{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:25:31Z","timestamp":1785522331227,"version":"3.56.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s12325-026-03639-8","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:11:53Z","timestamp":1780132313000},"page":"3369-3384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Management of Polycystic Ovary Syndrome in Adolescents with Obesity"],"prefix":"10.1007","volume":"43","author":[{"given":"Thomas M.","family":"Barber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Thadani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth V.","family":"Niven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kyrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal S.","family":"Randeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"issue":"6","key":"3639_CR1","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1210\/jc.2003-032046","volume":"89","author":"R Azziz","year":"2004","unstructured":"Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3639_CR2","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1093\/humrep\/des028","volume":"27","author":"R Sanchon","year":"2012","unstructured":"Sanchon R, Gambineri A, Alpanes M, Martinez-Garcia MA, Pasquali R, Escobar-Morreale HF. Prevalence of functional disorders of androgen excess in unselected premenopausal women: a study in blood donors. Hum Reprod. 2012;27(4):1209\u201316.","journal-title":"Hum Reprod"},{"issue":"10","key":"3639_CR3","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/humrep\/des232","volume":"27","author":"BO Yildiz","year":"2012","unstructured":"Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria. Hum Reprod. 2012;27(10):3067\u201373.","journal-title":"Hum Reprod"},{"issue":"7","key":"3639_CR4","first-page":"2434","volume":"85","author":"M Asuncion","year":"2000","unstructured":"Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000;85(7):2434\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"3639_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/humrep\/deh098","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41\u20137.","journal-title":"Hum Reprod"},{"issue":"5","key":"3639_CR6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1586\/17446651.2013.827373","volume":"8","author":"TM Barber","year":"2013","unstructured":"Barber TM, Franks S. Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome. Expert Rev Endocrinol Metab. 2013;8(5):427\u20139.","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"5","key":"3639_CR7","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s00330-009-1643-8","volume":"20","author":"TM Barber","year":"2010","unstructured":"Barber TM, Alvey C, Greenslade T, et al. Patterns of ovarian morphology in polycystic ovary syndrome: a study utilising magnetic resonance imaging. Eur Radiol. 2010;20(5):1207\u201313.","journal-title":"Eur Radiol"},{"issue":"4","key":"3639_CR8","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/cen.14421","volume":"95","author":"TM Barber","year":"2021","unstructured":"Barber TM, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol (Oxf). 2021;95(4):531\u201341.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"3639_CR9","first-page":"34","volume":"58","author":"TM Barber","year":"2007","unstructured":"Barber TM, McCarthy MI, Franks S, Wass JA. Metabolic syndrome in polycystic ovary syndrome. Endokrynol Pol. 2007;58(1):34\u201341.","journal-title":"Endokrynol Pol"},{"issue":"5","key":"3639_CR10","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1542\/peds.2006-2481","volume":"118","author":"A Diaz","year":"2006","unstructured":"American Academy of Pediatrics Committee on Adolescence, American College of Obstetricians and Gynecologists Committee on Adolescent Health Care, Diaz A, Laufer MR, Breech LL. Menstruation in girls and adolescents: using the menstrual cycle as a vital sign. Pediatrics. 2006;118(5):2245\u201350.","journal-title":"Pediatrics"},{"key":"3639_CR11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1749-6632.2000.tb06230.x","volume":"900","author":"RS Legro","year":"2000","unstructured":"Legro RS. The genetics of obesity. Lessons for polycystic ovary syndrome. Ann N Y Acad Sci. 2000;900:193\u2013202.","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"3639_CR12","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1093\/oxfordjournals.humrep.a136243","volume":"10","author":"AH Balen","year":"1995","unstructured":"Balen AH, Conway GS, Kaltsas G, et al. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 1995;10(8):2107\u201311.","journal-title":"Hum Reprod"},{"issue":"2","key":"3639_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1365-2265.2006.02587.x","volume":"65","author":"TM Barber","year":"2006","unstructured":"Barber TM, McCarthy MI, Wass JA, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol (Oxf). 2006;65(2):137\u201345.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"3639_CR14","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1093\/humupd\/dms030","volume":"18","author":"SS Lim","year":"2012","unstructured":"Lim SS, Davies MJ, Norman RJ, Moran LJ. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(6):618\u201337.","journal-title":"Hum Reprod Update"},{"issue":"7","key":"3639_CR15","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s00125-008-1028-6","volume":"51","author":"TM Barber","year":"2008","unstructured":"Barber TM, Bennett AJ, Groves CJ, et al. Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia. 2008;51(7):1153\u20138.","journal-title":"Diabetologia"},{"issue":"7","key":"3639_CR16","doi-asserted-by":"publisher","first-page":"e66250","DOI":"10.1371\/journal.pone.0066250","volume":"8","author":"T Li","year":"2013","unstructured":"Li T, Wu K, You L, et al. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS ONE. 2013;8(7):e66250.","journal-title":"PLoS ONE"},{"issue":"1","key":"3639_CR17","doi-asserted-by":"publisher","first-page":"e16390","DOI":"10.1371\/journal.pone.0016390","volume":"6","author":"KG Ewens","year":"2011","unstructured":"Ewens KG, Jones MR, Ankener W, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS ONE. 2011;6(1):e16390.","journal-title":"PLoS ONE"},{"issue":"3","key":"3639_CR18","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s12020-009-9257-0","volume":"36","author":"Q Yan","year":"2009","unstructured":"Yan Q, Hong J, Gu W, et al. Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women. Endocrine. 2009;36(3):377\u201382.","journal-title":"Endocrine"},{"issue":"5826","key":"3639_CR19","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1141634","volume":"316","author":"TM Frayling","year":"2007","unstructured":"Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316(5826):889\u201394.","journal-title":"Science"},{"issue":"6","key":"3639_CR20","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/ng2048","volume":"39","author":"C Dina","year":"2007","unstructured":"Dina C, Meyre D, Gallina S, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39(6):724\u20136.","journal-title":"Nat Genet"},{"issue":"12","key":"3639_CR21","doi-asserted-by":"publisher","first-page":"e1007813","DOI":"10.1371\/journal.pgen.1007813","volume":"14","author":"F Day","year":"2018","unstructured":"Day F, Karaderi T, Jones MR, et al. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 2018;14(12):e1007813.","journal-title":"PLoS Genet"},{"key":"3639_CR22","doi-asserted-by":"publisher","first-page":"117955811987404","DOI":"10.1177\/1179558119874042","volume":"13","author":"TM Barber","year":"2019","unstructured":"Barber TM, Hanson P, Weickert MO, Franks S. Obesity and polycystic ovary syndrome: implications for pathogenesis and novel management strategies. Clin Med Insights Reprod Health. 2019;13:1179558119874042.","journal-title":"Clin Med Insights Reprod Health"},{"key":"3639_CR23","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-2458-9-88","volume":"9","author":"DP Guh","year":"2009","unstructured":"Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88.","journal-title":"BMC Public Health"},{"issue":"3","key":"3639_CR24","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/cen.12092","volume":"78","author":"SA Saboor Aftab","year":"2013","unstructured":"Saboor Aftab SA, Kumar S, Barber TM. The role of obesity and type\u00a02 diabetes mellitus in the development of male obesity-associated secondary hypogonadism. Clin Endocrinol (Oxf). 2013;78(3):330\u20137.","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"Spec No 2","key":"3639_CR25","doi-asserted-by":"publisher","first-page":"R124","DOI":"10.1093\/hmg\/ddl215","volume":"15","author":"AJ Walley","year":"2006","unstructured":"Walley AJ, Blakemore AI, Froguel P. Genetics of obesity and the prediction of risk for health. Hum Mol Genet. 2006;15(Spec No 2):R124\u201330.","journal-title":"Hum Mol Genet"},{"issue":"6","key":"3639_CR26","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1210\/jc.2005-1494","volume":"91","author":"JM Vink","year":"2006","unstructured":"Vink JM, Sadrzadeh S, Lambalk CB, Boomsma DI. Heritability of polycystic ovary syndrome in a Dutch twin-family study. J Clin Endocrinol Metab. 2006;91(6):2100\u20134.","journal-title":"J Clin Endocrinol Metab"},{"issue":"13","key":"3639_CR27","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1056\/NEJM199509283331307","volume":"333","author":"S Franks","year":"1995","unstructured":"Franks S. Polycystic ovary syndrome. N Engl J Med. 1995;333(13):853\u201361.","journal-title":"N Engl J Med"},{"key":"3639_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1159\/000341682","volume":"40","author":"TM Barber","year":"2013","unstructured":"Barber TM, Franks S. Genetics of polycystic ovary syndrome. Front Horm Res. 2013;40:28\u201339.","journal-title":"Front Horm Res"},{"issue":"3","key":"3639_CR29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S2213-8587(19)30026-9","volume":"7","author":"LM Jaacks","year":"2019","unstructured":"Jaacks LM, Vandevijvere S, Pan A, et al. The obesity transition: stages of the global epidemic. Lancet Diabetes Endocrinol. 2019;7(3):231\u201340.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"3639_CR30","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11571-024-10185-y","volume":"19","author":"H Wang","year":"2025","unstructured":"Wang H, Xu X, Yang Z, Zhang T. Alterations of synaptic plasticity and brain oscillation are associated with autophagy induced synaptic pruning during adolescence. Cogn Neurodyn. 2025;19(1):2.","journal-title":"Cogn Neurodyn"},{"key":"3639_CR31","unstructured":"Commission CQ. Monitoring the Mental Health Act in 2022\/23: Children and young people. https:\/\/www.cqc.org.uk\/publications\/monitoring-mental-health-act\/2022-2023\/children-young-people; 2024."},{"issue":"3","key":"3639_CR32","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S2213-8587(22)00339-4","volume":"11","author":"J Argente","year":"2023","unstructured":"Argente J, Dunkel L, Kaiser UB, et al. Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications. Lancet Diabetes Endocrinol. 2023;11(3):203\u201316.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"3639_CR33","first-page":"e44337","volume":"15","author":"S Zeydabadi Nejad","year":"2017","unstructured":"Zeydabadi Nejad S, Ramezani Tehrani F, Zadeh-Vakili A. The role of kisspeptin in female reproduction. Int J Endocrinol Metab. 2017;15(3):e44337.","journal-title":"Int J Endocrinol Metab"},{"key":"3639_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000438840","volume":"29","author":"A Lomniczi","year":"2016","unstructured":"Lomniczi A, Ojeda SR. The emerging role of epigenetics in the regulation of female puberty. Endocr Dev. 2016;29:1\u201316.","journal-title":"Endocr Dev"},{"key":"3639_CR35","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/1741-7015-11-113","volume":"11","author":"Z Hochberg","year":"2013","unstructured":"Hochberg Z, Belsky J. Evo-devo of human adolescence: beyond disease models of early puberty. BMC Med. 2013;11:113.","journal-title":"BMC Med"},{"issue":"5","key":"3639_CR36","doi-asserted-by":"publisher","first-page":"e2412854","DOI":"10.1001\/jamanetworkopen.2024.12854","volume":"7","author":"Z Wang","year":"2024","unstructured":"Wang Z, Asokan G, Onnela JP, et al. Menarche and time to cycle regularity among individuals born between 1950 and 2005 in the US. JAMA Netw Open. 2024;7(5):e2412854.","journal-title":"JAMA Netw Open"},{"issue":"6","key":"3639_CR37","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.jpag.2015.12.002","volume":"29","author":"A Papadimitriou","year":"2016","unstructured":"Papadimitriou A. The evolution of the age at menarche from prehistorical to modern times. J Pediatr Adolesc Gynecol. 2016;29(6):527\u201330.","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"1","key":"3639_CR38","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3109\/00016358008997719","volume":"38","author":"J Taranger","year":"1980","unstructured":"Taranger J, Hagg U. The timing and duration of adolescent growth. Acta Odontol Scand. 1980;38(1):57\u201367.","journal-title":"Acta Odontol Scand"},{"issue":"8","key":"3639_CR39","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1001\/jamapediatrics.2024.1576","volume":"178","author":"X Zhang","year":"2024","unstructured":"Zhang X, Liu J, Ni Y, et al. Global prevalence of overweight and obesity in children and adolescents: a systematic review and meta-analysis. JAMA Pediatr. 2024;178(8):800\u201313.","journal-title":"JAMA Pediatr"},{"issue":"2","key":"3639_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/obr.12334","volume":"17","author":"M Simmonds","year":"2016","unstructured":"Simmonds M, Llewellyn A, Owen CG, Woolacott N. Predicting adult obesity from childhood obesity: a systematic review and meta-analysis. Obes Rev. 2016;17(2):95\u2013107.","journal-title":"Obes Rev"},{"issue":"1","key":"3639_CR41","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3945\/ajcn.2010.29383","volume":"92","author":"LB Shomaker","year":"2010","unstructured":"Shomaker LB, Tanofsky-Kraff M, Savastano DM, et al. Puberty and observed energy intake: boy, can they eat! Am J Clin Nutr. 2010;92(1):123\u20139.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"3639_CR42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s13668-024-00517-z","volume":"13","author":"SJ Dicken","year":"2024","unstructured":"Dicken SJ, Batterham RL. Ultra-processed food and obesity: what is the evidence? Curr Nutr Rep. 2024;13(1):23\u201338.","journal-title":"Curr Nutr Rep"},{"key":"3639_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/nu16111720","author":"AM Tzounakou","year":"2024","unstructured":"Tzounakou AM, Stathori G, Paltoglou G, et al. Childhood obesity, hypothalamic inflammation, and the onset of puberty: a narrative review. Nutrients. 2024. https:\/\/doi.org\/10.3390\/nu16111720.","journal-title":"Nutrients"},{"key":"3639_CR44","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead053","author":"LJ Dobbie","year":"2023","unstructured":"Dobbie LJ, Pittam B, Zhao SS, et al. Childhood, adolescent, and adulthood adiposity are associated with risk of PCOS: a Mendelian randomization study with meta-analysis. Hum Reprod. 2023. https:\/\/doi.org\/10.1093\/humrep\/dead053.","journal-title":"Hum Reprod"},{"key":"3639_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-019-0318-z","author":"E Koivuaho","year":"2019","unstructured":"Koivuaho E, Laru J, Ojaniemi M, et al. Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS. Int J Obes (Lond). 2019. https:\/\/doi.org\/10.1038\/s41366-019-0318-z.","journal-title":"Int J Obes (Lond)"},{"issue":"2","key":"3639_CR46","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.fertnstert.2013.04.001","volume":"100","author":"SB Christensen","year":"2013","unstructured":"Christensen SB, Black MH, Smith N, et al. Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril. 2013;100(2):470\u20137.","journal-title":"Fertil Steril"},{"issue":"3","key":"3639_CR47","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1159\/000515294","volume":"14","author":"J Aarestrup","year":"2021","unstructured":"Aarestrup J, Pedersen DC, Thomas PE, et al. Birthweight, childhood body mass index, height and growth, and risk of polycystic ovary syndrome. Obes Facts. 2021;14(3):283\u201390.","journal-title":"Obes Facts"},{"issue":"9","key":"3639_CR48","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/oby.21935","volume":"25","author":"F de Zegher","year":"2017","unstructured":"de Zegher F, Reinehr T, Malpique R, Darendeliler F, Lopez-Bermejo A, Ibanez L. Reduced prenatal weight gain and\/or augmented postnatal weight gain precedes polycystic ovary syndrome in adolescent girls. Obesity (Silver Spring). 2017;25(9):1486\u20139.","journal-title":"Obesity (Silver Spring)"},{"key":"3639_CR49","volume-title":"The anxious generation","author":"J John","year":"2025","unstructured":"John J, Miller MD. The anxious generation. Psychiatric Times; 2025."},{"issue":"4","key":"3639_CR50","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.biopsych.2013.01.033","volume":"74","author":"MM Silveri","year":"2013","unstructured":"Silveri MM, Sneider JT, Crowley DJ, et al. Frontal lobe gamma-aminobutyric acid levels during adolescence: associations with impulsivity and response inhibition. Biol Psychiatry. 2013;74(4):296\u2013304.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"3639_CR51","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12889-023-15032-z","volume":"23","author":"LJ Forster","year":"2023","unstructured":"Forster LJ, Vogel M, Stein R, et al. Mental health in children and adolescents with overweight or obesity. BMC Public Health. 2023;23(1):135.","journal-title":"BMC Public Health"},{"issue":"6","key":"3639_CR52","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S2352-4642(24)00019-1","volume":"8","author":"SL Simon","year":"2024","unstructured":"Simon SL, Phimphasone-Brady P, McKenney KM, et al. Comprehensive transition of care for polycystic ovary syndrome from adolescence to adulthood. Lancet Child Adolesc Health. 2024;8(6):443\u201355.","journal-title":"Lancet Child Adolesc Health"},{"key":"3639_CR53","doi-asserted-by":"crossref","unstructured":"O\u2019Connor EA, Evans CV, Burda BU, Walsh ES, Eder M, Lozano P. Screening for obesity and interventions for weight management in children and adolescents: a systematic evidence review for the US Preventive Services Task Force. U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews. Rockville (MD); 2017.","DOI":"10.1001\/jama.2017.0332"},{"issue":"3","key":"3639_CR54","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s13679-021-00437-x","volume":"10","author":"JM Moore","year":"2021","unstructured":"Moore JM, Waldrop SW, Cree-Green M. Weight management in adolescents with polycystic ovary syndrome. Curr Obes Rep. 2021;10(3):311\u201321.","journal-title":"Curr Obes Rep"},{"key":"3639_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103209","author":"TM Barber","year":"2020","unstructured":"Barber TM, Kabisch S, Pfeiffer AFH, Weickert MO. The health benefits of dietary fibre. Nutrients. 2020. https:\/\/doi.org\/10.3390\/nu12103209.","journal-title":"Nutrients"},{"key":"3639_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12185921","author":"E Carmina","year":"2023","unstructured":"Carmina E, Longo RA. Semaglutide treatment of excessive body weight in obese PCOS patients unresponsive to lifestyle programs. J Clin Med. 2023. https:\/\/doi.org\/10.3390\/jcm12185921.","journal-title":"J Clin Med"},{"issue":"10","key":"3639_CR57","doi-asserted-by":"publisher","first-page":"108834","DOI":"10.1016\/j.jdiacomp.2024.108834","volume":"38","author":"B Austregesilo de Athayde De Hollanda","year":"2024","unstructured":"Austregesilo de Athayde De Hollanda Morais B, Martins Prizao V, de Moura de Souza M, et al. The efficacy and safety of GLP-1 agonists in PCOS women living with obesity in promoting weight loss and hormonal regulation: a meta-analysis of randomized controlled trials. J Diabetes Complicat. 2024;38(10):108834.","journal-title":"J Diabetes Complicat"},{"issue":"22","key":"3639_CR58","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1056\/NEJMoa1916038","volume":"382","author":"AS Kelly","year":"2020","unstructured":"Kelly AS, Auerbach P, Barrientos-Perez M, et al. A randomized, controlled trial of liraglutide for adolescents with obesity. N Engl J Med. 2020;382(22):2117\u201328.","journal-title":"N Engl J Med"},{"issue":"24","key":"3639_CR59","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1056\/NEJMoa2208601","volume":"387","author":"D Weghuber","year":"2022","unstructured":"Weghuber D, Barrett T, Barrientos-Perez M, et al. Once-weekly semaglutide in adolescents with obesity. N Engl J Med. 2022;387(24):2245\u201357.","journal-title":"N Engl J Med"},{"issue":"8","key":"3639_CR60","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1111\/dom.14725","volume":"24","author":"JPH Wilding","year":"2022","unstructured":"Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553\u201364.","journal-title":"Diabetes Obes Metab"},{"issue":"8","key":"3639_CR61","doi-asserted-by":"publisher","first-page":"e3217","DOI":"10.1210\/clinem\/dgac294","volume":"107","author":"L Hu","year":"2022","unstructured":"Hu L, Ma L, Xia X, et al. Efficacy of bariatric surgery in the treatment of women with obesity and polycystic ovary syndrome. J Clin Endocrinol Metab. 2022;107(8):e3217\u201329.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3639_CR62","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1016\/j.fertnstert.2009.08.028","volume":"94","author":"GG Gosman","year":"2010","unstructured":"Gosman GG, King WC, Schrope B, et al. Reproductive health of women electing bariatric surgery. Fertil Steril. 2010;94(4):1426\u201331.","journal-title":"Fertil Steril"},{"issue":"1","key":"3639_CR63","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1186\/s12893-025-03039-9","volume":"25","author":"O Tammo","year":"2025","unstructured":"Tammo O, Soylemez E, Bayhan H. Comparison of the effects of laparoscopic sleeve gastrectomy and endoscopic intragastric balloon placement on hormone profile and menstrual cycle in obese women with polycystic ovary syndrome. BMC Surg. 2025;25(1):297.","journal-title":"BMC Surg"},{"issue":"10","key":"3639_CR64","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1007\/s11695-023-06745-6","volume":"33","author":"G Carlino","year":"2023","unstructured":"Carlino G, Benson AA, Bove V, et al. Impact of pregnancy on weight loss after endoscopic sleeve gastroplasty. Obes Surg. 2023;33(10):3097\u2013105.","journal-title":"Obes Surg"},{"issue":"3","key":"3639_CR65","first-page":"e55876","volume":"16","author":"RL Vadan","year":"2024","unstructured":"Vadan RL, Varela N, Zhuravko N, Ogidan NO, Adedara VO, Keku E. Comparative management methods for adolescents with polycystic ovarian syndrome: a systemic review. Cureus. 2024;16(3):e55876.","journal-title":"Cureus"},{"issue":"8","key":"3639_CR66","first-page":"101241","volume":"52","author":"K Itriyeva","year":"2022","unstructured":"Itriyeva K. The effects of obesity on the menstrual cycle. Curr Probl Pediatr Adolesc Health Care. 2022;52(8):101241.","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"issue":"1","key":"3639_CR67","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jadohealth.2022.02.009","volume":"71","author":"KN Maher","year":"2022","unstructured":"Maher KN, Quint EH, Weyand AC. Management of contraception in adolescent females with hormone-related venous thromboembolism. J Adolesc Health. 2022;71(1):127\u201331.","journal-title":"J Adolesc Health"},{"issue":"7","key":"3639_CR68","doi-asserted-by":"publisher","first-page":"103230","DOI":"10.1016\/j.rpth.2025.103230","volume":"9","author":"D Citla-Sridhar","year":"2025","unstructured":"Citla-Sridhar D, Rajpurkar M, Srivaths L, Bannow BS, Rosovsky RP, Sokkary N. Venous thromboembolism in obese hormonal contraceptive users: a large national database study. Res Pract Thromb Haemost. 2025;9(7):103230.","journal-title":"Res Pract Thromb Haemost"},{"key":"3639_CR69","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.thromres.2016.03.021","volume":"141","author":"T Ishola","year":"2016","unstructured":"Ishola T, Kirk SE, Guffey D, Voigt K, Shah MD, Srivaths L. Risk factors and co-morbidities in adolescent thromboembolism are different than those in younger children. Thromb Res. 2016;141:178\u201382.","journal-title":"Thromb Res"},{"key":"3639_CR70","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.thromres.2019.11.019","volume":"185","author":"K Gariani","year":"2020","unstructured":"Gariani K, Hugon-Rodin J, Philippe J, Righini M, Blondon M. Association between polycystic ovary syndrome and venous thromboembolism: a systematic review and meta-analysis. Thromb Res. 2020;185:102\u20138.","journal-title":"Thromb Res"},{"issue":"5","key":"3639_CR71","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1007\/s00404-025-08083-7","volume":"312","author":"A Diterlizzi","year":"2025","unstructured":"Diterlizzi A, Tropea A, De Luca E, et al. Use of progestin-only drospirenone-based pills in hyperandrogenic women with polycystic ovary syndrome. Arch Gynecol Obstet. 2025;312(5):1773\u20139.","journal-title":"Arch Gynecol Obstet"},{"issue":"11","key":"3639_CR72","doi-asserted-by":"publisher","first-page":"3106","DOI":"10.1007\/s43032-021-00765-2","volume":"29","author":"JV Kolhe","year":"2022","unstructured":"Kolhe JV, Chhipa AS, Butani S, Chavda V, Patel SS. PCOS and depression: common links and potential targets. Reprod Sci. 2022;29(11):3106\u201323.","journal-title":"Reprod Sci"},{"issue":"3","key":"3639_CR73","doi-asserted-by":"publisher","first-page":"262","DOI":"10.7861\/clinmedicine.16-3-262","volume":"16","author":"TM Barber","year":"2016","unstructured":"Barber TM, Dimitriadis GK, Andreou A, Franks S. Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance. Clin Med (Lond). 2016;16(3):262\u20136.","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"3639_CR74","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.jhep.2019.10.023","volume":"72","author":"SA Harrison","year":"2020","unstructured":"Harrison SA, Alkhouri N, Davison BA, et al. Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase\u00a0IIb study. J Hepatol. 2020;72(4):613\u201326.","journal-title":"J Hepatol"},{"issue":"3","key":"3639_CR75","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1517\/14740338.2011.534982","volume":"10","author":"KG Tolman","year":"2011","unstructured":"Tolman KG. The safety of thiazolidinediones. Expert Opin Drug Saf. 2011;10(3):419\u201328.","journal-title":"Expert Opin Drug Saf"},{"key":"3639_CR76","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15020085","author":"TM Barber","year":"2025","unstructured":"Barber TM, Kabisch S, Pfeiffer AFH, Weickert MO. Optimised skeletal muscle mass as a key strategy for obesity management. Metabolites. 2025. https:\/\/doi.org\/10.3390\/metabo15020085.","journal-title":"Metabolites"},{"issue":"12","key":"3639_CR77","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/S2468-1253(23)00198-X","volume":"8","author":"M Noureddin","year":"2023","unstructured":"Noureddin M, Khan S, Portell F, et al. Safety and efficacy of once-daily HU6 versus placebo in people with non-alcoholic fatty liver disease and high BMI: a randomised, double-blind, placebo-controlled, phase\u00a02a trial. Lancet Gastroenterol Hepatol. 2023;8(12):1094\u2013105.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"3639_CR78","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2026.2647962","author":"TM Barber","year":"2026","unstructured":"Barber TM, Niven EV, Tymms P. The intersection of education and health: schools as a catalyst for childhood obesity prevention. Expert Rev Endocrinol Metab. 2026. https:\/\/doi.org\/10.1080\/17446651.2026.2647962.","journal-title":"Expert Rev Endocrinol Metab"},{"key":"3639_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/nu16162714","author":"TM Barber","year":"2024","unstructured":"Barber TM, Kabisch S, Pfeiffer AFH, Weickert MO. Dietary and lifestyle strategies for obesity. Nutrients. 2024. https:\/\/doi.org\/10.3390\/nu16162714.","journal-title":"Nutrients"},{"issue":"1","key":"3639_CR80","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s13679-023-00495-3","volume":"12","author":"S Westbury","year":"2023","unstructured":"Westbury S, Oyebode O, van Rens T, Barber TM. Obesity stigma: causes, consequences, and potential solutions. Curr Obes Rep. 2023;12(1):10\u201323.","journal-title":"Curr Obes Rep"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03639-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-026-03639-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03639-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:14:05Z","timestamp":1785518045000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-026-03639-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":80,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3639"],"URL":"https:\/\/doi.org\/10.1007\/s12325-026-03639-8","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]},"assertion":[{"value":"14 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Thomas M Barber, Puja Thadani, Elizabeth V\u00a0Niven, Ioannis Kyrou, and Harpal S Randeva have nothing to disclose.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}