{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:25:46Z","timestamp":1770881146563,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s12328-019-01010-9","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T13:20:50Z","timestamp":1562246450000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A case of Fontan-related hepatocellular carcinoma successfully treated with proton beam therapy"],"prefix":"10.1007","volume":"13","author":[{"given":"Yuri","family":"Ogasawara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-4324","authenticated-orcid":false,"given":"Tomomi","family":"Kogiso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Sagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Taniai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruko","family":"Numajiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsutoshi","family":"Tokushige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"1010_CR1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1136\/thx.26.3.240","volume":"26","author":"F Fontan","year":"1971","unstructured":"Fontan F, Baudet E. Surgical repair of tricuspid atresia. Thorax. 1971;26:240\u20138.","journal-title":"Thorax"},{"key":"1010_CR2","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0022-5223(19)39097-X","volume":"86","author":"JH Lemmer","year":"1983","unstructured":"Lemmer JH, Coran AG, Behrendt DM, Heidelberger KP, Stern AM. Liver fibrosis (cardiac cirrhosis) five years after modified Fontan operation for tricuspid atresia. J Thorac Cardiovasc Surg. 1983;86:757\u201360.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1010_CR3","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.jtcvs.2004.10.005","volume":"129","author":"AA Ghaferi","year":"2005","unstructured":"Ghaferi AA, Hutchins GM. Progression of liver pathology in patients undergoing the Fontan procedure: chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma. J Thorac Cardiovasc Surg. 2005;129:1348\u201352.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1010_CR4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1136\/hrt.2006.094516","volume":"93","author":"CH Kiesewetter","year":"2007","unstructured":"Kiesewetter CH, Sheron N, Vettukattill JJ, et al. Hepatic changes in the failing Fontan circulation. Heart. 2007;93:579\u201384.","journal-title":"Heart"},{"key":"1010_CR5","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.2169\/internalmedicine.55.6869","volume":"55","author":"Y Takuma","year":"2016","unstructured":"Takuma Y, Fukada Y, Iwadou S, et al. Surgical resection for hepatocellular carcinoma with cardiac cirrhosis after the Fontan procedure. Intern Med. 2016;55:3265\u201372.","journal-title":"Intern Med"},{"key":"1010_CR6","doi-asserted-by":"crossref","unstructured":"Khairy P, Veldtman GR. Late complications following the Fontan operation. In: Gatzoulis MA, Webb GD, Daubeney PEF, editors. Diagnosis and management of adult congenital heart disease, 3rd edn. Elsevier; 2018, p. 183.","DOI":"10.1016\/B978-0-7020-6929-1.00013-7"},{"key":"1010_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/chd.12570","volume":"13","author":"LS Kverneland","year":"2018","unstructured":"Kverneland LS, Kramer P, Ovroutski S. Five decades of the Fontan operation: a systematic review of international reports on outcomes after univentricular palliation. Congenit Heart Dis. 2018;13:181\u201393.","journal-title":"Congenit Heart Dis"},{"key":"1010_CR8","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S0003-4975(03)01010-5","volume":"76","author":"SP Kumar","year":"2003","unstructured":"Kumar SP, Rubinstein CS, Simsic JM, et al. Lateral tunnel versus extracardiac conduit Fontan procedure: a concurrent comparison. Ann Thorac Surg. 2003;76:1389\u201396 (discussion 1396\u20137).","journal-title":"Ann Thorac Surg"},{"key":"1010_CR9","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s11748-007-0143-5","volume":"55","author":"Y Ueda","year":"2007","unstructured":"Ueda Y, Osada H, Osugi H, Japanese Association for Thoracic Surgery Committee for Scientific Affairs. Thoracic and cardiovascular surgery in Japan during, 2005. Annual report by the Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg. 2007;55:377\u201399.","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"1010_CR10","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s11748-016-0695-3","volume":"64","author":"M Masuda","year":"2016","unstructured":"Masuda M, Okumura M, Doki Y, et al. Thoracic and cardiovascular surgery in Japan during 2014: annual report by The Japanese Association for Thoracic Surgery. Gen Thorac Cardiovasc Surg. 2016;64:665\u201397.","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"1010_CR11","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1007\/s00380-015-0743-4","volume":"31","author":"M Shimizu","year":"2016","unstructured":"Shimizu M, Miyamoto K, Nishihara Y, et al. Risk factors and serological markers of liver cirrhosis after Fontan procedure. Heart Vessel. 2016;31:1514\u201321.","journal-title":"Heart Vessel"},{"key":"1010_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1067\/j.cpradiol.2017.04.002","volume":"47","author":"SB Nandwana","year":"2018","unstructured":"Nandwana SB, Olaiya B, Cox K, Sahu A, Mittal P. Abdominal imaging surveillance in adult patients after Fontan procedure: risk of chronic liver disease and hepatocellular carcinoma. Curr Probl Diagn Radiol. 2018;47:19\u201322.","journal-title":"Curr Probl Diagn Radiol"},{"key":"1010_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10110412","author":"M Kudo","year":"2018","unstructured":"Kudo M. Systemic therapy for hepatocellular carcinoma: latest advances. Cancers (Basel). 2018. \nhttps:\/\/doi.org\/10.3390\/cancers10110412\n\n.","journal-title":"Cancers (Basel)"},{"key":"1010_CR14","doi-asserted-by":"publisher","first-page":"e4823","DOI":"10.1097\/MD.0000000000004823","volume":"95","author":"C Oh","year":"2016","unstructured":"Oh C, Youn JK, Han JW, Kim GB, Kim HY, Jung SE. Hepatocellular carcinoma after the Fontan procedure in a 16-year-old girl: a case report. Medicine (Baltimore). 2016;95:e4823.","journal-title":"Medicine (Baltimore)."},{"key":"1010_CR15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.21037\/tgh.2018.07.10","volume":"3","author":"KS Lo","year":"2018","unstructured":"Lo KS, Chan MY, Ma KW, Tsang SH, Cheung TT, Lo CM. Left hepatectomy in a patient with a Fontan circulation. Transl Gastroenterol Hepatol. 2018;3:51.","journal-title":"Transl Gastroenterol Hepatol."},{"key":"1010_CR16","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1002\/hep.30194","volume":"69","author":"C Mazzarelli","year":"2019","unstructured":"Mazzarelli C, Cannon MD, Hudson M, et al. Hepatocellular carcinoma as a complication of vascular disease of the liver after Fontan procedure. Hepatology. 2019;69:911\u20133.","journal-title":"Hepatology"},{"key":"1010_CR17","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/bja\/aeh195","volume":"93","author":"A Chouk\u00e8r","year":"2004","unstructured":"Chouk\u00e8r A, Schachtner T, Schauer R, et al. Effects of Pringle manoeuvre and ischaemic preconditioning on haemodynamic stability in patients undergoing elective hepatectomy: a randomized trial. Br J Anaesth. 2004;93:204\u201311.","journal-title":"Br J Anaesth"},{"key":"1010_CR18","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.ijrobp.2010.07.015","volume":"81","author":"M Mizumoto","year":"2011","unstructured":"Mizumoto M, Okumura T, Hashimoto T, et al. Proton beam therapy for hepatocellular carcinoma: a comparison of three treatment protocols. Int J Radiat Oncol Biol Phys. 2011;81:1039\u201345.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1010_CR19","doi-asserted-by":"publisher","first-page":"e529","DOI":"10.1016\/j.ijrobp.2011.05.056","volume":"82","author":"M Mizumoto","year":"2012","unstructured":"Mizumoto M, Okumura T, Hashimoto T, et al. Evaluation of liver function after proton beam therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2012;82:e529\u201335.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"1010_CR20","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1097\/MEG.0b013e32832e2bec","volume":"22","author":"T Saliba","year":"2010","unstructured":"Saliba T, Dorkhom S, O'Reilly EM, Ludwig E, Gansukh B, Abou-Alfa GK. Hepatocellular carcinoma in two patients with cardiac cirrhosis. Eur J Gastroenterol Hepatol. 2010;22:889\u201391.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"1010_CR21","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1056\/NEJMc1214222","volume":"368","author":"SK Asrani","year":"2013","unstructured":"Asrani SK, Warnes CA, Kamath PS. Hepatocellular carcinoma after the Fontan procedure. N Engl J Med. 2013;368:1756\u20137.","journal-title":"N Engl J Med."},{"issue":"5","key":"1010_CR22","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1056\/NEJMc1306854","volume":"369","author":"RW Elder","year":"2013","unstructured":"Elder RW, Parekh S, Book WM. More on hepatocellular carcinoma after the Fontan procedure. New Engl J Med. 2013;369(5):490.","journal-title":"New Engl J Med"},{"issue":"7","key":"1010_CR23","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/qjmed\/hcu020","volume":"107","author":"N Rajoriya","year":"2014","unstructured":"Rajoriya N, Clift P, Thorne S, Hirschfield GM, Ferguson JW. A liver mass post-Fontan operation. QJM. 2014;107(7):571\u20132.","journal-title":"QJM"},{"key":"1010_CR24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1213\/XAA.0000000000000012","volume":"2","author":"PD Weyker","year":"2014","unstructured":"Weyker PD, Allen-John Webb C, Emond JC, Brentjens TE, Johnston TA. Anesthetic implications of extended right hepatectomy in a patient with fontan physiology. A A Case Rep. 2014;2:99\u2013101.","journal-title":"A A Case Rep"},{"issue":"4","key":"1010_CR25","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1111\/ped.12619","volume":"57","author":"K Yamada","year":"2015","unstructured":"Yamada K, Shinmoto H, Kawamura Y, Wakamatsu H, Kawauchi T, Soga S, Ogata S, Kaji T. Transarterial embolization for pediatric hepatocellular carcinoma with cardiac cirrhosis. Pediatr Int. 2015;57(4):766\u201370.","journal-title":"Pediatr Int"},{"key":"1010_CR26","first-page":"E55","volume":"6","author":"S Kwon","year":"2015","unstructured":"Kwon S, Scovel L, Yeh M, et al. Surgical management of hepatocellular carcinoma after Fontan procedure. J Gastrointest Oncol. 2015;6:E55\u201360.","journal-title":"J Gastrointest Oncol"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-019-01010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12328-019-01010-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-019-01010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T23:39:35Z","timestamp":1593733175000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12328-019-01010-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1010"],"URL":"https:\/\/doi.org\/10.1007\/s12328-019-01010-9","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,4]]},"assertion":[{"value":"30 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Professor Katsutoshi Tokushige received research funding from Sumitomo Dainippon Pharma; Astellas Pharma; Eisai; TAIHO Pharmaceutical; Chugai Pharmaceutical; Daiichi Sankyo Pharmaceutical; AbbVie GK; Takeda Pharmaceutical Company; Asahi Kasei Corporation; AJINOMOTO; and Otsuka Pharmaceutical. The other authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were performed in accordance with the ethical standards mandated in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human\/animal rights"}},{"value":"Informed consent was obtained from the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}