{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:23:36Z","timestamp":1792783416537,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Kanazawa University","id":[{"id":"https:\/\/ror.org\/02hwp6a56","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Adv Ther"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12325-026-03727-9","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:13:49Z","timestamp":1785226429000},"page":"4953-4967","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with Favorable One-Year Outcomes After PreserFlo MicroShunt Implantation: Insights from Anterior Segment Optical Coherence Tomography"],"prefix":"10.1007","volume":"43","author":[{"given":"Takahiro","family":"Minami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Takemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Muroya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Udagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimikazu","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Wajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-4587","authenticated-orcid":false,"given":"Tomomi","family":"Higashide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"3727_CR1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"HA Quigley","year":"2006","unstructured":"Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90:262\u20137.","journal-title":"Br J Ophthalmol"},{"key":"3727_CR2","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121:2081\u201390.","journal-title":"Ophthalmology"},{"key":"3727_CR3","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","volume":"120","author":"A Heijl","year":"2002","unstructured":"Heijl A, Leske MC, Bengtsson B, et al. Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. Arch Ophthalmol. 2002;120:1268\u201379.","journal-title":"Arch Ophthalmol"},{"key":"3727_CR4","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1001\/jamaophthalmol.2013.5059","volume":"131","author":"E Rulli","year":"2013","unstructured":"Rulli E, Biagioli E, Riva I, et al. Efficacy and safety of trabeculectomy vs nonpenetrating surgical procedures: a systematic review and meta-analysis. JAMA Ophthalmol. 2013;131:1573\u201382.","journal-title":"JAMA Ophthalmol"},{"key":"3727_CR5","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.ajo.2011.10.026","volume":"153","author":"SJ Gedde","year":"2012","unstructured":"Gedde SJ, Schiffman JC, Feuer WJ, et al. Treatment outcomes in the Tube Versus Trabeculectomy (TVT) study after five years of follow-up. Am J Ophthalmol. 2012;153:789\u2013803.","journal-title":"Am J Ophthalmol"},{"key":"3727_CR6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.ophtha.2011.09.049","volume":"119","author":"HD Jampel","year":"2012","unstructured":"Jampel HD, Solus JF, Tracey PA, et al. Outcomes and bleb-related complications of trabeculectomy. Ophthalmology. 2012;119:712\u201322.","journal-title":"Ophthalmology"},{"key":"3727_CR7","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ogla.2021.07.008","volume":"5","author":"HJ Beckers","year":"2022","unstructured":"Beckers HJ, Aptel F, Webers CA, et al. Safety and effectiveness of the PRESERFLO\u00ae MicroShunt in primary open-angle glaucoma: results from a 2-year multicenter study. Ophthalmol Glaucoma. 2022;5:195\u2013209.","journal-title":"Ophthalmol Glaucoma"},{"key":"3727_CR8","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1097\/IJG.0000000000000368","volume":"25","author":"JF Batlle","year":"2016","unstructured":"Batlle JF, Fantes F, Riss I, et al. Three-year follow-up of a novel aqueous humor microshunt. J Glaucoma. 2016;25:e58\u201365.","journal-title":"J Glaucoma"},{"key":"3727_CR9","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1007\/s00417-023-06075-4","volume":"261","author":"M Jamke","year":"2023","unstructured":"Jamke M, Herber R, Haase MA, Jasper CS, Pillunat LE, Pillunat KR. MicroShunt versus trabeculectomy: 1-year results on efficacy and safety. Graefes Arch Clin Exp Ophthalmol. 2023;261:2901\u201315.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3727_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ogla.2026.03.001","volume":"9","author":"K Singh","year":"2026","unstructured":"Singh K, Aung T, Topouzis F, Susanna R Jr. Trabeculectomy remains essential for glaucoma care. Ophthalmol Glaucoma. 2026;9:239\u201340.","journal-title":"Ophthalmol Glaucoma"},{"key":"3727_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13213373","volume":"13","author":"SM Hasan","year":"2023","unstructured":"Hasan SM, Theilig T, Meller D. Comparison of bleb morphology following PRESERFLO\u00ae MicroShunt and trabeculectomy using anterior segment OCT. Diagnostics (Basel). 2023;13:3373.","journal-title":"Diagnostics (Basel)"},{"key":"3727_CR12","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/IJG.0000000000002126","volume":"32","author":"Y Mambo","year":"2023","unstructured":"Mambo Y, Higashide T, Ohkubo S, et al. Trabeculectomy tenon advancement technique may reduce bleb-related infections. J Glaucoma. 2023;32:107\u201316.","journal-title":"J Glaucoma"},{"key":"3727_CR13","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00417-010-1311-3","volume":"248","author":"N Nakano","year":"2010","unstructured":"Nakano N, Hangai M, Nakanishi H, et al. Early trabeculectomy bleb walls on anterior-segment optical coherence tomography. Graefes Arch Clin Exp Ophthalmol. 2010;248:1173\u201382.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3727_CR14","first-page":"15","volume-title":"Guidelines on design and reporting of glaucoma surgical trials","author":"DK Heuer","year":"2009","unstructured":"Heuer DK, Barton K, Grehn F, et al. Consensus on definition of success. In: Shaarawy T, Sherwood M, Grehn F, editors., et al., Guidelines on design and reporting of glaucoma surgical trials. The Hague, Amsterdam, The Netherlands: World Glaucoma Association, Kugler Publications; 2009. p. 15\u201324."},{"key":"3727_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286884","volume":"18","author":"M Ibarz Barber\u00e1","year":"2023","unstructured":"Ibarz Barber\u00e1 M, Hern\u00e1ndez-Verdejo JL, Bragard J, et al. Bleb geometry and morphology after preserflo microshunt surgery: risk factors for surgical failure. PLoS One. 2023;18:e0286884.","journal-title":"PLoS One"},{"key":"3727_CR16","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.12.11.4","volume":"12","author":"SM Hasan","year":"2023","unstructured":"Hasan SM, Theilig T, Lehmann T, Meller D. Factors correlated with mid-term morphology of functional blebs following implantation of preserflo microShunt using AS-OCT. Transl Vis Sci Technol. 2023;12:4.","journal-title":"Transl Vis Sci Technol"},{"key":"3727_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13142318","volume":"13","author":"SM Hasan","year":"2023","unstructured":"Hasan SM, Theilig T, Papadimitriou M, Meller D. A comparative analysis of morphology and dimensions of functional blebs following PreserFlo-MicroShunt and XEN-gel-stent, a study using anterior segment OCT. Diagnostics (Basel). 2023;13:2318.","journal-title":"Diagnostics (Basel)"},{"key":"3727_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12051250","volume":"12","author":"G Gambini","year":"2022","unstructured":"Gambini G, Carl\u00e0 MM, Giannuzzi F, et al. Anterior segment-optical coherence tomography bleb morphology comparison in minimally invasive glaucoma surgery: XEN gel stent vs. preserFlo microShunt. Diagnostics (Basel). 2022;12:1250.","journal-title":"Diagnostics (Basel)"},{"key":"3727_CR19","doi-asserted-by":"publisher","first-page":"e797","DOI":"10.1111\/aos.16642","volume":"102","author":"S Schneider","year":"2024","unstructured":"Schneider S, Kallab M, Murauer O, et al. Bleb vessel density as a predictive factor for surgical revisions after preserflo microshunt implantation. Acta Ophthalmol. 2024;102:e797\u2013804.","journal-title":"Acta Ophthalmol"},{"key":"3727_CR20","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ajo.2023.11.011","volume":"259","author":"A Rabiolo","year":"2024","unstructured":"Rabiolo A, Toscani R, Sacchi M, et al. Risk factors for failure in glaucoma patients undergoing microshunt implantation. Am J Ophthalmol. 2024;259:117\u201330.","journal-title":"Am J Ophthalmol"},{"key":"3727_CR21","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1038\/s41433-025-03843-w","volume":"39","author":"T Theilig","year":"2025","unstructured":"Theilig T, Papadimitriou M, Meller D, Hasan SM. PRESERFLO\u2122 MicroShunt as a treatment option for highly increased intraocular pressure in primary open angle glaucoma and pseudoexfoliation glaucoma. Eye (Lond). 2025;39:2253\u20139.","journal-title":"Eye (Lond)"},{"key":"3727_CR22","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.ajo.2026.03.014","volume":"287","author":"H Mieno","year":"2026","unstructured":"Mieno H, Mori K, Kano K, et al. Outcomes and risk factors for failure after PRESERFLO\u2122 microshunt implantation in a multicenter Japanese cohort. Am J Ophthalmol. 2026;287:14\u201323.","journal-title":"Am J Ophthalmol"},{"key":"3727_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-92879-9","volume":"15","author":"H Mieno","year":"2025","unstructured":"Mieno H, Mori K, Yoshii K, et al. Risk factors and protective strategies for hypotony following preserflo microshunt implantation. Sci Rep. 2025;15:8344.","journal-title":"Sci Rep"},{"key":"3727_CR24","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1055\/a-2239-0636","volume":"241","author":"J George","year":"2024","unstructured":"George J, Abouzeid H. Preserflo microshunt in severe myopia: a case report and review of the literature. Klin Monbl Augenheilkd. 2024;241:361\u20136.","journal-title":"Klin Monbl Augenheilkd"},{"key":"3727_CR25","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/APO.0000000000000234","volume":"5","author":"YL Wong","year":"2016","unstructured":"Wong YL, Saw SM. Epidemiology of pathologic myopia in Asia and worldwide. Asia Pac J Ophthalmol (Phila). 2016;5:394\u2013402.","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"3727_CR26","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/OPX.0000000000000516","volume":"92","author":"CW Pan","year":"2015","unstructured":"Pan CW, Dirani M, Cheng CY, Wong TY, Saw SM. The age-specific prevalence of myopia in Asia: a meta-analysis. Optom Vis Sci. 2015;92:258\u201366.","journal-title":"Optom Vis Sci"},{"key":"3727_CR27","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","volume":"123","author":"BA Holden","year":"2016","unstructured":"Holden BA, Fricke TR, Wilson DA, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 2016;123:1036\u201342.","journal-title":"Ophthalmology"},{"key":"3727_CR28","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.ophtha.2011.03.012","volume":"118","author":"MW Marcus","year":"2011","unstructured":"Marcus MW, de Vries MM, Montolio FGJ, Jansonius NM. Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. Ophthalmology. 2011;118:1989\u201394.","journal-title":"Ophthalmology"},{"key":"3727_CR29","doi-asserted-by":"publisher","unstructured":"Iemura H, Yoshimoto S, Sugisawa K, et al. Short-term efficacy and safety of Preserflo MicroShunt surgery in glaucoma eyes with and without high myopia. J Glaucoma. Published ahead of print. https:\/\/doi.org\/10.1097\/IJG.0000000000002703.","DOI":"10.1097\/IJG.0000000000002703"},{"key":"3727_CR30","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1007\/s40123-025-01149-4","volume":"14","author":"J Garcia-Feijoo","year":"2025","unstructured":"Garcia-Feijoo J, Batlle JF, Aptel F, et al. Pooled analysis of three MicroShunt studies in primary open-angle glaucoma evaluating different concentrations of applied Mitomycin C. Ophthalmol Ther. 2025;14:1533\u201349.","journal-title":"Ophthalmol Ther."},{"key":"3727_CR31","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1136\/bjophthalmol-2021-320631","volume":"107","author":"A Tanner","year":"2023","unstructured":"Tanner A, Haddad F, Fajardo-Sanchez J, et al. One-year surgical outcomes of the PreserFlo MicroShunt in glaucoma: a multicenter analysis. Br J Ophthalmol. 2023;107:1104\u201311.","journal-title":"Br J Ophthalmol"},{"key":"3727_CR32","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/j.ophtha.2021.05.023","volume":"128","author":"ND Baker","year":"2021","unstructured":"Baker ND, Barnebey HS, Moster MR, et al. Ab-externo microshunt versus trabeculectomy in primary open-angle glaucoma: one-year results from a 2-year randomized, multicenter study. Ophthalmology. 2021;128:1710\u201321.","journal-title":"Ophthalmology"},{"key":"3727_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0256670","volume":"16","author":"M Nobl","year":"2021","unstructured":"Nobl M, Freissinger S, Kassumeh S, Priglinger S, Mackert MJ. One-year outcomes of microshunt implantation in pseudoexfoliation glaucoma. PLoS One. 2021;16:e0256670.","journal-title":"PLoS One"},{"key":"3727_CR34","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.ogla.2025.03.003","volume":"8","author":"J Chami","year":"2025","unstructured":"Chami J, Tan JC, Manning D, et al. Comparative study of early safety and effectiveness outcomes of the PreserFlo MicroShunt with and without an intraluminal suture stent. Ophthalmol Glaucoma. 2025;8:367\u201374.","journal-title":"Ophthalmol Glaucoma"},{"key":"3727_CR35","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1007\/s00417-024-06567-x","volume":"262","author":"R Verma-Fuehring","year":"2024","unstructured":"Verma-Fuehring R, Dakroub M, Bamousa A, Kann G, Hillenkamp J, Kampik D. The use of intraluminal PRESERFLO stenting in avoiding early postoperative hypotony. Graefes Arch Clin Exp Ophthalmol. 2024;262:3925\u201332.","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Advances in Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03727-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12325-026-03727-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12325-026-03727-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:39:33Z","timestamp":1790609973000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12325-026-03727-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["3727"],"URL":"https:\/\/doi.org\/10.1007\/s12325-026-03727-9","relation":{},"ISSN":["0741-238X","1865-8652"],"issn-type":[{"value":"0741-238X","type":"print"},{"value":"1865-8652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"assertion":[{"value":"24 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Takahiro Minami, Daisuke Takemoto, Taro Muroya, Sachiko Udagawa, Shunsuke Tsuchiya, Kimikazu Sakaguchi, Ryotaro Wajima, Yoko Yamashita, Kazuhisa Sugiyama, and Tomomi Higashide have nothing to disclose.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This was a single-center, prospective observational cohort study. The study was approved by the Medical Ethics Committee of Kanazawa University Hospital (2020-008) and adhered to the tenets of the Declaration of Helsinki. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}