{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:12:50Z","timestamp":1793293970985,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12325-021-01876-7","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T18:02:27Z","timestamp":1629655347000},"page":"5144-5164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["H\u00fcrthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1363-8559","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Coca-Pelaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0890","authenticated-orcid":false,"given":"Juan P.","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6444-6592","authenticated-orcid":false,"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5563-8840","authenticated-orcid":false,"given":"Alvaro","family":"Sanabria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abir","family":"Al Ghuzlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok R.","family":"Shaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Angelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana M.","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0451-2404","authenticated-orcid":false,"given":"Antti A.","family":"M\u00e4kitie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry D.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall P.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2542-3830","authenticated-orcid":false,"given":"Gregory W.","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Sim\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph P.","family":"Tufano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz P.","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Zafereo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-6709","authenticated-orcid":false,"given":"Alessandra","family":"Rinaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8247-8002","authenticated-orcid":false,"given":"Alfio","family":"Ferlito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"1876_CR1","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/1097-0142(19860415)57:8<1613::AID-CNCR2820570829>3.0.CO;2-3","volume":"57","author":"G Har-el","year":"1986","unstructured":"Har-el G, Hadar T, Segal K, Levy R, Sidi J. Hurthle cell carcinoma of the thyroid gland. A tumor of moderate malignancy. Cancer. 1986;57:1613\u20137.","journal-title":"Cancer"},{"key":"1876_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1089\/thy.2005.15.121","volume":"15","author":"P Caturegli","year":"2005","unstructured":"Caturegli P, Ruggere C. Karl H\u00fcrthle! Now, who was he? Thyroid. 2005;15:121\u20133.","journal-title":"Thyroid"},{"key":"1876_CR3","volume-title":"WHO classification of tumours of endocrine organs","author":"RV Lloyd","year":"2017","unstructured":"Lloyd RV, Osamura RY, Kl\u00f6ppel GRJ. WHO classification of tumours of endocrine organs. 4th ed. Lyon: International Agency for Research on Cancer; 2017.","edition":"4"},{"key":"1876_CR4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1440-1827.1992.tb02879.x","volume":"42","author":"G Tallini","year":"2008","unstructured":"Tallini G, Carcangiu ML, Rosai J. Oncocytic neoplasms of the thyroid gland. Pathol Int. 2008;42:305\u201315.","journal-title":"Pathol Int"},{"key":"1876_CR5","doi-asserted-by":"publisher","first-page":"6873","DOI":"10.2147\/OTT.S119980","volume":"9","author":"S Ahmadi","year":"2016","unstructured":"Ahmadi S, Stang M, Jiang XS, Sosa JA. H\u00fcrthle cell carcinoma: current perspectives. Onco Targets Ther. 2016;9:6873\u201384.","journal-title":"Onco Targets Ther"},{"key":"1876_CR6","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.5858\/2008-132-1241-TTHOCA","volume":"132","author":"KT Montone","year":"2008","unstructured":"Montone KT, Baloch ZW, LiVolsi VA. The thyroid H\u00fcrthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review. Arch Pathol Lab Med. 2008;132:1241\u201350.","journal-title":"Arch Pathol Lab Med"},{"key":"1876_CR7","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1177\/000348940911800510","volume":"118","author":"M Gross","year":"2009","unstructured":"Gross M, Eliashar R, Ben-Yaakov A, Weinberger JM, Maly B. Clinicopathologic features and outcome of the oncocytic variant of papillary thyroid carcinoma. Ann Otol Rhinol Laryngol. 2009;118:374\u201381.","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"1876_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1089\/thy.2019.0190","volume":"30","author":"Y Ren","year":"2020","unstructured":"Ren Y, Kyriazidis N, Faquin WC, et al. The presence of H\u00fcrthle cells does not increase the risk of malignancy in most Bethesda categories in thyroid fine-needle aspirates. Thyroid. 2020;30:425\u201331.","journal-title":"Thyroid"},{"key":"1876_CR9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ccell.2018.07.002","volume":"34","author":"I Ganly","year":"2018","unstructured":"Ganly I, Makarov V, Deraje S, et al. Integrated genomic analysis of H\u00fcrthle cell cancer reveals oncogenic drivers, recurrent mitochondrial mutations, and unique chromosomal landscapes. Cancer Cell. 2018;34:256-270.e5.","journal-title":"Cancer Cell"},{"key":"1876_CR10","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ccell.2018.06.013","volume":"34","author":"RK Gopal","year":"2018","unstructured":"Gopal RK, K\u00fcbler K, Calvo SE, et al. Widespread chromosomal losses and mitochondrial DNA alterations as genetic drivers in H\u00fcrthle cell carcinoma. Cancer Cell. 2018;34:242-255.e5.","journal-title":"Cancer Cell"},{"key":"1876_CR11","doi-asserted-by":"publisher","first-page":"g7647","DOI":"10.1136\/bmj.g7647","volume":"350","author":"L Shamseer","year":"2015","unstructured":"Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;350:g7647.","journal-title":"BMJ"},{"key":"1876_CR12","volume":"13","author":"A Ramirez","year":"2012","unstructured":"Ramirez A, Cox C. Improving on the range rule of thumb. Rose Hulman Undergrad Math J. 2012;13: 1.","journal-title":"Rose Hulman Undergrad Math J"},{"key":"1876_CR13","first-page":"197","volume":"9","author":"A Stojadinovic","year":"2002","unstructured":"Stojadinovic A, Hoos A, Ghossein RA, et al. H\u00fcrthle cell carcinoma: a 60-year experience. Ann Surg Oncol. 2002;9:197\u2013203.","journal-title":"Ann Surg Oncol"},{"key":"1876_CR14","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/cncr.11176","volume":"97","author":"L Lopez-Penabad","year":"2003","unstructured":"Lopez-Penabad L, Chiu AC, Hoff AO, et al. Prognostic factors in patients with H\u00fcrthle cell neoplasms of the thyroid. Cancer. 2003;97:1186\u201394.","journal-title":"Cancer"},{"key":"1876_CR15","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.surg.2005.08.034","volume":"138","author":"PI Haigh","year":"2005","unstructured":"Haigh PI, Urbach DR. The treatment and prognosis of H\u00fcrthle cell follicular thyroid carcinoma compared with its non-H\u00fcrthle cell counterpart. Surgery. 2005;138:1152\u20137 (discussion 1157-8).","journal-title":"Surgery"},{"key":"1876_CR16","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1002\/cncr.21825","volume":"106","author":"RA Ghossein","year":"2006","unstructured":"Ghossein RA, Hiltzik DH, Carlson DL, et al. Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 cases. Cancer. 2006;106:1669\u201376.","journal-title":"Cancer"},{"key":"1876_CR17","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1001\/archotol.132.1.54","volume":"132","author":"EL Maxwell","year":"2006","unstructured":"Maxwell EL, Palme CE, Freeman J. H\u00fcrthle cell tumors: applying molecular markers to define a new management algorithm. Arch Otolaryngol Head Neck Surg. 2006;132:54\u20138.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1876_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/01.mnm.0000202862.74917.0c","volume":"27","author":"N Ozlem K\u00fc\u00e7\u00fck","year":"2006","unstructured":"Ozlem K\u00fc\u00e7\u00fck N, Kulak H, Tokmak E, Tar P, Ibi\u015f E, Aras G. H\u00fcrthle cell carcinoma: a clinicopathological study of thirteen cases. Nucl Med Commun. 2006;27:377\u20139.","journal-title":"Nucl Med Commun"},{"key":"1876_CR19","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1445-2197.2007.04389.x","volume":"78","author":"M Ahmed","year":"2008","unstructured":"Ahmed M, Bin Yousef H, Greer W, et al. Hurthle cell neoplasm of the thyroid gland. ANZ J Surg. 2008;78:139\u201343.","journal-title":"ANZ J Surg"},{"key":"1876_CR20","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.amjsurg.2007.06.001","volume":"195","author":"Y Kushchayeva","year":"2008","unstructured":"Kushchayeva Y, Duh Q-Y, Kebebew E, D\u2019Avanzo A, Clark OH. Comparison of clinical characteristics at diagnosis and during follow-up in 118 patients with Hurthle cell or follicular thyroid cancer. Am J Surg. 2008;195:457\u201362.","journal-title":"Am J Surg"},{"key":"1876_CR21","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1245\/s10434-008-0079-8","volume":"15","author":"YW Zhang","year":"2008","unstructured":"Zhang YW, Greenblatt DY, Repplinger D, et al. Older age and larger tumor size predict malignancy in H\u00fcrthle cell neoplasms of the thyroid. Ann Surg Oncol. 2008;15:2842\u20136.","journal-title":"Ann Surg Oncol"},{"key":"1876_CR22","first-page":"305","volume":"29","author":"A Barnabei","year":"2009","unstructured":"Barnabei A, Ferretti E, Baldelli R, Procaccini A, Spriano G, Appetecchia M. Hurthle cell tumours of the thyroid. Personal experience and review of the literature. Acta Otorhinolaryngol Ital. 2009;29:305\u201311.","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"1876_CR23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ejso.2008.06.007","volume":"35","author":"SC Mills","year":"2009","unstructured":"Mills SC, Haq M, Smellie WJB, Harmer C. H\u00fcrthle cell carcinoma of the thyroid: retrospective review of 62 patients treated at the Royal Marsden Hospital between 1946 and 2003. Eur J Surg Oncol. 2009;35:230\u20134.","journal-title":"Eur J Surg Oncol"},{"key":"1876_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.7150\/jca.1.23","volume":"1","author":"MA Guerrero","year":"2010","unstructured":"Guerrero MA, Suh I, Vriens MR, et al. Age and tumor size predicts lymph node involvement in H\u00fcrthle cell carcinoma. J Cancer. 2010;1:23\u20136.","journal-title":"J Cancer"},{"key":"1876_CR25","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1007\/s00268-009-0357-z","volume":"34","author":"A Pisanu","year":"2010","unstructured":"Pisanu A, Di Chiara B, Reccia I, Uccheddu A. Oncocytic cell tumors of the thyroid: factors predicting malignancy and influencing prognosis, treatment decisions, and outcomes. World J Surg. 2010;34:836\u201343.","journal-title":"World J Surg"},{"key":"1876_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1749-4486.2011.02212.x","volume":"36","author":"S Kutun","year":"2011","unstructured":"Kutun S, Turanli S, Kavlakoglu B, Cetin A. The predicting factors for clinical outcomes in patients with H\u00fcrthle cell carcinoma: how we do it. Clin Otolaryngol. 2011;36:73\u20137.","journal-title":"Clin Otolaryngol"},{"key":"1876_CR27","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1002\/cncr.27770","volume":"119","author":"P Goffredo","year":"2013","unstructured":"Goffredo P, Roman SA, Sosa JA. Hurthle cell carcinoma: a population-level analysis of 3311 patients. Cancer. 2013;119:504\u201311.","journal-title":"Cancer"},{"key":"1876_CR28","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1245\/s10434-013-2965-y","volume":"20","author":"K Sugino","year":"2013","unstructured":"Sugino K, Kameyama K, Ito K, et al. Does H\u00fcrthle cell carcinoma of the thyroid have a poorer prognosis than ordinary follicular thyroid carcinoma? Ann Surg Oncol. 2013;20:2944\u201350.","journal-title":"Ann Surg Oncol"},{"key":"1876_CR29","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3904\/kjim.2014.29.3.325","volume":"29","author":"WG Kim","year":"2014","unstructured":"Kim WG, Kim TY, Kim TH, et al. Follicular and Hurthle cell carcinoma of the thyroid in iodine-sufficient area: retrospective analysis of Korean multicenter data. Korean J Intern Med. 2014;29:325\u201333.","journal-title":"Korean J Intern Med"},{"key":"1876_CR30","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1186\/1471-2407-14-777","volume":"14","author":"R Petric","year":"2014","unstructured":"Petric R, Gazic B, Besic N. Prognostic factors for disease-specific survival in 108 patients with H\u00fcrthle cell thyroid carcinoma: a single-institution experience. BMC Cancer. 2014;14:777.","journal-title":"BMC Cancer"},{"key":"1876_CR31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1210\/jc.2014-1634","volume":"100","author":"A-M Chindris","year":"2015","unstructured":"Chindris A-M, Casler JD, Bernet VJ, et al. Clinical and molecular features of H\u00fcrthle cell carcinoma of the thyroid. J Clin Endocrinol Metab. 2015;100:55\u201362.","journal-title":"J Clin Endocrinol Metab"},{"key":"1876_CR32","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1089\/thy.2016.0246","volume":"26","author":"CL Jillard","year":"2016","unstructured":"Jillard CL, Youngwirth L, Scheri RP, Roman S, Sosa JA. Radioactive iodine treatment is associated with improved survival for patients with H\u00fcrthle cell carcinoma. Thyroid. 2016;26:959\u201364.","journal-title":"Thyroid"},{"key":"1876_CR33","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1186\/s12885-017-3370-x","volume":"17","author":"B Oluic","year":"2017","unstructured":"Oluic B, Paunovic I, Loncar Z, et al. Survival and prognostic factors for survival, cancer specific survival and disease free interval in 239 patients with Hurthle cell carcinoma: a single center experience. BMC Cancer. 2017;17:371.","journal-title":"BMC Cancer"},{"key":"1876_CR34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/COC.0000000000000180","volume":"40","author":"P Zavitsanos","year":"2017","unstructured":"Zavitsanos P, Amdur RJ, Drew PA, Cusi K, Werning JW, Morris CG. Favorable outcome of Hurthle cell carcinoma of the thyroid treated with total thyroidectomy, radioiodine, and selective use of external-beam radiotherapy. Am J Clin Oncol. 2017;40:433\u20137.","journal-title":"Am J Clin Oncol"},{"key":"1876_CR35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.endinu.2017.12.006","volume":"65","author":"LA Ernaga","year":"2018","unstructured":"Ernaga LA, Migueliz Bermejo I, Anda Api\u00f1\u00e1niz E, et al. Comparison of clinical characteristics of patients with follicular thyroid carcinoma and H\u00fcrthle cell carcinoma. Endocrinol Diabetes Nutr. 2018;65:136\u201342.","journal-title":"Endocrinol Diabetes Nutr"},{"key":"1876_CR36","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1097\/MNM.0000000000001049","volume":"40","author":"W Amouri","year":"2019","unstructured":"Amouri W, Charfeddine S, Charfi S, Jardak I, Boudawara T, Guermazi F. Clinicopathological features and outcomes after radioactive iodine treatment of oncocytic well-differentiated thyroid carcinomas. Nucl Med Commun. 2019;40:888\u201393.","journal-title":"Nucl Med Commun"},{"key":"1876_CR37","first-page":"300","volume":"63","author":"NO Santana","year":"2019","unstructured":"Santana NO, Freitas RMC, Marcos VN, et al. Diagnostic performance of thyroid ultrasound in H\u00fcrthle cell carcinomas. Arch Endocrinol Metab. 2019;63:300\u20135.","journal-title":"Arch Endocrinol Metab"},{"key":"1876_CR38","doi-asserted-by":"publisher","first-page":"e7458","DOI":"10.7717\/peerj.7458","volume":"7","author":"Q Yang","year":"2019","unstructured":"Yang Q, Zhao Z, Zhong G, Jin A, Yu K. Effect of adjuvant radioactive iodine therapy on survival in rare oxyphilic subtype of thyroid cancer (H\u00fcrthle cell carcinoma). PeerJ. 2019;7:e7458.","journal-title":"PeerJ"},{"key":"1876_CR39","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00259-020-04952-2","volume":"48","author":"V Wenter","year":"2021","unstructured":"Wenter V, Albert NL, Unterrainer M, et al. Clinical impact of follicular oncocytic (H\u00fcrthle cell) carcinoma in comparison with corresponding classical follicular thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2021;48:449\u201360.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"1876_CR40","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/cancers13010026","volume":"13","author":"S Kure","year":"2020","unstructured":"Kure S, Ohashi R. Thyroid H\u00fcrthle cell carcinoma: clinical, pathological, and molecular features. Cancers (Basel). 2020;13:26.","journal-title":"Cancers (Basel)"},{"key":"1876_CR41","doi-asserted-by":"publisher","first-page":"E1852","DOI":"10.1210\/jc.2013-2292","volume":"98","author":"MN Nikiforova","year":"2013","unstructured":"Nikiforova MN, Wald AI, Roy S, Durso MB, Nikiforov YE. Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer. J Clin Endocrinol Metab. 2013;98:E1852\u201360.","journal-title":"J Clin Endocrinol Metab"},{"key":"1876_CR42","doi-asserted-by":"publisher","first-page":"E962","DOI":"10.1210\/jc.2012-3539","volume":"98","author":"I Ganly","year":"2013","unstructured":"Ganly I, Ricarte Filho J, Eng S, et al. Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy. J Clin Endocrinol Metab. 2013;98:E962\u201372.","journal-title":"J Clin Endocrinol Metab"},{"key":"1876_CR43","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1038\/sj.bjc.6602547","volume":"92","author":"V M\u00e1ximo","year":"2005","unstructured":"M\u00e1ximo V, Botelho T, Capela J, et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (H\u00fcrthle cell) tumours of the thyroid. Br J Cancer. 2005;92:1892\u20138.","journal-title":"Br J Cancer"},{"key":"1876_CR44","doi-asserted-by":"publisher","first-page":"e4577","DOI":"10.1210\/clinem\/dgaa655","volume":"105","author":"J Metovic","year":"2020","unstructured":"Metovic J, Vignale C, Annaratone L, et al. The oncocytic variant of poorly differentiated thyroid carcinoma shows a specific immune-related gene expression profile. J Clin Endocrinol Metab. 2020;105:e4577\u201392.","journal-title":"J Clin Endocrinol Metab"},{"key":"1876_CR45","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.surg.2013.06.029","volume":"154","author":"S Nagar","year":"2013","unstructured":"Nagar S, Aschebrook-Kilfoy B, Kaplan EL, Angelos P, Grogan RH. Hurthle cell carcinoma: an update on survival over the last 35 years. Surgery. 2013;154:1263\u201371 (discussion 1271).","journal-title":"Surgery"},{"key":"1876_CR46","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1001\/archotol.129.2.207","volume":"129","author":"N Bhattacharyya","year":"2003","unstructured":"Bhattacharyya N. Survival and prognosis in H\u00fcrthle cell carcinoma of the thyroid gland. Arch Otolaryngol Head Neck Surg. 2003;129:207\u201310.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"1876_CR47","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1089\/thy.2011.0407","volume":"22","author":"JA Bishop","year":"2012","unstructured":"Bishop JA, Wu G, Tufano RP, Westra WH. Histological patterns of locoregional recurrence in H\u00fcrthle cell carcinoma of the thyroid gland. Thyroid. 2012;22:690\u20134.","journal-title":"Thyroid"},{"key":"1876_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1\u2013133.","journal-title":"Thyroid"},{"key":"1876_CR49","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1089\/105072503322238845","volume":"13","author":"N Besic","year":"2003","unstructured":"Besic N, Vidergar-Kralj B, Frkovic-Grazio S, Movrin-Stanovnik T, Auersperg M. The role of radioactive iodine in the treatment of H\u00fcrthle cell carcinoma of the thyroid. Thyroid. 2003;13:577\u201384.","journal-title":"Thyroid"},{"key":"1876_CR50","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/S1055-3207(18)30251-5","volume":"7","author":"CR McHenry","year":"1998","unstructured":"McHenry CR, Sandoval BA. Management of follicular and H\u00fcrthle cell neoplasms of the thyroid gland. Surg Oncol Clin N Am. 1998;7:893\u2013910.","journal-title":"Surg Oncol Clin N Am"},{"key":"1876_CR51","first-page":"1260","volume":"47","author":"DA Pryma","year":"2006","unstructured":"Pryma DA, Sch\u00f6der H, G\u00f6nen M, Robbins RJ, Larson SM, Yeung HWD. Diagnostic accuracy and prognostic value of 18F-FDG PET in H\u00fcrthle cell thyroid cancer patients. J Nucl Med. 2006;47:1260\u20136.","journal-title":"J Nucl Med"},{"key":"1876_CR52","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12885-016-2179-3","volume":"16","author":"N Besic","year":"2016","unstructured":"Besic N, Schwarzbartl-Pevec A, Vidergar-Kralj B, Crnic T, Gazic B, Marolt MM. Treatment and outcome of 32 patients with distant metastases of H\u00fcrthle cell thyroid carcinoma: a single-institution experience. BMC Cancer. 2016;16:162.","journal-title":"BMC Cancer"},{"key":"1876_CR53","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.3390\/cancers11081185","volume":"11","author":"MD Aydemirli","year":"2019","unstructured":"Aydemirli MD, Corver W, Beuk R, et al. Targeted treatment options of recurrent radioactive iodine refractory H\u00fcrthle cell cancer. Cancers (Basel). 2019;11:1185.","journal-title":"Cancers (Basel)"},{"key":"1876_CR54","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0140-6736(14)60421-9","volume":"384","author":"MS Brose","year":"2014","unstructured":"Brose MS, Nutting CM, Jarzab B, et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet. 2014;384:319\u201328.","journal-title":"Lancet"},{"key":"1876_CR55","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1056\/NEJMoa1406470","volume":"372","author":"M Schlumberger","year":"2015","unstructured":"Schlumberger M, Tahara M, Wirth LJ, et al. Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med. 2015;372:621\u201330.","journal-title":"N Engl J Med"},{"key":"1876_CR56","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0360-3016(03)00199-8","volume":"56","author":"RL Foote","year":"2003","unstructured":"Foote RL, Brown PD, Garces YI, McIver B, Kasperbauer JL. Is there a role for radiation therapy in the management of H\u00fcrthle cell carcinoma? Int J Radiat Oncol Biol Phys. 2003;56:1067\u201372.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1876_CR57","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1089\/thy.2011.0243","volume":"22","author":"N Besic","year":"2012","unstructured":"Besic N, Auersperg M, Gazic B, Dremelj M, Zagar I. Neoadjuvant chemotherapy in 29 patients with locally advanced follicular or H\u00fcrthle cell thyroid carcinoma: a phase 2 study. Thyroid. 2012;22:131\u20137.","journal-title":"Thyroid"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01876-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-021-01876-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01876-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T22:19:55Z","timestamp":1675635595000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-021-01876-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,22]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["1876"],"URL":"https:\/\/doi.org\/10.1007\/s12325-021-01876-7","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,22]]},"assertion":[{"value":"1 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}