{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:59:39Z","timestamp":1786982379942,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12325-021-01826-3","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T13:03:03Z","timestamp":1626094983000},"page":"4413-4424","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Intravenous Iron Supplementation on Hematinic Parameters and Erythropoietin Requirements in Hemodialysis Patients"],"prefix":"10.1007","volume":"38","author":[{"given":"Sepideh","family":"Zununi Vahed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ahmadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh Mina","family":"Hejazian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahnoosh","family":"Farnood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"issue":"7","key":"1826_CR1","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1097\/01.asn.0000131523.17045.56","volume":"15","author":"A Cooper","year":"2004","unstructured":"Cooper A, Mikhail A, Lethbridge MW, Kemeny DM, Macdougall IC. Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failure. J Am Soc Nephrol. 2004;15(7):1877\u201382. https:\/\/doi.org\/10.1097\/01.asn.0000131523.17045.56.","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"1826_CR2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.4314\/ejhs.v30i5.23","volume":"30","author":"WS Shiferaw","year":"2020","unstructured":"Shiferaw WS, Akalu TY, Aynalem YA. Risk factors for anemia in patients with chronic renal failure: a systematic review and meta-analysis. Ethiop J Health Sci. 2020;30(5):829\u201342. https:\/\/doi.org\/10.4314\/ejhs.v30i5.23.","journal-title":"Ethiop J Health Sci"},{"key":"1826_CR3","doi-asserted-by":"crossref","unstructured":"Hanna RM, Streja E, Kalantar-Zadeh K. Burden of anemia in chronic kidney disease: beyond erythropoietin. Adv Ther. 2020;38(1):52\u201375.","DOI":"10.1007\/s12325-020-01524-6"},{"issue":"1","key":"1826_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.blre.2009.09.001","volume":"24","author":"CE Lankhorst","year":"2010","unstructured":"Lankhorst CE, Wish JB. Anemia in renal disease: diagnosis and management. Blood Rev. 2010;24(1):39\u201347.","journal-title":"Blood Rev"},{"issue":"1","key":"1826_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-37186-2","volume":"9","author":"F Ghasemi","year":"2019","unstructured":"Ghasemi F, Abdi A, Salari N, Tohidi MR, Faraji A. Comparing the effects of intravenous and subcutaneous erythropoietin on blood indices in hemodialysis patients. Sci Rep. 2019;9(1):1\u20138.","journal-title":"Sci Rep"},{"issue":"4","key":"1826_CR6","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/01.asn.0000131523.17045.56","volume":"9","author":"IC Macdougall","year":"2014","unstructured":"Macdougall IC, Strauss WE, McLaughlin J, Li Z, Dellanna F, Hertel J. A randomized comparison of ferumoxytol and iron sucrose for treating iron deficiency anemia in patients with CKD. J Am Soc Nephrol. 2014;9(4):705\u201312. https:\/\/doi.org\/10.1097\/01.asn.0000131523.17045.56.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"1826_CR7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/kisup.2012.37","volume":"2","author":"JJ McMurray","year":"2012","unstructured":"McMurray JJ, Parfrey PS, Adamson JW, et al. Kidney disease: improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney Int Supp. 2012;2(4):279\u2013335.","journal-title":"Kidney Int Supp"},{"issue":"3","key":"1826_CR8","doi-asserted-by":"publisher","first-page":"e0172735","DOI":"10.1371\/journal.pone.0172735","volume":"12","author":"V Saglimbene","year":"2017","unstructured":"Saglimbene V, Palmer SC, Craig JC, et al. Low versus high dose erythropoiesis-stimulating agents in hemodialysis patients with anemia: a randomized clinical trial. PLoS One. 2017;12(3):e0172735.","journal-title":"PLoS One"},{"key":"1826_CR9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/978-3-319-56042-7_11","volume-title":"Cardio-nephrology","author":"N Gupta","year":"2017","unstructured":"Gupta N, Wish JB. Erythropoietin and its cardiovascular effects. In: Rangaswami J, Lerma EV, Ronco C, editors. Cardio-nephrology. Cham: Springer; 2017. p. 119\u201328."},{"issue":"4","key":"1826_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1159\/000493551","volume":"48","author":"IC Macdougall","year":"2018","unstructured":"Macdougall IC, White C, Anker SD, et al. Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL): study design and baseline data. Am J Nephrol. 2018;48(4):260\u20138.","journal-title":"Am J Nephrol"},{"issue":"2","key":"1826_CR11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1159\/000478735","volume":"46","author":"T Kim","year":"2017","unstructured":"Kim T, Streja E, Soohoo M, et al. Serum ferritin variations and mortality in incident hemodialysis patients. Am J Nephrol. 2017;46(2):120\u201330.","journal-title":"Am J Nephrol"},{"issue":"1","key":"1826_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1080\/14740338.2021.1853098","volume":"20","author":"X Kassianides","year":"2021","unstructured":"Kassianides X, Hazara AM, Bhandari S. Improving the safety of intravenous iron treatments for patients with chronic kidney disease. Expert Opin Drug Saf. 2021;20(1):23\u201335.","journal-title":"Expert Opin Drug Saf"},{"key":"1826_CR13","volume-title":"Anemia and quality of life: unrecognized and undertreated","author":"DR Thomas","year":"2004","unstructured":"Thomas DR. Anemia and quality of life: unrecognized and undertreated. Oxford: Oxford University Press; 2004."},{"issue":"3","key":"1826_CR14","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1038\/ijo.2013.111","volume":"38","author":"S Winther","year":"2014","unstructured":"Winther S, Finer N, Sharma A, Torp-Pedersen C, Andersson C. Association of anemia with the risk of cardiovascular adverse events in overweight\/obese patients. Int J Obes (Lond). 2014;38(3):432\u20137. https:\/\/doi.org\/10.1038\/ijo.2013.111.","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"1826_CR15","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s10654-014-9929-9","volume":"29","author":"A Martinsson","year":"2014","unstructured":"Martinsson A, Andersson C, Andell P, Koul S, Engstr\u00f6m G, Smith JG. Anemia in the general population: prevalence, clinical correlates and prognostic impact. Eur J Epidemiol. 2014;29(7):489\u201398. https:\/\/doi.org\/10.1007\/s10654-014-9929-9.","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"1826_CR16","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1053\/j.ajkd.2008.05.029","volume":"52","author":"E Streja","year":"2008","unstructured":"Streja E, Kovesdy CP, Greenland S, et al. Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysis. Am J Kidney Dis. 2008;52(4):727\u201336. https:\/\/doi.org\/10.1053\/j.ajkd.2008.05.029.","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"1826_CR17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1440-1797.2007.00810.x","volume":"12","author":"DW Johnson","year":"2007","unstructured":"Johnson DW, Pollock CA, Macdougall ICJN. Erythropoiesis-stimulating agent hyporesponsiveness. Nephrology (Carlton). 2007;12(4):321\u201330. https:\/\/doi.org\/10.1111\/j.1440-1797.2007.00810.x.","journal-title":"Nephrology (Carlton)"},{"issue":"4","key":"1826_CR18","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1053\/j.ajkd.2015.11.012","volume":"67","author":"LE Ratcliffe","year":"2016","unstructured":"Ratcliffe LE, Thomas W, Glen J, et al. Diagnosis and management of iron deficiency in CKD: a summary of the NICE guideline recommendations and their rationale. Am J Kidney Dis. 2016;67(4):548\u201358. https:\/\/doi.org\/10.1053\/j.ajkd.2015.11.012.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"1826_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41100-017-0114-y","volume":"3","author":"H Yamamoto","year":"2017","unstructured":"Yamamoto H, Nishi S, Tomo T, et al. 2015 Japanese Society for Dialysis Therapy: guidelines for renal anemia in chronic kidney disease. Ren Replace Ther. 2017;3(1):1\u201346.","journal-title":"Ren Replace Ther"},{"issue":"2","key":"1826_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000499758","volume":"48","author":"M Sato","year":"2019","unstructured":"Sato M, Hanafusa N, Tsuchiya K, Kawaguchi H, Nitta K. Impact of transferrin saturation on all-cause mortality in patients on maintenance hemodialysis. Blood Pur. 2019;48(2):158\u201366.","journal-title":"Blood Pur"},{"issue":"2","key":"1826_CR21","doi-asserted-by":"publisher","first-page":"e87231","DOI":"10.1371\/journal.pone.0087231","volume":"9","author":"HM Koo","year":"2014","unstructured":"Koo HM, Kim CH, Doh FM, et al. The relationship of initial transferrin saturation to cardiovascular parameters and outcomes in patients initiating dialysis. PLoS One. 2014;9(2):e87231.","journal-title":"PLoS One"},{"issue":"9","key":"1826_CR22","doi-asserted-by":"publisher","first-page":"e0236277","DOI":"10.1371\/journal.pone.0236277","volume":"15","author":"T Kuragano","year":"2020","unstructured":"Kuragano T, Joki N, Hase H, et al. Low transferrin saturation (TSAT) and high ferritin levels are significant predictors for cerebrovascular and cardiovascular disease and death in maintenance hemodialysis patients. PLoS One. 2020;15(9):e0236277.","journal-title":"PLoS One"},{"issue":"5","key":"1826_CR23","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1056\/NEJMoa1810742","volume":"380","author":"IC Macdougall","year":"2019","unstructured":"Macdougall IC, White C, Anker SD, et al. Intravenous iron in patients undergoing maintenance hemodialysis. N Engl J Med. 2019;380(5):447\u201358. https:\/\/doi.org\/10.1056\/NEJMoa1810742.","journal-title":"N Engl J Med"},{"issue":"5","key":"1826_CR24","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1681\/ASN.2019090972","volume":"31","author":"IC Macdougall","year":"2020","unstructured":"Macdougall IC, Bhandari S, White C, et al. Intravenous iron dosing and infection risk in patients on hemodialysis: a prespecified secondary analysis of the PIVOTAL trial. J Am Soc Nephrol. 2020;31(5):1118\u201327. https:\/\/doi.org\/10.1681\/ASN.2019090972.","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"1826_CR25","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2215\/CJN.05390517","volume":"13","author":"I Hougen","year":"2018","unstructured":"Hougen I, Collister D, Bourrier M, et al. Safety of intravenous iron in dialysis: a systematic review and meta-analysis. Clin J Am Soc Nephrol. 2018;13(3):457\u201367. https:\/\/doi.org\/10.2215\/CJN.05390517.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"1826_CR26","doi-asserted-by":"publisher","first-page":"89","DOI":"10.23876\/j.krcp.20.120","volume":"40","author":"X Kassianides","year":"2021","unstructured":"Kassianides X, Gordon A, Sturmey R, Bhandari S. The comparative effects of intravenous iron on oxidative stress and inflammation in patients with chronic kidney disease and iron deficiency: a randomized controlled pilot study. Kidney Res Clin Pract. 2021;40(1):89\u201398. https:\/\/doi.org\/10.23876\/j.krcp.20.120.","journal-title":"Kidney Res Clin Pract"},{"issue":"12","key":"1826_CR27","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1093\/ndt\/gfy190","volume":"33","author":"A Karaboyas","year":"2018","unstructured":"Karaboyas A, Morgenstern H, Pisoni RL, et al. Association between serum ferritin and mortality: findings from the USA, Japan and European Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant. 2018;33(12):2234\u201344. https:\/\/doi.org\/10.1093\/ndt\/gfy190.","journal-title":"Nephrol Dial Transplant"},{"key":"1826_CR28","volume-title":"Handbook of dialysis","author":"JT Daugirdas","year":"2012","unstructured":"Daugirdas JT, Blake PG, Ing TS. Handbook of dialysis. Philadelphia: Lippincott Williams & Wilkins; 2012."}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01826-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-021-01826-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01826-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T16:10:23Z","timestamp":1672762223000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-021-01826-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,12]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1826"],"URL":"https:\/\/doi.org\/10.1007\/s12325-021-01826-3","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,12]]},"assertion":[{"value":"28 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}