{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:51:28Z","timestamp":1768344688607,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:00:00Z","timestamp":1601078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"MEDA Pharmaceuticals Switzerland GmbH."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s12325-020-01490-z","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T11:02:29Z","timestamp":1601118149000},"page":"4549-4567","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Management of Dyslipidemia in Individuals with Low-to-Moderate Cardiovascular Risk: Role of Nutraceuticals"],"prefix":"10.1007","volume":"37","author":[{"given":"Maryna Mykolaivna","family":"Dolzhenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Yulianivna","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalampos","family":"Grassos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia Volodymirivna","family":"Dragomiretska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borys Ivanovych","family":"Goloborodko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana Oleksandrivna","family":"Ilashchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostiantyn Oleksandrovych","family":"Zuiev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena Vyacheslavovna","family":"Karpenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena Vadymivna","family":"Kolesnikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetiana Volodymirivna","family":"Kolesnyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana Volodymirivna","family":"Talaieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Petrovych","family":"Vakaliuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara Dmitrievna","family":"Tiabut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina Leontievna","family":"Mesnikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olesia Vadymivna","family":"Zinych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,26]]},"reference":[{"key":"1490_CR1","unstructured":"World Health Organization. Cardiovascular diseases (CVDs). https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds). Accessed 9 July 2019."},{"key":"1490_CR2","unstructured":"World Health Organization. Raised cholesterol. https:\/\/www.who.int\/gho\/ncd\/risk_factors\/cholesterol_text\/en\/. Accessed 9 July 2019."},{"key":"1490_CR3","unstructured":"World Health Organization. Noncommunicable diseases (NCD) country profiles. 2018. https:\/\/www.who.int\/nmh\/countries\/ukr_en.pdf. Accessed 9 July 2019."},{"key":"1490_CR4","unstructured":"Ukraine Institute for Health Metrics and Evaluation. https:\/\/www.healthdata.org\/ukraine. Accessed 9 July 2019."},{"issue":"1","key":"1490_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/2278-019X.105328","volume":"2","author":"SK Kota","year":"2013","unstructured":"Kota SK, Jammula S, Kota SK, et al. Nutraceuticals in dyslipidemia management. J Med Nutr Nutraceut. 2013;2(1):26\u201340.","journal-title":"J Med Nutr Nutraceut"},{"key":"1490_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","volume":"41","author":"F Mach","year":"2020","unstructured":"Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41:111\u201388.","journal-title":"Eur Heart J"},{"key":"1490_CR7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1177\/1559827609334518","volume":"3","author":"SA Leon","year":"2009","unstructured":"Leon SA, Bronas UG. Dyslipidemia and risk of coronary heart disease: role of lifestyle approaches for its management. Am J Lifestyle Med. 2009;3:257\u201373.","journal-title":"Am J Lifestyle Med"},{"key":"1490_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosissup.2016.10.003","volume":"24","author":"V Barrios","year":"2017","unstructured":"Barrios V, Escobar C, Cicero AF, et al. A nutraceutical approach (Armolipid Plus) to reduce total and LDL cholesterol in individuals with mild to moderate dyslipidemia: review of the clinical evidence. Atheroscler Suppl. 2017;24:1\u201315.","journal-title":"Atheroscler Suppl"},{"key":"1490_CR9","doi-asserted-by":"publisher","first-page":"e2089","DOI":"10.7759\/cureus.2089","volume":"10","author":"G Nepal","year":"2018","unstructured":"Nepal G, Tuladhar ET, Acharya K, et al. Dyslipidemia and associated cardiovascular risk factors among young Nepalese university students. Cureus. 2018;10:e2089. https:\/\/doi.org\/10.7759\/cureus.2089.","journal-title":"Cureus"},{"key":"1490_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jacl.2015.02.003","volume":"9","author":"TA Jacobson","year":"2015","unstructured":"Jacobson TA, Ito MK, Maki KC, et al. National lipid association recommendations for patient-centered management of dyslipidemia: Part 1\u2014full report. J Clin Lipidol. 2015;9:129\u201369.","journal-title":"J Clin Lipidol"},{"key":"1490_CR11","first-page":"CD009825","volume":"8","author":"K Rees","year":"2013","unstructured":"Rees K, Hartley L, Flowers N, et al. 'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;8:CD009825.","journal-title":"Cochrane Database Syst Rev"},{"key":"1490_CR12","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.cjca.2010.12.077","volume":"27","author":"J Huang","year":"2011","unstructured":"Huang J, Frohlich J, Ignaszewski AP. The impact of dietary changes and dietary supplements on lipid profile. Can J Cardiol. 2011;27:488\u2013505.","journal-title":"Can J Cardiol"},{"key":"1490_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/bcp.13496","volume":"84","author":"A Santini","year":"2018","unstructured":"Santini A, Cammarata SM, Capone G, et al. Nutraceuticals: opening the debate for a regulatory framework. Br J Clin Pharmacol. 2018;84:659\u201372.","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"1490_CR14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1080\/17512433.2018.1464911","volume":"11","author":"A Santini","year":"2018","unstructured":"Santini A, Novellino E. Nutraceuticals\u2014shedding light on the grey area between pharmaceuticals and food. Expert Rev Clin Pharmacol. 2018;11(6):545\u20137.","journal-title":"Expert Rev Clin Pharmacol"},{"key":"1490_CR15","unstructured":"The US-Food and Drug Administration. Dietary supplements. https:\/\/www.fda.gov\/food\/dietary-supplements. Accessed 20 Aug 2020."},{"key":"1490_CR16","unstructured":"European Food Safety Authority. Food supplements. https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/food-supplements. Accessed 20 Aug 2020."},{"key":"1490_CR17","unstructured":"GOV.UK. Guidance: food supplement use and labels. https:\/\/www.gov.uk\/government\/publications\/food-supplements-guidance-and-faqs. Accessed 20 Aug 2020."},{"issue":"2","key":"1490_CR18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1079\/NRR200363","volume":"16","author":"T Shimizu","year":"2003","unstructured":"Shimizu T. Health claims on functional foods: the Japanese regulations and an international comparison. Nutr Res Rev. 2003;16(2):241\u201352.","journal-title":"Nutr Res Rev"},{"issue":"6","key":"1490_CR19","doi-asserted-by":"publisher","first-page":"1199S","DOI":"10.1093\/jn\/138.6.1199S","volume":"138","author":"Y Yang","year":"2008","unstructured":"Yang Y. Scientific substantiation of functional food health claims in China. J Nutr. 1199S;138(6):1199S\u2013S1205205.","journal-title":"J Nutr"},{"key":"1490_CR20","doi-asserted-by":"publisher","first-page":"1221S","DOI":"10.1093\/jn\/138.6.1221S","volume":"138","author":"MR Labbe","year":"2008","unstructured":"Labbe MR, Dumais L, Chao E, et al. Health claims on foods in Canada. J Nutr. 1221S;138:1221S\u20137S. https:\/\/doi.org\/10.1093\/jn\/138.6.1221S.","journal-title":"J Nutr"},{"key":"1490_CR21","doi-asserted-by":"publisher","unstructured":"Tutelyan V, Sukhanov B, Kochetkova A, et al. Russian regulations on nutraceuticals, functional foods, and foods for special dietary uses. In: Bagchi D, editor. Nutraceutical and functional food regulations in the United States and around the world. London: Academic; 2019. p. 399\u2013416.\nhttps:\/\/doi.org\/10.1016\/B978-0-12-816467-9.00026-5.","DOI":"10.1016\/B978-0-12-816467-9.00026-5"},{"key":"1490_CR22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.numecd.2016.11.122","volume":"27","author":"M Pirro","year":"2017","unstructured":"Pirro M, Vetrani C, Bianchi C, Mannarino MR, Bernini F, Rivellese AA. Joint position statement on \"Nutraceuticals for the treatment of hypercholesterolemia\" of the Italian Society of Diabetology (SID) and of the Italian Society for the Study of Arteriosclerosis (SISA). Nutr Metab Cardiovasc Dis. 2017;27:2\u201317.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1490_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/157340721001140724145924","volume":"10","author":"A Santini","year":"2014","unstructured":"Santini A, Novellino E. Nutraceuticals: beyond the diet before the drugs. Curr Bioact Compd. 2014;10:1\u201312.","journal-title":"Curr Bioact Compd"},{"issue":"11","key":"1490_CR24","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1111\/bph.13636","volume":"174","author":"A Santini","year":"2017","unstructured":"Santini A, Novellino E. Nutraceuticals in hypercholesterolaemia: an overview. Br J Pharmacol. 2017;174(11):1450\u201363.","journal-title":"Br J Pharmacol"},{"key":"1490_CR25","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/foods9030370","volume":"9","author":"A Durazzo","year":"2020","unstructured":"Durazzo A, Lucarini M, Santini A. Nutraceuticals in human health. Foods. 2020;9:370. https:\/\/doi.org\/10.3390\/foods9030370.","journal-title":"Foods"},{"key":"1490_CR26","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.phymed.2015.10.011","volume":"23","author":"AF Cicero","year":"2016","unstructured":"Cicero AF, Colletti A. Combinations of phytomedicines with different lipid lowering activity for dyslipidemia management: the available clinical data. Phytomedicine. 2016;23:1113\u20138.","journal-title":"Phytomedicine"},{"issue":"11\u201312","key":"1490_CR27","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.nut.2016.04.007","volume":"32","author":"A Sahebkar","year":"2016","unstructured":"Sahebkar A, Serban MC, Gluba-Brz\u00f3zka A, et al. Lipid-modifying effects of nutraceuticals: an evidence-based approach. Nutrition. 2016;32(11\u201312):1179\u201392.","journal-title":"Nutrition"},{"issue":"1","key":"1490_CR28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jacc.2018.04.040","volume":"72","author":"M Banach","year":"2018","unstructured":"Banach M, Patti AM, Giglio RV, et al. The role of nutraceuticals in statin intolerant patients. J Am Coll Cardiol. 2018;72(1):96\u2013118.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1490_CR29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1017\/S0007114514000750","volume":"112","author":"RT Ras","year":"2014","unstructured":"Ras RT, Geleijnse JM, Trautwein EA. LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. Br J Nutr. 2014;112(2):214\u20139.","journal-title":"Br J Nutr"},{"issue":"6","key":"1490_CR30","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1055\/s-0032-1328321","volume":"79","author":"H Dong","year":"2013","unstructured":"Dong H, Zhao Y, Zhao L, et al. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med. 2013;79(6):437\u201346.","journal-title":"Planta Med"},{"issue":"8","key":"1490_CR31","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.numecd.2015.04.008","volume":"25","author":"X Zhu","year":"2015","unstructured":"Zhu X, Sun X, Wang M, et al. Quantitative assessment of the effects of beta-glucan consumption on serum lipid profile and glucose level in hypercholesterolemic subjects. Nutr Metab Cardiovasc Dis. 2015;25(8):714\u201323.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"1490_CR32","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1093\/ajcn\/88.4.1167","volume":"88","author":"N Sood","year":"2008","unstructured":"Sood N, Baker WL, Coleman CI. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Am J Clin Nutr. 2008;88(4):1167\u201375.","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"1490_CR33","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1017\/S0007114515002603","volume":"114","author":"OA Tokede","year":"2015","unstructured":"Tokede OA, Onabanjo TA, Yansane A, et al. Soya products and serum lipids: a meta-analysis of randomised controlled trials. Br J Nutr. 2015;114(6):831\u201343.","journal-title":"Br J Nutr"},{"issue":"6","key":"1490_CR34","doi-asserted-by":"publisher","first-page":"e98611","DOI":"10.1371\/journal.pone.0098611","volume":"9","author":"Y Li","year":"2014","unstructured":"Li Y, Jiang L, Jia Z, et al. A meta-analysis of red yeast rice: an effective and relatively safe alternative approach for dyslipidemia. PLoS One. 2014;9(6):e98611.","journal-title":"PLoS One"},{"issue":"3","key":"1490_CR35","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.aimed.2014.06.001","volume":"1","author":"VC Chung","year":"2014","unstructured":"Chung VC, Liu S, Sit RW. Is red yeast rice capsule beneficial for treating dyslipidemia amongst statin-intolerant patients as compared to placebo? Adv Integr Med. 2014;1(3):151\u20132.","journal-title":"Adv Integr Med"},{"issue":"9","key":"1490_CR36","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/nutrit\/nux047","volume":"75","author":"AFG Cicero","year":"2017","unstructured":"Cicero AFG, Colletti A, Bajraktari G, et al. Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Nutr Rev. 2017;75(9):731\u201367.","journal-title":"Nutr Rev"},{"issue":"8","key":"1490_CR37","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1177\/0091270009337509","volume":"49","author":"JJ Li","year":"2009","unstructured":"Li JJ, Lu ZL, Kou WR, et al. Beneficial impact of Xuezhikang on cardiovascular events and mortality in elderly hypertensive patients with previous myocardial infarction from the China Coronary Secondary Prevention Study (CCSPS). J Clin Pharmacol. 2009;49(8):947\u201356.","journal-title":"J Clin Pharmacol"},{"issue":"8","key":"1490_CR38","first-page":"e05368","volume":"16","author":"M Younes","year":"2018","unstructured":"EFSA Panel on Food Additives, and Nutrient Sources added to Food (ANS), Younes M, Aggett P, et al. Scientific opinion on the safety of monacolins in red yeast rice. EFSA J. 2018;16(8):e05368.","journal-title":"EFSA J"},{"key":"1490_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2019.02.028","volume":"143","author":"F Fogacci","year":"2019","unstructured":"Fogacci F, Banach M, Mikhailidis DP, et al. Safety of red yeast rice supplementation: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;143:1\u201316.","journal-title":"Pharmacol Res"},{"key":"1490_CR40","unstructured":"Armolipid Product Monograph. Mylan (Mylan data on file). 2019."},{"key":"1490_CR41","first-page":"703","volume":"2","author":"S Persiani","year":"2014","unstructured":"Persiani S, Sala F, Zangarini M, et al. Effect of food on the oral bioavailability of berberine and monacolin administered in combination in healthy male volunteers. J Pharm Pharmacol. 2014;2:703\u201312.","journal-title":"J Pharm Pharmacol"},{"key":"1490_CR42","first-page":"660","volume":"2","author":"S Persiani","year":"2014","unstructured":"Persiani S, Sala F, Manzotti C, et al. Effect of a combination of berberine and monacolin on CYP enzymes: an oral cocktail interaction study in healthy volunteers. J Pharm Pharmacol. 2014;2:660\u20138.","journal-title":"J Pharm Pharmacol"},{"key":"1490_CR43","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1016\/j.nutres.2016.07.005","volume":"36","author":"T Heinz","year":"2016","unstructured":"Heinz T, Schuchardt JP, M\u00f6ller K, et al. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nutr Res. 2016;36:1162\u201370.","journal-title":"Nutr Res"},{"key":"1490_CR44","doi-asserted-by":"crossref","unstructured":"Sanidas E, Grassos C. The role of nutraceuticals in the treatment of primary dyslipidemia. Hellenic J Cardiol. 2020;61:60\u20132.","DOI":"10.1016\/j.hjc.2018.07.009"},{"key":"1490_CR45","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3233\/s12349-010-0028-5","volume":"3","author":"AFG Cicero","year":"2010","unstructured":"Cicero AFG, Benvenuti C, Moweb AR, et al. Efficacy of a red yeast rice-based nutraceutical in large subgroupsof hypercholesterolemic subjects in every day clinical practice. Mediterr J NutrMetab. 2010;3:239\u201346.","journal-title":"Mediterr J NutrMetab"},{"key":"1490_CR46","doi-asserted-by":"publisher","first-page":"e101978","DOI":"10.1371\/journal.pone.0101978","volume":"9","author":"R Sol\u00e0","year":"2014","unstructured":"Sol\u00e0 R, Valls RM, Puzo J, et al. Effects of poly-bioactive compounds on lipid profile and body weight in a moderately hypercholesterolemic population with low cardiovascular disease risk: a multicenter randomized trial. PLoS One. 2014;9:e101978.","journal-title":"PLoS One"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01490-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-020-01490-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01490-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:10:56Z","timestamp":1632615056000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-020-01490-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,26]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["1490"],"URL":"https:\/\/doi.org\/10.1007\/s12325-020-01490-z","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,26]]},"assertion":[{"value":"13 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2020","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}