{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:08:57Z","timestamp":1791227337432,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s12325-024-02820-1","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T16:57:50Z","timestamp":1710349070000},"page":"1896-1910","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Adverse Drug Events Observed with the Newly Approved Remimazolam in Comparison to Propofol for General Anesthesia in Patients Undergoing Surgery: A Meta-analysis"],"prefix":"10.1007","volume":"41","author":[{"given":"Lidan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"issue":"2","key":"2820_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/14656566.2017.1280461","volume":"18","author":"KKS Poon","year":"2017","unstructured":"Poon KKS, Wong SHS. New and developing anesthesia drugs. Expert Opin Pharmacother. 2017;18(2):195\u2013204.","journal-title":"Expert Opin Pharmacother"},{"issue":"47","key":"2820_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023194","volume":"99","author":"H Kim","year":"2020","unstructured":"Kim H, Park S-S, Shim J. Differences in midazolam premedication effects on recovery after short-duration ambulatory anesthesia with propofol or sevoflurane for gynecologic surgery in young patients: a randomized controlled trial. Medicine (Baltimore). 2020;99(47):e23194.","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"2820_CR3","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1177\/0310057X0002800507","volume":"28","author":"LB Ong","year":"2000","unstructured":"Ong LB, Plummer JL, Waldow WC, Owen H. Timing of midazolam and propofol administration for co-induction of anaesthesia. Anaesth Intensive Care. 2000;28(5):527\u201331.","journal-title":"Anaesth Intensive Care"},{"issue":"3","key":"2820_CR4","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0736-4679(97)00022-X","volume":"15","author":"SP Nordt","year":"1997","unstructured":"Nordt SP, Clark RF. Midazolam: a review of therapeutic uses and toxicity. J Emerg Med. 1997;15(3):357\u201365.","journal-title":"J Emerg Med"},{"issue":"8","key":"2820_CR5","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/EJA.0b013e328348a977","volume":"28","author":"A Perel","year":"2011","unstructured":"Perel A. Non-anaesthesiologists should not be allowed to administer propofol for procedural sedation: a consensus statement of 21 European National Societies of Anaesthesia. Eur J Anaesthesiol. 2011;28(8):580\u20134.","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"2820_CR6","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.bja.2018.12.025","volume":"122","author":"S Hemphill","year":"2019","unstructured":"Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofol infusion syndrome: a structured literature review and analysis of published case reports. Br J Anaesth. 2019;122(4):448\u201359.","journal-title":"Br J Anaesth"},{"issue":"6","key":"2820_CR7","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s40265-020-01299-8","volume":"80","author":"SJ Keam","year":"2020","unstructured":"Keam SJ. Remimazolam: first approval. Drugs. 2020;80(6):625\u201333.","journal-title":"Drugs"},{"key":"2820_CR8","doi-asserted-by":"publisher","first-page":"690875","DOI":"10.3389\/fphar.2021.690875","volume":"12","author":"GJ Kilpatrick","year":"2021","unstructured":"Kilpatrick GJ. Remimazolam: non-clinical and clinical profile of a new sedative\/anesthetic agent. Front Pharmacol. 2021;12:690875.","journal-title":"Front Pharmacol"},{"issue":"3","key":"2820_CR9","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4103\/1658-354X.136627","volume":"8","author":"BG Goudra","year":"2014","unstructured":"Goudra BG, Singh PM. Remimazolam: the future of its sedative potential. Saudi J Anaesth. 2014;8(3):388\u201391.","journal-title":"Saudi J Anaesth"},{"issue":"1","key":"2820_CR10","doi-asserted-by":"publisher","first-page":"24514","DOI":"10.52965\/001c.24514","volume":"9","author":"N Noor","year":"2021","unstructured":"Noor N, Legendre R, Cloutet A, Chitneni A, Varrassi G, Kaye AD. A comprehensive review of remimazolam for sedation. Health Psychol Res. 2021;9(1):24514.","journal-title":"Health Psychol Res"},{"issue":"10","key":"2820_CR11","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s40265-021-01544-8","volume":"81","author":"A Lee","year":"2021","unstructured":"Lee A, Shirley M. Remimazolam: a review in procedural sedation. Drugs. 2021;81(10):1193\u2013201.","journal-title":"Drugs"},{"key":"2820_CR12","doi-asserted-by":"publisher","first-page":"d5928","DOI":"10.1136\/bmj.d5928","volume":"343","author":"JPT Higgins","year":"2011","unstructured":"Higgins JPT, Altman DG, G\u00f8tzsche PC, et al. The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.","journal-title":"BMJ"},{"issue":"9","key":"2820_CR13","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603\u20135.","journal-title":"Eur J Epidemiol"},{"key":"2820_CR14","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.","journal-title":"BMJ"},{"key":"2820_CR15","doi-asserted-by":"publisher","first-page":"110955","DOI":"10.1016\/j.jclinane.2022.110955","volume":"82","author":"JY Choi","year":"2022","unstructured":"Choi JY, Lee HS, Kim JY, et al. Comparison of remimazolam-based and propofol-based total intravenous anesthesia on postoperative quality of recovery: a randomized non-inferiority trial. J Clin Anesth. 2022;82:110955.","journal-title":"J Clin Anesth"},{"issue":"10","key":"2820_CR16","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.23736\/S0375-9393.21.15517-8","volume":"87","author":"G Dai","year":"2021","unstructured":"Dai G, Pei L, Duan F, et al. Safety and efficacy of remimazolam compared with propofol in induction of general anesthesia. Minerva Anestesiol. 2021;87(10):1073\u20139.","journal-title":"Minerva Anestesiol"},{"issue":"4","key":"2820_CR17","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00540-020-02788-6","volume":"34","author":"M Doi","year":"2020","unstructured":"Doi M, Morita K, Takeda J, et al. Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase\u00a0IIb\/III trial. J Anesth. 2020;34(4):543\u201353.","journal-title":"J Anesth"},{"issue":"49","key":"2820_CR18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036440","volume":"102","author":"Y-G Jeon","year":"2023","unstructured":"Jeon Y-G, Kim S, Park J-H, et al. Incidence of intraoperative hypotension in older patients undergoing total intravenous anesthesia by remimazolam versus propofol: a randomized controlled trial. Medicine (Baltimore). 2023;102(49): e36440.","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"2820_CR19","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1053\/j.jvca.2023.06.027","volume":"37","author":"Q Kuang","year":"2023","unstructured":"Kuang Q, Zhong N, Ye C, Zhu X, Wei F. Propofol versus remimazolam on cognitive function, hemodynamics, and oxygenation during one-lung ventilation in older patients undergoing pulmonary lobectomy: a randomized controlled trial. J Cardiothorac Vasc Anesth. 2023;37(10):1996\u20132005.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"2820_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.851","volume":"9","author":"T Liu","year":"2021","unstructured":"Liu T, Lai T, Chen J, et al. Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: a randomized, double-blind, controlled trial. Pharmacol Res Perspect. 2021;9(5):e00851.","journal-title":"Pharmacol Res Perspect"},{"issue":"1","key":"2820_CR21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12871-023-02092-2","volume":"23","author":"WLM Sun","year":"2023","unstructured":"Sun WLM, Wan J, et al. Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial. BMC Anesthesiol. 2023;23(1):182.","journal-title":"BMC Anesthesiol"},{"issue":"16","key":"2820_CR22","first-page":"1199","volume":"27","author":"Y Mao","year":"2022","unstructured":"Mao Y, Guo J, Yuan J, Zhao E, Yang J. Quality of recovery after general anesthesia with remimazolam in patients\u2019 undergoing urologic surgery: a randomized controlled trial comparing remimazolam with propofol. Drug Des DevelTher. 2022;27(16):1199\u2013209.","journal-title":"Drug Des DevelTher"},{"issue":"16","key":"2820_CR23","doi-asserted-by":"publisher","first-page":"5402","DOI":"10.3390\/jcm12165402","volume":"12","author":"A Matsumoto","year":"2023","unstructured":"Matsumoto A, Satomi S, Kakuta N, et al. Remimazolam\u2019s effects on postoperative nausea and vomiting are similar to those of propofol after laparoscopic gynecological surgery: a randomized controlled trial. J Clin Med. 2023;12(16):5402.","journal-title":"J Clin Med"},{"key":"2820_CR24","doi-asserted-by":"publisher","first-page":"111223","DOI":"10.1016\/j.jclinane.2023.111223","volume":"90","author":"EJ Oh","year":"2023","unstructured":"Oh EJ, Chung YJ, Lee J-H, et al. Comparison of propofol vs remimazolam on emergence profiles after general anesthesia: a randomized clinical trial. J Clin Anesth. 2023;90:111223.","journal-title":"J Clin Anesth"},{"issue":"1","key":"2820_CR25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s00540-021-03021-8","volume":"36","author":"T Sato","year":"2022","unstructured":"Sato T, Nishiwaki K. Comparison of remimazolam and propofol in anesthetic management for awake craniotomy: a retrospective study. J Anesth. 2022;36(1):152\u20135.","journal-title":"J Anesth"},{"issue":"15","key":"2820_CR26","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2147\/IJGM.S345390","volume":"13","author":"Fu Shi","year":"2022","unstructured":"Shi Fu, Chen Y, Li H, Zhang Y, Zhao T. Efficacy and safety of remimazolam tosilate versus propofol for general anesthesia in cirrhotic patients undergoing endoscopic variceal ligation. Int J Gen Med. 2022;13(15):583\u201391.","journal-title":"Int J Gen Med"},{"issue":"34","key":"2820_CR27","doi-asserted-by":"publisher","first-page":"10595","DOI":"10.12998\/wjcc.v9.i34.10595","volume":"9","author":"F Tang","year":"2021","unstructured":"Tang F, Yi J-M, Gong H-Y, et al. Remimazolam benzenesulfonate anesthesia effectiveness in cardiac surgery patients under general anesthesia. World J Clin Cases. 2021;9(34):10595\u2013603.","journal-title":"World J Clin Cases"},{"issue":"8","key":"2820_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjao.2023.100237","volume":"28","author":"L Tang","year":"2023","unstructured":"Tang L, Sun Y, Hao X, et al. Effect of general anaesthesia with remimazolam versus propofol on postoperative quality of recovery in patients undergoing ambulatory arthroscopic meniscus repair: a randomised clinical trial. BJA Open. 2023;28(8):100237.","journal-title":"BJA Open"},{"issue":"9","key":"2820_CR29","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1111\/cts.13572","volume":"16","author":"L Yue","year":"2023","unstructured":"Yue L, Ma X, Li Na, et al. Remimazolam versus propofol in combination with esketamine for surgical abortion: a double-blind randomized controlled trial. Clin Transl Sci. 2023;16(9):1606\u201316.","journal-title":"Clin Transl Sci"},{"issue":"1","key":"2820_CR30","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12871-022-01641-5","volume":"22","author":"J Zhang","year":"2022","unstructured":"Zhang J, Wang X, Zhang Q, Wang Z, Zhu S. Application effects of remimazolam and propofol on elderly patients undergoing hip replacement. BMC Anesthesiol. 2022;22(1):118.","journal-title":"BMC Anesthesiol"},{"key":"2820_CR31","doi-asserted-by":"publisher","first-page":"655042","DOI":"10.3389\/fmed.2021.655042","volume":"8","author":"X Zhu","year":"2021","unstructured":"Zhu X, Wang H, Yuan S, et al. Efficacy and safety of remimazolam in endoscopic sedation-a systematic review and meta-analysis. Front Med (Lausanne). 2021;8:655042.","journal-title":"Front Med (Lausanne)"},{"issue":"6","key":"2820_CR32","first-page":"553","volume":"89","author":"Wu Xueyan","year":"2023","unstructured":"Xueyan Wu, Wang C, Gao H, et al. Comparison of remimazolam and propofol about safety outcome indicators during general anesthesia in surgical patients: a systematic review and meta-analysis. Minerva Anestesiol. 2023;89(6):553\u201364.","journal-title":"Minerva Anestesiol"},{"issue":"8","key":"2820_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.641866","volume":"27","author":"B-H Bo-JyunJhuang","year":"2021","unstructured":"Bo-JyunJhuang B-H, Huang Y-T, Lai P-C. Efficacy and safety of remimazolam for procedural sedation: a meta-analysis of randomized controlled trials with trial sequential analysis. Front Med (Lausanne). 2021;27(8):641866.","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"2820_CR34","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/jcpt.13525","volume":"47","author":"S Zhang","year":"2022","unstructured":"Zhang S, Wang J, Ran R, Peng Y, Xiao Y. Efficacy and safety of remimazolam tosylate in hysteroscopy: a randomized, single-blind, parallel controlled trial. J Clin Pharm Ther. 2022;47(1):55\u201360.","journal-title":"J Clin Pharm Ther"},{"issue":"1","key":"2820_CR35","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12871-021-01373-y","volume":"21","author":"X Zhang","year":"2021","unstructured":"Zhang X, Li S, Liu J. Efficacy and safety of remimazolam besylate versus propofol during hysteroscopy: single-centre randomized controlled trial. BMC Anesthesiol. 2021;21(1):156.","journal-title":"BMC Anesthesiol"},{"key":"2820_CR36","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.2147\/DDDT.S339535","volume":"15","author":"X Liu","year":"2021","unstructured":"Liu X, Ding B, Shi F, et al. The efficacy and safety of remimazolam tosilate versus etomidate-propofol in elderly outpatients undergoing colonoscopy: a prospective, randomized, single-blind, non-inferiority trial. Drug Des Devel Ther. 2021;15:4675\u201385.","journal-title":"Drug Des Devel Ther"},{"issue":"8","key":"2820_CR37","first-page":"4594","volume":"12","author":"S Chen","year":"2020","unstructured":"Chen S, Wang J, Xu X, et al. The efficacy and safety of remimazolam tosylate versus propofol in patients undergoing colonoscopy: a multicentered, randomized, positive-controlled, phase\u00a0III clinical trial. Am J Transl Res. 2020;12(8):4594\u2013603.","journal-title":"Am J Transl Res"},{"issue":"46","key":"2820_CR38","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036081","volume":"102","author":"Y Toyota","year":"2023","unstructured":"Toyota Y, Kondo T, Oshita K, et al. Remimazolam-based anesthesia with flumazenil allows faster emergence than propofol-based anesthesia in older patients undergoing spinal surgery: a randomized controlled trial. Medicine (Baltimore). 2023;102(46):e36081.","journal-title":"Medicine (Baltimore)"},{"issue":"93","key":"2820_CR39","volume":"5","author":"J Zhang","year":"2023","unstructured":"Zhang J, Zhang J, Wang Y, et al. Effect of remimazolam vs propofol on emergence from general anesthesia in patients undergoing cerebral endovascular procedures: a randomized controlled, non-inferiority trial. J Clin Anesth. 2023;5(93):111356.","journal-title":"J Clin Anesth"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-024-02820-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-024-02820-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-024-02820-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T13:12:07Z","timestamp":1714137127000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-024-02820-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["2820"],"URL":"https:\/\/doi.org\/10.1007\/s12325-024-02820-1","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"27 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors Lidan Huang, Hong Liu, Xue Zou, Jiawang Ding, and Song Tao declare that they have no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This meta-analysis is based on previously published studies and does not contain any studies with human participants or animals performed by any of the authors. Therefore, no ethical approval was required for this meta-analysis.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}