{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:40:11Z","timestamp":1758901211123,"version":"3.44.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Chinese National Key Technology R&D Program, Ministry of Science and Technology","award":["2023YFC2507204","2024YFC2510301"],"award-info":[{"award-number":["2023YFC2507204","2024YFC2510301"]}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2021-I2M-1-005"],"award-info":[{"award-number":["2021-I2M-1-005"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-013"],"award-info":[{"award-number":["2022-PUMCH-B-013"]}]},{"name":"National High Level Hospital Clinical Research Funding Provincial People's Hospital","award":["2022-PUMCH-D-009"],"award-info":[{"award-number":["2022-PUMCH-D-009"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-A-008"],"award-info":[{"award-number":["2022-PUMCH-A-008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s12325-025-03317-1","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T05:52:20Z","timestamp":1755582740000},"page":"5255-5267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Parameters Associated with Delayed Diagnosis in Thrombotic Antiphospholipid Syndrome: Data from China Prospective APS Cohort"],"prefix":"10.1007","volume":"42","author":[{"given":"Ruijie","family":"Mo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangzhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-2858","authenticated-orcid":false,"given":"Jiuliang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"3317_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4:295\u2013306.","journal-title":"J Thromb Haemost"},{"key":"3317_CR2","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1056\/NEJMra1705454","volume":"378","author":"D Garcia","year":"2018","unstructured":"Garcia D, Erkan D. Diagnosis and management of the antiphospholipid syndrome. N Engl J Med. 2018;378:2010\u201321.","journal-title":"N Engl J Med"},{"key":"3317_CR3","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1002\/art.42624","volume":"75","author":"M Barbhaiya","year":"2023","unstructured":"Barbhaiya M, Zuily S, Naden R, et al. The 2023 ACR\/EULAR antiphospholipid syndrome classification criteria. Arthritis Rheumatol. 2023;75:1687\u2013702.","journal-title":"Arthritis Rheumatol"},{"key":"3317_CR4","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/nrrheum.2017.124","volume":"13","author":"S Sciascia","year":"2017","unstructured":"Sciascia S, Amigo MC, Roccatello D, Khamashta M. Diagnosing antiphospholipid syndrome: \u2018extra-criteria\u2019 manifestations and technical advances. Nat Rev Rheumatol. 2017;13:548\u201360.","journal-title":"Nat Rev Rheumatol"},{"key":"3317_CR5","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1002\/art.41401","volume":"72","author":"M Radin","year":"2020","unstructured":"Radin M, Sciascia S, Bazzan M, et al. Antiphospholipid syndrome is still a rare disease-estimated prevalence in the piedmont and aosta valley regions of northwest Italy: comment on the article by Duarte-Garcia et al. Arthritis Rheumatol. 2020;72:1774\u20136.","journal-title":"Arthritis Rheumatol"},{"key":"3317_CR6","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s13023-021-01906-1","volume":"16","author":"M Radin","year":"2021","unstructured":"Radin M, Foddai SG, Barinotti A, et al. Reducing the diagnostic delay in antiphospholipid syndrome over time: a real world observation. Orphanet J Rare Dis. 2021;16:280.","journal-title":"Orphanet J Rare Dis"},{"key":"3317_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2478\/rir-2022-0033","volume":"3","author":"C Huang","year":"2022","unstructured":"Huang C, Zhao J, Tian X, et al. RheumCloud app: a novel mobile application for the management of rheumatic diseases patients in China. Rheumatol Immunol Res. 2022;3:184\u20139.","journal-title":"Rheumatol Immunol Res"},{"key":"3317_CR8","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","volume":"7","author":"V Pengo","year":"2009","unstructured":"Pengo V, Tripodi A, Reber G, et al. Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost. 2009;7:1737\u201340.","journal-title":"J Thromb Haemost"},{"key":"3317_CR9","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1365-2141.2007.06973.x","volume":"140","author":"GD Lowe","year":"2008","unstructured":"Lowe GD. Common risk factors for both arterial and venous thrombosis. Br J Haematol. 2008;140:488\u201395.","journal-title":"Br J Haematol"},{"key":"3317_CR10","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13075-022-02814-w","volume":"24","author":"W Qi","year":"2022","unstructured":"Qi W, Zhao J, Huang C, et al. Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study. Arthritis Res Ther. 2022;24:140.","journal-title":"Arthritis Res Ther"},{"key":"3317_CR11","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1001\/jama.1972.03200200011003","volume":"221","author":"T Gordon","year":"1972","unstructured":"Gordon T, Kannel WB. Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study. JAMA. 1972;221:661\u20136.","journal-title":"JAMA"},{"key":"3317_CR12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/s41569-022-00787-6","volume":"20","author":"PL Lutsey","year":"2023","unstructured":"Lutsey PL, Zakai NA. Epidemiology and prevention of venous thromboembolism. Nat Rev Cardiol. 2023;20:248\u201362.","journal-title":"Nat Rev Cardiol"},{"key":"3317_CR13","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1093\/rheumatology\/kead498","volume":"63","author":"H Jiang","year":"2024","unstructured":"Jiang H, Huang C, Shi Y, et al. Effect of smoking on thrombotic antiphospholipid syndrome: a 10-year prospective cohort study. Rheumatology (Oxford). 2024;63:1917\u201322.","journal-title":"Rheumatology (Oxford)"},{"key":"3317_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11926-021-01038-2","volume":"23","author":"JY Dabit","year":"2022","unstructured":"Dabit JY, Valenzuela-Almada MO, Vallejo-Ramos S, et al. Epidemiology of antiphospholipid syndrome in the general population. Curr Rheumatol Rep. 2022;23:85.","journal-title":"Curr Rheumatol Rep"},{"key":"3317_CR15","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/rheumatology\/keab475","volume":"61","author":"J Pardos-Gea","year":"2022","unstructured":"Pardos-Gea J, Marques-Soares JR, Bujan S, et al. Persistent thrombocytopenia predicts poor long-term survival in patients with antiphospholipid syndrome: a 38-year follow-up study. Rheumatology (Oxford). 2022;61:1053\u201361.","journal-title":"Rheumatology (Oxford)"},{"key":"3317_CR16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11926-014-0494-8","volume":"17","author":"B Artim-Esen","year":"2015","unstructured":"Artim-Esen B, Diz-Kucukkaya R, Inanc M. The significance and management of thrombocytopenia in antiphospholipid syndrome. Curr Rheumatol Rep. 2015;17:14.","journal-title":"Curr Rheumatol Rep"},{"key":"3317_CR17","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1007\/s10067-023-06699-1","volume":"42","author":"A Ruffatti","year":"2023","unstructured":"Ruffatti A, Tonello M, Calligaro A, et al. Prevalence and adverse consequences of delayed diagnosis and misdiagnosis in thrombotic antiphospholipid syndrome. An observational cohort study and a review of the literature. Clin Rheumatol. 2023;42:3007\u201319.","journal-title":"Clin Rheumatol"},{"key":"3317_CR18","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s13023-020-01374-z","volume":"15","author":"C Faviez","year":"2020","unstructured":"Faviez C, Chen XY, Garcelon N, et al. Diagnosis support systems for rare diseases: a scoping review. Orphanet J Rare Dis. 2020;15:94.","journal-title":"Orphanet J Rare Dis"},{"key":"3317_CR19","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1177\/0961203320903810","volume":"29","author":"S Sciascia","year":"2020","unstructured":"Sciascia S, Radin M, Baldovino S, et al. Filling the gap in antiphospholipid syndrome diagnosis: a patient\u2019s story. Lupus. 2020;29:236\u20138.","journal-title":"Lupus"},{"key":"3317_CR20","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1191\/096120301678416097","volume":"10","author":"N Espinola-Zavaleta","year":"2001","unstructured":"Espinola-Zavaleta N, Amigo MC, Vargas-Barron J, et al. Two- and three-dimensional echocardiography in primary antiphospholipid syndrome: misdiagnosis as rheumatic valve disease. Lupus. 2001;10:511\u20133.","journal-title":"Lupus"},{"key":"3317_CR21","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1007\/s00246-002-0273-6","volume":"24","author":"SB Clauss","year":"2003","unstructured":"Clauss SB, Manco-Johnson MJ, Quivers E, et al. Primary antiphospholipid antibody syndrome and cardiac involvement in a child. Pediatr Cardiol. 2003;24:292\u20134.","journal-title":"Pediatr Cardiol"},{"key":"3317_CR22","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.ejim.2006.02.018","volume":"17","author":"FJ Fernandez-Fernandez","year":"2006","unstructured":"Fernandez-Fernandez FJ, Rivera-Gallego A, de la Fuente-Aguado J, et al. Antiphospholipid syndrome mimicking multiple sclerosis in two patients. Eur J Intern Med. 2006;17:500\u20132.","journal-title":"Eur J Intern Med"},{"key":"3317_CR23","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1445-5994.2012.02718.x","volume":"42","author":"J Zhang","year":"2012","unstructured":"Zhang J, Jiang JJ, Zhang X, et al. A 67-year-old man with persistent fever and high titers of serum anticardiolipin antibody. Intern Med J. 2012;42:344\u20135.","journal-title":"Intern Med J"},{"key":"3317_CR24","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1002\/ppul.23079","volume":"50","author":"J Veskitkul","year":"2015","unstructured":"Veskitkul J, Ruangchira-urai R, Charuvanij S, et al. Asthma-like symptoms as a presentation of antiphospholipid syndrome. Pediatr Pulmonol. 2015;50:E1-4.","journal-title":"Pediatr Pulmonol"},{"key":"3317_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/00005792-200001000-00006","volume":"79","author":"MJ Cuadrado","year":"2000","unstructured":"Cuadrado MJ, Khamashta MA, Ballesteros A, et al. Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature. Medicine (Baltimore). 2000;79:57\u201368.","journal-title":"Medicine (Baltimore)"},{"key":"3317_CR26","doi-asserted-by":"publisher","first-page":"856","DOI":"10.2169\/internalmedicine.39.856","volume":"39","author":"R Mizuno","year":"2000","unstructured":"Mizuno R, Fujimoto S, Fujimoto T, et al. Catastrophic antiphospholipid antibody syndrome in systemic lupus erythematosus: an autopsy case report of a young woman. Intern Med. 2000;39:856\u20139.","journal-title":"Intern Med"},{"key":"3317_CR27","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1177\/0009922808315216","volume":"47","author":"N Canpolat","year":"2008","unstructured":"Canpolat N, Topal N, Civilibal M, et al. A case of catastrophic antiphospholipid syndrome in an adolescent girl with parvovirus B19 infection. Clin Pediatr (Phila). 2008;47:593\u20137.","journal-title":"Clin Pediatr (Phila)"},{"key":"3317_CR28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1055\/s-0035-1549841","volume":"4","author":"M Voigtlaender","year":"2015","unstructured":"Voigtlaender M, Conradi L, Hinsch A, et al. Right atrial thrombosis in antiphospholipid syndrome with secondary immune thrombocytopenia. Thorac Cardiovasc Surg Rep. 2015;4:40\u20133.","journal-title":"Thorac Cardiovasc Surg Rep"},{"key":"3317_CR29","doi-asserted-by":"publisher","first-page":"E445","DOI":"10.1532\/hsf.2579","volume":"22","author":"N Al-Sarraf","year":"2019","unstructured":"Al-Sarraf N, Abdelmoaty A, Abu Alam S, et al. Right atrial mass mimicking a myxoma as a first presentation of antiphospholipid syndrome. Heart Surg Forum. 2019;22:E445\u20137.","journal-title":"Heart Surg Forum"},{"key":"3317_CR30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2478\/rir-2022-0016","volume":"3","author":"H You","year":"2022","unstructured":"You H, Zhao J, Li M, et al. Recurrent non-stroke central neurologic manifestations in primary antiphospholipid syndrome. Rheumatol Immunol Res. 2022;3:93\u20134.","journal-title":"Rheumatol Immunol Res"},{"key":"3317_CR31","first-page":"707","volume":"112","author":"A Sipek-Dolnicar","year":"2000","unstructured":"Sipek-Dolnicar A, Hojnik M, Rozman B, et al. Small vessel thrombosis without major thrombotic events in systemic lupus erythematosus patients with antiphospholipid syndrome. Wien Klin Wochenschr. 2000;112:707\u201310.","journal-title":"Wien Klin Wochenschr"},{"key":"3317_CR32","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10067-007-0711-1","volume":"27","author":"T Cornelis","year":"2008","unstructured":"Cornelis T, Breynaert C, Blockmans D. An abdominal pain syndrome in a lupus patient. Clin Rheumatol. 2008;27:257\u20139.","journal-title":"Clin Rheumatol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-025-03317-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-025-03317-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-025-03317-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:09:00Z","timestamp":1758899340000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-025-03317-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["3317"],"URL":"https:\/\/doi.org\/10.1007\/s12325-025-03317-1","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"type":"print","value":"0741-238X"},{"type":"electronic","value":"1865-8652"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"18 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ruijie Mo, Yuan Zhao, Hui Jiang, Yangzhong Zhou, Can Huang, Qian Wang, Xinping Tian, Mengtao Li, Xiaofeng Zeng, and Jiuliang Zhao declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was conducted in accordance with the protocol and consensus ethical principles derived from international guidelines including the Declaration of Helsinki, CIOMS International Ethical Guidelines, applicable ICH GCP Guidelines, and other applicable laws and regulations. The protocol was reviewed and approved by the Ethical Committee of PUMCH (HS-3309), and informed consent was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}