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Anastasia Lampropoulou was an employee and minor shareholder of Eli Lilly and Company at the time the work was conducted and is a\u00a0current employee and minor shareholder of Novartis. Erik Spaepen is an external consultant of Eli Lilly and Company. Carel Le Roux has received consulting fees for advisory board participation from Eli Lilly, NovoNordisk, Johnson & Johnson, Boehringer Ingelheim, GI Dynamics, Herbalife, Altimmune, Irish Life Health, Roche and AstraZeneca; speaker fees from NovoNordisk, Herbalife, Johnson & Johnson, Eli Lilly, Boehringer Ingelheim, Rhythm Pharmaceuticals and Currax Pharmaceuticals; support for travel to\/attending meetings from NovoNordisk, Herbalife, Johnson & Johnson, Eli Lilly and Boehringer Ingelheim; institutional grants from the Irish Research Council, Health Research Board, Science Foundation Ireland, and Anabio; and holds stock or stock options in Keyron and Beyond BMI. Dror Dicker has received royalties or licenses, consulting fees, speaker fees, and support for travel to\/attending meetings from NovoNordisk, Eli Lilly and Boehringer Ingelheim; institutional grants from NovoNordisk and Eli Lilly; and institutional provision of goods (equipment, materials, drugs, etc.)\/services from NovoNordisk. He has participated in advisory boards for NovoNordisk, Eli Lilly and Boehringer Ingelheim. Atif Adam, Xiaoyu Lin, Mengyuan Shang, and Sarah Seager have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All analyses performed in this study were conducted in accordance with Data Use Agreement terms as specified by the data owners. For the databases for France, Germany, Italy, the UK, Australia, and Japan, there was no Institutional Review Board applicable to the usage and dissemination of the results of this study or required registration of the protocol with additional ethics oversight. For the database for Spain LPD, the Ethics Committee of the Hospital Clinic de Barcelona (Spain) reviewed and approved the protocol.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}