{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:27:52Z","timestamp":1774592872004,"version":"3.50.1"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 37-year-old woman developed severe colitis with diffuse mucosal erythema and ulcerations throughout the entire colon after the 3rd vaccination of COVID-19. Stool culture was negative, and the pathological findings showed increased lymphoplasmacytic and neutrophilic infiltration in the colonic lamina propria, which were consistent with ulcerative colitis. After the treatment with anti-tumor necrosis factor-\u03b1 agent, the ulceration markedly improved with development of severe colonic stenosis, which was successfully dilated with endoscopic balloon dilation. In case of COVID-19 vaccination, it should be noted that vaccination could be a trigger for the onset of UC.<\/jats:p>","DOI":"10.1007\/s12328-024-01926-x","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:03:27Z","timestamp":1707815007000},"page":"447-450","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Severe ulcerative colitis induced by COVID-19 vaccination"],"prefix":"10.1007","volume":"17","author":[{"given":"Takashi","family":"Taida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1869-2135","authenticated-orcid":false,"given":"Jun","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Akizue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Okimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Matsusaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"issue":"12","key":"1926_CR1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.40364","volume":"4","author":"AL Beatty","year":"2021","unstructured":"Beatty AL, Peyser ND, Butcher XE, et al. Analysis of COVID-19 Vaccine Type and Adverse Effects Following Vaccination. JAMA Netw Open. 2021;4(12): e2140364.","journal-title":"JAMA Netw Open"},{"issue":"40","key":"1926_CR2","doi-asserted-by":"publisher","first-page":"5798","DOI":"10.1016\/j.vaccine.2022.08.036","volume":"40","author":"J Fraiman","year":"2022","unstructured":"Fraiman J, Erviti J, Jones M, et al. Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults. Vaccine. 2022;40(40):5798\u2013805.","journal-title":"Vaccine"},{"issue":"4","key":"1926_CR3","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/imm.13443","volume":"165","author":"Y Chen","year":"2022","unstructured":"Chen Y, Xu Z, Wang P, et al. New-onset autoimmune phenomena post-COVID-19 vaccination. Immunology. 2022;165(4):386\u2013401.","journal-title":"Immunology"},{"issue":"8","key":"1926_CR4","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1111\/1756-185X.14637","volume":"26","author":"HL Kuo","year":"2023","unstructured":"Kuo HL, Lin TY, Leong PY. Case report of new-onset ulcerative colitis after MVC-COVI1901 vaccine injection for SARS-CoV-2. Int J Rheum Dis. 2023;26(8):1594\u20138.","journal-title":"Int J Rheum Dis"},{"issue":"66","key":"1926_CR5","doi-asserted-by":"publisher","first-page":"eabl5344","DOI":"10.1126\/sciimmunol.abl5344","volume":"6","author":"G Guerrera","year":"2021","unstructured":"Guerrera G, Picozza M, D\u2019Orso S, et al. BNT162b2 vaccination induces durable SARS-CoV-2-specific T cells with a stem cell memory phenotype. Sci Immunol. 2021;6(66):eabl5344.","journal-title":"Sci Immunol."},{"issue":"10","key":"1926_CR6","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1093\/ibd\/izab302","volume":"28","author":"KN Weaver","year":"2022","unstructured":"Weaver KN, Zhang X, Dai X, et al. Impact of SARS-CoV-2 Vaccination on Inflammatory Bowel Disease Activity and Development of Vaccine-Related Adverse Events: Results From PREVENT-COVID. Inflamm Bowel Dis. 2022;28(10):1497\u2013505.","journal-title":"Inflamm Bowel Dis"},{"issue":"8","key":"1926_CR7","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.14309\/ajg.0000000000002205","volume":"118","author":"TR Card","year":"2023","unstructured":"Card TR, Nakafero G, Grainge MJ, et al. Is Vaccination Against COVID-19 Associated With Inflammatory Bowel Disease Flare? Self-Controlled Case Series Analysis Using the UK CPRD. Am J Gastroenterol. 2023;118(8):1388\u201394.","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"1926_CR8","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s00535-023-02029-z","volume":"58","author":"K Watanabe","year":"2023","unstructured":"Watanabe K, Nojima M, Nakase H, et al. Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study. J-COMBAT J Gastroenterol. 2023;58(10):1015\u201329.","journal-title":"J-COMBAT J Gastroenterol"},{"issue":"6","key":"1926_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab297","volume":"28","author":"Y Shimodaira","year":"2022","unstructured":"Shimodaira Y, Watanabe K, Takahashi S, et al. Inflammatory Bowel Disease Triggered by BNT162b2 mRNA Vaccination for SARS-CoV-2. Inflamm Bowel Dis. 2022;28(6): e75.","journal-title":"Inflamm Bowel Dis"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-024-01926-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-024-01926-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-024-01926-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T13:11:45Z","timestamp":1716642705000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-024-01926-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1926"],"URL":"https:\/\/doi.org\/10.1007\/s12328-024-01926-x","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"25 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human rights"}},{"value":"Informed consent was obtained from the patient described in the report.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}