{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:52:11Z","timestamp":1763967131183,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:00:00Z","timestamp":1620345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12325-021-01742-6","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T10:03:20Z","timestamp":1620381800000},"page":"3185-3202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Retrospective Study of COVID-19-Related Urgent Medical Visits and Hospitalizations After Outpatient COVID-19 Diagnosis in the US"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-7769","authenticated-orcid":false,"given":"Wenhui","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumathi","family":"Sivapalasingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Mellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory P.","family":"Geba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica J.","family":"Jalbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,7]]},"reference":[{"key":"1742_CR1","unstructured":"Centers for Disease Control and Prevention. CDC COVID Data Tracker. Available from: https:\/\/covid.cdc.gov\/covid-data-tracker\/#cases_casesper100klast7days. Accessed 2021 15 January"},{"key":"1742_CR2","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMoa2007764","volume":"383","author":"JH Beigel","year":"2020","unstructured":"Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the treatment of Covid-19: preliminary report. N Engl J Med. 2020;383:1813\u201326.","journal-title":"N Engl J Med"},{"key":"1742_CR3","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMoa2022926","volume":"383","author":"P Horby","year":"2020","unstructured":"The Recovery Collaborative Group, Horby P, Lim WS, et al. Dexamethasone in hospitalized patients with COVID-19: preliminary report. N Engl J Med. 2020;383:1813.","journal-title":"N Engl J Med"},{"issue":"3","key":"1742_CR4","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1056\/NEJMoa2035002","volume":"384","author":"DM Weinreich","year":"2021","unstructured":"Weinreich DM, Sivapalasingam S, Norton T, et al. REGN-COV2, a neutralizing antibody cocktail, in outpatients with COVID-19. N Engl J Med. 2021;384(3):238\u201351.ACTIV-TICO LY-CoV555 Study Group,","journal-title":"N Engl J Med"},{"key":"1742_CR5","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1056\/NEJMoa2033130","volume":"384","author":"JD Lundgren","year":"2020","unstructured":"ACTIV-TICO LY-CoV555 Study Group, Lundgren JD, Grund B, et al. A neutralizing monoclonal antibody for hospitalized patients with COVID-19. N Engl J Med. 2020;384:905\u201314.","journal-title":"N Engl J Med"},{"key":"1742_CR6","unstructured":"Eli Lilly and Company. Fact Sheet for Health Care Providers Emergency Use Authorization (EUA) of Bamlanivimab 2020. Available from: https:\/\/pi.lilly.com\/eua\/bamlanivimab-eua-factsheet-hcp.pdf. Accessed 2021 10 January"},{"key":"1742_CR7","unstructured":"Regeneron Pharmaceuticals Inc. Fact Sheet for Health Care Providers Emergency Use Authorization (EUA) of Casirivimab and Imdevimab 2020. Available from: https:\/\/www.fda.gov\/media\/143892\/download. Accessed 2021 10 January"},{"issue":"22","key":"1742_CR8","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1001\/jama.2020.22760","volume":"324","author":"EJ Lenze","year":"2020","unstructured":"Lenze EJ, Mattar C, Zorumski CF, et al. Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial. JAMA. 2020;324(22):2292\u2013300.","journal-title":"JAMA"},{"key":"1742_CR9","unstructured":"United States Department of Health and Human Services\u2019 (HHS). 45 CFR 164.514(b)(1). Other requirements relating to uses and disclosures of protected health information. Available from: https:\/\/www.ecfr.gov\/cgi-bin\/text-idx?node=pt45.1.164#se45.2.164_1514. Accessed 2021 February 24"},{"key":"1742_CR10","unstructured":"United States Department of Health and Human Services\u2019 (HHS) Office of Civil Rights (OCR). Guidance Regarding Methods for De-identification of Protected Health Information in Accordance with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule. November 26, 2012. Available from: https:\/\/www.hhs.gov\/sites\/default\/files\/ocr\/privacy\/hipaa\/understanding\/coveredentities\/De-identification\/hhs_deid_guidance.pdf. Accessed 2021 February 24"},{"key":"1742_CR11","unstructured":"Centers for Disease Control and Prevention. Coronavirus disease 2019 (COVID-19): people with certain medical conditions 2020. Available from: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/people-with-medical-conditions.html. Accessed 2020 11 November"},{"issue":"25","key":"1742_CR12","doi-asserted-by":"publisher","first-page":"790","DOI":"10.15585\/mmwr.mm6925e1","volume":"69","author":"ME Killerby","year":"2020","unstructured":"Killerby ME, Link-Gelles R, Haight SC, et al. Characteristics associated with hospitalization among patients with COVID-19: metropolitan atlanta, georgia, march-april 2020. MMWR Morb Mortal Wkly Rep. 2020;69(25):790\u20134.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"18","key":"1742_CR13","doi-asserted-by":"publisher","first-page":"545","DOI":"10.15585\/mmwr.mm6918e1","volume":"69","author":"JAW Gold","year":"2020","unstructured":"Gold JAW, Wong KK, Szablewski CM, et al. Characteristics and clinical outcomes of adult patients hospitalized with COVID-19: Georgia, March 2020. MMWR Morb Mortal Wkly Rep. 2020;69(18):545\u201350.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"15","key":"1742_CR14","doi-asserted-by":"publisher","first-page":"458","DOI":"10.15585\/mmwr.mm6915e3","volume":"69","author":"S Garg","year":"2020","unstructured":"Garg S, Kim L, Whitaker M, et al. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed Coronavirus disease 2019 - COVID-NET, 14 states, March 1\u201330, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(15):458\u201364.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"16","key":"1742_CR15","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1001\/jama.2020.5394","volume":"323","author":"G Grasselli","year":"2020","unstructured":"Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the lombardy region. Italy JAMA. 2020;323(16):1574\u201381.","journal-title":"Italy JAMA"},{"issue":"8","key":"1742_CR16","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1158\/1078-0432.CCR-11-2097","volume":"18","author":"JJ Dignam","year":"2012","unstructured":"Dignam JJ, Zhang Q, Kocherginsky M. The use and interpretation of competing risks regression models. Clin Cancer Res. 2012;18(8):2301\u20138.","journal-title":"Clin Cancer Res"},{"key":"1742_CR17","unstructured":"Centers for Disease Control and Prevention. Symptoms of coronavirus. Coronavirus disease 2019 (COVID-19) 2020. Available from: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/symptoms-testing\/symptoms.html. Accessed 2020 18 November"},{"issue":"6","key":"1742_CR18","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/ije\/dyaa190","volume":"49","author":"D Prieto-Alhambra","year":"2021","unstructured":"Prieto-Alhambra D, Ballo E, Coma E, et al. Filling the gaps in the characterization of the clinical management of COVID-19: 30-day hospital admission and fatality rates in a cohort of 118 150 cases diagnosed in outpatient settings in Spain. Int J Epidemiol. 2021;49(6):1930\u20139.","journal-title":"Int J Epidemiol"},{"key":"1742_CR19","doi-asserted-by":"publisher","first-page":"m1966","DOI":"10.1136\/bmj.m1966","volume":"369","author":"CM Petrilli","year":"2020","unstructured":"Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966.","journal-title":"BMJ"},{"issue":"9","key":"1742_CR20","doi-asserted-by":"publisher","first-page":"e2022310","DOI":"10.1001\/jamanetworkopen.2020.22310","volume":"3","author":"GN Ioannou","year":"2020","unstructured":"Ioannou GN, Locke E, Green P, et al. Risk factors for hospitalization, mechanical ventilation, or death among 10131 US veterans with SARS-CoV-2 infection. JAMA Netw Open. 2020;3(9):e2022310.","journal-title":"JAMA Netw Open"},{"key":"1742_CR21","doi-asserted-by":"publisher","first-page":"104299","DOI":"10.1016\/j.archger.2020.104299","volume":"93","author":"TI Hariyanto","year":"2021","unstructured":"Hariyanto TI, Putri C, Arisa J, Situmeang RFV, Kurniawan A. Dementia and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: a systematic review and meta-analysis. Arch Gerontol Geriatr. 2021;93:104299.","journal-title":"Arch Gerontol Geriatr"},{"issue":"10","key":"1742_CR22","doi-asserted-by":"publisher","first-page":"773","DOI":"10.7326\/M20-3742","volume":"173","author":"SY Tartof","year":"2020","unstructured":"Tartof SY, Qian L, Hong V, et al. Obesity and mortality among patients diagnosed with COVID-19: results from an integrated health care organization. Ann Intern Med. 2020;173(10):773\u201381.","journal-title":"Ann Intern Med"},{"issue":"6","key":"1742_CR23","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1053\/j.gastro.2020.08.028","volume":"159","author":"S Singh","year":"2020","unstructured":"Singh S, Bilal M, Pakhchanian H, et al. Impact of obesity on outcomes of patients with coronavirus disease 2019 in the United States: a multicenter electronic health records network study. Gastroenterology. 2020;159(6):2221\u20135.","journal-title":"Gastroenterology"},{"issue":"4","key":"1742_CR24","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.dsx.2020.05.020","volume":"14","author":"A Tamara","year":"2020","unstructured":"Tamara A, Tahapary DL. Obesity as a predictor for a poor prognosis of COVID-19: a systematic review. Diabetes Metab Syndr. 2020;14(4):655\u20139.","journal-title":"Diabetes Metab Syndr"},{"issue":"15","key":"1742_CR25","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/cid\/ciaa415","volume":"71","author":"J Lighter","year":"2020","unstructured":"Lighter J, Phillips M, Hochman S, et al. Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clin Infect Dis. 2020;71(15):896\u20137.","journal-title":"Clin Infect Dis"},{"issue":"25","key":"1742_CR26","doi-asserted-by":"publisher","first-page":"769","DOI":"10.15585\/mmwr.mm6925a1","volume":"69","author":"S Ellington","year":"2020","unstructured":"Ellington S, Strid P, Tong VT, et al. Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status - United States, January 22-June 7, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(25):769\u201375.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"44","key":"1742_CR27","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.15585\/mmwr.mm6944e3","volume":"69","author":"LD Zambrano","year":"2020","unstructured":"Zambrano LD, Ellington S, Strid P, et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(44):1641\u20137.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"38","key":"1742_CR28","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.15585\/mmwr.mm6938e1","volume":"69","author":"MJ Delahoy","year":"2020","unstructured":"Delahoy MJ, Whitaker M, O\u2019Halloran A, et al. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19 - COVID-NET, 13 States, March 1-August 22, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(38):1347\u201354.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"24","key":"1742_CR29","doi-asserted-by":"publisher","first-page":"759","DOI":"10.15585\/mmwr.mm6924e2","volume":"69","author":"EK Stokes","year":"2020","unstructured":"Stokes EK, Zambrano LD, Anderson KN, et al. Coronavirus disease 2019 case surveillance - United States, January 22-May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(24):759\u201365.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"8","key":"1742_CR30","doi-asserted-by":"publisher","first-page":"e039849","DOI":"10.1136\/bmjopen-2020-039849","volume":"10","author":"FS Vahidy","year":"2020","unstructured":"Vahidy FS, Nicolas JC, Meeks JR, et al. Racial and ethnic disparities in SARS-CoV-2 pandemic: analysis of a COVID-19 observational registry for a diverse US metropolitan population. BMJ Open. 2020;10(8):e039849.","journal-title":"BMJ Open"},{"key":"1742_CR31","unstructured":"Centers for Disease Control and Prevention. Health equity considerations and racial and ethnic minority groups 2020. Available from: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/community\/health-equity\/race-ethnicity.html. Accessed 2020 18 November"},{"key":"1742_CR32","doi-asserted-by":"publisher","DOI":"10.1101\/2020.12.08.20246017","author":"S Newton","year":"2020","unstructured":"Newton S, Zollinger B, Freeman J, et al. (2020) Factors associated with clinical severity in Emer- gency Department patients presenting with symp- tomatic SARS-CoV-2 infection. medRxiv. https:\/\/doi.org\/10.1101\/2020.12.08.20246017.","journal-title":"medRxiv"},{"issue":"4","key":"1742_CR33","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1177\/1932296820924469","volume":"14","author":"B Bode","year":"2020","unstructured":"Bode B, Garrett V, Messler J, et al. Glycemic characteristics and clinical outcomes of COVID-19 patients hospitalized in the United States. J Diabetes Sci Technol. 2020;14(4):813\u201321.","journal-title":"J Diabetes Sci Technol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01742-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-021-01742-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01742-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T03:49:00Z","timestamp":1623296940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-021-01742-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,7]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1742"],"URL":"https:\/\/doi.org\/10.1007\/s12325-021-01742-6","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"type":"print","value":"0741-238X"},{"type":"electronic","value":"1865-8652"}],"subject":[],"published":{"date-parts":[[2021,5,7]]},"assertion":[{"value":"10 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}