth and effect of early therapy with calcitriol and phosphate in X-linked hypophosphatemic rickets. Pediatr Endocrinol Rev. 2017;15(Suppl 1):119\u201322.","journal-title":"Pediatr Endocrinol Rev"},{"issue":"2","key":"1178_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00467-010-1705-9","volume":"26","author":"M Zivicnjak","year":"2011","unstructured":"Zivicnjak M, Schnabel D, Billing H, et al. Age-related stature and linear body segments in children with X-linked hypophosphatemic rickets. Pediatr Nephrol. 2011;26(2):223\u201331.","journal-title":"Pediatr Nephrol"},{"issue":"8","key":"1178_CR9","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1210\/jc.2003-030036","volume":"88","author":"O Makitie","year":"2003","unstructured":"Makitie O, Doria A, Kooh SW, Cole WG, Daneman A, Sochett E. Early treatment improves growth and biochemical and radiographic outcome in X-linked hypophosphatemic rickets. J Clin Endocrinol Metab. 2003;88(8):3591\u20137.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1178_CR10","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1067\/mpd.2001.108955","volume":"138","author":"GI Baroncelli","year":"2001","unstructured":"Baroncelli GI, Bertelloni S, Ceccarelli C, Saggese G. Effect of growth hormone treatment on final height, phosphate metabolism, and bone mineral density in children with X-linked hypophosphatemic rickets. J Pediatr. 2001;138(2):236\u201343.","journal-title":"J Pediatr"},{"issue":"4","key":"1178_CR11","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1530\/eje.0.1490317","volume":"149","author":"SM Sch\u00fctt","year":"2003","unstructured":"Sch\u00fctt SM, Schumacher M, Holterhus PM, Felgenhauer S, Hiort O. Effect of GH replacement therapy in two male siblings with combined X-linked hypophosphatemia and partial GH deficiency. Eur J Endocrinol. 2003;149(4):317\u201321.","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"1178_CR12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1056\/NEJM196909042811001","volume":"281","author":"SL McNair","year":"1969","unstructured":"McNair SL, Stickler GB. Growth in familial hypophosphatemic vitamin-D-resistant rickets. N Engl J Med. 1969;281(10):512\u20136.","journal-title":"N Engl J Med"},{"issue":"6","key":"1178_CR13","doi-asserted-by":"publisher","first-page":"e593","DOI":"10.1542\/peds.113.6.e593","volume":"113","author":"D Haffner","year":"2004","unstructured":"Haffner D, Nissel R, Wuhl E, Mehls O. Effects of growth hormone treatment on body proportions and final height among small children with X-linked hypophosphatemic rickets. Pediatrics. 2004;113(6):e593\u20136.","journal-title":"Pediatrics"},{"issue":"1","key":"1178_CR14","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1530\/EC-13-0103","volume":"3","author":"A Linglart","year":"2014","unstructured":"Linglart A, Biosse-Duplan M, Briot K, et al. Therapeutic management of hypophosphatemic rickets from infancy to adulthood. Endocr Connect. 2014;3(1):R13\u201330.","journal-title":"Endocr Connect"},{"issue":"4","key":"1178_CR15","first-page":"839","volume":"76","author":"NE Friedman","year":"1993","unstructured":"Friedman NE, Lobaugh B, Drezner MK. Effects of calcitriol and phosphorus therapy on the growth of patients with X-linked hypophosphatemia. J Clin Endocrinol Metab. 1993;76(4):839\u201344.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1178_CR16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/01.bpo.0000218531.66856.b7","volume":"26","author":"E Novais","year":"2006","unstructured":"Novais E, Stevens PM. Hypophosphatemic rickets: the role of hemiepiphysiodesis. J Pediatr Orthop. 2006;26(2):238\u201344.","journal-title":"J Pediatr Orthop"},{"issue":"10","key":"1178_CR17","first-page":"1165","volume":"145","author":"DM Wilson","year":"1991","unstructured":"Wilson DM, Lee PD, Morris AH, et al. Growth hormone therapy in hypophosphatemic rickets. Am J Dis Child. 1991;145(10):1165\u201370.","journal-title":"Am J Dis Child"},{"issue":"7","key":"1178_CR18","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1210\/jc.2015-1551","volume":"100","author":"EA Imel","year":"2015","unstructured":"Imel EA, Zhang X, Ruppe MD, et al. Prolonged correction of serum phosphorus in adults with X-linked hypophosphatemia using monthly doses of KRN23. J Clin Endocrinol Metab. 2015;100(7):2565\u201373.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1178_CR19","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/jbmr.1810","volume":"28","author":"S W\u00f6hrle","year":"2013","unstructured":"W\u00f6hrle S, Henninger C, Bonny O, et al. Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. J Bone Miner Res. 2013;28(4):899\u2013911.","journal-title":"J Bone Miner Res"},{"issue":"12","key":"1178_CR20","doi-asserted-by":"publisher","first-page":"E2097","DOI":"10.1210\/jc.2011-0399","volume":"96","author":"M Zivicnjak","year":"2011","unstructured":"Zivicnjak M, Schnabel D, Staude H, et al. Three-year growth hormone treatment in short children with X-linked hypophosphatemic rickets: effects on linear growth and body disproportion. J Clin Endocrinol Metab. 2011;96(12):E2097\u2013105.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1178_CR21","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00467-017-3820-3","volume":"33","author":"N Meyerhoff","year":"2018","unstructured":"Meyerhoff N, Haffner D, Staude H, et al. Effects of growth hormone treatment on adult height in severely short children with X-linked hypophosphatemic rickets. Pediatr Nephrol. 2018;33(3):447\u201356.","journal-title":"Pediatr Nephrol"},{"issue":"21","key":"1178_CR22","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1056\/NEJMoa1714641","volume":"378","author":"TO Carpenter","year":"2018","unstructured":"Carpenter TO, Whyte MP, Imel EA, et al. Burosumab therapy in children with X-linked hypophosphatemia. N Engl J Med. 2018;378(21):1987\u201398.","journal-title":"N Engl J Med"},{"issue":"6","key":"1178_CR23","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/jor.1100140613","volume":"14","author":"NJ Wilsman","year":"1996","unstructured":"Wilsman NJ, Farnum CE, Leiferman EM, Fry M, Barreto C. Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics. J Orthop Res. 1996;14(6):927\u201336.","journal-title":"J Orthop Res"},{"key":"1178_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.bone.2018.08.004","volume":"116","author":"R Fuente","year":"2018","unstructured":"Fuente R, Gil-Pena H, Claramunt-Taberner D, et al. Marked alterations in the structure, dynamics and maturation of growth plate likely explain growth retardation and bone deformities of young Hyp mice. Bone. 2018;116:187\u201395.","journal-title":"Bone"},{"issue":"4","key":"1178_CR25","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.bone.2003.12.015","volume":"34","author":"D Miao","year":"2004","unstructured":"Miao D, Bai X, Panda DK, Karaplis AC, Goltzman D, McKee MD. Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice. Bone. 2004;34(4):638\u201347.","journal-title":"Bone"},{"issue":"27","key":"1178_CR26","doi-asserted-by":"publisher","first-page":"9637","DOI":"10.1073\/pnas.0502249102","volume":"102","author":"Y Sabbagh","year":"2005","unstructured":"Sabbagh Y, Carpenter TO, Demay MB. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proc Natl Acad Sci USA. 2005;102(27):9637\u201342.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"1178_CR27","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1074\/jbc.M112.410043","volume":"288","author":"M Kawai","year":"2013","unstructured":"Kawai M, Kinoshita S, Kimoto A, et al. FGF23 suppresses chondrocyte proliferation in the presence of soluble alpha-Klotho both in vitro and in vivo. J Biol Chem. 2013;288(4):2414\u201327.","journal-title":"J Biol Chem"},{"issue":"4","key":"1178_CR28","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1210\/en.2011-1831","volume":"153","author":"MY Zhang","year":"2012","unstructured":"Zhang MY, Ranch D, Pereira RC, Armbrecht HJ, Portale AA, Perwad F. Chronic inhibition of ERK1\/2 signaling improves disordered bone and mineral metabolism in hypophosphatemic (Hyp) mice. Endocrinology. 2012;153(4):1806\u201316.","journal-title":"Endocrinology"},{"issue":"7","key":"1178_CR29","doi-asserted-by":"publisher","first-page":"8349","DOI":"10.1096\/fj.201802007R","volume":"33","author":"R Fuente","year":"2019","unstructured":"Fuente R, Gil-Pe\u00f1a H, Claramunt-Taberner D, et al. MAPK inhibition and growth hormone: a promising therapy in XLH. FASEB J. 2019;33(7):8349\u201362.","journal-title":"FASEB J"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-01178-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-019-01178-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-019-01178-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T23:32:49Z","timestamp":1617147169000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-019-01178-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"references-count":29,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["1178"],"URL":"https:\/\/doi.org\/10.1007\/s12325-019-01178-z","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,31]]},"assertion":[{"value":"11 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}