{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:34:08Z","timestamp":1772120048811,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012330","name":"Okayama University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012330","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    -associated native-valve infective endocarditis is a rare disease that affects elderly patients with underlying risk factors such as diabetes mellitus, malignancy, and renal failure. Long-term use of calcium polystyrene sulfonate is a potential risk factor for gastrointestinal mucosal damage or even colorectal ulcers. Herein, we describe a fatal case of a 66-year-old Japanese man with diabetes mellitus and renal failure who was prescribed calcium polystyrene sulfonate (CPS) for 11\u00a0years and developed a CPS-induced rectal ulcer, leading to\n                    <jats:italic>E. coli<\/jats:italic>\n                    native-valve infective endocarditis. The patient was admitted to our hospital due to acute-onset impaired consciousness. As a result of the systemic investigation, he was diagnosed with\n                    <jats:italic>E. coli<\/jats:italic>\n                    bacteremia accompanied by multiple cerebral infarctions and an acute hemorrhagic rectal ulcer. Transesophageal echocardiography revealed a 20-mm vegetative structure on the mitral valve, resulting in a final diagnosis of\n                    <jats:italic>E. coli<\/jats:italic>\n                    -associated infective endocarditis. After rectal resection, mitral valve replacement surgery was performed; however, the patient died shortly after surgery. Pathological findings of the resected rectum showed deposition of a basophilic crystalline material suggesting the presence of CPS. Our case highlights the potential risk of colorectal ulcers in a long-term CPS user, which can trigger bacterial translocation and endocarditis as fatal complications.\n                  <\/jats:p>","DOI":"10.1007\/s12328-024-01949-4","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T17:40:13Z","timestamp":1711388413000},"page":"472-476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Calcium polystyrene sulfonate-induced rectal ulcer causing E. coli native-valve infective endocarditis"],"prefix":"10.1007","volume":"17","author":[{"given":"Shinnosuke","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideharu","family":"Hagiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoharu","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kou","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"1949_CR1","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1017\/S0950268816000613","volume":"144","author":"KB Laupland","year":"2016","unstructured":"Laupland KB, Pasquill K, Parfitt EC, et al. Burden of community-onset bloodstream infections, Western Interior, British Columbia, Canada. Epidemiol Infect. 2016;144:2440\u20136.","journal-title":"Epidemiol Infect"},{"key":"1949_CR2","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.01399-21","volume":"9","author":"T Kobayashi","year":"2021","unstructured":"Kobayashi T, Ikeda M, Okada Y, et al. Clinical and microbiological characteristics of recurrent Escherichia coli bacteremia. Microbiol Spectr. 2021;9: e0139921.","journal-title":"Microbiol Spectr"},{"key":"1949_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/s12872-018-0929-7","volume":"18","author":"N Akuzawa","year":"2018","unstructured":"Akuzawa N, Kurabayashi M. Native valve endocarditis due to Escherichia coli infection: a case report and review of the literature. BMC Cardiovasc Disord. 2018;18:195.","journal-title":"BMC Cardiovasc Disord"},{"key":"1949_CR4","doi-asserted-by":"publisher","first-page":"829","DOI":"10.7326\/0003-4819-147-12-200712180-00002","volume":"147","author":"S Morpeth","year":"2007","unstructured":"Morpeth S, Murdoch D, Cabell CH, et al. Non-HACEK gram-negative bacillus endocarditis. Ann Intern Med. 2007;147:829\u201335.","journal-title":"Ann Intern Med"},{"key":"1949_CR5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s10096-005-1379-6","volume":"24","author":"S Branger","year":"2005","unstructured":"Branger S, Casalta JP, Habib G, et al. Escherichia coli endocarditis: seven new cases in adults and review of the literature. Eur J Clin Microbiol Infect Dis. 2005;24:537\u201341.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"1949_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1469-0691.2006.01375.x","volume":"12","author":"R Micol","year":"2006","unstructured":"Micol R, Lortholary O, Jaureguy F, et al. Escherichia coli native valve endocarditis. Clin Microbiol Infect. 2006;12:401\u20133.","journal-title":"Clin Microbiol Infect"},{"key":"1949_CR7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1186\/s12879-021-06066-y","volume":"21","author":"MF Leonard","year":"2021","unstructured":"Leonard MF, Rodriguez-Villalobos H, Boisen N, et al. The causal relationship between O2:K7:H6 extra-intestinal pathogenic Escherichia coli (ExPEC) and native valve endocarditis: a case report. BMC Infect Dis. 2021;21:370.","journal-title":"BMC Infect Dis"},{"key":"1949_CR8","first-page":"217","volume":"21","author":"M Lupse","year":"2012","unstructured":"Lupse M, Flonta M, Straut M, et al. Recurrent Infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (E. coli) after therapeutic ERCP. J Gastrointestin Liver Dis. 2012;21:217\u20139.","journal-title":"J Gastrointestin Liver Dis"},{"key":"1949_CR9","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3393\/ac.2021.03.19","volume":"38","author":"S Piwchan","year":"2022","unstructured":"Piwchan S, Sripariwuth E, Sitthichaiyakul P. Calcium polystyrene sulfonate associated colonic mucosal injury-innocent bystander or pathogenic culprit? A case report and literature review. Ann Coloproctol. 2022;38:453\u20136.","journal-title":"Ann Coloproctol"},{"key":"1949_CR10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1056\/NEJMicm2205643","volume":"388","author":"RH Chan","year":"2023","unstructured":"Chan RH, Lin WH. Calcium polystyrene sulfonate-related colonic necrosis. N Engl J Med. 2023;388:164.","journal-title":"N Engl J Med"},{"key":"1949_CR11","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.3390\/cells9112481","volume":"9","author":"T Kim","year":"2020","unstructured":"Kim T, de Oliveira Silva Lautenschlager S, Ma Q, et al. Drug crystal-related gastrointestinal complications involve crystal-induced release of neutrophil and monocyte extracellular traps. Cells. 2020;9:2481.","journal-title":"Cells"},{"key":"1949_CR12","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1007\/s10620-011-1759-y","volume":"56","author":"CK Lin","year":"2011","unstructured":"Lin CK, Liang CC, Chang HT, et al. Acute hemorrhagic rectal ulcer: an important cause of lower gastrointestinal bleeding in the critically ill patients. Dig Dis Sci. 2011;56:3631\u20137.","journal-title":"Dig Dis Sci"},{"issue":"5","key":"1949_CR13","volume":"10","author":"C Vijayakumar","year":"2018","unstructured":"Vijayakumar C, Balagurunathan K, Prabhu R, et al. Stercoral ulcer not always indolent: a rare complication of fecal impaction. Cureus. 2018;10(5): e2613.","journal-title":"Cureus"},{"issue":"1","key":"1949_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12245-023-00578-x","volume":"17","author":"E Bae","year":"2024","unstructured":"Bae E, Tran J, Shah K. Stercoral colitis in the emergency department: a review of the literature. Int J Emerg Med. 2024;17(1):3.","journal-title":"Int J Emerg Med"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-024-01949-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-024-01949-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-024-01949-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T09:13:37Z","timestamp":1716628417000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-024-01949-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["1949"],"URL":"https:\/\/doi.org\/10.1007\/s12328-024-01949-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3090674\/v1","asserted-by":"object"}]},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]},"assertion":[{"value":"6 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No authors have any competing interests in this case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This case report is the author\u2019s original work and has not been previously published elsewhere.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Informed consent was obtained from the daughter of the patient for the publication of our information and images because the patient was deceased.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}