{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:59:43Z","timestamp":1780473583665,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100004286","name":"Santen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004286","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s12325-020-01239-8","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T06:03:06Z","timestamp":1582005786000},"page":"1436-1451","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost\/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study"],"prefix":"10.1007","volume":"37","author":[{"given":"Francesco","family":"Oddone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"K\u00f3thy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Holl\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The VISIONARY Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Faschinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Holl\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Nemeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Bator","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Tsorbatzoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Acs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ferencz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Sohajda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeno","family":"Toth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Volner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Biro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Facsk\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Nemes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Berta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Elek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Vetrugno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Iester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Marchini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Scorcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Staurenghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Salgarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bettin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Figus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Luca","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"De Cilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Grundmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Linavska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasma","family":"Volksone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guna","family":"Laganovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Baumane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lemij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell Gunnar","family":"Gundersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Zimina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery","family":"Erichev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Karlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Zakharova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Panova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Malyugin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inaki Rodriguez","family":"Aguirrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Lopez\u2013Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Moreno","family":"Valladares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Benitez","family":"del Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Parrilla","family":"Vallejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Garcia","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso Anton","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Torregrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Loscos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Kolko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejaz","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Broadway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Claridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ruben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kirwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Nita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micheal","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areeb","family":"Moosavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J. W.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kinsella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"1239_CR1","unstructured":"International Council of Ophthalmology. Guidelines for glaucoma care. 2016. http:\/\/www.icoph.org\/downloads\/ICOGlaucomaGuidelines.pdf. Accessed 7 Nov 2019."},{"key":"1239_CR2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/S0002-9394(98)00272-4","volume":"126","author":"Collaborative Normal-Tension Glaucoma Study Group","year":"1998","unstructured":"Collaborative Normal-Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma Study Group. Am J Ophthalmol. 1998;126:498\u2013505.","journal-title":"Am J Ophthalmol"},{"key":"1239_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","volume":"130","author":"The AGIS Investigators","year":"2000","unstructured":"The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol. 2000;130:429\u201340.","journal-title":"Am J Ophthalmol"},{"key":"1239_CR4","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","volume":"120","author":"A Heijl","year":"2002","unstructured":"Heijl A, Leske MC, Bengtsson B, et al. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2002;120:1268\u201379.","journal-title":"Arch Ophthalmol"},{"key":"1239_CR5","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1016\/S0161-6420(01)00874-0","volume":"108","author":"NK Janz","year":"2001","unstructured":"Janz NK, Wren PA, Lichter PR, et al. The Collaborative Initial Glaucoma Treatment Study: interim quality of life findings after initial medical or surgical treatment of glaucoma. Ophthalmology. 2001;108:1954\u201365.","journal-title":"Ophthalmology"},{"key":"1239_CR6","unstructured":"European Glaucoma Society. Terminology and guidelines for glaucoma. 2014. https:\/\/www.eugs.org\/eng\/egs_guidelines_download.asp Accessed Oct 2019."},{"issue":"1","key":"1239_CR7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s40265-017-0843-9","volume":"78","author":"G Holl\u00f3","year":"2018","unstructured":"Holl\u00f3 G, Katsanos A, Boboridis KG, Irkec M, Konstas AG. Preservative-free prostaglandin analogs and prostaglandin\/timolol fixed combinations in the treatment of glaucoma: efficacy, safety and potential advantages. Drugs. 2018;78(1):39\u201364.","journal-title":"Drugs"},{"issue":"1","key":"1239_CR8","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1016\/j.survophthal.2008.08.011","volume":"53","author":"R Tabet","year":"2008","unstructured":"Tabet R, Stewart WC, Feldman R, Konstas AG. A review of additivity to prostaglandin analogs: fixed and unfixed combinations. Surv Ophthalmol. 2008;53(1):S85\u201392.","journal-title":"Surv Ophthalmol"},{"issue":"12","key":"1239_CR9","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1517\/14656566.2014.936850","volume":"15","author":"G Holl\u00f3","year":"2014","unstructured":"Holl\u00f3 G, Topouzis F, Fechtner RD. Fixed-combination intraocular pressure lowering therapy for glaucoma and ocular hypertension: advantages in clinical practice. Expert Opin Pharmacother. 2014;15(12):1737\u201347.","journal-title":"Expert Opin Pharmacother"},{"key":"1239_CR10","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1080\/14656566.2018.1534958","volume":"19","author":"AG Konstas","year":"2018","unstructured":"Konstas AG, Katsanos A, Athanasopoulos GP, et al. Preservative-free tafluprost\/timolol fixed combination: comparative 24-h efficacy administered morning or evening in open-angle glaucoma patients. Expert Opin Pharmacother. 2018;19:1981\u20138.","journal-title":"Expert Opin Pharmacother"},{"key":"1239_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5301\/ejo.5000077","volume":"22","author":"AGP Konstas","year":"2012","unstructured":"Konstas AGP, Haidich AB, Rossetti L, et al. Prostaglandin-timolol fixed combinations efficacy: myth or reality? Editorial. Eur J Ophthalmol. 2012;22:1\u20134.","journal-title":"Eur J Ophthalmol"},{"key":"1239_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.5301\/ejo.5000009","volume":"22","author":"F Aptel","year":"2012","unstructured":"Aptel F, Cucherat M, Denis P. Efficacy and tolerability of prostaglandin-timolol fixed combinations: a meta-analysis of randomized clinical trials. Eur J Ophthalmol. 2012;22:5\u201318.","journal-title":"Eur J Ophthalmol"},{"key":"1239_CR13","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1089\/jop.2012.0186","volume":"29","author":"L Quaranta","year":"2013","unstructured":"Quaranta L, Biagioli E, Riva I, et al. Prostaglandin analogs and timolol-fixed versus unfixed combinations or monotherapy for open-angle glaucoma: a systematic review and meta-analysis. J Ocul Pharmacol Ther. 2013;29:382\u20139.","journal-title":"J Ocul Pharmacol Ther"},{"key":"1239_CR14","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1007\/s12325-014-0163-3","volume":"31","author":"N Pfeiffer","year":"2014","unstructured":"Pfeiffer N, Traverso CE, Lorenz K, et al. A 6-month study comparing efficacy, safety, and tolerability of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% versus each of its individual preservative-free components. Adv Ther. 2014;31:1228\u201346.","journal-title":"Adv Ther"},{"key":"1239_CR15","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1089\/jop.2013.0229","volume":"30","author":"G Holl\u00f3","year":"2014","unstructured":"Holl\u00f3 G, Hommer A, Ant\u00f3n L\u00f3pez A, et al. Efficacy, safety, and tolerability of preservative-free fixed combination of tafluprost 0.0015%\/timolol 0.5% versus concomitant use of the ingredients. J Ocul Pharmacol Ther. 2014;30:468\u201375.","journal-title":"J Ocul Pharmacol Ther"},{"key":"1239_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1517\/14740338.2015.1010507","volume":"14","author":"G Holl\u00f3","year":"2015","unstructured":"Holl\u00f3 G, Katsanos A. Safety and tolerability of the tafluprost\/timolol fixed combination for the treatment of glaucoma. Expert Opin Drug Saf. 2015;14:609\u201317.","journal-title":"Expert Opin Drug Saf"},{"key":"1239_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s40262-015-0331-x","volume":"55","author":"K Kaarniranta","year":"2016","unstructured":"Kaarniranta K, Ikaheimo K, Mannermaa E, et al. Pharmacokinetics, efficacy, and safety of the preservative-free fixed combination of tafluprost 0.0015% and timolol 0.5% in healthy volunteers: a phase I comparison vs. the corresponding preservative-free monotherapies. Clin Pharmacokinet. 2016;55:485\u201394.","journal-title":"Clin Pharmacokinet"},{"key":"1239_CR18","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1007\/s40265-015-0476-9","volume":"75","author":"SM Hoy","year":"2015","unstructured":"Hoy SM. Tafluprost\/timolol: a review in open-angle glaucoma or ocular hypertension. Drugs. 2015;75:1807\u201313.","journal-title":"Drugs"},{"issue":"3","key":"1239_CR19","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/112067210701700311","volume":"17","author":"N Jaenen","year":"2007","unstructured":"Jaenen N, Baudouin C, Pouliquen P, Manni G, Figueiredo A, Zeyen T. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol. 2007;17(3):341\u20139.","journal-title":"Eur J Ophthalmol"},{"issue":"7","key":"1239_CR20","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/j.1755-3768.2008.01250.x","volume":"86","author":"C Baudouin","year":"2008","unstructured":"Baudouin C. Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma. Acta Ophthalmol. 2008;86(7):716\u201326.","journal-title":"Acta Ophthalmol"},{"issue":"4","key":"1239_CR21","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1136\/bjo.86.4.418","volume":"86","author":"PJ Pisella","year":"2002","unstructured":"Pisella PJ, Pouliquen P, Baudouin C. Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Br J Ophthalmol. 2002;86(4):418\u201323.","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"1239_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.joco.2018.07.003","volume":"31","author":"K Asiedu","year":"2018","unstructured":"Asiedu K, Abu SL. The impact of topical intraocular pressure lowering medications on the ocular surface of glaucoma patients: a review. J Curr Ophthalmol. 2018;31(1):8\u201315.","journal-title":"J Curr Ophthalmol"},{"issue":"11","key":"1239_CR23","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1080\/17425255.2016.1209481","volume":"12","author":"A Aguayo Bonniard","year":"2016","unstructured":"Aguayo Bonniard A, Yeung JY, Chan CC, Birt CM. Ocular surface toxicity from glaucoma topical medications and associated preservatives such as benzalkonium chloride (BAK). Expert Opin Drug Metab Toxicol. 2016;12(11):1279\u201389.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"1239_CR24","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/IJG.0b013e31825af67d","volume":"22","author":"C Boimer","year":"2013","unstructured":"Boimer C, Birt CM. Preservative exposure and surgical outcomes in glaucoma patients: the PESO study. J Glaucoma. 2013;22:730\u20135.","journal-title":"J Glaucoma"},{"key":"1239_CR25","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1097\/IJG.0b013e31815c5f4f","volume":"17","author":"EW Leung","year":"2008","unstructured":"Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma. 2008;17:350\u20135.","journal-title":"J Glaucoma"},{"key":"1239_CR26","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s00417-008-0881-9","volume":"246","author":"C Erb","year":"2008","unstructured":"Erb C, Gast U, Schremmer D. German register for glaucoma patients with dry eye. I. Basic outcome with respect to dry eye. Graefes Arch Clin Exp Ophthalmol. 2008;246:1593\u2013601.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1239_CR27","first-page":"441","volume":"6","author":"J Garcia-Feijoo","year":"2012","unstructured":"Garcia-Feijoo J, Sampaolesi JR. A multicentre evaluation of ocular surface disease prevalence in patients with glaucoma. Clin Ophthalmol. 2012;6:441\u20136.","journal-title":"Clin Ophthalmol"},{"key":"1239_CR28","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1080\/14740338.2018.1546842","volume":"17","author":"E Spitzer","year":"2018","unstructured":"Spitzer E, Cannon CP, Serruys PW. Should real-world evidence be incorporated into regulatory approvals? Expert Opin Drug Saf. 2018;17:1155\u20139.","journal-title":"Expert Opin Drug Saf."},{"issue":"4","key":"1239_CR29","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/cpt.1226","volume":"105","author":"HG Eichler","year":"2019","unstructured":"Eichler HG, Bloechl-Daum B, Broich K, et al. Data rich, information poor: can we use electronic health records to create a learning healthcare system for pharmaceuticals? Clin Pharmacol Ther. 2019;105(4):912\u201322.","journal-title":"Clin Pharmacol Ther"},{"key":"1239_CR30","unstructured":"Food and Drug Administration. Use of real-world evidence to support regulatory decision-making for medical devices: guidance for industry and Food and Drug Administration staff. 2018. http:\/\/www.fda.gov\/downloads\/MedicalDevices\/DeviceRegulationandGuidance\/GuidanceDocuments\/UCM513027.pdf. Accessed 7 Nov 2019."},{"key":"1239_CR31","unstructured":"NIDEK. Conversion table for representation of visual acuity. https:\/\/www.nidek-intl.com\/visual_acuity.html. Accessed 7 Nov 2019."},{"issue":"7","key":"1239_CR32","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1097\/00003226-200310000-00008","volume":"22","author":"AJ Bron","year":"2003","unstructured":"Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22(7):640\u201350.","journal-title":"Cornea"},{"issue":"313","key":"1239_CR33","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1080\/01621459.1966.10502021","volume":"61","author":"V Bhapkar","year":"1966","unstructured":"Bhapkar V. A note on the equivalence of two test criteria for hypotheses in categorical data. J Am Stat Assoc. 1966;61(313):228\u201335.","journal-title":"J Am Stat Assoc"},{"issue":"9","key":"1239_CR34","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1007\/s12325-014-0151-7","volume":"31","author":"G Holl\u00f3","year":"2014","unstructured":"Holl\u00f3 G, Vuorinen J, Tuominen J, Huttunen T, Ropo A, Pfeiffer N. Fixed-dose combination of tafluprost and timolol in the treatment of open-angle glaucoma and ocular hypertension: comparison with other fixed-combination products. Adv Ther. 2014;31(9):932\u201344.","journal-title":"Adv Ther"}],"updated-by":[{"DOI":"10.1007\/s12325-020-01407-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000}}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01239-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-020-01239-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01239-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T16:29:36Z","timestamp":1628612976000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-020-01239-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["1239"],"URL":"https:\/\/doi.org\/10.1007\/s12325-020-01239-8","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12325-020-01407-w","asserted-by":"object"}]},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"23 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2020","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original article, the The VISIONARY Study Group Principal Investigator Jose Javier Garcia-Medina.","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}