{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:54:50Z","timestamp":1761562490204},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12328-019-00952-4","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T11:03:06Z","timestamp":1553252586000},"page":"330-335","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunomodulator-associated Epstein\u2013Barr virus-positive mucocutaneous ulcer in a patient with refractory Crohn\u2019s disease"],"prefix":"10.1007","volume":"12","author":[{"given":"Shinsaku","family":"Hamanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mana","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Isshiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Kasamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Ishigami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Taida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Okimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Maruoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Ohwada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Sakaida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Nakaseko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"952_CR1","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00535-013-0873-3","volume":"49","author":"N Fukata","year":"2014","unstructured":"Fukata N, Okazaki K, Omiya M, et al. Hematologic malignancies in the Japanese patients with inflammatory bowel disease. J Gastroenterol. 2014;49:1299\u2013306.","journal-title":"J Gastroenterol"},{"key":"952_CR2","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, et al. World Health Organization classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008."},{"key":"952_CR3","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/MOT.0b013e3283465715","volume":"16","author":"KY Kamdar","year":"2011","unstructured":"Kamdar KY, Rooney CM, Heslop HE. Posttransplant lymphoproliferative disease following liver transplantation. Curr Opin Organ Transplant. 2011;16:274\u201380.","journal-title":"Curr Opin Organ Transplant"},{"key":"952_CR4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1086\/517260","volume":"176","author":"H Kanegane","year":"1997","unstructured":"Kanegane H, Wakiguchi H, Kanegane C, et al. Viral interleukin-10 in chronic active Epstein\u2013Barr virus infection. J Infect Dis. 1997;176:254\u20137.","journal-title":"J Infect Dis"},{"key":"952_CR5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1146\/annurev.pathol.1.110304.100209","volume":"1","author":"JL Kutok","year":"2006","unstructured":"Kutok JL, Wang F. Spectrum of Epstein\u2013Barr virus-associated diseases. Annu Rev Pathol. 2006;1:375\u2013404.","journal-title":"Annu Rev Pathol"},{"key":"952_CR6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/PAS.0b013e3181cf8622","volume":"34","author":"SD Dojcinov","year":"2010","unstructured":"Dojcinov SD, Venkataraman G, Raffeld M, et al. EBV positive mucocutaneous ulcer\u2014a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010;34:405\u201317.","journal-title":"Am J Surg Pathol"},{"key":"952_CR7","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/S0140-6736(09)61302-7","volume":"374","author":"L Beaugerie","year":"2009","unstructured":"Beaugerie L, Brousse N, Bouvier AM, et al. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet. 2009;374:1617\u201325.","journal-title":"Lancet"},{"key":"952_CR8","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.cgh.2014.05.015","volume":"13","author":"DS Kotlyar","year":"2015","unstructured":"Kotlyar DS, Lewis JD, Beaugerie L, et al. Risk of lymphoma in patients with inflammatory bowel disease treated with azathioprine and 6-mercaptopurine: a meta-analysis. Clin Gastroenterol Hepatol. 2015;13:847\u201358.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"952_CR9","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/gut.2004.051771","volume":"54","author":"J Askling","year":"2005","unstructured":"Askling J, Brandt L, Lapidus A, et al. Risk of haematopoietic cancer in patients with inflammatory bowel disease. Gut. 2005;54:617\u201322.","journal-title":"Gut"},{"key":"952_CR10","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1056\/NEJMoa0904492","volume":"362","author":"JF Colombel","year":"2010","unstructured":"Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn\u2019s disease. N Engl J Med. 2010;362:1383\u201395.","journal-title":"N Engl J Med"},{"key":"952_CR11","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cgh.2013.03.034","volume":"12","author":"MD Kappelman","year":"2014","unstructured":"Kappelman MD, Farkas DK, Long MD, et al. Risk of cancer in patients with inflammatory bowel diseases: a nationwide population-based cohort study with 30 years of follow-up evaluation. Clin Gastroenterol Hepatol. 2014;12:265\u201373.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"952_CR12","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1097\/MCG.0000000000000129","volume":"49","author":"SK Park","year":"2015","unstructured":"Park SK, Ye BD, Lee C, et al. Risk and clinical characteristics of lymphoma in Korean patients with inflammatory bowel diseases: a multicenter study. J Clin Gastroenterol. 2015;49:e11\u20136.","journal-title":"J Clin Gastroenterol"},{"key":"952_CR13","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1093\/ecco-jcc\/jjx040","volume":"11","author":"YS Jung","year":"2017","unstructured":"Jung YS, Han M, Kim WH, et al. Cancer risk in the early stages of inflammatory bowel disease in Korean patients: a nationwide population-based study. J Crohns Colitis. 2017;11:954\u201362.","journal-title":"J Crohns Colitis"},{"key":"952_CR14","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1053\/gast.2001.28703","volume":"121","author":"JD Lewis","year":"2001","unstructured":"Lewis JD, Bilker WB, Brensinger C, et al. Inflammatory bowel disease is not associated with an increased risk of lymphoma. Gastroenterology. 2001;121:1080\u20137.","journal-title":"Gastroenterology"},{"issue":"12","key":"952_CR15","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/S1542-3565(04)00543-9","volume":"2","author":"KV Winther","year":"2004","unstructured":"Winther KV, Jess T, Langholz E, et al. Long-term risk of cancer in ulcerative colitis: a population-based cohort study from Copenhagen County. Clin Gastroenterol Hepatol. 2004;2(12):1088\u201395.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"952_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3960\/jslrt.46.5","volume":"46","author":"K Aozasa","year":"2006","unstructured":"Aozasa K. Pyothorax-associated lymphoma. J Clin Exp Hematop. 2006;46:5\u201310.","journal-title":"J Clin Exp Hematop"},{"key":"952_CR17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1182\/blood-2013-03-489708","volume":"122","author":"CY Ok","year":"2013","unstructured":"Ok CY, Papathomas TG, Medeiros LJ, et al. EBV-positive diffuse large B-cell lymphoma of the elderly. Blood. 2013;122:328\u201340.","journal-title":"Blood"},{"key":"952_CR18","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1002\/ijc.28942","volume":"135","author":"M Cohen","year":"2014","unstructured":"Cohen M, Narbaitz M, Metrebian F, et al. Epstein-Barr virus-positive diffuse large B-cell lymphoma association is not only restricted to elderly patients. Int J Cancer. 2014;135:2816\u201324.","journal-title":"Int J Cancer"},{"key":"952_CR19","doi-asserted-by":"publisher","first-page":"13933","DOI":"10.18632\/oncotarget.4324","volume":"6","author":"CY Ok","year":"2015","unstructured":"Ok CY, Ye Q, Li L, et al. Age cutoff for Epstein\u2013Barr virus-positive diffuse large B-cell lymphoma\u2014is it necessary? Oncotarget. 2015;6:13933\u201345.","journal-title":"Oncotarget"},{"key":"952_CR20","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.clml.2011.07.003","volume":"11","author":"BE Beltran","year":"2011","unstructured":"Beltran BE, Morales D, Qui\u00f1ones P, et al. EBV-positive diffuse large b-cell lymphoma in young immunocompetent individuals. Clin Lymphoma Myeloma Leuk. 2011;11:512\u20136.","journal-title":"Clin Lymphoma Myeloma Leuk"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-019-00952-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12328-019-00952-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-019-00952-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T00:32:33Z","timestamp":1584750753000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12328-019-00952-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["952"],"URL":"https:\/\/doi.org\/10.1007\/s12328-019-00952-4","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]},"assertion":[{"value":"21 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This report was reviewed and approved by the Chiba University Ethical Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This article does not contain any studies directly involving human participants, as it is a review of data already collected in a hospital database.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"For this type of study, formal consent was not necessary.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}