{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:52:04Z","timestamp":1792601524968,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s12325-020-01568-8","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T11:22:56Z","timestamp":1606216976000},"page":"180-200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Burden of Chronic Kidney Disease by KDIGO Categories of Glomerular Filtration Rate and Albuminuria: A Systematic Review"],"prefix":"10.1007","volume":"38","author":[{"given":"Molly","family":"Murton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Goff-Leggett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bobrowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jose","family":"Garcia Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Wittbrodt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"S\u00f6rstadius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pecoits-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Tuttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"1568_CR1","unstructured":"American Society of Nephrology (ASN), European Renal Association \u2013 European Dialysis and Transplant Association (ERA-EDTA), International Society of Nephrology (ISN). The hidden epidemic: worldwide, over 850 million people suffer from kidney diseases. 2018. https:\/\/www.asn-online.org\/news\/2018\/0626-Joint_Hidden_Epidem.pdf. Accessed Sept 2020."},{"key":"1568_CR2","unstructured":"Bello AK, Levin A, Tonelli M, et al. Global Kidney Health Atlas: a report by the International Society of Nephrology on the current state of organization and structures for kidney care across the globe. 2017. https:\/\/www.kidneycareuk.org\/documents\/52\/ISN_Global_kidney_health_atlas.pdf. Accessed Sept 2020."},{"key":"1568_CR3","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382:260\u201372.","journal-title":"Lancet"},{"key":"1568_CR4","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"B Bikbov","year":"2020","unstructured":"Bikbov B, Purcell CA, Levey AS, et al. Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395:709\u201333.","journal-title":"Lancet"},{"key":"1568_CR5","unstructured":"Kidney Care UK. An estimated 1 in 10 people worldwide have chronic kidney disease. 2017. https:\/\/www.kidneycareuk.org\/news-and-campaigns\/news\/estimated-1-10-people-worldwide-have-chronic-kidney-disease\/. Accessed Dec 2019."},{"key":"1568_CR6","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.kint.2018.04.011","volume":"94","author":"Y Xie","year":"2018","unstructured":"Xie Y, Bowe B, Mokdad AH, et al. Analysis of the global burden of disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016. Kidney Int. 2018;94:567\u201381.","journal-title":"Kidney Int"},{"key":"1568_CR7","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","volume":"388","author":"GBD 2015 Mortality and Causes of Death Collaborators","year":"2016","unstructured":"GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1459\u2013544.","journal-title":"Lancet"},{"key":"1568_CR8","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","volume":"388","author":"GBD 2015 Disease and Injury Incidence and Prevalence Collaborators","year":"2016","unstructured":"GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1545\u2013602.","journal-title":"Lancet"},{"key":"1568_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ki.2013.444","volume":"85","author":"A Levin","year":"2014","unstructured":"Levin A, Stevens PE. Summary of KDIGO 2012 CKD guideline: behind the scenes, need for guidance, and a framework for moving forward. Kidney Int. 2014;85:49\u201361.","journal-title":"Kidney Int"},{"key":"1568_CR10","doi-asserted-by":"publisher","first-page":"e512","DOI":"10.3399\/bjgp18X697973","volume":"68","author":"M Iwagami","year":"2018","unstructured":"Iwagami M, Caplin B, Smeeth L, et al. Chronic kidney disease and cause-specific hospitalisation: a matched cohort study using primary and secondary care patient data. Br J Gen Pract. 2018;68:e512\u201323.","journal-title":"Br J Gen Pract"},{"key":"1568_CR11","first-page":"S163","volume":"23","author":"L Golestaneh","year":"2017","unstructured":"Golestaneh L, Alvarez PJ, Reaven NL, et al. All-cause costs increase exponentially with increased chronic kidney disease stage. Am J Manag Care. 2017;23:S163-s172.","journal-title":"Am J Manag Care"},{"key":"1568_CR12","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1001\/jama.2015.0602","volume":"313","author":"AS Levey","year":"2015","unstructured":"Levey AS, Becker C, Inker LA. Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA. 2015;313:837\u201346.","journal-title":"JAMA"},{"key":"1568_CR13","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1681\/ASN.2008070730","volume":"20","author":"SI Hallan","year":"2009","unstructured":"Hallan SI, Ritz E, Lydersen S, et al. Combining GFR and albuminuria to classify CKD improves prediction of ESRD. J Am Soc Nephrol. 2009;20:1069\u201377.","journal-title":"J Am Soc Nephrol"},{"key":"1568_CR14","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1681\/ASN.2008111212","volume":"20","author":"RT Gansevoort","year":"2009","unstructured":"Gansevoort RT, de Jong PE. The case for using albuminuria in staging chronic kidney disease. J Am Soc Nephrol. 2009;20:465\u20138.","journal-title":"J Am Soc Nephrol"},{"key":"1568_CR15","doi-asserted-by":"publisher","first-page":"65","DOI":"10.7326\/0003-4819-154-1-201101040-00012","volume":"154","author":"AS Levey","year":"2011","unstructured":"Levey AS, Tangri N, Stevens LA. Classification of chronic kidney disease: a step forward. Ann Intern Med. 2011;154:65\u20137.","journal-title":"Ann Intern Med"},{"key":"1568_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.7326\/0003-4819-154-1-201101040-00003","volume":"154","author":"M Tonelli","year":"2011","unstructured":"Tonelli M, Muntner P, Lloyd A, et al. Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study. Ann Intern Med. 2011;154:12\u201321.","journal-title":"Ann Intern Med"},{"key":"1568_CR17","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1681\/ASN.2016121374","volume":"28","author":"J Coresh","year":"2017","unstructured":"Coresh J. Update on the burden of CKD. J Am Soc Nephrol. 2017;28:1020\u20132.","journal-title":"J Am Soc Nephrol"},{"key":"1568_CR18","doi-asserted-by":"publisher","first-page":"e0158765","DOI":"10.1371\/journal.pone.0158765","volume":"11","author":"NR Hill","year":"2016","unstructured":"Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease\u2014a systematic review and meta-analysis. PLoS One. 2016;11:e0158765.","journal-title":"PLoS One"},{"key":"1568_CR19","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1038\/ki.2015.230","volume":"88","author":"KT Mills","year":"2015","unstructured":"Mills KT, Xu Y, Zhang W, et al. A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010. Kidney Int. 2015;88:950\u20137.","journal-title":"Kidney Int"},{"key":"1568_CR20","unstructured":"Centre for Reviews and Dissemination. Systematic Reviews: CRD's guidance for undertaking reviews in health care: Centre for Reviews and Dissemination. 2009.\u00a0https:\/\/www.york.ac.uk\/media\/crd\/Systematic_Reviews.pdf. Accessed Nov 2020."},{"key":"1568_CR21","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Thomas J, Chandler J, et al. Cochrane Handbook for Systematic Reviews of Interventions: Cochrane. 2019.\u00a0https:\/\/training.cochrane.org\/handbook\/current. Accessed Nov 2020.","DOI":"10.1002\/9781119536604"},{"key":"1568_CR22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/XEB.0000000000000054","volume":"13","author":"Z Munn","year":"2015","unstructured":"Munn Z, Moola S, Lisy K, et al. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc. 2015;13:147\u201353.","journal-title":"Int J Evid Based Healthc"},{"key":"1568_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/ndt\/gfy058","volume":"34","author":"B Stengel","year":"2019","unstructured":"Stengel B, Metzger M, Combe C, et al. Risk profile, quality of life and care of patients with moderate and advanced CKD: the French CKD-REIN Cohort Study. Nephrol Dial Transplant. 2019;34:277\u201386.","journal-title":"Nephrol Dial Transplant"},{"key":"1568_CR24","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1053\/j.ajkd.2013.04.010","volume":"62","author":"X Hui","year":"2013","unstructured":"Hui X, Matsushita K, Sang Y, et al. CKD and cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study: interactions with age, sex, and race. Am J Kidney Dis. 2013;62:691\u2013702.","journal-title":"Am J Kidney Dis"},{"key":"1568_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/kisup.2012.73","volume":"3","author":"A Levin","year":"2013","unstructured":"Levin A, Stevens PE, Bilous RW, et al. Kidney Disease: Improving Global Outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1\u2013150.","journal-title":"Kidney Int Suppl"},{"key":"1568_CR26","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1053\/j.ajkd.2014.04.024","volume":"64","author":"MC Odden","year":"2014","unstructured":"Odden MC, Amadu AR, Smit E, et al. Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988\u20131994 and 1999\u20132002. Am J Kidney Dis. 2014;64:550\u20137.","journal-title":"Am J Kidney Dis"},{"key":"1568_CR27","unstructured":"United States Renal Data System. USRDS annual data report: Epidemiology of kidney disease in the United States. Chapter 1: CKD in the General Population. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. 2018.\u00a0https:\/\/www.usrds.org\/annual-data-report\/previous-adrs\/. Accessed Dec 2019."},{"key":"1568_CR28","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.2215\/CJN.00550113","volume":"8","author":"RM Tanner","year":"2013","unstructured":"Tanner RM, Calhoun DA, Bell EK, et al. Prevalence of apparent treatment-resistant hypertension among individuals with CKD. Clin J Am Soc Nephrol. 2013;8:1583\u201390.","journal-title":"Clin J Am Soc Nephrol"},{"key":"1568_CR29","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1471-2369-15-36","volume":"15","author":"B Lin","year":"2014","unstructured":"Lin B, Shao L, Luo Q, et al. Prevalence of chronic kidney disease and its association with metabolic diseases: a cross-sectional survey in Zhejiang province, Eastern China. BMC Nephrol. 2014;15:36.","journal-title":"BMC Nephrol"},{"key":"1568_CR30","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.ekir.2018.05.011","volume":"3","author":"F Wang","year":"2018","unstructured":"Wang F, He K, Wang J, et al. Prevalence and risk factors for CKD: a comparison between the adult populations in China and the United States. Kidney Int Rep. 2018;3:1135\u201343.","journal-title":"Kidney Int Rep"},{"key":"1568_CR31","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1681\/ASN.2013060591","volume":"25","author":"A Pani","year":"2014","unstructured":"Pani A, Bragg-Gresham J, Masala M, et al. Prevalence of CKD and its relationship to eGFR-related genetic loci and clinical risk factors in the SardiNIA study cohort. J Am Soc Nephrol. 2014;25:1533\u201344.","journal-title":"J Am Soc Nephrol"},{"key":"1568_CR32","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.2337\/dc16-0748","volume":"39","author":"G Ruiz-Hurtado","year":"2016","unstructured":"Ruiz-Hurtado G, Ruilope LM, de la Sierra A, et al. Association between high and very high albuminuria and nighttime blood pressure: influence of diabetes and chronic kidney disease. Diabetes Care. 2016;39:1729\u201337.","journal-title":"Diabetes Care"},{"key":"1568_CR33","doi-asserted-by":"crossref","unstructured":"Villain C, Metzger M, Combe C, et al. Prevalence of atheromatous and non-atheromatous cardiovascular disease by age in chronic kidney disease. Nephrol Dial Transplant. 2018;35:827\u201336.","DOI":"10.1093\/ndt\/gfy277"},{"key":"1568_CR34","doi-asserted-by":"crossref","unstructured":"Levey AS, Eckardt K-U, Dorman NM, et al. Nomenclature for kidney function and disease: report of a kidney disease: improving global outcomes (KDIGO) consensus conference. Kidney Int. 2020;97:1117\u201329.","DOI":"10.1016\/j.kint.2020.02.010"},{"key":"1568_CR35","doi-asserted-by":"publisher","first-page":"e0190493","DOI":"10.1371\/journal.pone.0190493","volume":"13","author":"S Iimori","year":"2018","unstructured":"Iimori S, Naito S, Noda Y, et al. Prognosis of chronic kidney disease with normal-range proteinuria: the CKD-ROUTE study. PLoS One. 2018;13:e0190493.","journal-title":"PLoS One"},{"key":"1568_CR36","doi-asserted-by":"publisher","first-page":"e1918169","DOI":"10.1001\/jamanetworkopen.2019.18169","volume":"2","author":"KR Tuttle","year":"2019","unstructured":"Tuttle KR, Alicic RZ, Duru OK, et al. clinical characteristics of and risk factors for chronic kidney disease among adults and children: an analysis of the CURE-CKD registry. JAMA Netw Open. 2019;2:e1918169.","journal-title":"JAMA Netw Open"},{"key":"1568_CR37","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/S0140-6736(10)60674-5","volume":"375","author":"K Matsushita","year":"2010","unstructured":"Matsushita K, van der Velde M, Astor BC, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375:2073\u201381.","journal-title":"Lancet"},{"key":"1568_CR38","first-page":"67","volume":"35","author":"KR Polkinghorne","year":"2014","unstructured":"Polkinghorne KR. Estimated glomerular filtration rate versus albuminuria in the assessment of kidney function: what\u2019s more important? Clin Biochem Rev. 2014;35:67\u201373.","journal-title":"Clin Biochem Rev"},{"key":"1568_CR39","doi-asserted-by":"publisher","first-page":"e307","DOI":"10.1016\/S2214-109X(16)00071-1","volume":"4","author":"B Ene-Iordache","year":"2016","unstructured":"Ene-Iordache B, Perico N, Bikbov B, et al. Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study. Lancet Glob Health. 2016;4:e307\u201319.","journal-title":"Lancet Glob Health"},{"key":"1568_CR40","doi-asserted-by":"crossref","unstructured":"GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117\u201371.","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"1568_CR41","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.kint.2019.07.024","volume":"96","author":"PF Orlandi","year":"2019","unstructured":"Orlandi PF, Huang J, Fukagawa M, et al. A collaborative, individual-level analysis compared longitudinal outcomes across the International Network of Chronic Kidney Disease (iNETCKD) cohorts. Kidney Int. 2019;96:1217\u201333.","journal-title":"Kidney Int"},{"key":"1568_CR42","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/jch.13563","volume":"21","author":"R Pecoits-Filho","year":"2019","unstructured":"Pecoits-Filho R, Fliser D, Tu C, et al. Prescription of renin-angiotensin-aldosterone system inhibitors (RAASi) and its determinants in patients with advanced CKD under nephrologist care. J Clin Hypertens (Greenwich). 2019;21:991\u20131001.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"1568_CR43","doi-asserted-by":"publisher","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","volume":"158","author":"PE Stevens","year":"2013","unstructured":"Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the Kidney Disease: Improving Global Outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825\u201330.","journal-title":"Ann Intern Med"},{"key":"1568_CR44","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/kisup.2013.79","volume":"3","author":"R Kazancio\u011flu","year":"2013","unstructured":"Kazancio\u011flu R. Risk factors for chronic kidney disease: an update. Kidney Int Suppl. 2013;3:368\u201371.","journal-title":"Kidney Int Suppl"},{"key":"1568_CR45","unstructured":"Whitman W. US Renal Data System, USRDS 2004 Annual Data Report: Atlas of End-Stage Renal Disease in the United States: Bethesda, National Institutes of Health, National Institute of Diabetes and\u00a0Digestive and Kidney Diseases. 2004.\u00a0https:\/\/www.usrds.org\/annual-data-report\/previous-adrs\/. Accessed Dec 2019."},{"key":"1568_CR46","volume-title":"Nomenclature and criteria for diagnosis of diseases of the heart and great vessels","author":"M Dolgin","year":"1994","unstructured":"Dolgin M, Fox AC, Gorlin R, et al. Nomenclature and criteria for diagnosis of diseases of the heart and great vessels. Boston: Lippincott Williams and Wilkins; 1994."},{"key":"1568_CR47","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1053\/j.ajkd.2016.08.034","volume":"69","author":"SH Ballew","year":"2017","unstructured":"Ballew SH, Chen Y, Daya NR, et al. Frailty, kidney function, and polypharmacy: the Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis. 2017;69:228\u201336.","journal-title":"Am J Kidney Dis"},{"key":"1568_CR48","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1053\/j.ajkd.2016.09.018","volume":"69","author":"J Ishigami","year":"2017","unstructured":"Ishigami J, Grams ME, Chang AR, et al. CKD and risk for hospitalization with infection: the Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis. 2017;69:752\u201361.","journal-title":"Am J Kidney Dis"},{"key":"1568_CR49","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1053\/j.ajkd.2012.03.011","volume":"60","author":"S Waheed","year":"2012","unstructured":"Waheed S, Matsushita K, Sang Y, et al. Combined association of albuminuria and cystatin C-based estimated GFR with mortality, coronary heart disease, and heart failure outcomes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2012;60:207\u201316.","journal-title":"Am J Kidney Dis"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01568-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12325-020-01568-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-020-01568-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T16:35:33Z","timestamp":1612283733000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12325-020-01568-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["1568"],"URL":"https:\/\/doi.org\/10.1007\/s12325-020-01568-8","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]},"assertion":[{"value":"13 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}