{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:59:39Z","timestamp":1786982379903,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Paolo Procacci Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12325-020-01422-x","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T06:04:05Z","timestamp":1595484245000},"page":"3692-3706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Vasopressor-Sparing Action of Methylene Blue in Severe Sepsis and Shock: A Narrative Review"],"prefix":"10.1007","volume":"37","author":[{"given":"Filomena","family":"Puntillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Giglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pasqualucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Brienza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Paladini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-2923","authenticated-orcid":false,"given":"Giustino","family":"Varrassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"issue":"9","key":"1422_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1056\/NEJMra1208623","volume":"369","author":"DC Angus","year":"2013","unstructured":"Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840\u201351. https:\/\/doi.org\/10.1056\/NEJMra1208623.","journal-title":"N Engl J Med"},{"issue":"1","key":"1422_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13613-019-0498-7","volume":"9","author":"TWL Scheeren","year":"2019","unstructured":"Scheeren TWL, Bakker J, DeBacker D, et al. Current use of vasopressors in septic shock. Ann Intensive Care. 2019;9(1):20. https:\/\/doi.org\/10.1186\/s13613-019-0498-7.","journal-title":"Ann Intensive Care"},{"issue":"5","key":"1422_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1177\/0885066609340519","volume":"24","author":"MW D\u00fcnser","year":"2009","unstructured":"D\u00fcnser MW, Hasibeder WR. Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J Intensive Care Med. 2009;24(5):293\u2013316. https:\/\/doi.org\/10.1177\/0885066609340519.","journal-title":"J Intensive Care Med"},{"issue":"3","key":"1422_CR4","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1002\/phar.2199","volume":"39","author":"MS Buckley","year":"2019","unstructured":"Buckley MS, Barletta JF, Smithburger PL, Radosevich JJ, Kane-Gill SL. Catecholamine vasopressor support sparing strategies in vasodilatory shock. Pharmacotherapy. 2019;39(3):382\u201398. https:\/\/doi.org\/10.1002\/phar.2199.","journal-title":"Pharmacotherapy"},{"key":"1422_CR5","first-page":"159","volume":"25","author":"G Varrassi","year":"1974","unstructured":"Varrassi G, Marino B, Cosmi EV. Influence of methylprednisolone sodium succinate on the microcirculation. Acta Anaesth It. 1974;25:159\u201371.","journal-title":"Acta Anaesth It"},{"issue":"Suppl 1","key":"1422_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13054-019-2433-6","volume":"23","author":"D De Backer","year":"2019","unstructured":"De Backer D, Foulon P. Minimizing catecholamines and optimizing perfusion. Crit Care. 2019;23(Suppl 1):149. https:\/\/doi.org\/10.1186\/s13054-019-2433-6.","journal-title":"Crit Care"},{"issue":"1","key":"1422_CR7","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13054-018-2102-1","volume":"22","author":"S Lambden","year":"2018","unstructured":"Lambden S, Creagh-Brown BC, Hunt J, Summers C, Forni LG. Definitions and pathophysiology of vasoplegic shock. Crit Care. 2018;22(1):174. https:\/\/doi.org\/10.1186\/s13054-018-2102-1.","journal-title":"Crit Care"},{"issue":"1","key":"1422_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.kint.2018.11.047","volume":"96","author":"JL Vincent","year":"2019","unstructured":"Vincent JL. Fluid management in the critically ill. Kidney Int. 2019;96(1):52\u20137. https:\/\/doi.org\/10.1016\/j.kint.2018.11.047.","journal-title":"Kidney Int"},{"issue":"3","key":"1422_CR9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/MCC.0b013e32811e14dd","volume":"13","author":"M Hadian","year":"2007","unstructured":"Hadian M, Pinsky M. Functional hemodynamic monitoring. Curr Opin Crit Care. 2007;13(3):318\u201323. https:\/\/doi.org\/10.1097\/MCC.0b013e32811e14dd.","journal-title":"Curr Opin Crit Care"},{"issue":"1","key":"1422_CR10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13054-015-0794-z","volume":"19","author":"M Leone","year":"2015","unstructured":"Leone M, Asfar P, Radermacher P, Vincent JL, Martin C. Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature. Crit Care. 2015;19(1):101. https:\/\/doi.org\/10.1186\/s13054-015-0794-z.","journal-title":"Crit Care"},{"issue":"12","key":"1422_CR11","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s00134-014-3525-z","volume":"40","author":"M Cecconi","year":"2014","unstructured":"Cecconi M, De Backer D, Antonelli M, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014;40(12):1795\u2013815. https:\/\/doi.org\/10.1007\/s00134-014-3525-z.","journal-title":"Intensive Care Med"},{"issue":"Suppl 3","key":"1422_CR12","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1186\/cc14726","volume":"19","author":"C Ince","year":"2015","unstructured":"Ince C. Hemodynamic coherence and the rationale for monitoring the microcirculation. Crit Care. 2015;19(Suppl 3):S8. https:\/\/doi.org\/10.1186\/cc14726.","journal-title":"Crit Care"},{"issue":"4","key":"1422_CR13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/cc4969","volume":"10","author":"P Elbers","year":"2006","unstructured":"Elbers P, Ince C. Mechanisms of critical illness\u2014classifying microcirculatory flow abnormalities in distributive shock. Crit Care. 2006;10(4):221. https:\/\/doi.org\/10.1186\/cc4969.","journal-title":"Crit Care"},{"issue":"829\u2013837","key":"1422_CR14","doi-asserted-by":"publisher","first-page":"837a","DOI":"10.1093\/eurheartj\/ehr304","volume":"33","author":"U Forstermann","year":"2012","unstructured":"Forstermann U, Sessa W. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(829\u2013837):837a\u2013. https:\/\/doi.org\/10.1093\/eurheartj\/ehr304.","journal-title":"Eur Heart J"},{"key":"1422_CR15","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/sj.ki.5002340","volume":"72","author":"A Cauwels","year":"2007","unstructured":"Cauwels A. Nitric oxide in shock. Kidney Int. 2007;72:557\u201365. https:\/\/doi.org\/10.1038\/sj.ki.5002340.","journal-title":"Kidney Int"},{"issue":"1","key":"1422_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12325-019-01148-5","volume":"37","author":"M Rekatsina","year":"2020","unstructured":"Rekatsina M, Paladini A, Piroli A, Zis P, Pergolizzi J, Varrassi G. Pathophysiology and therapeutic perspectives of oxidative stress and neurodegenerative diseases: a narrative review. Adv Ther. 2020;37(1):113\u201339. https:\/\/doi.org\/10.1007\/s12325-019-01148-5.","journal-title":"Adv Ther"},{"issue":"2\u20133","key":"1422_CR17","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/s0005-2728(99)00031-6","volume":"1411","author":"M Titheradge","year":"1999","unstructured":"Titheradge M. Nitric oxide in septic shock. Biochim Biophys Acta. 1999;1411(2\u20133):437\u201355. https:\/\/doi.org\/10.1016\/s0005-2728(99)00031-6.","journal-title":"Biochim Biophys Acta"},{"issue":"22","key":"1422_CR18","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.2174\/13816128113196660752","volume":"20","author":"Y Su","year":"2014","unstructured":"Su Y. Regulation of endothelial nitric oxide synthase activity by protein\u2013protein interaction. Curr Pharm Des. 2014;20(22):3514\u201320. https:\/\/doi.org\/10.2174\/13816128113196660752.","journal-title":"Curr Pharm Des"},{"key":"1422_CR19","doi-asserted-by":"publisher","first-page":"472","DOI":"10.2174\/138955708784223477","volume":"8","author":"SP Stawicki","year":"2008","unstructured":"Stawicki SP, Sims C, Sarani B, Grossman MD, Gracias VH. Methylene blue and vasoplegia: who, when, and how? Mini Rev Med Chem. 2008;8:472\u201390. https:\/\/doi.org\/10.2174\/138955708784223477.","journal-title":"Mini Rev Med Chem"},{"issue":"3","key":"1422_CR20","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s13181-013-0298-7","volume":"9","author":"DH Jang","year":"2013","unstructured":"Jang DH, Nelson LS, Hoffman RS. Methylene blue for distributive shock: a potential new use of an old antidote. J Med Toxicol. 2013;9(3):242\u20139. https:\/\/doi.org\/10.1007\/s13181-013-0298-7.","journal-title":"J Med Toxicol"},{"key":"1422_CR21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jcrc.2020.02.011","volume":"57","author":"S Tchen","year":"2020","unstructured":"Tchen S, Sullivan JB. Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock. J Crit Care. 2020;57:148\u201356. https:\/\/doi.org\/10.1016\/j.jcrc.2020.02.011.","journal-title":"J Crit Care"},{"issue":"2","key":"1422_CR22","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.chest.2019.08.2211","volume":"157","author":"PRB Evora","year":"2020","unstructured":"Evora PRB. Broad spectrum vasopressors support sparing strategies in vasodilatory shock beyond the vascular receptors. Chest. 2020;157(2):471\u20132. https:\/\/doi.org\/10.1016\/j.chest.2019.08.2211.","journal-title":"Chest"},{"issue":"1","key":"1422_CR23","doi-asserted-by":"publisher","first-page":"84","DOI":"10.5935\/1678-9741.20140115","volume":"30","author":"PRB Evora","year":"2015","unstructured":"Evora PRB, Alves Junior L, Ferreira CA, et al. Twenty years of vasoplegic syndrome treatment in heart surgery. Methylene blue revised. Rev Bras Cir Cardiovasc. 2015;30(1):84\u201392. https:\/\/doi.org\/10.5935\/1678-9741.20140115.","journal-title":"Rev Bras Cir Cardiovasc"},{"issue":"4, Suppl","key":"1422_CR24","doi-asserted-by":"publisher","first-page":"206A","DOI":"10.1378\/chest.2267413","volume":"148","author":"M Kavanaugh","year":"2015","unstructured":"Kavanaugh M, Berumen J, Chu F, Yin J, Beitler J. Methylene blue utilization for refractory septic shock in the setting of cirrhosis as a bridge to successful liver-kidney transplant: case report and review of the literature. Chest. 2015;148(4, Suppl):206A. https:\/\/doi.org\/10.1378\/chest.2267413.","journal-title":"Chest"},{"issue":"4","key":"1422_CR25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.6002\/ect.2016.0041","volume":"16","author":"KH Vilalva","year":"2018","unstructured":"Vilalva KH, Mumic FT, Silveira MRG, Mente ED, Evora PRB, Castro e Silva O. Use of methylene blue to treat hypovolemic shock followed by ischemia-reperfusion injury in the postoperative orthotopic liver transplant patient: a case report. Exp Clin Transplant. 2018;16(4):511\u20134. https:\/\/doi.org\/10.6002\/ect.2016.0041.","journal-title":"Exp Clin Transplant"},{"issue":"7","key":"1422_CR26","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1093\/ndt\/16.7.1436","volume":"16","author":"G Peer","year":"2001","unstructured":"Peer G, Itzhakov E, Wollman Y, et al. Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension. Nephrol Dial Transplant. 2001;16(7):1436\u201341. https:\/\/doi.org\/10.1093\/ndt\/16.7.1436.","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"1422_CR27","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1177\/0310057X0203000606","volume":"30","author":"D Memis","year":"2002","unstructured":"Memis D, Karamanlioglu B, Yuksel M, Gemlik I, Pamukcu Z. The influence of methylene blue infusion on cytokine levels during severe sepsis. Anaesth Intensive Care. 2002;30(6):755\u201362. https:\/\/doi.org\/10.1177\/0310057X0203000606.","journal-title":"Anaesth Intensive Care"},{"issue":"10","key":"1422_CR28","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1097\/00003246-200110000-00002","volume":"29","author":"MY Kirov","year":"2001","unstructured":"Kirov MY, Evgenov OV, Evgenov NV, et al. Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study. Crit Care Med. 2001;29(10):1860\u20137. https:\/\/doi.org\/10.1097\/00003246-200110000-00002.","journal-title":"Crit Care Med"},{"issue":"12","key":"1422_CR29","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1590\/s0100-879x1999001200009","volume":"32","author":"R Weingartner","year":"1999","unstructured":"Weingartner R, Oliveira E, Oliveira ES, et al. Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue. Braz J Med Biol Res. 1999;32(12):1505\u201313. https:\/\/doi.org\/10.1590\/s0100-879x1999001200009.","journal-title":"Braz J Med Biol Res"},{"issue":"10","key":"1422_CR30","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1097\/00003246-200210000-00015","volume":"30","author":"A Donati","year":"2002","unstructured":"Donati A, Conti G, Loggi S, et al. Does methylene blue administration to septic shock patients affect vascular permeability and blood volume? Crit Care Med. 2002;30(10):2271\u20137. https:\/\/doi.org\/10.1097\/00003246-200210000-00015.","journal-title":"Crit Care Med"},{"issue":"852","key":"1422_CR31","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1136\/pgmj.72.852.612","volume":"72","author":"G Brown","year":"1996","unstructured":"Brown G, Frankl D, Phang T. Continuous infusion of methylene blue for septic shock. Postgrad Med J. 1996;72(852):612\u20134. https:\/\/doi.org\/10.1136\/pgmj.72.852.612.","journal-title":"Postgrad Med J"},{"issue":"2","key":"1422_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3904\/kjim.2005.20.2.123","volume":"20","author":"B-K Park","year":"2005","unstructured":"Park B-K, Shim T-S, Lim C-M, et al. The effects of methylene blue on hemodynamic parameters and cytokine levels in refractory septic shock. Korean J Intern Med. 2005;20(2):123\u20138. https:\/\/doi.org\/10.3904\/kjim.2005.20.2.123.","journal-title":"Korean J Intern Med"},{"issue":"4","key":"1422_CR33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/s0883-9441(98)90001-6","volume":"13","author":"M Andresen","year":"1998","unstructured":"Andresen M, Dougnac A, Diaz O, et al. Use of methylene blue in patients with refractory septic shock: impact on hemodynamics and gas exchange. J Crit Care. 1998;13(4):164\u20138. https:\/\/doi.org\/10.1016\/s0883-9441(98)90001-6.","journal-title":"J Crit Care"},{"issue":"12","key":"1422_CR34","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/BF01700666","volume":"21","author":"B Gachot","year":"1995","unstructured":"Gachot B, Bedos JP, Veber B, Wolff M, Regnier B. Short-term effects of methylene blue on hemodynamics and gas exchange in humans with septic shock. Intensive Care Med. 1995;21(12):1027\u201331. https:\/\/doi.org\/10.1007\/BF01700666.","journal-title":"Intensive Care Med"},{"issue":"4","key":"1422_CR35","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12630-011-9458-x","volume":"58","author":"TC Dumbarton","year":"2011","unstructured":"Dumbarton TC, Minor S, Yeung CK, Green R. Prolonged methylene blue infusion in refractory septic shock: a case report. Can J Anesth. 2011;58(4):401\u20135. https:\/\/doi.org\/10.1007\/s12630-011-9458-x.","journal-title":"Can J Anesth"},{"issue":"11","key":"1422_CR36","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3760\/cma.j.issn.2095-4352.2017.11.005","volume":"29","author":"X Zhang","year":"2017","unstructured":"Zhang X, Gao Y, Pan P, Wang Y, Li W, Yu X. Methylene blue in the treatment of vasodilatory shock: a meta-analysis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29(11):982\u20137. https:\/\/doi.org\/10.3760\/cma.j.issn.2095-4352.2017.11.005.","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"issue":"3","key":"1422_CR37","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1590\/s0102-76382009000400005","volume":"24","author":"PRB Evora","year":"2009","unstructured":"Evora PRB, de Freitas Ribeiro PJ, de Andrade Vicente WV, et al. Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties. Rev Bras Cir Cardiovasc. 2009;24(3):279\u201388. https:\/\/doi.org\/10.1590\/s0102-76382009000400005.","journal-title":"Rev Bras Cir Cardiovasc"},{"issue":"4","key":"1422_CR38","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s13181-013-0333-8","volume":"9","author":"PRB Evora","year":"2013","unstructured":"Evora PRB. Methylene blue does not have to be considered only as rescue therapy for distributive shock. J Med Toxicol. 2013;9(4):426. https:\/\/doi.org\/10.1007\/s13181-013-0333-8.","journal-title":"J Med Toxicol"},{"issue":"11","key":"1422_CR39","doi-asserted-by":"publisher","first-page":"e0142605","DOI":"10.1371\/journal.pone.0142605","volume":"10","author":"A Belletti","year":"2015","unstructured":"Belletti A, Musu M, Silvetti S, et al. Non-adrenergic vasopressors in patients with or at risk for vasodilatory shock. A systematic review and meta-analysis of randomized trials. PLoS One. 2015;10(11):e0142605. https:\/\/doi.org\/10.1371\/journal.pone.0142605.","journal-title":"PLoS One"},{"issue":"1","key":"1422_CR40","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1038\/s41598-020-58828-4","volume":"10","author":"M Porizka","year":"2020","unstructured":"Porizka M, Kopecky P, Dvorakova H, et al. Methylene blue administration in patients with refractory distributive shock\u2014a retrospective study. Sci Rep. 2020;10(1):1828. https:\/\/doi.org\/10.1038\/s41598-020-58828-4.","journal-title":"Sci Rep"},{"key":"1422_CR41","doi-asserted-by":"publisher","first-page":"8747326","DOI":"10.1155\/2017\/8747326","volume":"2017","author":"F Manji","year":"2017","unstructured":"Manji F, Benjamin Wierstra B, Posadas J. Severe undifferentiated vasoplegic shock refractory to vasoactive agents treated with methylene blue. Case Rep Crit Care. 2017;2017:8747326. https:\/\/doi.org\/10.1155\/2017\/8747326.","journal-title":"Case Rep Crit Care"},{"issue":"11","key":"1422_CR42","first-page":"CS102","volume":"9","author":"AM Oliveira Neto","year":"2003","unstructured":"Oliveira Neto AM, Duarte NM, Vicente WVA, Viaro F, Evora PRB. Methylene blue: an effective treatment for contrast medium-induced anaphylaxis. Med Sci Monit. 2003;9(11):CS102\u2013CS106.","journal-title":"Med Sci Monit"},{"key":"1422_CR43","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/15563650.2013.870343","volume":"52","author":"J Fisher","year":"2014","unstructured":"Fisher J, Taori G, Braitberg G, Graudins A. Methylene blue used in the treatment of refractory shock resulting from drug poisoning. Clin Toxicol. 2014;52:63\u20135. https:\/\/doi.org\/10.3109\/15563650.2013.870343.","journal-title":"Clin Toxicol"},{"key":"1422_CR44","doi-asserted-by":"publisher","first-page":"bcr201521022","DOI":"10.1136\/bcr-2015-210229","volume":"2014","author":"RE Graham","year":"2015","unstructured":"Graham RE, Cartner M, Winearls J. A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy. BMJ Case Rep. 2015;2014:bcr201521022. https:\/\/doi.org\/10.1136\/bcr-2015-210229.","journal-title":"BMJ Case Rep"},{"key":"1422_CR45","doi-asserted-by":"publisher","first-page":"bcr2012007402","DOI":"10.1136\/bcr-2012-007402","volume":"2013","author":"N Aggarwal","year":"2013","unstructured":"Aggarwal N, Kupfer Y, Seneviratne C, Tessler S. Methylene blue reverses recalcitrant shock in \u03b2-blocker and calcium channel blocker overdose. BMJ Case Rep. 2013;2013:bcr2012007402. https:\/\/doi.org\/10.1136\/bcr-2012-007402.","journal-title":"BMJ Case Rep"},{"issue":"4","key":"1422_CR46","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1007\/s13181-015-0500-1","volume":"11","author":"JR Laes","year":"2015","unstructured":"Laes JR, Williams DM, Cole JB. Improvement in hemodynamics after methylene blue administration in drug-induced vasodilatory shock: a case report. J Med Toxicol. 2015;11(4):460\u20133. https:\/\/doi.org\/10.1007\/s13181-015-0500-1.","journal-title":"J Med Toxicol"},{"issue":"4 Pt 1","key":"1422_CR47","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1164\/ajrccm.156.4.97-01052","volume":"156","author":"VM Ranieri","year":"1997","unstructured":"Ranieri VM, Brienza N, Santostasi S, et al. Impairment of lung and chest wall mechanics in patients with acute respiratory distress syndrome: role of abdominal distension. Am J Respir Crit Care Med. 1997;156(4 Pt 1):1082\u201391.","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"1422_CR48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/ACO.0000000000000548","volume":"31","author":"SL McCartney","year":"2017","unstructured":"McCartney SL, Duce L, Ghadimi K. Intraoperative vasoplegia: methylene blue to the rescue! Curr Opin Anesthesiol. 2017;31(1):43\u20139. https:\/\/doi.org\/10.1097\/ACO.0000000000000548.","journal-title":"Curr Opin Anesthesiol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01422-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-020-01422-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01422-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T20:23:36Z","timestamp":1626985416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-020-01422-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["1422"],"URL":"https:\/\/doi.org\/10.1007\/s12325-020-01422-x","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]},"assertion":[{"value":"31 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}