{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:23:47Z","timestamp":1791923027689,"version":"4.3.4"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Sanofi R&D"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s12325-025-03330-4","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T06:29:30Z","timestamp":1758176970000},"page":"5380-5396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fatigue Experience in Oncology; a Targeted Qualitative Literature Review and Novel Patient-Centric Conceptual Model"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-2176","authenticated-orcid":false,"given":"Chloe","family":"Carmichael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8820-8822","authenticated-orcid":false,"given":"Cecile","family":"Gousset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-5384","authenticated-orcid":false,"given":"Danielle","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2068-5951","authenticated-orcid":false,"given":"Jordan","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4737-0987","authenticated-orcid":false,"given":"Sophie","family":"Van Tomme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5519-0794","authenticated-orcid":false,"given":"Helen","family":"Kitchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-2205","authenticated-orcid":false,"given":"Harriet","family":"Makin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-7431","authenticated-orcid":false,"given":"Natalie","family":"Aldhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9236-2268","authenticated-orcid":false,"given":"Paul","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,18]]},"reference":[{"issue":"1","key":"3330_CR1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jpainsymman.2020.07.037","volume":"61","author":"M Al Maqbali","year":"2021","unstructured":"Al Maqbali M, Al Sinani M, Al Naamani Z, Al Badi K. Prevalence of fatigue in patients with cancer: a systematic review and meta-analysis. J Pain Symptom Manag. 2021;61(1):167-89.e14.","journal-title":"J Pain Symptom Manag"},{"issue":"14","key":"3330_CR2","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1200\/JCO.2001.19.14.3385","volume":"19","author":"D Cella","year":"2001","unstructured":"Cella D, Davis K, Breitbart W, Curt G, Coalition F. Cancer-related fatigue: prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. J Clin Oncol. 2001;19(14):3385\u201391.","journal-title":"J Clin Oncol"},{"issue":"8","key":"3330_CR3","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.6004\/jnccn.2015.0122","volume":"13","author":"AM Berger","year":"2015","unstructured":"Berger AM, Mooney K, Alvarez-Perez A, Breitbart WS, Carpenter KM, Cella D, et al. Cancer-related fatigue, version 22015. J Natl Compr Cancer Netw. 2015;13(8):1012\u201339.","journal-title":"J Natl Compr Cancer Netw."},{"key":"3330_CR4","unstructured":"National Comprehensive Cancer Network. Cancer-Related Fatigue, Version 1 2025. Available at https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/fatigue.pdf. Accessed Jan 2025."},{"issue":"36","key":"3330_CR5","doi-asserted-by":"publisher","first-page":"4329","DOI":"10.1200\/JCO.2016.67.7450","volume":"34","author":"K Behringer","year":"2016","unstructured":"Behringer K, Goergen H, M\u00fcller H, Thielen I, Brillant C, Kreissl S, et al. Cancer-related fatigue in patients with and survivors of hodgkin lymphoma: the impact on treatment outcome and social reintegration. J Clin Oncol. 2016;34(36):4329\u201337.","journal-title":"J Clin Oncol"},{"issue":"2","key":"3330_CR6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10549-006-9447-x","volume":"105","author":"M Groenvold","year":"2007","unstructured":"Groenvold M, Petersen MA, Idler E, Bjorner JB, Fayers PM, Mouridsen HT. Psychological distress and fatigue predicted recurrence and survival in primary breast cancer patients. Breast Cancer Res Treat. 2007;105(2):209\u201319.","journal-title":"Breast Cancer Res Treat"},{"issue":"6","key":"3330_CR7","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1002\/cam4.2166","volume":"8","author":"S Adam","year":"2019","unstructured":"Adam S, van de Poll-Franse LV, Mols F, Ezendam NPM, de Hingh I, Arndt V, et al. The association of cancer-related fatigue with all-cause mortality of colorectal and endometrial cancer survivors: results from the population-based PROFILES registry. Cancer Med. 2019;8(6):3227\u201336.","journal-title":"Cancer Med"},{"issue":"2","key":"3330_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11864-020-0707-5","volume":"21","author":"MSY Thong","year":"2020","unstructured":"Thong MSY, van Noorden CJF, Steindorf K, Arndt V. Cancer-related fatigue: causes and current treatment options. Curr Treat Options Oncol. 2020;21(2):17.","journal-title":"Curr Treat Options Oncol"},{"issue":"4","key":"3330_CR9","first-page":"2063","volume":"29","author":"ME Schmidt","year":"2021","unstructured":"Schmidt ME, Bergbold S, Hermann S, Steindorf K. Knowledge, perceptions, and management of cancer-related fatigue: the patients\u2019 perspective. Support Care Cancer. 2021;29(4):2063\u201371.","journal-title":"Support Care Cancer"},{"issue":"3","key":"3330_CR10","first-page":"1041","volume":"27","author":"F Roila","year":"2019","unstructured":"Roila F, Fumi G, Ruggeri B, Antonuzzo A, Ripamonti C, Fatigoni S, et al. Prevalence, characteristics, and treatment of fatigue in oncological cancer patients in Italy: a cross-sectional study of the Italian Network for Supportive Care in Cancer (NICSO). Support Care Cancer. 2019;27(3):1041\u20137.","journal-title":"Support Care Cancer"},{"issue":"3","key":"3330_CR11","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1089\/jayao.2017.0037","volume":"6","author":"A Spathis","year":"2017","unstructured":"Spathis A, Hatcher H, Booth S, Gibson F, Stone P, Abbas L, et al. Cancer-related fatigue in adolescents and young adults after cancer treatment: persistent and poorly managed. J Adolesc Young Adult Oncol. 2017;6(3):489\u201393.","journal-title":"J Adolesc Young Adult Oncol"},{"issue":"19","key":"3330_CR12","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1200\/JCO.18.01579","volume":"37","author":"TG Smith","year":"2019","unstructured":"Smith TG, Troeschel AN, Castro KM, Arora NK, Stein K, Lipscomb J, et al. Perceptions of patients with breast and colon cancer of the management of cancer-related pain, fatigue, and emotional distress in community oncology. J Clin Oncol. 2019;37(19):1666\u201376.","journal-title":"J Clin Oncol"},{"issue":"5","key":"3330_CR13","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/S0033-3182(09)70835-7","volume":"50","author":"LF Brown","year":"2009","unstructured":"Brown LF, Kroenke K. Cancer-related fatigue and its associations with depression and anxiety: a systematic review. Psychosomatics. 2009;50(5):440\u20137.","journal-title":"Psychosomatics"},{"issue":"2","key":"3330_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/cncr.20777","volume":"103","author":"DJ Brown","year":"2005","unstructured":"Brown DJ, McMillan DC, Milroy R. The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer. Cancer. 2005;103(2):377\u201382.","journal-title":"Cancer"},{"issue":"1","key":"3330_CR15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s40487-022-00219-y","volume":"11","author":"L Barrett","year":"2023","unstructured":"Barrett L, Elliott E, Voorhaar M, Ingelg\u00e5rd A, Griebsch I, Wong B, et al. A mixed-methods study to better measure patient-reported pain and fatigue in soft tissue sarcoma. Oncol Therapy. 2023;11(1):129\u201343.","journal-title":"Oncol Therapy"},{"issue":"12","key":"3330_CR16","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1016\/j.jval.2021.06.010","volume":"24","author":"KS Gries","year":"2021","unstructured":"Gries KS, Fastenau J, Seo C, Potrata B, Iaconangelo C, Serrano D. Development of the multiple myeloma symptom and impact questionnaire: a new patient-reported outcome instrument to assess symptom and impacts in patients with multiple myeloma. Value Health. 2021;24(12):1807\u201319.","journal-title":"Value Health"},{"key":"3330_CR17","unstructured":"Critical Appraisal Skills Programme. CASP qualitative checklist. Available online at https:\/\/casp-uk.net\/images\/checklist\/documents\/CASP-Qualitative-Studies-Checklist\/CASP-Qualitative-Checklist-2018_fillable_form.pdf. Last accessed 01-June-2023."},{"issue":"9","key":"3330_CR18","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1177\/1049732305276687","volume":"15","author":"H-F Hsieh","year":"2005","unstructured":"Hsieh H-F, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277\u201388.","journal-title":"Qual Health Res"},{"key":"3330_CR19","doi-asserted-by":"crossref","unstructured":"Lincoln YS, Guba EG. Naturalistic inquiry. Sage; 1985.","DOI":"10.1016\/0147-1767(85)90062-8"},{"key":"3330_CR20","doi-asserted-by":"crossref","unstructured":"Carmichael C, Collins E, Marshall C, Macey J. Qualitative Content Analysis for Concept Elicitation (CACE) in clinical outcome assessment development. ISPOR Europe; 2023; Copenhagen. 2023.","DOI":"10.1016\/j.jval.2023.09.2212"},{"issue":"4","key":"3330_CR21","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1080\/08870446.2021.1973468","volume":"38","author":"TI Bootsma","year":"2023","unstructured":"Bootsma TI, Schellekens MP, van Woezik RA, van der Lee ML, Slatman J. Navigating severe chronic cancer-related fatigue: an interpretative phenomenological analysis. Psychol Health. 2023;38(4):494\u2013517.","journal-title":"Psychol Health"},{"issue":"6","key":"3330_CR22","first-page":"1069","volume":"11","author":"I Arizona","year":"2020","unstructured":"Arizona I, Sukartini T, Efendi F. \u201cI Feel Like a Baby\u201d: a cancer-related fatigue experience based on a male perspective. Syst Rev Pharm. 2020;11(6):1069\u201374.","journal-title":"Syst Rev Pharm"},{"key":"3330_CR23","first-page":"4827","volume":"29","author":"C Charles","year":"2021","unstructured":"Charles C, Di Meglio A, Arnedos M, Arvis J, Baciarello G, Blanchard P, et al. QualFatigue study: which factors influence the use of specific interventions for breast cancer survivors with fatigue? A cross-sectional exploratory study. Support Care Cancer. 2021;29:4827\u201334.","journal-title":"Support Care Cancer"},{"issue":"5\u20136","key":"3330_CR24","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1111\/jocn.15114","volume":"29","author":"S Kim","year":"2020","unstructured":"Kim S, Han J, Lee MY, Jang MK. The experience of cancer-related fatigue, exercise and exercise adherence among women breast cancer survivors: insights from focus group interviews. J Clin Nurs. 2020;29(5\u20136):758\u201369.","journal-title":"J Clin Nurs"},{"issue":"1","key":"3330_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/08964289.2017.1399100","volume":"45","author":"I Levkovich","year":"2019","unstructured":"Levkovich I, Cohen M, Karkabi K. The experience of fatigue in breast cancer patients 1\u201312 month post-chemotherapy: a qualitative study. Behav Med. 2019;45(1):7\u201318.","journal-title":"Behav Med"},{"issue":"8","key":"3330_CR26","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1177\/02692163231184926","volume":"37","author":"H Li","year":"2023","unstructured":"Li H, Ng MSN, Jin X, Wong CL. \u2018Life became slow down\u2019: a descriptive qualitative study of the experiences of cancer-related fatigue amongst people with advanced lung cancer. Palliat Med. 2023;37(8):1168\u201382.","journal-title":"Palliat Med"},{"key":"3330_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ejon.2019.04.005","volume":"41","author":"MK Mikkelsen","year":"2019","unstructured":"Mikkelsen MK, Nielsen DL, Vinther A, Lund CM, Jarden M. Attitudes towards physical activity and exercise in older patients with advanced cancer during oncological treatment\u2014a qualitative interview study. Eur J Oncol Nurs. 2019;41:16\u201323.","journal-title":"Eur J Oncol Nurs"},{"key":"3330_CR28","unstructured":"Homkes DL. The lived experience of lung cancer patients with psychological health and physical activity. Walden University; 2023."},{"issue":"6","key":"3330_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/jnr.0000000000000453","volume":"29","author":"X Dong","year":"2021","unstructured":"Dong X, Peng J, Li X, Zhao Q, Xiuwei Z. Home coping strategies for fatigue used by patients with lung cancer receiving chemotherapy in rural China: a qualitative study. J Nurs Res. 2021;29(6): e178.","journal-title":"J Nurs Res"},{"issue":"2","key":"3330_CR30","doi-asserted-by":"publisher","first-page":"E97","DOI":"10.1097\/NCC.0000000000000683","volume":"43","author":"D Milne","year":"2020","unstructured":"Milne D, Hyatt A, Billett A, Gough K, Krishnasamy M. Exploring the experiences of people treated with immunotherapies for advanced melanoma and those caring for them: \u201creal-world\u201d data. Cancer Nurs. 2020;43(2):E97\u2013104.","journal-title":"Cancer Nurs"},{"key":"3330_CR31","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s13555-023-00945-9","volume":"13","author":"G Konidaris","year":"2023","unstructured":"Konidaris G, Rofail D, Randall J, LaFontaine PR, Chen C-I, Bury D, et al. Qualitative patient interviews to characterize the human burden of advanced basal cell carcinoma following Hedgehog pathway inhibitor treatment. Dermatol Therapy. 2023;13:1747\u201361.","journal-title":"Dermatol Therapy"},{"key":"3330_CR32","volume":"25","author":"ND Dolgoy","year":"2020","unstructured":"Dolgoy ND, O\u2019Krafka P, McNeely ML. Cancer-related fatigue in head and neck cancer survivors: energy and functional impacts. Cancer Treat Res Commun. 2020;25: 100244.","journal-title":"Cancer Treat Res Commun"},{"key":"3330_CR33","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s11764-022-01279-9","volume":"18","author":"I Guillemin","year":"2024","unstructured":"Guillemin I, Darpelly M, Wong B, Ingelg\u00e5rd A, Griebsch I. Development of a disease conceptual model of patient experience with metastatic colorectal cancer: identification of the most salient symptoms and impacts. J Cancer Surviv. 2024;18:761\u201371.","journal-title":"J Cancer Surviv"},{"key":"3330_CR34","unstructured":"Cancer Support Community. Cancer cachexia: voice of the patient report. 2021 [updated 2021; cited]. Available from: https:\/\/www.cancersupportcommunity.org\/sites\/default\/files\/file\/2022-10\/CCommSupport_Cachexia_Report_Final.pdf."},{"key":"3330_CR35","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s40271-020-00440-9","volume":"14","author":"D Eek","year":"2021","unstructured":"Eek D, Blowfield M, Krogh C, Chung H, Eyre TA. Development of a conceptual model of chronic lymphocytic leukemia to better understand the patient experience. Patient-Patient-Cent Outcomes Res. 2021;14:75\u201387.","journal-title":"Patient-Patient-Cent Outcomes Res"},{"key":"3330_CR36","doi-asserted-by":"publisher","first-page":"S76","DOI":"10.1016\/j.jval.2018.09.448","volume":"21","author":"J Gable","year":"2018","unstructured":"Gable J, Ayer D, Girvan A, Bowman L, Abada P, Ervin C, et al. PCN366-qualitative patient interviews to support the FACT Hepatobiliary Symptom Index-8 among patients with hepatocellular carcinoma and elevated baseline alpha-fetoprotein. Value Health. 2018;21:S76.","journal-title":"Value Health"},{"issue":"1","key":"3330_CR37","doi-asserted-by":"publisher","first-page":"E28","DOI":"10.1097\/NCC.0000000000000446","volume":"41","author":"H Poort","year":"2018","unstructured":"Poort H, Meade CD, Knoop H, Gielissen MF, Pinilla-Ibarz J, Jacobsen PB. Adapting an evidence-based intervention to address targeted therapy-related fatigue in chronic myeloid leukemia patients. Cancer Nurs. 2018;41(1):E28.","journal-title":"Cancer Nurs"},{"issue":"3","key":"3330_CR38","volume":"27","author":"CC Tang","year":"2018","unstructured":"Tang CC, Draucker C, Tejani M, Von Ah D. Symptom experiences in patients with advanced pancreatic cancer as reported during healthcare encounters. Eur J Cancer Care. 2018;27(3): e12838.","journal-title":"Eur J Cancer Care"},{"key":"3330_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41687-020-00235-4","volume":"4","author":"JJ Trudeau","year":"2020","unstructured":"Trudeau JJ, He J, Rose E, Panter C, Randhawa S, Gater A. Content validity of patient-reported outcomes for use in lower-risk myelodysplastic syndromes. J Patient-Rep Outcomes. 2020;4:1\u201313.","journal-title":"J Patient-Rep Outcomes"},{"issue":"6","key":"3330_CR40","doi-asserted-by":"publisher","first-page":"E48","DOI":"10.1097\/NCC.0000000000000506","volume":"41","author":"S Stuhlfauth","year":"2018","unstructured":"Stuhlfauth S, Melby L, Helles\u00f8 R. Everyday life after colon cancer: the visible and invisible challenges. Cancer Nurs. 2018;41(6):E48\u201357.","journal-title":"Cancer Nurs"},{"issue":"1","key":"3330_CR41","volume":"6","author":"A Bradford","year":"2023","unstructured":"Bradford A, Young K, Whitechurch A, Burbury K, Pearson EJM. Disabled, invisible and dismissed\u2014the lived experience of fatigue in people with myeloproliferative neoplasms. Cancer Rep. 2023;6(1): e1655.","journal-title":"Cancer Rep"},{"issue":"1","key":"3330_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2022.10.012","volume":"14","author":"M Parthipan","year":"2023","unstructured":"Parthipan M, Feng G, Toledano N, Donison V, Breunis H, Sudharshan A, et al. Symptom experiences of older adults during treatment for metastatic prostate cancer: a qualitative investigation. J Geriatr Oncol. 2023;14(1): 101397.","journal-title":"J Geriatr Oncol"},{"key":"3330_CR43","first-page":"219","volume":"27","author":"WY Cheung","year":"2019","unstructured":"Cheung WY, White MK, Bayliss MS, Stroupe A, Lovley A, King-Kallimanis BL, et al. Patient-reported treatment-related symptom burden for patients with advanced melanoma in Canada. Support Care Cancer. 2019;27:219\u201327.","journal-title":"Support Care Cancer"},{"issue":"3","key":"3330_CR44","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/03007995.2021.2006534","volume":"38","author":"T Iguchi","year":"2022","unstructured":"Iguchi T, Nakamura Y, Akiyama T, Chand K, Yu E. Descriptive study on burden and communication of fatigue among castration-resistant prostate cancer patients in Japan. Curr Med Res Opin. 2022;38(3):417\u201326.","journal-title":"Curr Med Res Opin"},{"issue":"6","key":"3330_CR45","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.jpainsymman.2010.02.006","volume":"39","author":"AM Barsevick","year":"2010","unstructured":"Barsevick AM, Cleeland CS, Manning DC, O\u2019Mara AM, Reeve BB, Scott JA, et al. ASCPRO recommendations for the assessment of fatigue as an outcome in clinical trials. J Pain Symptom Manag. 2010;39(6):1086\u201399.","journal-title":"J Pain Symptom Manag"},{"key":"3330_CR46","unstructured":"Food and Drug Administration (FDA). Patient-focused drug development: selecting, developing, or modifying fit-for-purpose clinical outcome assessments. Guidance for Industry, food and drug administration staff, and other stakeholders. Draft guidance. 2022."},{"key":"3330_CR47","unstructured":"Food and Drug Administration (FDA). Guidance for industry patient-reported outcome measures: use in medical product development to support labeling claims. 2009."},{"key":"3330_CR48","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s11136-011-0054-x","volume":"21","author":"CF Snyder","year":"2012","unstructured":"Snyder CF, Aaronson NK, Choucair AK, Elliott TE, Greenhalgh J, Halyard MY, et al. Implementing patient-reported outcomes assessment in clinical practice: a review of the options and considerations. Qual Life Res. 2012;21:1305\u201314.","journal-title":"Qual Life Res"},{"key":"3330_CR49","unstructured":"Food and Drug Administration (FDA). Patient-focused drug development: incorporating clinical outcome assessments into endpoints for regulatory decision-making. guidance for industry, food and drug administration staff, and other stakeholders. Draft guidance. 2023."}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-025-03330-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-025-03330-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-025-03330-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:02:28Z","timestamp":1762030948000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-025-03330-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,18]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["3330"],"URL":"https:\/\/doi.org\/10.1007\/s12325-025-03330-4","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,18]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was funded by Sanofi, and Sophie Van Tomme, Cecile Gousset, and Paul Cordero are employees of Sanofi and may hold stocks. Chloe Carmichael, Jordan Miller, Danielle Burns, Harriet Makin, Helen Kitchen, and Natalie Aldhouse are employees and stockholders of Clarivate, which received funding from Sanofi to conduct the analysis and for writing support. The authors have no other relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}