{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T15:36:02Z","timestamp":1782056162930,"version":"3.54.5"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s12325-026-03519-1","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T03:43:17Z","timestamp":1771990997000},"page":"1756-1774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["System Preparedness for Rising Kidney Replacement Therapy Demand: Late-Stage CKD Drives Costs, Healthcare Resource Utilisation and Environmental Impact in Switzerland"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-0515","authenticated-orcid":false,"given":"Thomas","family":"Campbell-James","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Buff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-7524","authenticated-orcid":false,"given":"Giliane","family":"Nanchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-6306","authenticated-orcid":false,"given":"Thomas","family":"Rosemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3088-7197","authenticated-orcid":false,"given":"Lindsay","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Priest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-3563","authenticated-orcid":false,"given":"Anthony","family":"Zara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Hubbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Vecchio Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Wharton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-1851","authenticated-orcid":false,"given":"Menno","family":"Pruijm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"3519_CR1","unstructured":"Kidney Disease: Improving Global Outcomes CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024;105(4S):S117\u2013314."},{"issue":"11","key":"3519_CR2","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1093\/ndt\/gfz174","volume":"34","author":"KJ Jager","year":"2019","unstructured":"Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850\u00a0million individuals have kidney diseases. Nephrol Dial Transplant. 2019;34(11):1803\u20135.","journal-title":"Nephrol Dial Transplant"},{"issue":"10159","key":"3519_CR3","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","volume":"392","author":"KJ Foreman","year":"2018","unstructured":"Foreman KJ, Marquez N, Dolgert A, et al. Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016\u201340 for 195 countries and territories. Lancet. 2018;392(10159):2052\u201390.","journal-title":"Lancet"},{"issue":"1","key":"3519_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-025-13687-5","volume":"25","author":"D Bukanova-Berend","year":"2025","unstructured":"Bukanova-Berend D, Campbell-James T, Vogel J. Hospitalizations and inpatient resource consumption of patients suffering from chronic disease\u2014past trend and forecast for Switzerland. BMC Health Serv Res. 2025;25(1):1514.","journal-title":"BMC Health Serv Res"},{"key":"3519_CR5","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2016.14313","volume":"146","author":"VF Ogna","year":"2016","unstructured":"Ogna VF, Ogna A, Ponte B, et al. Prevalence and determinants of chronic kidney disease in the Swiss population. Swiss Med Wkly. 2016;146:w14313.","journal-title":"Swiss Med Wkly"},{"issue":"9","key":"3519_CR6","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1093\/ndt\/gft206","volume":"28","author":"B Ponte","year":"2013","unstructured":"Ponte B, Pruijm M, Marques-Vidal P, et al. Determinants and burden of chronic kidney disease in the population-based CoLaus study: a cross-sectional analysis. Nephrol Dial Transplant. 2013;28(9):2329\u201339.","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"3519_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-04028-z","volume":"26","author":"J Guo","year":"2025","unstructured":"Guo J, Jiao W, Xia S, et al. The global, regional, and national patterns of change in the burden of chronic kidney disease from 1990 to 2021. BMC Nephrol. 2025;26(1):136.","journal-title":"BMC Nephrol"},{"key":"3519_CR8","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2019.20094","volume":"149","author":"CE Aubert","year":"2019","unstructured":"Aubert CE, Fankhauser N, Marques-Vidal P, et al. Patterns of multimorbidity in internal medicine patients in Swiss university hospitals: a multicentre cohort study. Swiss Med Wkly. 2019;149:w20094.","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"3519_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-10124-3","volume":"23","author":"M Stucki","year":"2023","unstructured":"Stucki M, Sch\u00e4rer X, Trottmann M, Scholz-Odermatt S, Wieser S. What drives health care spending in Switzerland? Findings from a decomposition by disease, health service, sex, and age. BMC Health Serv Res. 2023;23(1):1149.","journal-title":"BMC Health Serv Res"},{"key":"3519_CR10","unstructured":"Swiss Society of Nephrology. Screening and identification of chronic kidney disease for general practitioners. [Accessed February 20, 2024]. https:\/\/www.swissnephrology.ch\/wp\/wp-content\/uploads\/2023\/01\/161121_SGN_Pocketguide_CKD_Web_A4_e_WZ.pdf."},{"issue":"8","key":"3519_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272662","volume":"17","author":"L J\u00e4ger","year":"2022","unstructured":"J\u00e4ger L, Rosemann T, Burgstaller JM, Senn O, Markun S. Quality and variation of care for chronic kidney disease in Swiss general practice: a retrospective database study. PLoS ONE. 2022;17(8):e0272662.","journal-title":"PLoS ONE"},{"key":"3519_CR12","doi-asserted-by":"publisher","DOI":"10.1177\/20543581231166484","volume":"10","author":"CE Stigant","year":"2023","unstructured":"Stigant CE, Rajan T, Barraclough KA, Miller FA. The necessity of environmentally sustainable kidney care. Can J Kidney Health Dis. 2023;10:20543581231166484.","journal-title":"Can J Kidney Health Dis"},{"issue":"1","key":"3519_CR13","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s12325-024-03039-w","volume":"42","author":"JJ Garcia Sanchez","year":"2025","unstructured":"Garcia Sanchez JJ, Barraclough KA, Cases A, et al. Using chronic kidney disease as a model framework to estimate healthcare-related environmental impact. Adv Ther. 2025;42(1):348\u201361.","journal-title":"Adv Ther"},{"issue":"7","key":"3519_CR14","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/ckj\/sfab070","volume":"14","author":"R Vanholder","year":"2021","unstructured":"Vanholder R, Annemans L, Bello AK, et al. Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney. Clin Kidney J. 2021;14(7):1719\u201330.","journal-title":"Clin Kidney J"},{"key":"#cr-split#-3519_CR15.1","unstructured":"Federal Statistical Office. Permanent resident population by age, sex and citizenship category, 2010-2022. 2023 [updated 2023 Aug 24"},{"key":"#cr-split#-3519_CR15.2","unstructured":"Accessed March 01, 2024]. https:\/\/www.bfs.admin.ch\/asset\/de\/26565150."},{"issue":"2","key":"3519_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad281","volume":"17","author":"BA Boerstra","year":"2021","unstructured":"Boerstra BA, Boenink R, Astley ME, et al. The ERA Registry Annual Report 2021: a summary. Clin Kidney J. 2023;17(2):sfad281.","journal-title":"Clin Kidney J"},{"issue":"4","key":"3519_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231375","volume":"15","author":"A Gandjour","year":"2020","unstructured":"Gandjour A, Armsen W, Wehmeyer W, Multmeier J, Tschulena U. Costs of patients with chronic kidney disease in Germany. PLoS ONE. 2020;15(4):e0231375.","journal-title":"PLoS ONE"},{"issue":"21","key":"3519_CR18","doi-asserted-by":"publisher","first-page":"14007","DOI":"10.3390\/ijerph192114007","volume":"19","author":"A Shukri","year":"2022","unstructured":"Shukri A, Mettang T, Scheckel B, et al. Hemodialysis and peritoneal dialysis in Germany from a health economic view-a propensity score matched analysis. Int J Environ Res Public Health. 2022;19(21):14007.","journal-title":"Int J Environ Res Public Health"},{"issue":"2\u20133","key":"3519_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10754-007-9020-0","volume":"7","author":"W Kleophas","year":"2007","unstructured":"Kleophas W, Reichel H. International study of health care organization and financing: development of renal replacement therapy in Germany. Int J Health Care Finance Econ. 2007;7(2\u20133):185\u2013200.","journal-title":"Int J Health Care Finance Econ"},{"key":"3519_CR20","unstructured":"Wieser S, Tomonaga Y, Riguzzi M, et al. Die Kosten der nicht\u00fcbertragbaren Krankheiten in der Schweiz: Schlussbericht. 2014 [updated 2014; Accessed February 21, 2024]. https:\/\/digitalcollection.zhaw.ch\/handle\/11475\/14988."},{"issue":"8","key":"3519_CR21","first-page":"468","volume":"375","author":"Y Vuignier","year":"2013","unstructured":"Vuignier Y, Pruijm M, Jarrayah F, Burnier M. Dialyse et \u00e9cologie: est-il possible de faire mieux \u00e0 l\u2019avenir? Rev Med Suisse. 2013;375(8):468\u201372.","journal-title":"Rev Med Suisse"},{"issue":"6","key":"3519_CR22","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae144","volume":"17","author":"M Pruijm","year":"2024","unstructured":"Pruijm M, Rho E, Woywodt A, Segerer S. Ten tips from the Swiss Working Group on Sustainable Nephrology on how to go green in your dialysis unit. Clin Kidney J. 2024;17(6):sfae144.","journal-title":"Clin Kidney J"},{"key":"3519_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2025.10.019","author":"KA Barraclough","year":"2026","unstructured":"Barraclough KA, Cases A, Eckelman MJ, et al. International environmental impact of CKD care. Kidney Int Rep. 2026. https:\/\/doi.org\/10.1016\/j.ekir.2025.10.019.","journal-title":"Kidney Int Rep"},{"key":"3519_CR24","unstructured":"Healthcare without Harm. Global road map for health care decarbonization: Switzerland. [Accessed September 19, 2025]. https:\/\/healthcareclimateaction.org\/fact-sheets\/en\/English%20-%20Switzerland."},{"key":"3519_CR25","doi-asserted-by":"crossref","unstructured":"Neuen BL, Bello AK, Levin A, et al. National health policies and strategies for addressing chronic kidney disease: data from the International Society of Nephrology Global Kidney Health Atlas. PLOS Global Public Health; 2023.","DOI":"10.1371\/journal.pgph.0001467"},{"key":"3519_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2024.105244","volume":"152","author":"C Johnston-Webber","year":"2025","unstructured":"Johnston-Webber C, Bencomo-Bermudez I, Wharton G, et al. A conceptual framework to assess the health, socioeconomic and environmental burden of chronic kidney disease. Health Policy. 2025;152:105244.","journal-title":"Health Policy"},{"issue":"11","key":"3519_CR27","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1016\/j.ekir.2024.08.015","volume":"9","author":"S Brown","year":"2024","unstructured":"Brown S, Garcia Sanchez JJ, Guiang H, et al. IMPACT CKD: holistic disease model projecting 10-year population burdens. Kidney Int Rep. 2024;9(11):3156\u201366.","journal-title":"Kidney Int Rep"},{"issue":"7","key":"3519_CR28","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/j.ekir.2025.03.051","volume":"10","author":"N Rao","year":"2025","unstructured":"Rao N, Brotons-Munto F, Moura AF, et al. Holistic impact of CKD: a clinical, economic, and environmental analysis by IMPACT CKD. Kidney Int Rep. 2025;10(7):2116\u201327.","journal-title":"Kidney Int Rep"},{"issue":"8","key":"3519_CR29","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1007\/s12325-024-02913-x","volume":"41","author":"H Heerspink","year":"2024","unstructured":"Heerspink H, Nolan S, Carrero J-J, et al. Clinical outcomes in patients with CKD and rapid or non-rapid eGFR decline: a report from the DISCOVER CKD retrospective cohort. Adv Ther. 2024;41(8):3264\u201377.","journal-title":"Adv Ther"},{"key":"3519_CR30","unstructured":"OECD. Exchange rates: national currency units\/US dollar 2000\u20132022. [Accessed February 21, 2024]. https:\/\/www.oecd.org\/en\/data\/indicators\/exchange-rates.html."},{"key":"3519_CR31","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2018.14626","volume":"148","author":"Z Ademi","year":"2018","unstructured":"Ademi Z, Tomonaga Y, van Stiphout J, et al. Adaptation of cost-effectiveness analyses to a single country: the case of bariatric surgery for obesity and overweight. Swiss Med Wkly. 2018;148:w14626.","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"3519_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-019-0733-2","volume":"19","author":"PR Blank","year":"2019","unstructured":"Blank PR, Tomonaga Y, Szucs TD, Schwenkglenks M. Economic burden of symptomatic iron deficiency\u2014a survey among Swiss women. BMC Womens Health. 2019;19(1):39.","journal-title":"BMC Womens Health"},{"key":"#cr-split#-3519_CR33.1","unstructured":"Federal Statistical Office. Natural population movement by sex, 1871-2022. 2023 [updated 2023 Sep 26"},{"key":"#cr-split#-3519_CR33.2","unstructured":"Accessed February 20, 2024]. https:\/\/www.bfs.admin.ch\/asset\/de\/27225498."},{"key":"#cr-split#-3519_CR34.1","unstructured":"Federal Statistical Office. Balance of the permanent resident population, 1861-2022. 2023 [updated 2023 Aug 24"},{"key":"#cr-split#-3519_CR34.2","unstructured":"Accessed February 20, 2024]. https:\/\/www.bfs.admin.ch\/asset\/de\/26565327."},{"key":"3519_CR35","unstructured":"Federal Statistical Office. Medical statistics of hospitals 2013\u20132022. (data-on-file)."},{"key":"#cr-split#-3519_CR36.1","unstructured":"Federal Statistical Office. Medical statistics of hospitals 2019. 2020 [updated 2020 Nov 20"},{"key":"#cr-split#-3519_CR36.2","unstructured":"Accessed February 20, 2024]. https:\/\/www.bfs.admin.ch\/asset\/de\/14841425."},{"key":"#cr-split#-3519_CR37.1","unstructured":"Federal Statistical Office. Deaths and death rates from major causes of death, by age, women. 2023 [updated 2023 Dec 11"},{"key":"#cr-split#-3519_CR37.2","unstructured":"Accessed February 22, 2024]. https:\/\/www.bfs.admin.ch\/asset\/de\/29125009."},{"key":"#cr-split#-3519_CR38.1","unstructured":"Federal Statistical Office. Deaths and death rates from major causes of death, by age, men. 2023 [updated 2023 Dec 11"},{"key":"#cr-split#-3519_CR38.2","unstructured":"Accessed February 22, 2024]. https:\/\/www.bfs.admin.ch\/asset\/de\/29125011."},{"key":"3519_CR39","unstructured":"Institute of Primary Care at University of Zurich. FIRE project: FIRE data analysis report for the IMPACT-CKD project (data-on-file). 2024."},{"key":"3519_CR40","unstructured":"ERA-EDTA Registry. ERA-EDTA Registry Annual Report 2017. Amsterdam UMC, location AMC, Department of Medical Informatics, Amsterdam, the Netherlands. 2019 [updated 2019; Accessed February 28, 2024]. https:\/\/era-edta-reg.org\/files\/annualreports\/AnnRep2017.pdf."},{"key":"3519_CR41","unstructured":"ERA-EDTA Registry. ERA-EDTA Registry Annual Report 2019. Amsterdam UMC, location AMC, Department of Medical Informatics, Amsterdam, the Netherlands. 2021 [updated 2021; Accessed February 28, 2024]. https:\/\/www.era-online.org\/wp-content\/uploads\/2022\/11\/ERA-Registry-Annual-Report-2019.pdf."},{"key":"#cr-split#-3519_CR42.1","unstructured":"ERA Registry. ERA Registry Annual Report 2020. Amsterdam UMC, location AMC, Department of Medical Informatics, Amsterdam, the Netherlands. 2022 [updated 2022"},{"key":"#cr-split#-3519_CR42.2","unstructured":"Accessed February 28, 2024]. https:\/\/www.era-online.org\/wp-content\/uploads\/2022\/12\/ERA-Registry-Annual-Report2020.pdf."},{"key":"3519_CR43","unstructured":"Pr\u00e9 Sustainability. ReCiPe. 2016 [updated 2016 Aug 29; Accessed April 17, 2024]. https:\/\/pre-sustainability.com\/articles\/recipe\/."},{"issue":"5","key":"3519_CR44","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1177\/0272989X12458348","volume":"32","author":"AH Briggs","year":"2012","unstructured":"Briggs AH, Weinstein MC, Fenwick EAL, et al. Model parameter estimation and uncertainty analysis: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force Working Group-6. Med Decis Making. 2012;32(5):722\u201332.","journal-title":"Med Decis Making"},{"issue":"5","key":"3519_CR45","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1177\/0272989X12454579","volume":"32","author":"DM Eddy","year":"2012","unstructured":"Eddy DM, Hollingworth W, Caro JJ, et al. Model transparency and validation: a report of the ISPOR-SMDM Modeling Good Research Practices Task Force-7. Med Decis Making. 2012;32(5):733\u201343.","journal-title":"Med Decis Making"},{"issue":"6","key":"3519_CR46","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/ijc.11334","volume":"106","author":"SJ Goldie","year":"2003","unstructured":"Goldie SJ, Grima D, Kohli M, Wright TC, Weinstein M, Franco E. A comprehensive natural history model of HPV infection and cervical cancer to estimate the clinical impact of a prophylactic HPV-16\/18 vaccine. Int J Cancer. 2003;106(6):896\u2013904.","journal-title":"Int J Cancer"},{"issue":"1","key":"3519_CR47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2165\/11584610-000000000-00000","volume":"29","author":"J Karnon","year":"2011","unstructured":"Karnon J, Vanni T. Calibrating models in economic evaluation: a comparison of alternative measures of goodness of fit, parameter search strategies and convergence criteria. Pharmacoeconomics. 2011;29(1):51\u201362.","journal-title":"Pharmacoeconomics"},{"key":"#cr-split#-3519_CR48.1","unstructured":"Federal Statistical Office. Health care costs and financing in 2022. 2024 [updated 2024 Apr 18"},{"key":"#cr-split#-3519_CR48.2","unstructured":"Accessed June 10, 2024]. https:\/\/www.bfs.admin.ch\/asset\/en\/31225973."},{"key":"3519_CR49","unstructured":"ICAO Carbon Emissions Calculator (ICEC). [Accessed September 19, 2025]. https:\/\/www.icao.int\/icao-carbon-emissions-calculator."},{"key":"3519_CR50","unstructured":"Fina. Fina facilities rules (2021\u20132025). [Accessed September 19, 2025]. https:\/\/resources.fina.org\/fina\/document\/2022\/02\/08\/77c3058d-b549-4543-8524-ad51a857864e\/210805-Facilities-Rules_clean.pdf."},{"key":"3519_CR51","unstructured":"EWZ. Historischer Stromverbrauch der Stadt Z\u00fcrich. [Accessed September 19, 2025]. https:\/\/www.ewz.ch\/de\/ueber-ewz\/newsroom\/aus-aktuellem-anlass\/strommangellage\/historischer-stromverbrauch-der-stadt-zuerich.html."},{"issue":"9","key":"3519_CR52","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1111\/j.1600-6143.2005.01024.x","volume":"5","author":"M de Klerk","year":"2005","unstructured":"de Klerk M, Keizer KM, Claas FHJ, Witvliet M, Haase-Kromwijk BJJM, Weimar W. The Dutch national living donor kidney exchange program. Am J Transplant. 2005;5(9):2302\u20135.","journal-title":"Am J Transplant"},{"key":"3519_CR53","unstructured":"Boes S, Weisstanner D, Durvy B. Health systems in action (HSiA) insights: Switzerland 2024. [Accessed September 22, 2025]. https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/7d189cca-1094-46c0-8000-116ed4d2928e\/content."},{"key":"3519_CR54","unstructured":"Lerch B, Colombier C, Brandle T. Determinants of healthcare expenditure: evidence from Switzerland between 1960\u20132022. 2025 [updated 2024 Jun; Accessed September 22, 2025]. https:\/\/wwz.unibas.ch\/fileadmin\/user_upload\/wwz\/02_Forschung\/Publikationen\/2025_05_Determinants_of_Healthcare_Expenditure.pdf."},{"key":"3519_CR55","first-page":"1498","volume":"884","author":"AJ Scheen","year":"2024","unstructured":"Scheen AJ. Sous-utilisation des gliflozines chez les patients \u00e0 haut risque cardior\u00e9nal. Rev Med Suisse. 2024;884:1498\u2013502.","journal-title":"Rev Med Suisse"},{"key":"3519_CR56","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2019.20134","volume":"149","author":"L Bachmann","year":"2019","unstructured":"Bachmann L, Ulyt\u0117 A, Dressel H. Clinical practice guidelines of medical societies in Switzerland: analysis of the current state. Swiss Med Wkly. 2019;149:w20134.","journal-title":"Swiss Med Wkly"},{"key":"3519_CR57","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2020.20323","volume":"150","author":"S De Geest","year":"2020","unstructured":"De Geest S, Z\u00fa\u00f1iga F, Brunkert T, et al. Powering Swiss health care for the future: implementation science to bridge \u201cthe valley of death.\u201d Swiss Med Wkly. 2020;150:w20323.","journal-title":"Swiss Med Wkly"},{"key":"3519_CR58","volume":"43","author":"BL Neuen","year":"2024","unstructured":"Neuen BL, Jun M, Wick J, et al. Estimating the population-level impacts of improved uptake of SGLT2 inhibitors in patients with chronic kidney disease: a cross-sectional observational study using routinely collected Australian primary care data. Lancet Reg Health West Pac. 2024;43:100988.","journal-title":"Lancet Reg Health West Pac"},{"issue":"1","key":"3519_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-06566-2","volume":"21","author":"C Escobar","year":"2021","unstructured":"Escobar C, Palacios B, Aranda U, et al. Costs and healthcare utilisation of patients with chronic kidney disease in Spain. BMC Health Serv Res. 2021;21(1):536.","journal-title":"BMC Health Serv Res"},{"key":"3519_CR60","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2147\/AMEP.S115149","volume":"7","author":"T Birrenbach","year":"2016","unstructured":"Birrenbach T, Kraehenmann S, Perrig M, Berendonk C, Huwendiek S. Physicians\u2019 attitudes toward, use of, and perceived barriers to clinical guidelines: a survey among Swiss physicians. Adv Med Educ Pract. 2016;7:673\u201380.","journal-title":"Adv Med Educ Pract"},{"issue":"1","key":"3519_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-025-13526-7","volume":"25","author":"H Sundqvist","year":"2025","unstructured":"Sundqvist H, Hagn\u00e4s M, Jokelainen J, et al. Association of kidney function impairment with healthcare service utilisation in individuals with type\u00a02 diabetes: an observational follow-up study in primary care. BMC Health Serv Res. 2025;25(1):1340.","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"3519_CR62","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03466-5","volume":"25","author":"DR Farrell","year":"2024","unstructured":"Farrell DR, Vassalotti JA. Screening, identifying, and treating chronic kidney disease: why, who, when, how, and what? BMC Nephrol. 2024;25(1):34.","journal-title":"BMC Nephrol"},{"issue":"1","key":"3519_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-10424-8","volume":"23","author":"Y Li","year":"2023","unstructured":"Li Y, Barve K, Cockrell M, et al. Managing comorbidities in chronic kidney disease reduces utilization and costs. BMC Health Serv Res. 2023;23(1):1418.","journal-title":"BMC Health Serv Res"},{"key":"#cr-split#-3519_CR64.1","unstructured":"European Kidney Health Alliance. Kidney Manifesto - An EU strategy to improve kidney care during the 2024-2029 mandate. 2025 [updated 2025"},{"key":"#cr-split#-3519_CR64.2","unstructured":"Accessed September 19, 2025]. https:\/\/ekha.eu\/wp-content\/uploads\/2025\/01\/EKHA_Manifesto_Jan25_v1.1.pdf."},{"issue":"3","key":"3519_CR65","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaf005","volume":"18","author":"R Vanholder","year":"2025","unstructured":"Vanholder R, B\u00e9 A, De Barbieri I, et al. Combating the rising tide of kidney advocacy in Europe: the seminal role of the European Kidney Health Alliance (EKHA). Clin Kidney J. 2025;18(3):sfaf005.","journal-title":"Clin Kidney J"},{"issue":"8","key":"3519_CR66","doi-asserted-by":"publisher","first-page":"2608","DOI":"10.1016\/j.ekir.2025.05.039","volume":"10","author":"N Tangri","year":"2025","unstructured":"Tangri N, Priest S, Zara A, et al. Impact of improved diagnosis and treatment on holistic CKD burden. Kidney Int Rep. 2025;10(8):2608\u201320.","journal-title":"Kidney Int Rep"},{"issue":"1","key":"3519_CR67","doi-asserted-by":"publisher","first-page":"184","DOI":"10.36469\/jheor.2025.134075","volume":"12","author":"G Agathangelou","year":"2025","unstructured":"Agathangelou G, Graham-Brown M, McMahon AC, Xydopoulos G, Gofman L, Jaffe J. Economic evaluation of population-level chronic kidney disease interventions in the UK National Health Service. J Health Econ Outcomes Res. 2025;12(1):184\u201390.","journal-title":"J Health Econ Outcomes Res"},{"issue":"0506","key":"3519_CR68","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13508","volume":"142","author":"R Kessler","year":"2012","unstructured":"Kessler R, Keusch GW, Szucs TD, et al. Health economic modelling of the cost-effectiveness of microalbuminuria screening in Switzerland. Swiss Med Wkly. 2012;142(0506):w13508-w.","journal-title":"Swiss Med Wkly"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03519-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-026-03519-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03519-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:03:00Z","timestamp":1775728980000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-026-03519-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["3519"],"URL":"https:\/\/doi.org\/10.1007\/s12325-026-03519-1","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"11 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This publication was funded by AstraZeneca. At the time of redaction, Thomas Campbell-James and Stefan Buff were employed by AstraZeneca. Andrew Hall, Thomas Rosemann, Caterina Vecchio Rodriguez, and Menno Pruijm received compensation from AstraZeneca for participating in two advisory boards to validate the model\u2019s input data and results. The London School of Economics and Political Science (LSE) received an unrestricted grant for the development of the conceptual framework underlying IMPACT-CKD. At the time of redaction, George Wharton was employed by LSE. Maverex Limited and EVERSANA received consulting fees to conduct modelling and support manuscript development. At the time of redaction, Lindsay Nicholson and Luke Hubbert were employed by Maverex Limited. At the time of redaction, Stacey Priest and Anthony Zara were employed by EVERSANA. Giliane Nanchen has nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not applicable. Only publicly available aggregated data were utilised, making individual identification impossible. Data from the Medical Statistics of Hospitals is available upon request from the Swiss Federal Statistical Office (FSO). Data from the FIRE Project is available upon request from the Institute of Primary Care, University of Zurich.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}