{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:30:20Z","timestamp":1787653820743,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003790","name":"Hiroshima University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003790","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>A 70-year-old woman presented to our hospital with abdominal pain. Imaging examinations showed diffuse and extensive wall thickening at the perihilar bile duct; however, the degree of stricture was mild, and the mucosal epithelium was smooth. A transpapillary biopsy was performed considering cholangiocarcinoma and IgG4 sclerosing cholangitis as differential diagnoses; however, no pathologic diagnosis was obtained. Peroral cholangioscopy revealed a regular epithelium at the stricture, and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the enlarged lymph node confirmed the diagnosis of diffuse large B-cell lymphoma. Multiagent chemotherapy was administered, which led to complete remission. Because primary bile duct malignant lymphomas are rare and specific, clinical, and imaging findings are lacking, and many of those reported so far have been diagnosed by postoperative pathology. As chemotherapy is the first-line treatment for malignant lymphoma, obtaining an accurate diagnosis is crucial. Our findings support that smooth and mild biliary strictures with mainly submucosal wall thickening may be characteristic imaging findings of primary bile duct malignant lymphoma, and that peroral cholangioscopy and EUS-FNA may be helpful for an accurate diagnosis.<\/jats:p>","DOI":"10.1007\/s12328-024-02075-x","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T10:48:39Z","timestamp":1732963719000},"page":"176-182","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration"],"prefix":"10.1007","volume":"18","author":[{"given":"Noriaki","family":"Iijima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3545-8743","authenticated-orcid":false,"given":"Yasutaka","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Tatsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juri","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Arihiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"2075_CR1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000350051","volume":"87","author":"S Nakamura","year":"2013","unstructured":"Nakamura S, Matsumoto T. Gastrointestinal lymphoma: recent advances in diagnosis and treatment. Digestion. 2013;87:182\u20138.","journal-title":"Digestion"},{"key":"2075_CR2","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3748\/wjg.v28.i10.985","volume":"28","author":"T Okamoto","year":"2022","unstructured":"Okamoto T. Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer. World J Gastroenterol. 2022;28:985\u20131008.","journal-title":"World J Gastroenterol"},{"key":"2075_CR3","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s12328-022-01692-8","volume":"15","author":"M Sakashita","year":"2022","unstructured":"Sakashita M, Matsuda K, Omizo T, et al. Bile duct MALT lymphoma diagnosed with direct cholangioscopy: a case report. Clin J Gastroenterol. 2022;15:1145\u201350.","journal-title":"Clin J Gastroenterol"},{"key":"2075_CR4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.3346\/jkms.2009.24.5.956","volume":"24","author":"MA Yoon","year":"2009","unstructured":"Yoon MA, Lee JM, Kim SH, et al. Primary biliary lymphoma mimicking cholangiocarcinoma: a characteristic feature of discrepant CT and direct cholangiography findings. J Korean Med Sci. 2009;24:956\u20139.","journal-title":"J Korean Med Sci"},{"key":"2075_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.asjsur.2013.09.009","volume":"40","author":"A Zakaria","year":"2017","unstructured":"Zakaria A, Al-Obeidi S, Daradkeh S. Primary non-Hodgkin\u2019s lymphoma of the common bile duct: a case report and literature review. Asian J Surg. 2017;40:81\u20137.","journal-title":"Asian J Surg"},{"key":"2075_CR6","doi-asserted-by":"publisher","first-page":"e26110","DOI":"10.1097\/MD.0000000000026110","volume":"100","author":"J Wu","year":"2021","unstructured":"Wu J, Zhou Y, Li Q, et al. Primary biliary non-Hodgkin\u2019s lymphoma: a case report. Medicine. 2021;100:e26110.","journal-title":"Medicine"},{"key":"2075_CR7","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1007\/s11605-020-04569-8","volume":"24","author":"DL Wong","year":"2020","unstructured":"Wong DL, Deschner BW, King LC, et al. Primary diffuse large B cell lymphoma of the common bile duct. J Gastrointest Surg. 2020;24:2376\u20138.","journal-title":"J Gastrointest Surg"},{"key":"2075_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","volume":"103","author":"CP Hans","year":"2004","unstructured":"Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275\u201382.","journal-title":"Blood"},{"key":"2075_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0140-6736(03)13868-8","volume":"362","author":"LS Evans","year":"2003","unstructured":"Evans LS, Hancock BW. Non-Hodgkin lymphoma. Lancet. 2003;362:139\u201346.","journal-title":"Lancet"},{"key":"2075_CR10","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1002\/1097-0142(19821115)50:10<2218::AID-CNCR2820501041>3.0.CO;2-4","volume":"50","author":"GK Nguyen","year":"1982","unstructured":"Nguyen GK. Primary extranodal non-Hodgkin\u2019s lymphoma of the extrahepatic bile. Report of a case. Cancer. 1982;50:2218\u201322.","journal-title":"Cancer"},{"key":"2075_CR11","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2169\/internalmedicine.5429-20","volume":"60","author":"K Ohtsubo","year":"2021","unstructured":"Ohtsubo K, Yamashita K, Yanagimura N, et al. Multiple malignant lymphomas of the bile duct developing after spontaneous regression of an autoimmune pancreatitis-like Mass. Intern Med. 2021;60:409\u201315.","journal-title":"Intern Med"},{"key":"2075_CR12","doi-asserted-by":"publisher","first-page":"493","DOI":"10.2169\/internalmedicine.1776-23","volume":"63","author":"Y Imai","year":"2024","unstructured":"Imai Y, Sekine M, Aoyama K, et al. Primary bile duct diffuse large B-cell lymphoma diagnosed by repeated endoscopic ultrasound-guided fine-needle aspiration and endoscopic retrograde cholangiopancreatography. Intern Med. 2024;63:493\u2013501.","journal-title":"Intern Med"},{"key":"2075_CR13","first-page":"190","volume":"30","author":"C Durham","year":"2017","unstructured":"Durham C, Jaiswal D, Wong L. Bile duct lymphoma disguised as cholangiocarcinoma. Proc (Bayl Univ Med Cent). 2017;30:190\u20131.","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"2075_CR14","first-page":"843","volume":"24","author":"S Corbinais","year":"2000","unstructured":"Corbinais S, Caulet-Maugendre S, Pagenault M, et al. Primary T-cell lymphoma of the common bile duct. Gastroenterol Clin Biol. 2000;24:843\u20137 ((in French)).","journal-title":"Gastroenterol Clin Biol"},{"key":"2075_CR15","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1067\/S0039-6060(03)00149-1","volume":"134","author":"K Das","year":"2003","unstructured":"Das K, Fisher A, Wilson DJ, et al. Primary non-Hodgkin\u2019s lymphoma of the bile ducts mimicking cholangiocarcinoma. Surgery. 2003;134:496\u2013500.","journal-title":"Surgery"},{"key":"2075_CR16","doi-asserted-by":"crossref","unstructured":"Torrealba M, Berzosa M, Raijman I. Single-operator cholangioscopy for the diagnosis of bile duct lymphoma: a case report and brief review of the literature. Endoscopy. 2013;45 Supplement 2 UCTN:E359\u201360.","DOI":"10.1055\/s-0033-1344593"},{"key":"2075_CR17","first-page":"307","volume":"112","author":"R Ikuta","year":"2015","unstructured":"Ikuta R, Ueda M, Yamamoto T, et al. A case of obstructive jaundice caused by MALT lymphoma of the common bile duct and the papilla of Vater. Nihon Shokakibyo Gakkai Zasshi. 2015;112:307\u201316 ((in Japanese)).","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"2075_CR18","first-page":"345","volume":"117","author":"S Inoue","year":"2020","unstructured":"Inoue S, Takeda K, Okita M, et al. A case of mucosa-associated lymphoid tissue lymphoma of the bile duct diagnosed using intraductal ultrasonography and transpapillary investigation of the bile duct. Nihon Shokakibyo Gakkai Zasshi. 2020;117:345\u201353 ((in Japanese)).","journal-title":"Nihon Shokakibyo Gakkai Zasshi"},{"key":"2075_CR19","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3892\/mco.2022.2548","volume":"17","author":"N Pararas","year":"2022","unstructured":"Pararas N, Foukas PG, Pikoulis A, et al. Primary non-Hodgkin lymphoma of the extra-hepatic bile duct: a case report. Mol Clin Oncol. 2022;17:115.","journal-title":"Mol Clin Oncol"},{"key":"2075_CR20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s13691-015-0238-2","volume":"5","author":"H Kato","year":"2016","unstructured":"Kato H, Tsujie M, Wakasa T, et al. Primary diffuse large B cell lymphoma of the common bile duct causing obstructive jaundice. Int Canc Conf J. 2016;5:107\u201312.","journal-title":"Int Canc Conf J"},{"key":"2075_CR21","first-page":"45","volume":"52","author":"S Nakamura","year":"2017","unstructured":"Nakamura S, Yanai S, Kawasaki K, et al. Clinical classifications for diagnosis and treatment for gastric lymphomas. Stomach Intestine. 2017;52:45\u201352 ((in Japanese)).","journal-title":"Stomach Intestine"},{"key":"2075_CR22","first-page":"315","volume":"41","author":"S Ohhashi","year":"2006","unstructured":"Ohhashi S, Miyahara R, Matsuura T, et al. Stomach and intestine. 2006;41:315\u201322 ((in Japanese)).","journal-title":"Stomach and intestine"},{"key":"2075_CR23","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s12876-020-01429-2","volume":"20","author":"Y Ishii","year":"2020","unstructured":"Ishii Y, Serikawa M, Tsuboi T, et al. Usefulness of peroral cholangioscopy in the differential diagnosis of IgG4-related sclerosing cholangitis and extrahepatic cholangiocarcinoma: a single-center retrospective study. BMC Gastroenterol. 2020;20:287.","journal-title":"BMC Gastroenterol"},{"key":"2075_CR24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1055\/s-0032-1326631","volume":"45","author":"M Osanai","year":"2013","unstructured":"Osanai M, Itoi T, Igarashi Y, et al. Peroral video cholangioscopy to evaluate indeterminate bile duct lesions and preoperative mucosal cancerous extension: a prospective multicenter study. Endoscopy. 2013;45:635\u201342.","journal-title":"Endoscopy"},{"key":"2075_CR25","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s00535-012-0652-6","volume":"48","author":"T Itoi","year":"2013","unstructured":"Itoi T, Kamisawa T, Igarashi Y, et al. The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis. J Gastroenterol. 2013;48:504\u201314.","journal-title":"J Gastroenterol"},{"key":"2075_CR26","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.gie.2023.06.005","volume":"98","author":"LL Fujii-Lau","year":"2023","unstructured":"Fujii-Lau LL, Thosani NC, Al-Haddad M, et al. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: Summary and recommendations. Gastrointest Endosc. 2023;98:685\u201393.","journal-title":"Gastrointest Endosc"},{"key":"2075_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11894-020-00797-9","volume":"22","author":"NS Martinez","year":"2020","unstructured":"Martinez NS, Trindade AJ, Sejpal DV. Determining the indeterminate biliary stricture: Cholangioscopy and beyond. Curr Gastroenterol Rep. 2020;22:58.","journal-title":"Curr Gastroenterol Rep"},{"key":"2075_CR28","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1007\/s00535-009-0048-4","volume":"44","author":"O Nakahara","year":"2009","unstructured":"Nakahara O, Yamao K, Bhatia V, et al. Usefulness of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for undiagnosed intra-abdominal lymphadenopathy. J Gastroenterol. 2009;44:562\u20137.","journal-title":"J Gastroenterol"},{"key":"2075_CR29","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1136\/gutjnl-2011-301748","volume":"61","author":"SA Khan","year":"2012","unstructured":"Khan SA, Davidson BR, Goldin RD, et al. Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut. 2012;61:1657\u201369.","journal-title":"Gut"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-024-02075-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-024-02075-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-024-02075-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T13:16:42Z","timestamp":1738329402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-024-02075-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["2075"],"URL":"https:\/\/doi.org\/10.1007\/s12328-024-02075-x","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]},"assertion":[{"value":"18 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures were performed in accordance with the ethical standards of the 1964 Declaration of Helsinki and its amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human rights"}},{"value":"The patient presented in this case report provided informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}