{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:39:23Z","timestamp":1770971963885,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100019832","name":"Galapagos NV","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019832","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s12325-022-02168-4","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:02:51Z","timestamp":1653498171000},"page":"3403-3422","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["MANTA and MANTA-RAy: Rationale and Design of Trials Evaluating Effects of Filgotinib on Semen Parameters in Patients with Inflammatory Diseases"],"prefix":"10.1007","volume":"39","clinical-trial-number":[{"clinical-trial-number":"nct03926195","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-959X","authenticated-orcid":false,"given":"Wayne J. G.","family":"Hellstrom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radboud J. E. M.","family":"Dolhain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy E.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Arterburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goele","family":"Dekkers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angi","family":"Gillen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Tonussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leen","family":"Gilles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Oortwijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrien","family":"Van Beneden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick E.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh C.","family":"Sikka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Vanderschueren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Reinisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"issue":"1","key":"2168_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","volume":"5","author":"S Alatab","year":"2020","unstructured":"Alatab S, Sepanlou SG, Ikuta K, et al. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990\u20132017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 2020;5(1):17\u201330.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"11","key":"2168_CR2","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1136\/annrheumdis-2019-215920","volume":"78","author":"S Safiri","year":"2019","unstructured":"Safiri S, Kolahi AA, Hoy D, et al. Global, regional and national burden of rheumatoid arthritis 1990\u20132017: a systematic analysis of the global burden of disease study 2017. Ann Rheum Dis. 2019;78(11):1463\u201371.","journal-title":"Ann Rheum Dis"},{"key":"2168_CR3","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","volume":"25","author":"D Furman","year":"2019","unstructured":"Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25:1822\u201332.","journal-title":"Nat Med"},{"issue":"9853","key":"2168_CR4","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1016\/S0140-6736(12)60026-9","volume":"380","author":"DC Baumgart","year":"2012","unstructured":"Baumgart DC, Sandborn WJ. Crohn\u2019s disease. Lancet. 2012;380(9853):1590\u2013605.","journal-title":"Lancet"},{"issue":"10080","key":"2168_CR5","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756\u201370.","journal-title":"Lancet"},{"issue":"7","key":"2168_CR6","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1097\/MIB.0000000000001081","volume":"23","author":"P Valer","year":"2017","unstructured":"Valer P, Algaba A, Santos D, et al. Evaluation of the quality of semen and sexual function in men with inflammatory bowel disease. Inflamm Bowel Dis. 2017;23(7):1144\u201353.","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"2168_CR7","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1093\/ecco-jcc\/jjx100","volume":"11","author":"P Riviere","year":"2017","unstructured":"Riviere P, Zallot C, Desobry P, et al. Frequency of and factors associated with sexual dysfunction in patients with inflammatory bowel disease. J Crohns Colitis. 2017;11(11):1347\u201352.","journal-title":"J Crohns Colitis"},{"issue":"6","key":"2168_CR8","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1111\/j.1572-0241.2001.03877.x","volume":"96","author":"EC de Rooy","year":"2001","unstructured":"de Rooy EC, Toner BB, Maunder RG, et al. Concerns of patients with inflammatory bowel disease: results from a clinical population. Am J Gastroenterol. 2001;96(6):1816\u201321.","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"2168_CR9","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1111\/jsm.12913","volume":"12","author":"LG Bel","year":"2015","unstructured":"Bel LG, Vollebregt AM, Van der Meulen-de Jong AE, et al. Sexual dysfunctions in men and women with inflammatory bowel disease: the influence of IBD-related clinical factors and depression on sexual function. J Sex Med. 2015;12(7):1557\u201367.","journal-title":"J Sex Med"},{"issue":"4","key":"2168_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3109\/00365521.2013.772229","volume":"48","author":"M Manosa","year":"2013","unstructured":"Manosa M, Navarro-Llavat M, Marin L, et al. Fecundity, pregnancy outcomes, and breastfeeding in patients with inflammatory bowel disease: a large cohort survey. Scand J Gastroenterol. 2013;48(4):427\u201332.","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"2168_CR11","doi-asserted-by":"publisher","first-page":"e206","DOI":"10.1016\/j.crohns.2012.09.010","volume":"7","author":"CP Selinger","year":"2013","unstructured":"Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohns Colitis. 2013;7(6):e206\u201313.","journal-title":"J Crohns Colitis"},{"issue":"1","key":"2168_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1590\/S1677-5538.IBJU.2014.0595","volume":"42","author":"BC Tiseo","year":"2016","unstructured":"Tiseo BC, Cocuzza M, Bonfa E, Srougi M, Silva CA. Male fertility potential alteration in rheumatic diseases: a systematic review. Int Braz J Urol. 2016;42(1):11\u201321.","journal-title":"Int Braz J Urol"},{"issue":"2","key":"2168_CR13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.5312\/wjo.v5.i2.107","volume":"5","author":"AG Tristano","year":"2014","unstructured":"Tristano AG. Impact of rheumatoid arthritis on sexual function. World J Orthop. 2014;5(2):107\u201311.","journal-title":"World J Orthop"},{"issue":"3","key":"2168_CR14","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.semarthrit.2020.02.002","volume":"50","author":"LF Perez-Garcia","year":"2020","unstructured":"Perez-Garcia LF, Te Winkel B, Carrizales JP, et al. Sexual function and reproduction can be impaired in men with rheumatic diseases: a systematic review. Semin Arthritis Rheum. 2020;50(3):557\u201373.","journal-title":"Semin Arthritis Rheum"},{"issue":"12","key":"2168_CR15","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1136\/annrheumdis-2021-220709","volume":"80","author":"LF Perez-Garcia","year":"2021","unstructured":"Perez-Garcia LF, Roder E, Goekoop RJ, et al. Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicentre study (iFAME-Fertility). Ann Rheum Dis. 2021;80(12):1545\u201352.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"2168_CR16","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1093\/humupd\/dmaa022","volume":"26","author":"LF Perez-Garcia","year":"2020","unstructured":"Perez-Garcia LF, Dolhain RJEM, Vorstenbosch S, et al. The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review. Hum Reprod Update. 2020;26(6):961\u20131001.","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2168_CR17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1159\/000496739","volume":"37","author":"S Danese","year":"2019","unstructured":"Danese S, Allez M, van Bodegraven AA, et al. Unmet medical needs in ulcerative colitis: an expert group consensus. Dig Dis. 2019;37(4):266\u201383.","journal-title":"Dig Dis"},{"issue":"7","key":"2168_CR18","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1097\/MEG.0000000000000378","volume":"27","author":"JP Gordon","year":"2015","unstructured":"Gordon JP, McEwan PC, Maguire A, Sugrue DM, Puelles J. Characterizing unmet medical need and the potential role of new biologic treatment options in patients with ulcerative colitis and Crohn\u2019s disease: a systematic review and clinician surveys. Eur J Gastroenterol Hepatol. 2015;27(7):804\u201312.","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"12","key":"2168_CR19","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1002\/art.11358","volume":"48","author":"K Redlich","year":"2003","unstructured":"Redlich K, Schett G, Steiner G, et al. Rheumatoid arthritis therapy after tumor necrosis factor and interleukin-1 blockade. Arthritis Rheum. 2003;48(12):3308\u201319.","journal-title":"Arthritis Rheum"},{"issue":"12","key":"2168_CR20","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/nrd.2017.201","volume":"16","author":"DM Schwartz","year":"2017","unstructured":"Schwartz DM, Kanno Y, Villarino A, et al. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases [published correction appears in Nat Rev Drug Discov. 2017;17(1):78]. Nat Rev Drug Discov. 2017;16(12):843\u201362.","journal-title":"Nat Rev Drug Discov"},{"issue":"18","key":"2168_CR21","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s40265-020-01439-0","volume":"80","author":"S Dhillon","year":"2020","unstructured":"Dhillon S, Keam SJ. Filgotinib: first approval. Drugs. 2020;80(18):1987\u201397.","journal-title":"Drugs"},{"issue":"8","key":"2168_CR22","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s40262-015-0240-z","volume":"54","author":"F Namour","year":"2015","unstructured":"Namour F, Diderichsen PM, Cox E, et al. Pharmacokinetics and pharmacokinetic\/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of phase IIB dose selection. Clin Pharmacokinet. 2015;54(8):859\u201374.","journal-title":"Clin Pharmacokinet"},{"issue":"12","key":"2168_CR23","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1007\/s40262-015-0336-5","volume":"54","author":"F Namour","year":"2015","unstructured":"Namour F. Author\u2019s reply to Srinivas: \u201cPharmacokinetics and pharmacokinetic\/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of phase IIB dose selection.\u201d Clin Pharmacokinet. 2015;54(12):1297\u20138.","journal-title":"Clin Pharmacokinet"},{"key":"2168_CR24","unstructured":"European Medicines Agency. EMA Jyseleca summary of product characteristics. https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/jyseleca-epar-product-information_en.pdf. 2020. Accessed 7 Jun 2021."},{"issue":"10292","key":"2168_CR25","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1016\/S0140-6736(21)00666-8","volume":"397","author":"BG Feagan","year":"2021","unstructured":"Feagan BG, Danese S, Loftus EV Jr, et al. Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase\u00a02b\/3 double-blind, randomised, placebo-controlled trial. Lancet. 2021;397(10292):2372\u201384.","journal-title":"Lancet"},{"key":"2168_CR26","unstructured":"European Medicines Agency. EMA Jyseleca Public Assessment Report. https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/jyseleca-epar-public-assessment-report_en.pdf. 2020. Accessed 8 Nov 2021."},{"issue":"4","key":"2168_CR27","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1001\/jama.2019.9055","volume":"322","author":"MC Genovese","year":"2019","unstructured":"Genovese MC, Kalunian K, Gottenberg JE, et al. Effect of filgotinib vs placebo on clinical response in patients with moderate to severe rheumatoid arthritis refractory to disease-modifying antirheumatic drug therapy: the FINCH 2 randomized clinical trial. JAMA. 2019;322(4):315\u201325.","journal-title":"JAMA"},{"key":"2168_CR28","unstructured":"Food and Drug Administration. Testicular toxicity: evaluation during drug development guidance for industry. https:\/\/www.fda.gov\/media\/117948\/download. 2018. Accessed 8 Jun 2021."},{"issue":"5","key":"2168_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2164\/jandrol.107.004655","volume":"29","author":"RP Amann","year":"2008","unstructured":"Amann RP. The cycle of the seminiferous epithelium in humans: a need to revisit? J Androl. 2008;29(5):469\u201387.","journal-title":"J Androl"},{"key":"2168_CR30","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/humupd\/dmp048","volume":"16","author":"TG Cooper","year":"2010","unstructured":"Cooper TG, Noonan E, von Eckardstein S, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 2010;16:231\u201345.","journal-title":"Hum Reprod Update"},{"key":"2168_CR31","unstructured":"World Health Organization. WHO laboratory manual for the examination and processing of human semen (5th edn). https:\/\/apps.who.int\/iris\/handle\/10665\/44261 2010. Accessed Jan 2021."},{"issue":"2","key":"2168_CR32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/papr.12171","volume":"15","author":"SC Sikka","year":"2015","unstructured":"Sikka SC, Chen C, Almas M, et al. Pregabalin does not affect sperm production in healthy volunteers: a randomized, double-blind, placebo-controlled, noninferiority study. Pain Pract. 2015;15(2):150\u20138.","journal-title":"Pain Pract"},{"issue":"3","key":"2168_CR33","doi-asserted-by":"publisher","first-page":"392","DOI":"10.4103\/1008-682X.179161","volume":"18","author":"SC Sikka","year":"2016","unstructured":"Sikka SC, Hellstrom WJG. Current updates on laboratory techniques for the diagnosis of male reproductive failure. Asian J Androl. 2016;18(3):392\u2013401.","journal-title":"Asian J Androl"},{"issue":"5","key":"2168_CR34","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/ibd.20839","volume":"15","author":"R Mountifield","year":"2009","unstructured":"Mountifield R, Bampton P, Prosser R, Muller K, Andrews JM. Fear and fertility in inflammatory bowel disease: a mismatch of perception and reality affects family planning decisions. Inflamm Bowel Dis. 2009;15(5):720\u20135.","journal-title":"Inflamm Bowel Dis"},{"issue":"10066","key":"2168_CR35","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/S0140-6736(16)32537-5","volume":"389","author":"S Vermeire","year":"2017","unstructured":"Vermeire S, Schreiber S, Petryka R, et al. Clinical remission in patients with moderate-to-severe Crohn\u2019s disease treated with filgotinib (the FITZROY study): results from a phase\u00a02, double-blind, randomised, placebo-controlled trial. Lancet. 2017;389(10066):266\u201375.","journal-title":"Lancet"},{"key":"2168_CR36","unstructured":"World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction (4th edn). https:\/\/www.aab.org\/images\/WHO%204th%20manual.pdf. 1999. Accessed Jan 2021."},{"issue":"10","key":"2168_CR37","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1093\/humrep\/deg412","volume":"18","author":"E Carlsen","year":"2003","unstructured":"Carlsen E, Andersson AM, Petersen JH, Skakkebaek NE. History of febrile illness and variation in semen quality. Hum Reprod. 2003;18(10):2089\u201392.","journal-title":"Hum Reprod"},{"issue":"5","key":"2168_CR38","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.eururo.2007.09.046","volume":"53","author":"WJG Hellstrom","year":"2008","unstructured":"Hellstrom WJG, Gittelman M, Jarow J, et al. An evaluation of semen characteristics in men 45 years of age or older after daily dosing with tadalafil 20mg: results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study. Eur Urol. 2008;53(5):1058\u201365.","journal-title":"Eur Urol"},{"issue":"5","key":"2168_CR39","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/j.juro.2012.11.077","volume":"189","author":"JP Jarow","year":"2013","unstructured":"Jarow JP, Fang X, Hammad TA. Variability of semen parameters with time in placebo treated men. J Urol. 2013;189(5):1825\u20139.","journal-title":"J Urol"},{"key":"2168_CR40","unstructured":"European Medicines Agency. EMA Jyseleca European public assessment report. https:\/\/www.ema.europa.eu\/en\/documents\/rmp-summary\/jyseleca-epar-risk-management-plan-summary_en.pdf. 2020. Accessed 8 June 2021."},{"issue":"7","key":"2168_CR41","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1093\/humrep\/deu082","volume":"29","author":"E Leushuis","year":"2014","unstructured":"Leushuis E, van der Steeg JW, Steures P, et al. Semen analysis and prediction of natural conception. Hum Reprod. 2014;29(7):1360\u20137.","journal-title":"Hum Reprod"},{"issue":"6","key":"2168_CR42","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.fertnstert.2014.10.021","volume":"102","author":"C Wang","year":"2014","unstructured":"Wang C, Swerdloff RS. Limitations of semen analysis as a test of male fertility and anticipated needs from newer tests. Fertil Steril. 2014;102(6):1502\u20137.","journal-title":"Fertil Steril"},{"issue":"3","key":"2168_CR43","first-page":"123","volume":"16","author":"A Azenabor","year":"2015","unstructured":"Azenabor A, Ekun AO, Akinloye O. Impact of inflammation on male reproductive tract. J Reprod Infertil. 2015;16(3):123\u20139.","journal-title":"J Reprod Infertil"},{"issue":"20","key":"2168_CR44","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1001\/archinte.164.20.2283","volume":"164","author":"M Rossato","year":"2004","unstructured":"Rossato M, Foresta C. Antisperm antibodies in inflammatory bowel disease. Arch Intern Med. 2004;164(20):2283.","journal-title":"Arch Intern Med"},{"issue":"3","key":"2168_CR45","doi-asserted-by":"publisher","first-page":"361","DOI":"10.4292\/wjgpt.v7.i3.361","volume":"7","author":"T Shin","year":"2016","unstructured":"Shin T, Okada H. Infertility in men with inflammatory bowel disease. World J Gastrointest Pharmacol Ther. 2016;7(3):361\u20139.","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"2168_CR46","unstructured":"World Health Organization. Sexual health and its linkages to reproductive health: an operational approach. http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/258738\/9789241512886-eng.pdf;jsessionid=BB192F998AC613EA23169F9D723943EE?sequence=1. 2017. Accessed 3 Sept 2021."},{"key":"2168_CR47","first-page":"496","volume":"80","author":"LF Perez-Garcia","year":"2021","unstructured":"Perez-Garcia LF, Micu M, Gheyle L, et al. Sexual function in male and female patients with rheumatoid arthritis: a post-hoc analysis of the FINCH studies. Ann Rheum Dis. 2021;80:496\u20137.","journal-title":"Ann Rheum Dis"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-022-02168-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-022-02168-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-022-02168-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T05:29:59Z","timestamp":1656480599000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-022-02168-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,25]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["2168"],"URL":"https:\/\/doi.org\/10.1007\/s12325-022-02168-4","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,25]]},"assertion":[{"value":"21 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}