{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:20:00Z","timestamp":1783606800779,"version":"3.55.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Shionogi & Co., Ltd."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s12325-022-02237-8","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T13:25:57Z","timestamp":1659101157000},"page":"4285-4298","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetic Assessment and Treatment Effect of Lusutrombopag in Child\u2013Pugh Class\u00a0C Patients: Review of Patient Data from Two Clinical Studies and Post-Marketing Surveillance"],"prefix":"10.1007","volume":"39","clinical-trial-number":[{"clinical-trial-number":"nct02389621","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Steven L.","family":"Flamm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Peck-Radosavljevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Katsube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimitsu","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Tsukimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsue","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"2237_CR1","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.3748\/wjg.v20.i10.2595","volume":"20","author":"H Hayashi","year":"2014","unstructured":"Hayashi H, Beppu T, Shirabe K, Maehara Y, Baba H. Management of thrombocytopenia due to liver cirrhosis: a review. World J Gastroenterol. 2014;20:2595\u2013605.","journal-title":"World J Gastroenterol"},{"key":"2237_CR2","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1055\/s-0035-1550432","volume":"41","author":"EG Giannini","year":"2015","unstructured":"Giannini EG, Peck-Radosavljevic M. Platelet dysfunction: status of thrombopoietin in thrombocytopenia associated with chronic liver failure. Semin Thromb Hemost. 2015;41:455\u201361.","journal-title":"Semin Thromb Hemost"},{"key":"2237_CR3","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.cgh.2010.06.018","volume":"8","author":"EG Giannini","year":"2010","unstructured":"Giannini EG, Greco A, Marenco S, Andorno E, Valente U, Savarino V. Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease. Clin Gastroenterol Hepatol. 2010;8:899\u2013902.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2237_CR4","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1111\/liv.13317","volume":"37","author":"M Peck-Radosavljevic","year":"2017","unstructured":"Peck-Radosavljevic M. Thrombocytopenia in chronic liver disease. Liver Int. 2017;37:778\u201393.","journal-title":"Liver Int"},{"key":"2237_CR5","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1620\/tjem.229.213","volume":"229","author":"T Maruyama","year":"2013","unstructured":"Maruyama T, Murata S, Takahashi K, et al. Platelet transfusion improves liver function in patients with chronic liver disease and cirrhosis. Tohoku J Exp Med. 2013;229:213\u201320.","journal-title":"Tohoku J Exp Med"},{"issue":"suppl 1","key":"2237_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1365-2036.2007.03510.x","volume":"26","author":"F Poordad","year":"2007","unstructured":"Poordad F. Review article: thrombocytopenia in chronic liver disease. Aliment Pharmacol Ther. 2007;26(suppl 1):5\u201311.","journal-title":"Aliment Pharmacol Ther"},{"key":"2237_CR7","unstructured":"Shionogi & Co., Ltd. Shionogi launches MULPLETA\u00ae tablets 3mg in Japan for improvement of thrombocytopenia. 2015. https:\/\/www.shionogi.com\/content\/dam\/shionogi\/global\/news\/pdf\/2015\/151201_e.pdf. Accessed 9 May\u00a02022."},{"key":"2237_CR8","unstructured":"European Commission. Lusutrombopag [product information]. 2019. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/mulpleo. Accessed 9 May\u00a02022."},{"key":"2237_CR9","unstructured":"MULPLETA\u00ae (lusutrombopag tablets) for oral use [prescribing information]. Florham Park, NJ: Shionogi Inc.; July 2018."},{"key":"2237_CR10","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.cgh.2018.11.047","volume":"17","author":"H Hidaka","year":"2019","unstructured":"Hidaka H, Kurosaki M, Tanaka H, et al. Lusutrombopag reduces need for platelet transfusion in patients with thrombocytopenia undergoing invasive procedures. Clin Gastroenterol Hepatol. 2019;17:1192\u2013200.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2237_CR11","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/hep.30561","volume":"70","author":"M Peck-Radosavljevic","year":"2019","unstructured":"Peck-Radosavljevic M, Simon K, Iacobellis A, et al. Lusutrombopag for the treatment of thrombocytopenia in patients with chronic liver disease undergoing invasive procedures (L-PLUS\u00a02). Hepatology. 2019;70:1336\u201348.","journal-title":"Hepatology"},{"key":"2237_CR12","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s40262-019-00770-4","volume":"58","author":"T Katsube","year":"2019","unstructured":"Katsube T, Shimizu R, Fukuhara T, Kano T, Wajima T. Pharmacokinetic\/pharmacodynamic modelling and simulation of lusutrombopag, a novel thrombopoietin receptor agonist, for the treatment of thrombocytopenia in patients with chronic liver disease undergoing invasive procedures. Clin Pharmacokinet. 2019;58:1469\u201382.","journal-title":"Clin Pharmacokinet"},{"key":"2237_CR13","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/hepr.13392","volume":"49","author":"R Sasaki","year":"2019","unstructured":"Sasaki R, Shiino C, Imawari M, et al. Safety and effectiveness of lusutrombopag in Japanese chronic liver disease patients with thrombocytopenia undergoing invasive procedures: interim results of a postmarketing surveillance. Hepatol Res. 2019;49:1169\u201381.","journal-title":"Hepatol Res"},{"key":"2237_CR14","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/hepr.13544","volume":"50","author":"K Numata","year":"2020","unstructured":"Numata K, Tanaka K, Katsube T, et al. Is platelet monitoring during 7-day lusutrombopag treatment necessary in chronic liver disease patients with thrombocytopenia undergoing planned invasive procedures? A phase IIIb open-label study. Hepatol Res. 2020;50:1141\u201350.","journal-title":"Hepatol Res"},{"key":"2237_CR15","doi-asserted-by":"publisher","first-page":"s60","DOI":"10.7861\/clinmedicine.18-2-s60","volume":"18","author":"D Mansour","year":"2018","unstructured":"Mansour D, McPherson S. Management of decompensated cirrhosis. Clin Med (Lond). 2018;18:s60\u20135.","journal-title":"Clin Med (Lond)"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-022-02237-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-022-02237-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-022-02237-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T10:07:03Z","timestamp":1661335623000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-022-02237-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,29]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2237"],"URL":"https:\/\/doi.org\/10.1007\/s12325-022-02237-8","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,29]]},"assertion":[{"value":"12 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}