{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:43:23Z","timestamp":1787237003342,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12325-020-01504-w","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T03:03:56Z","timestamp":1601435036000},"page":"4797-4807","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Management of Cutaneous Calciphylaxis"],"prefix":"10.1007","volume":"37","author":[{"given":"Vijay","family":"Kodumudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Jeha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Mydlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"issue":"2","key":"1504_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4103\/0019-5154.108026","volume":"58","author":"U Wollina","year":"2013","unstructured":"Wollina U. Update on cutaneous calciphylaxis. Indian J Dermatol. 2013;58(2):87\u201392. https:\/\/doi.org\/10.4103\/0019-5154.108026.","journal-title":"Indian J Dermatol"},{"issue":"6","key":"1504_CR2","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1046\/j.1523-1755.2002.00375.x","volume":"61","author":"A Fine","year":"2002","unstructured":"Fine A, Zacharias J. Calciphylaxis is usually non-ulcerating: risk factors, outcome and therapy. Kidney Int. 2002;61(6):2210\u20137. https:\/\/doi.org\/10.1046\/j.1523-1755.2002.00375.x.","journal-title":"Kidney Int"},{"key":"1504_CR3","unstructured":"Westphal SG, Plumb T. Calciphylaxis. StatPearls. 2020. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30085562. Accessed 17 Aug 2020."},{"issue":"18","key":"1504_CR4","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1056\/NEJMra1505292","volume":"378","author":"SU Nigwekar","year":"2018","unstructured":"Nigwekar SU, Thadhani R, Brandenburg VM. Calciphylaxis. N Engl J Med. 2018;378(18):1704\u201314. https:\/\/doi.org\/10.1056\/NEJMra1505292.","journal-title":"N Engl J Med"},{"issue":"1","key":"1504_CR5","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/j.ajkd.2015.01.034","volume":"66","author":"SU Nigwekar","year":"2015","unstructured":"Nigwekar SU, Kroshinsky D, Nazarian RM, et al. Calciphylaxis: risk factors, diagnosis, and treatment. Am J Kidney Dis. 2015;66(1):133\u201346. https:\/\/doi.org\/10.1053\/j.ajkd.2015.01.034.","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"1504_CR6","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.jaad.2007.12.006","volume":"58","author":"RH Weenig","year":"2008","unstructured":"Weenig RH. Pathogenesis of calciphylaxis: Hans Selye to nuclear factor \u03ba-B. J Am Acad Dermatol. 2008;58(3):458\u201371. https:\/\/doi.org\/10.1016\/j.jaad.2007.12.006.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"1504_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.ASW.0000554443.14002.13","volume":"32","author":"JJ Chang","year":"2019","unstructured":"Chang JJ. Calciphylaxis: diagnosis, pathogenesis, and treatment. Adv Ski Wound Care. 2019;32(5):205\u201315. https:\/\/doi.org\/10.1097\/01.ASW.0000554443.14002.13.","journal-title":"Adv Ski Wound Care"},{"issue":"4","key":"1504_CR8","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/MNH.0000000000000328","volume":"26","author":"SU Nigwekar","year":"2017","unstructured":"Nigwekar SU. Calciphylaxis. Curr Opin Nephrol Hypertens. 2017;26(4):276\u201381. https:\/\/doi.org\/10.1097\/MNH.0000000000000328.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"11","key":"1504_CR9","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1681\/ASN.2015091065","volume":"27","author":"SU Nigwekar","year":"2016","unstructured":"Nigwekar SU, Zhao S, Wenger J, et al. A nationally representative study of calcific uremic arteriolopathy risk factors. J Am Soc Nephrol. 2016;27(11):3421\u20139. https:\/\/doi.org\/10.1681\/ASN.2015091065.","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"1504_CR10","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.mayocp.2018.06.001","volume":"93","author":"R Bajaj","year":"2018","unstructured":"Bajaj R, Courbebaisse M, Kroshinsky D, Thadhani RI, Nigwekar SU. Calciphylaxis in patients with normal renal function: a case series and systematic review. Mayo Clin Proc. 2018;93(9):1202\u201312. https:\/\/doi.org\/10.1016\/j.mayocp.2018.06.001.","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"1504_CR11","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1681\/ASN.2016060651","volume":"28","author":"SU Nigwekar","year":"2017","unstructured":"Nigwekar SU, Bloch DB, Nazarian RM, et al. Vitamin K-dependent carboxylation of matrix gla protein influences the risk of calciphylaxis. J Am Soc Nephrol. 2017;28(6):1717\u201322. https:\/\/doi.org\/10.1681\/ASN.2016060651.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"1504_CR12","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1093\/ndt\/gfs466","volume":"28","author":"R Kramann","year":"2013","unstructured":"Kramann R, Brandenburg VM, Schurgers LJ, et al. Novel insights into osteogenesis and matrix remodelling associated with calcific uraemic arteriolopathy. Nephrol Dial Transplant. 2013;28(4):856\u201368. https:\/\/doi.org\/10.1093\/ndt\/gfs466.","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"1504_CR13","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/ndt\/gfv438","volume":"32","author":"VM Brandenburg","year":"2017","unstructured":"Brandenburg VM, Kramann R, Rothe H, et al. Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry. Nephrol Dial Transplant. 2017;32(1):126\u201332. https:\/\/doi.org\/10.1093\/ndt\/gfv438.","journal-title":"Nephrol Dial Transplant"},{"issue":"10","key":"1504_CR14","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.mayocp.2016.06.026","volume":"91","author":"RA el-Azhary","year":"2016","unstructured":"el-Azhary RA, Patzelt MT, McBane RD, et al. Calciphylaxis: a disease of pannicular thrombosis. Mayo Clin Proc. 2016;91(10):1395\u2013402. https:\/\/doi.org\/10.1016\/j.mayocp.2016.06.026.","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"1504_CR15","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jaad.2006.08.065","volume":"56","author":"RH Weenig","year":"2007","unstructured":"Weenig RH, Sewell LD, Davis MDP, McCarthy JT, Pittelkow MR. Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol. 2007;56(4):569\u201379. https:\/\/doi.org\/10.1016\/j.jaad.2006.08.065.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"1504_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbrc.2014.05.005","volume":"449","author":"NX Chen","year":"2014","unstructured":"Chen NX, O\u2019Neill K, Akl NK, Moe SM. Adipocyte induced arterial calcification is prevented with sodium thiosulfate. Biochem Biophys Res Commun. 2014;449(1):151\u20136. https:\/\/doi.org\/10.1016\/j.bbrc.2014.05.005.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1504_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s11892-011-0183-1","volume":"11","author":"J Ye","year":"2011","unstructured":"Ye J. Adipose tissue vascularization: its role in chronic inflammation. Curr Diab Rep. 2011;11(3):203\u201310. https:\/\/doi.org\/10.1007\/s11892-011-0183-1.","journal-title":"Curr Diab Rep"},{"issue":"2","key":"1504_CR18","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jpainsymman.2006.03.009","volume":"32","author":"MN Polizzotto","year":"2006","unstructured":"Polizzotto MN, Bryan T, Ashby MA, Martin P. Symptomatic management of calciphylaxis: a case series and review of the literature. J Pain Symptom Manag. 2006;32(2):186\u201390. https:\/\/doi.org\/10.1016\/j.jpainsymman.2006.03.009.","journal-title":"J Pain Symptom Manag"},{"issue":"8","key":"1504_CR19","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/ijd.13622","volume":"56","author":"T Ghosh","year":"2017","unstructured":"Ghosh T, Winchester DS, Davis MDP, el-Azhary R, Comfere NI. Early clinical presentations and progression of calciphylaxis. Int J Dermatol. 2017;56(8):856\u201361. https:\/\/doi.org\/10.1111\/ijd.13622.","journal-title":"Int J Dermatol"},{"issue":"5","key":"1504_CR20","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1159\/000448245","volume":"232","author":"J Hafner","year":"2017","unstructured":"Hafner J. Calciphylaxis and Martorell hypertensive ischemic leg ulcer: same pattern-one pathophysiology. Dermatology. 2017;232(5):523\u201333. https:\/\/doi.org\/10.1159\/000448245.","journal-title":"Dermatology"},{"key":"1504_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.05.037","author":"E Shmidt","year":"2012","unstructured":"Shmidt E, Murthy NS, Knudsen JM, et al. Net-like pattern of calcification on plain soft-tissueradiographs in patients with calciphylaxis. J Am Acad Dermatol. 2012. https:\/\/doi.org\/10.1016\/j.jaad.2012.05.037.","journal-title":"J Am Acad Dermatol"},{"key":"1504_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2147\/cwcmr.s182417","volume":"6","author":"C Erfurt-Berge","year":"2019","unstructured":"Erfurt-Berge C, Renner R. Management of patients with calciphylaxis: current perspectives. Chronic Wound Care Manag Res. 2019;6:109\u201315. https:\/\/doi.org\/10.2147\/cwcmr.s182417.","journal-title":"Chronic Wound Care Manag Res"},{"issue":"10","key":"1504_CR23","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/j.mayocp.2016.06.025","volume":"91","author":"JT McCarthy","year":"2016","unstructured":"McCarthy JT, el-Azhary RA, Patzelt MT, et al. Survival, risk factors, and effect of treatment in101 patients with calciphylaxis. Mayo Clin Proc. 2016;91(10):1384\u201394. https:\/\/doi.org\/10.1016\/j.mayocp.2016.06.025.","journal-title":"Mayo Clin Proc"},{"issue":"10100","key":"1504_CR24","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","volume":"390","author":"T Vos","year":"2017","unstructured":"Vos T, Abajobir AA, Abbafati C, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1211\u201359. https:\/\/doi.org\/10.1016\/S0140-6736(17)32154-2.","journal-title":"Lancet"},{"issue":"3","key":"1504_CR25","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11916-020-0837-2","volume":"24","author":"AD Kaye","year":"2020","unstructured":"Kaye AD, Novitch MB, Carlson SF, et al. The role of exparel plus meloxicam for postoperative pain management. Curr Pain Headache Rep. 2020;24(3):6. https:\/\/doi.org\/10.1007\/s11916-020-0837-2.","journal-title":"Curr Pain Headache Rep"},{"issue":"7","key":"1504_CR26","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/nep.12433","volume":"20","author":"J An","year":"2015","unstructured":"An J, Devaney B, Ooi KY, Ford S, Frawley G, Menahem S. Hyperbaric oxygen in the treatment of calciphylaxis: a case series and literature review. Nephrology. 2015;20(7):444\u201350. https:\/\/doi.org\/10.1111\/nep.12433.","journal-title":"Nephrology"},{"issue":"6","key":"1504_CR27","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.nephro.2010.04.003","volume":"6","author":"G Jean","year":"2010","unstructured":"Jean G, Terrat JC, Vanel T, et al. Calciphylaxis in dialysis patients: to recognize and treat it as soon as possible. Nephrol Ther. 2010;6(6):499\u2013504. https:\/\/doi.org\/10.1016\/j.nephro.2010.04.003.","journal-title":"Nephrol Ther"},{"issue":"3","key":"1504_CR28","doi-asserted-by":"publisher","first-page":"238","DOI":"10.5414\/cnp58238","volume":"58","author":"R Russell","year":"2002","unstructured":"Russell R, Brookshire MA, Zekonis M, Moe SM. Distal calcific uremic arteriolopathy in a hemodialysis patient responds to lowering of Ca \u00d7 P product and aggressive wound care. Clin Nephrol. 2002;58(3):238\u201343. https:\/\/doi.org\/10.5414\/cnp58238.","journal-title":"Clin Nephrol"},{"issue":"6","key":"1504_CR29","doi-asserted-by":"publisher","first-page":"463","DOI":"10.5414\/CNP59463","volume":"59","author":"BR Don","year":"2003","unstructured":"Don BR, Chin AI. A strategy for the treatment of calcific uremic arteriolopathy (calciphylaxis) employing a combination of therapies. Clin Nephrol. 2003;59(6):463\u201370. https:\/\/doi.org\/10.5414\/CNP59463.","journal-title":"Clin Nephrol"},{"issue":"26","key":"1504_CR30","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1056\/NEJMe1212368","volume":"367","author":"V Perkovic","year":"2012","unstructured":"Perkovic V, Neal B. Trials in kidney disease\u2014time to EVOLVE. N Engl J Med. 2012;367(26):2541\u20132. https:\/\/doi.org\/10.1056\/NEJMe1212368.","journal-title":"N Engl J Med"},{"issue":"6","key":"1504_CR31","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.surg.2009.09.022","volume":"146","author":"G Lal","year":"2009","unstructured":"Lal G, Nowell AG, Liao J, Sugg SL, Weigel RJ, Howe JR. Determinants of survival in patients with calciphylaxis: a multivariate analysis. Surgery. 2009;146(6):1028\u201334. https:\/\/doi.org\/10.1016\/j.surg.2009.09.022.","journal-title":"Surgery"},{"issue":"4","key":"1504_CR32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/00005537-200004000-00012","volume":"110","author":"MD Kriskovich","year":"2000","unstructured":"Kriskovich MD, Holman JM, Haller JR. Calciphylaxis: is there a role for parathyroidectomy? Laryngoscope. 2000;110(4):603\u20137. https:\/\/doi.org\/10.1097\/00005537-200004000-00012.","journal-title":"Laryngoscope"},{"key":"1504_CR33","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.surg.2003.07.001","volume":"134","author":"JE Arch-Ferrer","year":"2003","unstructured":"Arch-Ferrer JE, Beenken SW, Rue LW, et al. Therapy for calciphylaxis: an outcome analysis. Surgery. 2003;134:941\u20134. https:\/\/doi.org\/10.1016\/j.surg.2003.07.001.","journal-title":"Surgery"},{"issue":"2","key":"1504_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4161\/oxim.3.2.11354","volume":"3","author":"KM Sowers","year":"2010","unstructured":"Sowers KM, Hayden MR. Calcific uremic arteriolopathy: pathophysiology, reactive oxygen species and therapeutic approaches. Oxid Med Cell Longev. 2010;3(2):109\u201321. https:\/\/doi.org\/10.4161\/oxim.3.2.11354.","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"1504_CR35","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1093\/ndt\/gfs548","volume":"28","author":"E Zitt","year":"2013","unstructured":"Zitt E, K\u00f6nig M, Vychytil A, et al. Use of sodium thiosulphate in a multi-interventional setting for the treatment of calciphylaxis in dialysis patients. Nephrol Dial Transplant. 2013;28(5):1232\u201340. https:\/\/doi.org\/10.1093\/ndt\/gfs548.","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"1504_CR36","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ekir.2018.10.002","volume":"4","author":"S Udomkarnjananun","year":"2019","unstructured":"Udomkarnjananun S, Kongnatthasate K, Praditpornsilpa K, Eiam-Ong S, Jaber BL, Susantitaphong P. Treatment of calciphylaxis in CKD: a systematic review and meta-analysis. Kidney Int Rep. 2019;4(2):231\u201344. https:\/\/doi.org\/10.1016\/j.ekir.2018.10.002.","journal-title":"Kidney Int Rep"},{"issue":"6","key":"1504_CR37","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1053\/j.ajkd.2011.06.022","volume":"58","author":"C Baldwin","year":"2011","unstructured":"Baldwin C, Farah M, Leung M, et al. Multi-intervention management of calciphylaxis: a report of 7 cases. Am J Kidney Dis. 2011;58(6):988\u201391. https:\/\/doi.org\/10.1053\/j.ajkd.2011.06.022.","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"1504_CR38","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1080\/09546630152696035","volume":"12","author":"J Tittelbach","year":"2001","unstructured":"Tittelbach J, Graefe T, Wollina U. Painful ulcers in calciphylaxis\u2014combined treatment with maggot therapy and oral pentoxyfillin. J Dermatol Treat. 2001;12(4):211\u20134. https:\/\/doi.org\/10.1080\/09546630152696035.","journal-title":"J Dermatol Treat"},{"issue":"10","key":"1504_CR39","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1097\/MPA.0000000000001183","volume":"47","author":"AM Bender","year":"2018","unstructured":"Bender AM, Thompson ED, Hackam DJ, Cameron JL, Rhee DS. Solid pseudopapillary neoplasm of the pancreas in a young pediatric patient: a case report and systematic review of the literature. Pancreas. 2018;47(10):1364\u20138. https:\/\/doi.org\/10.1097\/MPA.0000000000001183.","journal-title":"Pancreas"},{"issue":"6","key":"1504_CR40","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.nefroe.2018.09.001","volume":"38","author":"D Cucchiari","year":"2018","unstructured":"Cucchiari D, Torregrosa J-V. Calciphylaxis in patients with chronic kidney disease: a disease which is still bewildering and potentially fatal. Nefrologia. 2018;38(6):579\u201386. https:\/\/doi.org\/10.1016\/j.nefroe.2018.09.001.","journal-title":"Nefrologia"},{"issue":"21","key":"1504_CR41","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.2217\/fon.15.232","volume":"11","author":"S Thosani","year":"2015","unstructured":"Thosani S, Hu MI. Denosumab: a new agent in the management of hypercalcemia of malignancy. Future Oncol. 2015;11(21):2865\u201371. https:\/\/doi.org\/10.2217\/fon.15.232.","journal-title":"Future Oncol"},{"issue":"2","key":"1504_CR42","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2353\/ajpath.2009.080957","volume":"175","author":"S Helas","year":"2009","unstructured":"Helas S, Goettsch C, Schoppet M, et al. Inhibition of receptor activator of NF-\u03baB ligand by denosumab attenuates vascular calcium deposition in mice. Am J Pathol. 2009;175(2):473\u20138. https:\/\/doi.org\/10.2353\/ajpath.2009.080957.","journal-title":"Am J Pathol"},{"issue":"2","key":"1504_CR43","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/jbmr.2043","volume":"29","author":"EJ Samelson","year":"2014","unstructured":"Samelson EJ, Miller PD, Christiansen C, et al. RANKL inhibition with denosumab does not influence 3-year progression of aortic calcification or incidence of adverse cardiovascular events in postmenopausal women with osteoporosis and high cardiovascular risk. J Bone Miner Res. 2014;29(2):450\u20137. https:\/\/doi.org\/10.1002\/jbmr.2043.","journal-title":"J Bone Miner Res"},{"issue":"9","key":"1504_CR44","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1161\/CIRCULATIONAHA.119.044195","volume":"141","author":"P Raggi","year":"2020","unstructured":"Raggi P, Bellasi A, Bushinsky D, et al. Slowing progression of cardiovascular calcification with SNF472 in patients on hemodialysis. Circulation. 2020;141(9):728\u201339. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.119.044195.","journal-title":"Circulation"},{"issue":"12","key":"1504_CR45","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1111\/bcp.13752","volume":"84","author":"J Perell\u00f3","year":"2018","unstructured":"Perell\u00f3 J, Joubert PH, Ferrer MD, Canals AZ, Sinha S, Salcedo C. First-time-in-human randomized clinical trial in healthy volunteers and haemodialysis patients with SNF472, a novel inhibitor of vascular calcification. Br J Clin Pharmacol. 2018;84(12):2867\u201376. https:\/\/doi.org\/10.1111\/bcp.13752.","journal-title":"Br J Clin Pharmacol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01504-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-020-01504-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01504-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T19:38:04Z","timestamp":1632944284000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-020-01504-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1504"],"URL":"https:\/\/doi.org\/10.1007\/s12325-020-01504-w","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"assertion":[{"value":"20 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}