{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:29:06Z","timestamp":1769196546053,"version":"3.49.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s12328-020-01280-8","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T07:02:48Z","timestamp":1604386968000},"page":"198-203","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["IgA vasculitis in a patient with ulcerative colitis under infliximab: drug-induced or genetic?"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4808-7614","authenticated-orcid":false,"given":"Jun","family":"Urushikubo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunichi","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Toya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Asakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Gonai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Eizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Uesugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Sugai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"1280_CR1","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro R, Mehandru S, Allen PB, et al. Ulcerative colitis. Lancet. 2017;389:1756\u201370.","journal-title":"Lancet"},{"issue":"211","key":"1280_CR2","first-page":"e1","volume":"68","author":"B Thrash","year":"2013","unstructured":"Thrash B, Patel M, Shah KR, et al. Cutaneous manifestations of gastrointestinal disease: part II. J Am Acad Dermatol. 2013;68(211):e1-33.","journal-title":"J Am Acad Dermatol"},{"key":"1280_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/MD.0b013e3181441a68","volume":"86","author":"M Ramos-Casals","year":"2007","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, Mu\u00f1oz S, et al. Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases. Medicine (Baltimore). 2007;86:242\u201351.","journal-title":"Medicine (Baltimore)"},{"key":"1280_CR4","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.berh.2008.09.008","volume":"22","author":"M Ramos-Casals","year":"2008","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, Soto MJ, et al. Autoimmune diseases induced by TNF-targeted therapies. Best Pract Res Clin Rheumatol. 2008;22:847\u201361.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"1280_CR5","doi-asserted-by":"publisher","first-page":"6082","DOI":"10.3748\/wjg.v21.i19.6082","volume":"21","author":"Y Song","year":"2015","unstructured":"Song Y, Shi YH, He C, et al. Severe Henoch\u2013Sch\u00f6nlein purpura with infliximab for ulcerative colitis. World J Gastroenterol. 2015;21:6082\u20137.","journal-title":"World J Gastroenterol"},{"key":"1280_CR6","doi-asserted-by":"crossref","unstructured":"LaConti JJ, Jean A Donet JA, Cho-Vega JH, et al. Henoch-Sch\u00f6nlein purpura with adalimumab therapy for ulcerative colitis: a case report and review of the literature. Case Rep Rheumatol. 2016;2812980.","DOI":"10.1155\/2016\/2812980"},{"key":"1280_CR7","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/BOR.0b013e32835d8e2a","volume":"25","author":"M Piram","year":"2013","unstructured":"Piram M, Mahr A. Epidemiology of immunoglobulin A vasculitis (Henoch\u2013Sch\u00f6nlein): current state of knowledge. Curr Opin Rheumatol. 2013;25:171\u20138.","journal-title":"Curr Opin Rheumatol"},{"key":"1280_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13075-016-0959-4","volume":"18","author":"A Hocevar","year":"2016","unstructured":"Hocevar A, Rotar Z, Jurcic V, et al. IgA vasculitis in adults: the performance of the EULAR\/PRINTO\/PRES classification criteria in adults. Arthritis Res Ther. 2016;18:58.","journal-title":"Arthritis Res Ther"},{"key":"1280_CR9","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/ard.2009.116657","volume":"69","author":"S Ozen","year":"2010","unstructured":"Ozen S, Oistorio A, Lusan SM, et al. EULAR\/PRINTO\/PRES criteria for Henoch\u2013Sch\u00f6nlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008 part II: final classification criteria. Ann Rheum Dis. 2010;69:798\u2013806.","journal-title":"Ann Rheum Dis"},{"key":"1280_CR10","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1002\/art.1780330809","volume":"33","author":"JA Mills","year":"1990","unstructured":"Mills JA, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Henoch\u2013Sch\u00f6nlein purpura. Arthritis Rheumatol. 1990;33:1114\u201321.","journal-title":"Arthritis Rheumatol"},{"key":"1280_CR11","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.mayocp.2012.04.011","volume":"87","author":"O Sokumbi","year":"2012","unstructured":"Sokumbi O, Wetter DA, Makol A, et al. Vasculitis associated with tumor necrosis factor-\u03b1 inhibitors. Mayo Clin Proc. 2012;87:739\u201345.","journal-title":"Mayo Clin Proc"},{"key":"1280_CR12","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.crohns.2012.02.019","volume":"6","author":"I Marques","year":"2012","unstructured":"Marques I, Lagos A, Reis J, et al. Reversible Henoch\u2013Sch\u00f6nlein purpura complicating adalimumab therapy. J Crohns Colitis. 2012;6:796\u20139.","journal-title":"J Crohns Colitis"},{"key":"1280_CR13","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.crohns.2012.12.005","volume":"7","author":"SJ Park","year":"2013","unstructured":"Park SJ, Shin JI. Is there a link between the use of adalimumab and Henoch\u2013Sch\u00f6nlein purpura? J Crohns Colitis. 2013;7:600.","journal-title":"J Crohns Colitis"},{"key":"1280_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.semarthrit.2015.07.006","volume":"45","author":"A Sy","year":"2016","unstructured":"Sy A, Khalidi N, Dehghan N, et al. Vasculitis in patients with inflammatory bowel diseases: a study of 32 patients and systematic review of the literature. Semin Arthritis Rheum. 2016;45:475\u201382.","journal-title":"Semin Arthritis Rheum"},{"key":"1280_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/RHU.0b013e31819bca9e","volume":"15","author":"S Nobile","year":"2009","unstructured":"Nobile S, Catassi C, Felici L. Herpes zoster infection followed by Henoch\u2013Sch\u00f6nlein purpura in a girl receiving infliximab for ulcerative colitis. J Clin Rheumatol. 2009;15:101.","journal-title":"J Clin Rheumatol"},{"key":"1280_CR16","first-page":"E20","volume":"99","author":"C Laresche","year":"2017","unstructured":"Laresche C, Locatelli F, Biver-Dalle C, et al. Severe Henoch\u2013Sch\u00f6nlein purpura complicating infliximab therapy for ulcerative colitis. Cutis. 2017;99:E20\u20132.","journal-title":"Cutis"},{"key":"1280_CR17","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.jbspin.2006.02.010","volume":"73","author":"B Saint Marcoux","year":"2006","unstructured":"Saint Marcoux B, De Bandt M. CRI (Club Rhumatismes et Inflammation). Vasculitides induced by TNF antagonists: a study in 39 patients in France. Joint Bone Spine. 2006;73:710\u20133.","journal-title":"Joint Bone Spine"},{"key":"1280_CR18","first-page":"1955","volume":"31","author":"N Mohan","year":"2004","unstructured":"Mohan N, Edwards ET, Cupps TR, Slifman N, et al. Leukocytoclastic vasculitis associated with tumor necrosis factor-alpha blocking agents. Rheumatology. 2004;31:1955\u20138.","journal-title":"Rheumatology"},{"key":"1280_CR19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.autrev.2017.11.024","volume":"17","author":"R L\u00f3pez-Mej\u00edas","year":"2018","unstructured":"L\u00f3pez-Mej\u00edas R, Casta\u00f1eda S, Genre F, et al. Genetics of immunoglobulin-A vasculitis (Henoch\u2013Sch\u00f6nlein purpura): an updated review. Autoimmun Rev. 2018;17:301\u201315.","journal-title":"Autoimmun Rev"},{"key":"1280_CR20","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s00296-012-2661-4","volume":"33","author":"X He","year":"2013","unstructured":"He X, Yu C, Zhao P, et al. The genetics of Henoch-Sch\u00f6nlein purpura: a systematic review and meta-analysis. Rheumatol Int. 2013;33:1387\u201395.","journal-title":"Rheumatol Int"},{"key":"1280_CR21","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1038\/ng.482","volume":"41","author":"K Asano","year":"2009","unstructured":"Asano K, Matsushita T, Umeno J, et al. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet. 2009;41:1325\u20139.","journal-title":"Nat Genet"},{"key":"1280_CR22","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1399-0039.2009.01241.x","volume":"73","author":"H Aizawa","year":"2009","unstructured":"Aizawa H, Kinouchi Y, Negoro K, et al. HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis. Tissue Antigens. 2009;73:569\u201374.","journal-title":"Tissue Antigens"},{"issue":"864\u2013871","key":"1280_CR23","first-page":"e1","volume":"141","author":"Y Okada","year":"2011","unstructured":"Okada Y, Yamazaki K, Umeno J, et al. HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn\u02bcs disease. Gastroenterology. 2011;141(864\u2013871):e1-871.e5.","journal-title":"Gastroenterology"},{"key":"1280_CR24","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1136\/gut.46.3.336","volume":"46","author":"EV Loftus Jr","year":"2000","unstructured":"Loftus EV Jr, Silverstein MD, Sandborn WJ, et al. Ulcerative colitis in Olmsted County, Minnesota, 1940\u20131993: incidence, prevalence, and survival. Gut. 2000;46:336\u201343.","journal-title":"Gut"},{"key":"1280_CR25","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/j.1572-0241.2001.03756.x","volume":"96","author":"CN Bernstein","year":"2001","unstructured":"Bernstein CN, Blanchard JF, Rawsthorne P, et al. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol. 2001;96:1116\u201322.","journal-title":"Am J Gastroenterol"},{"key":"1280_CR26","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0022-3468(84)80269-9","volume":"19","author":"LA Martinez-Frontanilla","year":"1984","unstructured":"Martinez-Frontanilla LA, Haase GM, Ernster JA, et al. Surgical complications in Henoch\u2013Sch\u00f6nlein purpura. J Pediatr Surg. 1984;19:434\u20136.","journal-title":"J Pediatr Surg"},{"key":"1280_CR27","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1016\/j.crohns.2012.05.001","volume":"7","author":"GT de Oliveira","year":"2013","unstructured":"de Oliveira GT, Martins SS, Deboni M, et al. Cutaneous vasculitis in ulcerative colitis mimicking Henoch\u2013Schonlein purpura. J Crohns Colitis. 2013;7:e69-73.","journal-title":"J Crohns Colitis"},{"key":"1280_CR28","doi-asserted-by":"publisher","first-page":"e12036","DOI":"10.1097\/MD.0000000000012036","volume":"97","author":"B Lu","year":"2018","unstructured":"Lu B, Niu LL, Xu XG, et al. Ulcerative colitis in an adult patient mimicking Henoch\u2013Sch\u00f6nlein purpura: a case report. Medicine (Baltimore). 2018;97:e12036.","journal-title":"Medicine (Baltimore)"},{"key":"1280_CR29","doi-asserted-by":"publisher","first-page":"E1333","DOI":"10.1055\/a-0977-2777","volume":"7","author":"K Kawasaki","year":"2019","unstructured":"Kawasaki K, Nakamura S, Esaki M, et al. Gastrointestinal involvement in patients with vasculitis: IgA vasculitis and eosinophilic granulomatosis with polyangiitis. Endosc Int Open. 2019;7:E1333\u201343.","journal-title":"Endosc Int Open"},{"key":"1280_CR30","doi-asserted-by":"publisher","first-page":"e15643","DOI":"10.1097\/MD.0000000000015643","volume":"98","author":"Y Han","year":"2019","unstructured":"Han Y, Jin SY, Kim DW, et al. Endoscopic and microscopic findings of gastrointestinal tract in Henoch\u2013Sch\u00f6nlein purpura: single institute experience with review of literature. Medicine (Baltimore). 2019;98:e15643.","journal-title":"Medicine (Baltimore)"},{"key":"1280_CR31","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.crohns.2013.09.016","volume":"7","author":"V Annese","year":"2013","unstructured":"Annese V, Daperno M, Rutter MD, et al. European evidence based consensus for endoscopy in inflammatory bowel disease. J Crohns Colitis. 2013;7:982\u20131018.","journal-title":"J Crohns Colitis"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-020-01280-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12328-020-01280-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-020-01280-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:30:59Z","timestamp":1613694659000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12328-020-01280-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,3]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["1280"],"URL":"https:\/\/doi.org\/10.1007\/s12328-020-01280-8","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,3]]},"assertion":[{"value":"11 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Jun Urushikubo, Shunichi Yanai, Shotaro Nakamura, Yosuke Toya, Kensuke Asakura, Takahiro Gonai, Makoto Eizuka, Noriyuki Uesugi, Tamotsu Sugai and Takayuki Matsumoto declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Informed consent was obtained from all patients for being included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}