{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:06:06Z","timestamp":1791644766654,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s12325-021-01910-8","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T19:03:07Z","timestamp":1632942187000},"page":"5534-5547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Diquafosol Ophthalmic Solution on Clinical Parameters and Visual Function in Soft Contact Lens-Related Dry Eye"],"prefix":"10.1007","volume":"38","author":[{"given":"Tomohiro","family":"Ogami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-4127","authenticated-orcid":false,"given":"Takahiro","family":"Hiraoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Oshika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"1910_CR1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jtos.2016.09.003","volume":"15","author":"K Tsubota","year":"2017","unstructured":"Tsubota K, Yokoi N, Shimazaki J, et al. New perspectives on dry eye definition and diagnosis: a consensus report by the Asia Dry Eye Society. Ocul Surf. 2017;15:65\u201376.","journal-title":"Ocul Surf"},{"key":"1910_CR2","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1016\/j.ophtha.2011.05.029","volume":"118","author":"M Uchino","year":"2011","unstructured":"Uchino M, Nishiwaki Y, Michikawa T, et al. Prevalence and risk factors of dry eye disease in Japan: Koumi study. Ophthalmology. 2011;118:2361\u20137.","journal-title":"Ophthalmology"},{"key":"1910_CR3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/ICO.0b013e31826671ab","volume":"32","author":"AA Abusharha","year":"2013","unstructured":"Abusharha AA, Pearce EI. The effect of low humidity on the human tear film. Cornea. 2013;32:429\u201334.","journal-title":"Cornea"},{"key":"1910_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1542-0124(12)70082-4","volume":"5","author":"JA Smith","year":"2007","unstructured":"Smith JA, Albietz J, Begley C, et al. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:93\u2013107.","journal-title":"Ocul Surf"},{"key":"1910_CR5","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1097\/00006324-199910000-00022","volume":"76","author":"C Vajdic","year":"1999","unstructured":"Vajdic C, Holden BA, Sweeney DF, Cornish RM. The frequency of ocular symptoms during spectacle and daily soft and rigid contact lens wear. Optom Vis Sci. 1999;76:705\u201311.","journal-title":"Optom Vis Sci"},{"key":"1910_CR6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1097\/00006324-199708000-00023","volume":"74","author":"MJ Doughty","year":"1997","unstructured":"Doughty MJ, Fonn D, Richter D, Simpson T, Caffery B, Gordon K. A patient questionnaire approach to estimating the prevalence of dry eye symptoms in patients presenting to optometric practices across Canada. Optom Vis Sci. 1997;74:624\u201331.","journal-title":"Optom Vis Sci"},{"key":"1910_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1167\/iovs.02-0377","volume":"44","author":"JJ Nichols","year":"2003","unstructured":"Nichols JJ, King-Smith PE. Thickness of the pre-and post-contact lens tear film measured in vivo by interferometry. Investig Ophthalmol Vis Sci. 2003;44:68\u201377.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR8","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1167\/iovs.09-4389","volume":"51","author":"Q Chen","year":"2010","unstructured":"Chen Q, Wang J, Tao A, Shen M, Jiao S, Lu F. Ultrahigh-resolution measurement by optical coherence tomography of dynamic tear film changes on contact lenses. Invest Ophthalmol Vis Sci. 2010;51:1988\u201393.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1910_CR9","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1167\/iovs.13-13235","volume":"54","author":"JP Craig","year":"2013","unstructured":"Craig JP, Willcox MDP, Argueso P, et al. The TFOS International Workshop on Contact Lens Discomfort: report of the contact lens interactions with the tear film subcommittee. Investig Ophthalmol Vis Sci. 2013;54:123\u201356.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1097\/00003226-200308000-00010","volume":"22","author":"JJ Nichols","year":"2003","unstructured":"Nichols JJ, King-Smith PE. The effect of eye closure on the post-lens tear film thickness during silicone hydrogel contact lens wear. Cornea. 2003;22:539\u201344.","journal-title":"Cornea"},{"key":"1910_CR11","doi-asserted-by":"publisher","first-page":"6294","DOI":"10.1167\/iovs.09-4772","volume":"51","author":"SH Kimball","year":"2010","unstructured":"Kimball SH, King-Smith PE, Nichols JJ. Evidence for the major contribution of evaporation to tear film thinning between blinks. Investig Ophthalmol Vis Sci. 2010;51:6294\u20137.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/OPX.0b013e318181ae60","volume":"85","author":"PE King-Smith","year":"2008","unstructured":"King-Smith PE, Nichols JJ, Nichols KK, Fink BA, Braun RJ. Contributions of evaporation and other mechanisms to tear film thinning and break-up. Optom Vis Sci. 2008;85:623\u201330.","journal-title":"Optom Vis Sci"},{"key":"1910_CR13","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1097\/ICL.0b013e31818c5d00","volume":"34","author":"M Guillon","year":"2008","unstructured":"Guillon M, Maissa C. Contact lens wear affects tear film evaporation. Eye Contact Lens. 2008;34:326\u201330.","journal-title":"Eye Contact Lens"},{"key":"1910_CR14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/00006324-200206000-00012","volume":"79","author":"LC Thai","year":"2002","unstructured":"Thai LC, Tomlinson A, Ridder WH. Contact lens drying and visual performance: the vision cycle with contact lenses. Optom Vis Sci. 2002;79:381\u20138.","journal-title":"Optom Vis Sci"},{"key":"1910_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1167\/iovs.13-13166","volume":"54","author":"EB Papas","year":"2013","unstructured":"Papas EB, Ciolino JB, Jacobs D, et al. The TFOS International Workshop on Contact Lens Discomfort: report of the management and therapy subcommittee. Investig Ophthalmol Vis Sci. 2013;54:183\u2013203.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR16","doi-asserted-by":"publisher","first-page":"538","DOI":"10.5301\/EJO.2011.6324","volume":"21","author":"G Calv\u00e3o-Santos","year":"2011","unstructured":"Calv\u00e3o-Santos G, Borges C, Nunes S, Salgado-Borges J, Duarte L. Efficacy of 3 different artificial tears for the treatment of dry eye in frequent computer users and\/or contact lens users. Eur J Ophthalmol. 2011;21:538\u201344.","journal-title":"Eur J Ophthalmol"},{"key":"1910_CR17","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1001\/archopht.1990.01070040096038","volume":"108","author":"JM Chapman","year":"1990","unstructured":"Chapman JM, Cheeks L, Green K. Interactions of benzalkonium chloride with soft and hard contact lenses. Arch Ophthalmol. 1990;108:244\u20136.","journal-title":"Arch Ophthalmol"},{"key":"1910_CR18","first-page":"53","volume":"291","author":"K Hosoya","year":"1999","unstructured":"Hosoya K, Ueda H, Kim KJ, Lee VH. Nucleotide stimulation of Cl-secretion in the pigmented rabbit conjunctiva. J Pharmacol Exp Ther. 1999;291:53\u20139.","journal-title":"J Pharmacol Exp Ther"},{"key":"1910_CR19","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1006\/exer.1998.0520","volume":"67","author":"JE Jumblatt","year":"1998","unstructured":"Jumblatt JE, Jumblatt MM. Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp Eye Res. 1998;67:341\u20136.","journal-title":"Exp Eye Res"},{"key":"1910_CR20","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1016\/j.ophtha.2012.04.010","volume":"119","author":"Y Matsumoto","year":"2012","unstructured":"Matsumoto Y, Ohashi Y, Watanabe H, Tsubota K, Diquafosol Ophthalmic Solution Phase 2 Study Group. Efficacy and safety of diquafosol ophthalmic solution in patients with dry eye syndrome: a Japanese phase 2 clinical trial. Ophthalmology. 2012;119:1954\u201360.","journal-title":"Ophthalmology"},{"key":"1910_CR21","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1136\/bjophthalmol-2011-301448","volume":"96","author":"E Takamura","year":"2012","unstructured":"Takamura E, Tsubota K, Watanabe H, Ohashi Y, Diquafosol Ophthalmic Solution Phase 3 Study Group. A randomised, double-masked comparison study of diquafosol versus sodium hyaluronate ophthalmic solutions in dry eye patients. Br J Ophthalmol. 2012;96:1310\u20135.","journal-title":"Br J Ophthalmol"},{"key":"1910_CR22","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1007\/s10384-013-0251-y","volume":"57","author":"S Koh","year":"2013","unstructured":"Koh S, Ikeda C, Takai Y, Watanabe H, Maeda N, Nishida K. Long-term results of treatment with diquafosol ophthalmic solution for aqueous-deficient dry eye. Jpn J Ophthalmol. 2013;57:440\u20136.","journal-title":"Jpn J Ophthalmol"},{"key":"1910_CR23","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s12325-019-01188-x","volume":"37","author":"Y Ohashi","year":"2020","unstructured":"Ohashi Y, Munesue M, Shimazaki J, et al. Long-term safety and effectiveness of diquafosol for the treatment of dry eye in a real-world setting: a prospective observational study. Adv Ther. 2020;37:707\u201317.","journal-title":"Adv Ther"},{"key":"1910_CR24","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1097\/OPX.0000000000000877","volume":"93","author":"C Shigeyasu","year":"2016","unstructured":"Shigeyasu C, Yamada M, Akune Y, Fukui M. Diquafosol for soft contact lens dryness: clinical evaluation and tear analysis. Optom Vis Sci. 2016;93:973\u20138.","journal-title":"Optom Vis Sci"},{"key":"1910_CR25","first-page":"2251","volume":"9","author":"M Yamaguchi","year":"2015","unstructured":"Yamaguchi M, Nishijima T, Shimazaki J, et al. Real-world assessment of diquafosol in dry eye patients with risk factors such as contact lens, meibomian gland dysfunction, and conjunctivochalasis: subgroup analysis from a prospective observational study. Clin Ophthalmol. 2015;9:2251\u20136.","journal-title":"Clin Ophthalmol"},{"key":"1910_CR26","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1016\/j.jcrs.2014.02.035","volume":"40","author":"G Miyake","year":"2014","unstructured":"Miyake G, Ota I, Miyake K, Zako M, Iwaki M. Effects of topical diquafosol pretreatment on intraoperative corneal wetting. J Cataract Refract Surg. 2014;40:1682\u20138.","journal-title":"J Cataract Refract Surg"},{"key":"1910_CR27","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/00006324-199301000-00010","volume":"70","author":"SG Whittaker","year":"1993","unstructured":"Whittaker SG, Lovie-Kitchin J. Visual requirements for reading. Optom Vis Sci. 1993;70:54\u201365.","journal-title":"Optom Vis Sci"},{"key":"1910_CR28","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/01.opx.0000171336.40273.3f","volume":"82","author":"MD Crossland","year":"2005","unstructured":"Crossland MD, Culham LE, Rubin GS. Predicting reading fluency in patients with macular disease. Optom Vis Sci. 2005;82:11\u20137.","journal-title":"Optom Vis Sci"},{"key":"1910_CR29","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1097\/00006324-198205000-00009","volume":"59","author":"JA Marron","year":"1982","unstructured":"Marron JA, Bailey IL. Visual factors and orientation-mobility performance. Am J Optom Physiol Opt. 1982;59:413\u201326.","journal-title":"Am J Optom Physiol Opt"},{"key":"1910_CR30","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1001\/jama.279.14.1083","volume":"279","author":"C Owsley","year":"1998","unstructured":"Owsley C, Ball K, McGwin G Jr, et al. Visual processing impairment and risk of motor vehicle crash among older adults. JAMA. 1998;279:1083\u20138.","journal-title":"JAMA"},{"key":"1910_CR31","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/S0002-9394(01)01406-4","volume":"133","author":"IU Scott","year":"2002","unstructured":"Scott IU, Feuer WJ, Jacko JA. Impact of visual function on computer task accuracy and reaction time in a cohort of patients with age-related macular degeneration. Am J Ophthalmol. 2002;133:350\u20137.","journal-title":"Am J Ophthalmol"},{"key":"1910_CR32","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3928\/1081-597X-19980701-05","volume":"14","author":"RA Applegate","year":"1998","unstructured":"Applegate RA, Howland HC, Sharp RP, Cottingham AJ, Yee RW. Corneal aberrations and visual performance after radial keratotomy. J Refract Surg. 1998;14:397\u2013407.","journal-title":"J Refract Surg"},{"key":"1910_CR33","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1167\/iovs.05-0802","volume":"47","author":"M Dogru","year":"2006","unstructured":"Dogru M, Ishida K, Matsumoto Y, et al. Strip meniscometry: a new and simple method of tear meniscus evaluation. Investig Ophthalmol Vis Sci. 2006;47:1895\u2013901.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR34","first-page":"221","volume":"21","author":"MA Lemp","year":"1995","unstructured":"Lemp MA. Report of the National Eye Institute\/industry workshop on clinical trials in dry eyes. CLAO J. 1995;21:221\u201332.","journal-title":"CLAO J"},{"key":"1910_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/00003226-200207000-00007","volume":"21","author":"JJ Nichols","year":"2002","unstructured":"Nichols JJ, Mitchell GL, Nichols KK, Chalmers R, Begley C. The performance of the Contact Lens Dry Eye Questionnaire as a screening survey for contact lens-related dry eye. Cornea. 2002;21:469\u201375.","journal-title":"Cornea"},{"key":"1910_CR36","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1097\/OPX.0b013e318269c90d","volume":"89","author":"RL Chalmers","year":"2012","unstructured":"Chalmers RL, Begley GG, Moody K, Hickson-Curran SB. Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) and opinion of contact lens performance. Optom Vis Sci. 2012;89:1435\u201342.","journal-title":"Optom Vis Sci"},{"issue":"14","key":"1910_CR37","first-page":"DES3","volume":"59","author":"N Yokoi","year":"2018","unstructured":"Yokoi N, Georgiev GA. Tear film-oriented diagnosis and tear film-oriented therapy for dry eye based on tear film dynamics. Investig Ophthalmol Vis Sci. 2018;59(14):DES3\u2013DES2.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR38","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.2147\/OPTH.S86173","volume":"9","author":"Y Nagahara","year":"2015","unstructured":"Nagahara Y, Koh S, Nishida K, Watanabe H. Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses. Clin Ophthalmol. 2015;9:1029\u201331.","journal-title":"Clin Ophthalmol"},{"key":"1910_CR39","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1097\/ICL.0000000000000283","volume":"43","author":"Y Nagahara","year":"2017","unstructured":"Nagahara Y, Koh S, Oshita Y, et al. Diquafosol ophthalmic solution increases pre- and postlens tear film during contact lens wear in rabbit eyes. Eye Contact Lens. 2017;43:378\u201382.","journal-title":"Eye Contact Lens"},{"key":"1910_CR40","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1167\/iovs.07-0762","volume":"49","author":"S Koh","year":"2008","unstructured":"Koh S, Maeda N, Hirohara Y, et al. Serial measurements of higher-order aberrations after blinking in patients with dry eye. Investig Ophthalmol Vis Sci. 2008;49:133\u20138.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"1910_CR41","doi-asserted-by":"publisher","first-page":"e671","DOI":"10.1111\/aos.12443","volume":"92","author":"S Koh","year":"2014","unstructured":"Koh S, Maeda N, Ikeda C, et al. Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous-deficient dry eye. Acta Ophthalmol. 2014;92:e671-675.","journal-title":"Acta Ophthalmol"},{"key":"1910_CR42","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.visres.2012.03.025","volume":"62","author":"M Kwon","year":"2012","unstructured":"Kwon M, Legge GE. Spatial-frequency requirements for reading revisited. Vis Res. 2012;62:139\u201347.","journal-title":"Vis Res"},{"key":"1910_CR43","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.1167\/iovs.17-21894","volume":"58","author":"S Koh","year":"2017","unstructured":"Koh S, Maeda N, Ikeda C, et al. The effect of ocular surface regularity on contrast sensitivity and straylight in dry eye. Investig Ophthalmol Vis Sci. 2017;58:2647\u201351.","journal-title":"Investig Ophthalmol Vis Sci"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01910-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-021-01910-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-021-01910-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T05:26:02Z","timestamp":1634534762000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-021-01910-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["1910"],"URL":"https:\/\/doi.org\/10.1007\/s12325-021-01910-8","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]},"assertion":[{"value":"27 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}