{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:11:05Z","timestamp":1778231465391,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s12325-026-03516-4","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:48:55Z","timestamp":1773820135000},"page":"2217-2235","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medication Instruction and Mirogabalin Treatment Satisfaction in Patients with Neuropathic Pain due to Orthopedic Diseases: Results of MiroSearch, a Japanese Exploratory Interventional Study"],"prefix":"10.1007","volume":"43","author":[{"given":"Hiroaki","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyofumi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"issue":"8","key":"3516_CR1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","volume":"9","author":"R Baron","year":"2010","unstructured":"Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9(8):807\u201319. https:\/\/doi.org\/10.1016\/S1474-4422(10)70143-5.","journal-title":"Lancet Neurol"},{"issue":"15","key":"3516_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153203","volume":"10","author":"J Nijs","year":"2021","unstructured":"Nijs J, Lahousse A, Kapreli E, et al. Nociplastic pain criteria or recognition of central sensitization? Pain phenotyping in the past, present and future. J Clin Med. 2021;10(15):3203. https:\/\/doi.org\/10.3390\/jcm10153203.","journal-title":"J Clin Med"},{"issue":"1","key":"3516_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","volume":"160","author":"J Scholz","year":"2019","unstructured":"Scholz J, Finnerup NB, Attal N, Classification Committee of the Neuropathic Pain Special Interest Group (NeuPSIG), et al. The IASP classification of chronic pain for ICD-11: chronic neuropathic pain. Pain. 2019;160(1):53\u20139. https:\/\/doi.org\/10.1097\/j.pain.0000000000001365.","journal-title":"Pain"},{"issue":"2","key":"3516_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/2374373518786013","volume":"6","author":"MA Hadi","year":"2019","unstructured":"Hadi MA, McHugh GA, Closs SJ. Impact of chronic pain on patients\u2019 quality of life: a comparative mixed-methods study. J Patient Exp. 2019;6(2):133\u201341. https:\/\/doi.org\/10.1177\/2374373518786013.","journal-title":"J Patient Exp"},{"issue":"2","key":"3516_CR5","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/papr.12842","volume":"20","author":"M Due\u00f1as","year":"2020","unstructured":"Due\u00f1as M, Salazar A, de Sola H, Failde I. Limitations in activities of daily living in people with chronic pain: identification of groups using clusters analysis. Pain Pract. 2020;20(2):179\u201387. https:\/\/doi.org\/10.1111\/papr.12842.","journal-title":"Pain Pract"},{"key":"3516_CR6","volume-title":"Pain clinic treatment guidelines, revised 6th ed","author":"Japan Society of Pain Clinicians","year":"2021","unstructured":"Japan Society of Pain Clinicians. Pain clinic treatment guidelines, revised 6th ed. Tokyo: Sinko Trading; 2021."},{"issue":"3","key":"3516_CR7","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s40122-025-00709-7","volume":"14","author":"M Takahashi","year":"2025","unstructured":"Takahashi M, Kodama S, Akahane M, Yamamoto S, Yonemoto T, Seki H. The relationship between treatment satisfaction and medication understanding among patients taking a novel oral pain reliever: a questionnaire-based cross-sectional study. Pain Ther. 2025;14(3):931\u201345. https:\/\/doi.org\/10.1007\/s40122-025-00709-7.","journal-title":"Pain Ther"},{"issue":"4","key":"3516_CR8","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pmn.2010.04.004","volume":"13","author":"G Bozimowski","year":"2012","unstructured":"Bozimowski G. Patient perceptions of pain management therapy: a comparison of real-time assessment of patient education and satisfaction and registered nurse perceptions. Pain Manag Nurs. 2012;13(4):186\u201393. https:\/\/doi.org\/10.1016\/j.pmn.2010.04.004.","journal-title":"Pain Manag Nurs"},{"issue":"8","key":"3516_CR9","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1080\/14656566.2020.1743267","volume":"21","author":"T Ushida","year":"2020","unstructured":"Ushida T, Inoue T, Matsui D, et al. Cross-sectional study of patient satisfaction with oral analgesics in patients with chronic pain in Japan. Expert Opin Pharmacother. 2020;21(8):983\u201391. https:\/\/doi.org\/10.1080\/14656566.2020.1743267.","journal-title":"Expert Opin Pharmacother"},{"issue":"8","key":"3516_CR10","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1007\/s12325-021-01810-x","volume":"38","author":"T Deguchi","year":"2021","unstructured":"Deguchi T, Takatsuna H, Yokoyama M, et al. A cross-sectional web survey of satisfaction with treatment for pain in participants with suspected diabetic peripheral neuropathic pain in both feet. Adv Ther. 2021;38(8):4304\u201320. https:\/\/doi.org\/10.1007\/s12325-021-01810-x.","journal-title":"Adv Ther"},{"issue":"4","key":"3516_CR11","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00776-014-0567-6","volume":"19","author":"M Nakamura","year":"2014","unstructured":"Nakamura M, Nishiwaki Y, Sumitani M, et al. Investigation of chronic musculoskeletal pain (third report): with special reference to the importance of neuropathic pain and psychogenic pain. J Orthop Sci. 2014;19(4):667\u201375. https:\/\/doi.org\/10.1007\/s00776-014-0567-6.","journal-title":"J Orthop Sci"},{"issue":"5","key":"3516_CR12","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1097\/j.pain.0000000000001501","volume":"160","author":"J Kato","year":"2019","unstructured":"Kato J, Matsui N, Kakehi Y, Murayama E, Ohwada S, Sugihara M. Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients. Pain. 2019;160(5):1175\u201385. https:\/\/doi.org\/10.1097\/j.pain.0000000000001501.","journal-title":"Pain"},{"issue":"5","key":"3516_CR13","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1111\/jdi.13013","volume":"10","author":"M Baba","year":"2019","unstructured":"Baba M, Matsui N, Kuroha M, Wasaki Y, Ohwada S. Mirogabalin for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo-controlled phase III study in Asian patients. J Diabetes Investig. 2019;10(5):1299\u2013306. https:\/\/doi.org\/10.1111\/jdi.13013.","journal-title":"J Diabetes Investig"},{"issue":"11","key":"3516_CR14","doi-asserted-by":"publisher","first-page":"e1193","DOI":"10.1212\/WNL.0000000000201709","volume":"100","author":"T Ushida","year":"2023","unstructured":"Ushida T, Katayama Y, Hiasa Y, et al. Mirogabalin for central neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled, phase 3 study in Asia. Neurology. 2023;100(11):e1193\u2013206. https:\/\/doi.org\/10.1212\/WNL.0000000000201709.","journal-title":"Neurology"},{"key":"3516_CR15","unstructured":"Mirogabalin besylate (Tarlige\u00ae) tablets [package insert, version 9]. Tokyo: Daichii Sankyo Co., Ltd.; 2025. https:\/\/pins.japic.or.jp\/pdf\/newPINS\/00070625.pdf. Accessed 14 Jul 2025 (in Japanese)."},{"issue":"4","key":"3516_CR16","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s40122-022-00410-z","volume":"11","author":"T Nikaido","year":"2022","unstructured":"Nikaido T, Takatsuna H, Tabata S, Shiosakai K, Nakatani T, Konno SI. Efficacy and safety of add-on mirogabalin to NSAIDs in lumbar spinal stenosis with peripheral neuropathic pain: a randomized, open-label study. Pain Ther. 2022;11(4):1195\u2013214. https:\/\/doi.org\/10.1007\/s40122-022-00410-z.","journal-title":"Pain Ther"},{"issue":"3","key":"3516_CR17","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1007\/s40122-025-00722-w","volume":"14","author":"T Hirai","year":"2025","unstructured":"Hirai T, Okawa A, Takahashi H, Shiosakai K, Yoshii T, Miro-Cens investigators. Efficacy and safety of mirogabalin in patients with neuropathic pain due to cervical spondylotic radiculopathy: Miro-Cens, a randomized, controlled, interventional study. Pain Ther. 2025;14(3):1063\u201379. https:\/\/doi.org\/10.1007\/s40122-025-00722-w.","journal-title":"Pain Ther"},{"issue":"6","key":"3516_CR18","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1007\/s40122-025-00776-w","volume":"14","author":"H Suzuki","year":"2025","unstructured":"Suzuki H, Kaito T, Nakashima H, et al. Efficacy and safety of mirogabalin as an add-on to nonsteroidal anti-inflammatory drugs for neuropathic pain caused by lumbar disc herniation: a randomized controlled study (Miro-Hers). Pain Ther. 2025;14(6):1879\u201398. https:\/\/doi.org\/10.1007\/s40122-025-00776-w.","journal-title":"Pain Ther"},{"issue":"1","key":"3516_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.pain.2010.07.031","volume":"152","author":"M Haanp\u00e4\u00e4","year":"2011","unstructured":"Haanp\u00e4\u00e4 M, Attal N, Backonja M, et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152(1):14\u201327. https:\/\/doi.org\/10.1016\/j.pain.2010.07.031.","journal-title":"Pain"},{"issue":"1","key":"3516_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1093\/bja\/aen103","volume":"101","author":"H Breivik","year":"2008","unstructured":"Breivik H, Borchgrevink PC, Allen SM, et al. Assessment of pain. Br J Anaesth. 2008;101(1):17\u201324. https:\/\/doi.org\/10.1093\/bja\/aen103.","journal-title":"Br J Anaesth"},{"issue":"10","key":"3516_CR21","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","volume":"20","author":"M Herdman","year":"2011","unstructured":"Herdman M, Gudex C, Lloyd A, et al. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011;20(10):1727\u201336. https:\/\/doi.org\/10.1007\/s11136-011-9903-x.","journal-title":"Qual Life Res"},{"issue":"1","key":"3516_CR22","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159\u201374.","journal-title":"Biometrics"},{"issue":"9","key":"3516_CR23","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1080\/14740338.2023.2193395","volume":"22","author":"R Nakajima","year":"2023","unstructured":"Kato K, Kodama S, Shiosakai K, Kimura T. Relationship between the dose titration and adherence of mirogabalin in patients with peripheral neuropathic pain depending on renal function: a nationwide electronic medical record database study. Expert Opin Pharmacother. 2023;24(2):267\u2013282. https:\/\/doi.org\/10.1080\/14656566.2022.2155048.","journal-title":"Expert Opin Drug Saf"},{"issue":"2","key":"3516_CR24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1370\/afm.2949","volume":"21","author":"JC Licciardone","year":"2023","unstructured":"Licciardone JC, Patel S, Kandukuri P, Beeton G, Nyalakonda R, Aryal S. Patient satisfaction with medical care for chronic low back pain: a pain research registry study. Ann Fam Med. 2023;21(2):125\u201331. https:\/\/doi.org\/10.1370\/afm.2949.","journal-title":"Ann Fam Med"},{"issue":"1","key":"3516_CR25","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s13142-012-0158-z","volume":"3","author":"L Dorflinger","year":"2013","unstructured":"Dorflinger L, Kerns RD, Auerbach SM. Providers\u2019 roles in enhancing patients\u2019 adherence to pain self management. Transl Behav Med. 2013;3(1):39\u201346. https:\/\/doi.org\/10.1007\/s13142-012-0158-z.","journal-title":"Transl Behav Med"},{"issue":"4","key":"3516_CR26","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s11845-019-01999-5","volume":"188","author":"S Walsh","year":"2019","unstructured":"Walsh S, O\u2019Neill A, Hannigan A, Harmon D. Patient-rated physician empathy and patient satisfaction during pain clinic consultations. Ir J Med Sci. 2019;188(4):1379\u201384. https:\/\/doi.org\/10.1007\/s11845-019-01999-5.","journal-title":"Ir J Med Sci"},{"issue":"12","key":"3516_CR27","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1037\/pas0000626","volume":"31","author":"LA Clark","year":"2019","unstructured":"Clark LA, Watson D. Constructing validity: new developments in creating objective measuring instruments. Psychol Assess. 2019;31(12):1412\u201327. https:\/\/doi.org\/10.1037\/pas0000626.","journal-title":"Psychol Assess"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03516-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-026-03516-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03516-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:37:28Z","timestamp":1778229448000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-026-03516-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["3516"],"URL":"https:\/\/doi.org\/10.1007\/s12325-026-03516-4","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"assertion":[{"value":"24 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Hiroaki Nakashima, Kiyofumi Yamada, Yoshiaki Kato, and Shiro Imagama have no conflict of interests to be declared. Wataru Hashimoto and Taiki Toyama are employees of Daiichi Sankyo Co., Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study was approved by Nagoya University Clinical Research Review Board (CRB No. CRB4180004). It was conducted in accordance with the Clinical Trials Act in Japan and the Act on the Protection of Personal Information, as well as the ethical principles and relevant notifications stipulated in the Declaration of Helsinki (as revised in 2013). The MiroSearch study was registered in the Japan Registry of Clinical Trials under the identifier jRCTs041230059. All patients provided informed consent to participate in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}