{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:57:15Z","timestamp":1790657835287,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12325-026-03705-1","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:02:09Z","timestamp":1784358129000},"page":"4668-4683","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healthcare Utilization and Costs in People Living with HIV and Neuropsychiatric Disorders in the United States"],"prefix":"10.1007","volume":"43","author":[{"given":"Sean P.","family":"Fleming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Kamat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Prajapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Chirikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bounthavong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"issue":"16","key":"3705_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025428","volume":"100","author":"ND Williams","year":"2021","unstructured":"Williams ND, et al. The changing patterns of comorbidities associated with human immunodeficiency virus infection, a longitudinal retrospective cohort study of Medicare patients. Medicine (Baltimore). 2021;100(16):e25428.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"3705_CR2","doi-asserted-by":"publisher","first-page":"2361176","DOI":"10.1080\/25787489.2024.2361176","volume":"25","author":"M Paudel","year":"2024","unstructured":"Paudel M, et al. Comorbidity and polypharmacy among people with HIV stratified by age, sex, and race. HIV Res Clin Pract. 2024;25(1):2361176.","journal-title":"HIV Res Clin Pract"},{"issue":"8","key":"3705_CR3","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1080\/03007995.2022.2088714","volume":"38","author":"M Paudel","year":"2022","unstructured":"Paudel M, et al. Comorbidity and comedication burden among people living with HIV in the United States. Curr Med Res Opin. 2022;38(8):1443\u201350.","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"3705_CR4","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s13365-012-0108-z","volume":"18","author":"CC Watkins","year":"2012","unstructured":"Watkins CC, Treisman GJ. Neuropsychiatric complications of aging with HIV. J Neurovirol. 2012;18(4):277\u201390.","journal-title":"J Neurovirol"},{"issue":"Suppl 1","key":"3705_CR5","doi-asserted-by":"publisher","first-page":"S61","DOI":"10.1097\/00002030-200401001-00009","volume":"18","author":"T Ernst","year":"2004","unstructured":"Ernst T, Chang L. Effect of aging on brain metabolism in antiretroviral-naive HIV patients. AIDS. 2004;18(Suppl 1):S61\u20137.","journal-title":"AIDS"},{"issue":"Suppl 1","key":"3705_CR6","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1097\/00002030-200401001-00005","volume":"18","author":"M Cherner","year":"2004","unstructured":"Cherner M, et al. Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings. AIDS. 2004;18(Suppl 1):S27-34.","journal-title":"AIDS"},{"issue":"16","key":"3705_CR7","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1097\/01.aids.0000247565.80633.d2","volume":"20","author":"H Yeung","year":"2006","unstructured":"Yeung H, et al. Neuropsychiatric disorders in HIV infection: impact of diagnosis on economic costs of care. AIDS. 2006;20(16):2005\u20139.","journal-title":"AIDS"},{"issue":"3","key":"3705_CR8","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s11904-014-0220-1","volume":"11","author":"OA Uthman","year":"2014","unstructured":"Uthman OA, et al. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Curr HIV\/AIDS Rep. 2014;11(3):291\u2013307.","journal-title":"Curr HIV\/AIDS Rep"},{"issue":"2","key":"3705_CR9","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/QAI.0B013E31822D490A","volume":"58","author":"JS Gonzalez","year":"2011","unstructured":"Gonzalez JS, et al. Depression and HIV\/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011;58(2):181\u20137.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"12","key":"3705_CR10","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1080\/09540120902923006","volume":"21","author":"CJ Conover","year":"2009","unstructured":"Conover CJ, et al. Costs of care for people living with combined HIV\/AIDS, chronic mental illness, and substance abuse disorders. AIDS Care. 2009;21(12):1547\u201359.","journal-title":"AIDS Care"},{"issue":"2","key":"3705_CR11","first-page":"22m03374","volume":"25","author":"J Song","year":"2023","unstructured":"Song J, et al. The burden of neuropsychiatric disorders in Medicaid patients living with HIV-1 treated with integrase inhibitor or protease inhibitor antiretroviral therapies. Prim Care Companion CNS Disord. 2023;25(2):22m03374.","journal-title":"Prim Care Companion CNS Disord"},{"issue":"1","key":"3705_CR12","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12939-017-0683-y","volume":"16","author":"TD Ritchwood","year":"2017","unstructured":"Ritchwood TD, Bishu KG, Egede LE. Trends in healthcare expenditure among people living with HIV\/AIDS in the United States: evidence from 10 years of nationally representative data. Int J Equity Health. 2017;16(1):188.","journal-title":"Int J Equity Health"},{"key":"3705_CR13","unstructured":"Centers for Medicare and Medicaid Services. Chronic Conditions Data Warehouse (CCW). 2024 [cited 2024 July 31]. https:\/\/www2.ccwdata.org\/web\/guest\/condition-categories."},{"issue":"6","key":"3705_CR14","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/aje\/kwq433","volume":"173","author":"H Quan","year":"2011","unstructured":"Quan H, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173(6):676\u201382.","journal-title":"Am J Epidemiol"},{"key":"3705_CR15","unstructured":"US Bureau of Labor Statistics. Consumer Price Index for August 2024. 2024 [cited 2024 September 17].https:\/\/www.bls.gov\/cpi\/."},{"issue":"6","key":"3705_CR16","doi-asserted-by":"publisher","first-page":"558","DOI":"10.4097\/kja.19087","volume":"72","author":"JH Kim","year":"2019","unstructured":"Kim JH. Multicollinearity and misleading statistical results. Korean J Anesthesiol. 2019;72(6):558\u201369.","journal-title":"Korean J Anesthesiol"},{"issue":"8","key":"3705_CR17","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.27584","volume":"6","author":"LF Collins","year":"2023","unstructured":"Collins LF, et al. Aging-related comorbidity burden among women and men with or at-risk for HIV in the US, 2008\u20132019. JAMA Netw Open. 2023;6(8):e2327584.","journal-title":"JAMA Netw Open"},{"issue":"4","key":"3705_CR18","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/01.qai.0000243090.32866.4e","volume":"43","author":"AB Hutchinson","year":"2006","unstructured":"Hutchinson AB, et al. The economic burden of HIV in the United States in the era of highly active antiretroviral therapy: evidence of continuing racial and ethnic differences. J Acquir Immune Defic Syndr. 2006;43(4):451\u20137.","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"Suppl 3","key":"3705_CR19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10461-019-02596-4","volume":"23","author":"DH McCree","year":"2019","unstructured":"McCree DH, et al. U.S. Centers for Disease Control and Prevention and Health Resources and Services Administration initiatives to address disparate rates of HIV infection in the South. AIDS Behav. 2019;23(Suppl 3):313\u20138.","journal-title":"AIDS Behav"},{"issue":"4","key":"3705_CR20","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/QAI.0000000000001269","volume":"74","author":"A Fettiplace","year":"2017","unstructured":"Fettiplace A, et al. Psychiatric symptoms in patients receiving dolutegravir. J Acquir Immune Defic Syndr. 2017;74(4):423\u201331.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"3705_CR21","doi-asserted-by":"publisher","first-page":"1259290","DOI":"10.3389\/fpsyt.2024.1259290","volume":"15","author":"J Ji","year":"2024","unstructured":"Ji J, et al. People who living with HIV\/AIDS also have a high prevalence of anxiety disorders: a systematic review and meta-analysis. Front Psychiatry. 2024;15:1259290.","journal-title":"Front Psychiatry"},{"issue":"4","key":"3705_CR22","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/bmjspcare-2019-001952","volume":"9","author":"S Rezaei","year":"2019","unstructured":"Rezaei S, et al. Global prevalence of depression in HIV\/AIDS: a systematic review and meta-analysis. BMC Support Palliat Care. 2019;9(4):404\u201312.","journal-title":"BMC Support Palliat Care"},{"issue":"17","key":"3705_CR23","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000042305","volume":"104","author":"RC Rossom","year":"2025","unstructured":"Rossom RC, et al. Changes in utilization of in-person and virtual outpatient mental health visits before and during the COVID-19 pandemic: an observational cohort study. Medicine (Baltimore). 2025;104(17):e42305.","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"3705_CR24","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s10461-012-0212-3","volume":"16","author":"SA Springer","year":"2012","unstructured":"Springer SA, Dushaj A, Azar MM. The impact of DSM-IV mental disorders on adherence to combination antiretroviral therapy among adult persons living with HIV\/AIDS: a systematic review. AIDS Behav. 2012;16(8):2119\u201343.","journal-title":"AIDS Behav"},{"issue":"6","key":"3705_CR25","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1093\/jac\/dkx053","volume":"72","author":"J Pe\u00f1afiel","year":"2017","unstructured":"Pe\u00f1afiel J, et al. Tolerability of integrase inhibitors in a real-life setting. J Antimicrob Chemother. 2017;72(6):1752\u20139.","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"3705_CR26","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/hiv.12468","volume":"18","author":"C Hoffmann","year":"2017","unstructured":"Hoffmann C, et al. Higher rates of neuropsychiatric adverse events leading to dolutegravir discontinuation in women and older patients. HIV Med. 2017;18(1):56\u201363.","journal-title":"HIV Med"},{"issue":"1","key":"3705_CR27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.24875\/AIDSRev.19000023","volume":"21","author":"C Hoffmann","year":"2019","unstructured":"Hoffmann C, Llibre JM. Neuropsychiatric adverse events with dolutegravir and other integrase strand transfer inhibitors. AIDS Rev. 2019;21(1):4\u201310.","journal-title":"AIDS Rev"},{"issue":"11","key":"3705_CR28","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/cid\/cir627","volume":"53","author":"G Guaraldi","year":"2011","unstructured":"Guaraldi G, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011;53(11):1120\u20136.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"3705_CR29","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1111\/j.1475-6773.2011.01277.x","volume":"46","author":"Y Gorina","year":"2011","unstructured":"Gorina Y, Kramarow EA. Identifying chronic conditions in Medicare claims data: evaluating the Chronic Condition Data Warehouse algorithm. Health Serv Res. 2011;46(5):1610\u201327.","journal-title":"Health Serv Res"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03705-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-026-03705-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03705-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:14:51Z","timestamp":1790655291000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-026-03705-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3705"],"URL":"https:\/\/doi.org\/10.1007\/s12325-026-03705-1","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]},"assertion":[{"value":"25 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Sean P. Fleming and Girish Prajapati are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA and shareholders of Merck & Co., Inc., Rahway, NJ, USA. Shweta Kamat, Viktor Chirikov, and Wenying Quan are employees of OPEN Health Group, which was paid to conduct the study under contract with Merck & Co., Inc., Rahway, NJ, USA. Mark Bounthavong is an employee of the University of California San Diego and a consultant for Merck & Co., Inc., Rahway, NJ, USA.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study used de-identified data and therefore does not meet the National Institute of Health (NIH) guidelines for clinical research and thus, informed consent and Institutional Review Board\/Ethics Committee review were not required.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}