{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:03:14Z","timestamp":1768557794168,"version":"3.49.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s12328-016-0635-x","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T11:54:50Z","timestamp":1456919690000},"page":"99-103","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Primary biliary cirrhosis associated with Graves\u2019 disease in a male patient"],"prefix":"10.1007","volume":"9","author":[{"given":"Yuji","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Koeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kakisaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Takikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"635_CR1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","volume":"353","author":"MM Kaplan","year":"2005","unstructured":"Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med. 2005;353:1261\u201373.","journal-title":"N Engl J Med"},{"key":"635_CR2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0168-8278(02)00440-3","volume":"38","author":"P Invernizzi","year":"2003","unstructured":"Invernizzi P, Battezzati PM, Crosignani A, et al. Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis. J Hepatol. 2003;38:401\u20136.","journal-title":"J Hepatol"},{"key":"635_CR3","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/hep.20907","volume":"42","author":"ME Gershwin","year":"2005","unstructured":"Gershwin ME, Selmi C, Worman HJ, et al. Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients. Hepatology. 2005;42:1194\u2013202.","journal-title":"Hepatology"},{"key":"635_CR4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12016-014-8427-x","volume":"48","author":"A Floreani","year":"2015","unstructured":"Floreani A, Franceschet I, Cazzagon N, et al. Extrahepatic autoimmune conditions associated with primary biliary cirrhosis. Clin Rev Allergy Immunol. 2015;48:192\u20137.","journal-title":"Clin Rev Allergy Immunol"},{"key":"635_CR5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/BF01311724","volume":"28","author":"GH Elta","year":"1983","unstructured":"Elta GH, Sepersky RA, Goldberg MJ, et al. Increased incidence of hypothyroidism in primary biliary cirrhosis. Dig Dis Sci. 1983;28:971\u20135.","journal-title":"Dig Dis Sci"},{"key":"635_CR6","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/0016-5085(94)90028-0","volume":"106","author":"NP Thompson","year":"1994","unstructured":"Thompson NP, Leader S, Jamieson CP, et al. Reversible jaundice in primary biliary cirrhosis due to hyperthyroidism. Gastroenterology. 1994;106:1342\u20133.","journal-title":"Gastroenterology"},{"key":"635_CR7","first-page":"582","volume":"80","author":"A Floreani","year":"1989","unstructured":"Floreani A, Caroli A, Chiaramonte M, et al. Hyperthyroidism associated with primary cirrhosis. Two case reports. Recent Prog Med. 1989;80:582\u20133.","journal-title":"Recent Prog Med"},{"key":"635_CR8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0140-6736(03)14073-1","volume":"362","author":"DS Cooper","year":"2003","unstructured":"Cooper DS. Hyperthyroidism. Lancet. 2003;362:459\u201368.","journal-title":"Lancet."},{"key":"635_CR9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/00004836-198510000-00014","volume":"7","author":"S Nieri","year":"1985","unstructured":"Nieri S, Riccardo GG, Salvadori G, et al. Primary biliary cirrhosis and Graves\u2019 disease. J Clin Gastroenterol. 1985;7:434\u20137.","journal-title":"J Clin Gastroenterol"},{"key":"635_CR10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3109\/s10165-004-0342-1","volume":"14","author":"N Iikuni","year":"2004","unstructured":"Iikuni N, Hanzawa M, Ohta S, et al. A rare case of systemic sclerosis complicated with multiple autoimmune diseases (Sj\u00f6gren\u2019s syndrome, Graves\u2019 disease, and primary biliary cirrhosis). Mod Rheumatol. 2004;14:476\u20139.","journal-title":"Mod Rheumatol"},{"key":"635_CR11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s10067-005-0178-x","volume":"26","author":"T Nakamura","year":"2007","unstructured":"Nakamura T, Higashi S, Tomada K, et al. Primary biliary cirrhosis (PBC)-CREST overlap syndrome with coexistence of Sj\u00f6gren\u2019s syndrome and thyroid dysfunction. Clin Rheumatol. 2007;26:596\u2013600.","journal-title":"Clin Rheumatol"},{"key":"635_CR12","first-page":"198","volume":"18","author":"DG Ya\u015far","year":"2007","unstructured":"Ya\u015far DG, Ozenirler S, Do\u011fan M. A patient with primary biliary cirrhosis accompanied by Graves\u2019 disease and Hurthle cell adenoma. Turk J Gastroenterol. 2007;18:198\u2013200.","journal-title":"Turk J Gastroenterol"},{"key":"635_CR13","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jceh.2013.08.001","volume":"4","author":"S Shetty","year":"2014","unstructured":"Shetty S, Rajasekaran S, Venkatakrishnan L. Grave\u2019s disease and primary biliary cirrhosis\u2014an unusual and challenging association. J Clin Exp Hepatol. 2014;4:66\u20137.","journal-title":"J Clin Exp Hepatol"},{"key":"635_CR14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00004836-199204000-00010","volume":"14","author":"TL Fong","year":"1992","unstructured":"Fong TL, McHutchison JG, Reynolds TB. Hyperthyroidism and hepatic dysfunction. A case series analysis. J Clin Gastroenterol. 1992;14:240\u20134.","journal-title":"J Clin Gastroenterol"},{"key":"635_CR15","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1111\/j.1572-0241.1999.01380.x","volume":"94","author":"G Nalbandian","year":"1999","unstructured":"Nalbandian G, Van de Water J, Gish R. Is there a serological difference between men and women with primary biliary cirrhosis? Am J Gastroenterol. 1999;94:2482\u20136.","journal-title":"Am J Gastroenterol"},{"key":"635_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cmi.2009.104","volume":"7","author":"C Selmi","year":"2010","unstructured":"Selmi C, Meda F, Kasangian A, et al. Experimental evidence on the immunopathogenesis of primary biliary cirrhosis. Cell Mol Immunol. 2010;7:1\u201310.","journal-title":"Cell Mol Immunol"},{"key":"635_CR17","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/gut.27.11.1373","volume":"27","author":"MR Lucey","year":"1986","unstructured":"Lucey MR, Neuberger JM, Williams R. Primary biliary cirrhosis in men. Gut. 1986;27:1373\u20136.","journal-title":"Gut"},{"key":"635_CR18","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/0016-5085(84)90540-7","volume":"87","author":"WM Melia","year":"1984","unstructured":"Melia WM, Johnson PJ, Neuberger J, et al. Hepatocellular carcinoma in primary biliary cirrhosis: detection by alpha-fetoprotein estimation. Gastroenterology. 1984;87:660\u20133.","journal-title":"Gastroenterology"},{"key":"635_CR19","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1053\/j.gastro.2008.06.077","volume":"135","author":"BD Juran","year":"2008","unstructured":"Juran BD, Atkinson EJ, Schlicht EM, et al. Primary biliary cirrhosis is associated with a genetic variant in the 3\u2032 flanking region of the CTLA4 gene. Gastroenterology. 2008;135:1200\u20136.","journal-title":"Gastroenterology"},{"key":"635_CR20","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.4049\/jimmunol.165.11.6606","volume":"165","author":"T Kouki","year":"2000","unstructured":"Kouki T, Sawai Y, Gardine CA, et al. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves\u2019s disease. J Immunol. 2000;165:6606\u201311.","journal-title":"J Immunol"},{"key":"635_CR21","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.24705","volume":"55","author":"T Umemura","year":"2012","unstructured":"Umemura T, Joshita S, Ichijo T, et al. Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis. Hepatology. 2012;55:506\u201311.","journal-title":"Hepatology"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-016-0635-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12328-016-0635-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-016-0635-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T01:29:46Z","timestamp":1567646986000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12328-016-0635-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,2]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["635"],"URL":"https:\/\/doi.org\/10.1007\/s12328-016-0635-x","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,2]]}}}