{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T09:06:58Z","timestamp":1746004018296,"version":"3.40.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We describe a case of familial Mediterranean fever (FMF) with sigmoid colon stricture. The patient, a woman in her 30\u00a0s, had a 12-year history of ileocolitis-type Crohn\u2019s disease. The colonoscope could not pass because of the sigmoid colon stricture, and the patient was referred to our hospital with complaints of abdominal pain and fever. At 2-month postreferral, the patient presented with severe abdominal pain and fever. Computed tomography and intestinal ultrasonography revealed no bowel obstruction, whereas wall thickening was observed in the sigmoid colon and small bowel. Our medical interview revealed a cyclical nature to the symptoms. We diagnosed FMF and initiated colchicine. Subsequently, for more than 2\u00a0years, the patient remained asymptomatic, and the sigmoid colon stricture improved. FMF should be considered in patients with inflammatory bowel disease with periodic abdominal pain and fever.<\/jats:p>","DOI":"10.1007\/s12328-025-02095-1","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T12:28:46Z","timestamp":1736512126000},"page":"302-309","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Familial Mediterranean fever with sigmoid colon stricture"],"prefix":"10.1007","volume":"18","author":[{"given":"Yuki","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-2508","authenticated-orcid":false,"given":"Akira","family":"Madarame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakatsu","family":"Fukuzawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Ichimiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Morise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Muramastu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"2095_CR1","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s10067-017-3715-5","volume":"36","author":"M Alghamdi","year":"2017","unstructured":"Alghamdi M. Familial Mediterranean fever, review of the literature. Clin Rheumatol. 2017;36:1707\u201313.","journal-title":"Clin Rheumatol"},{"key":"2095_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/MD.0b013e318277cf75","volume":"91","author":"K Migita","year":"2012","unstructured":"Migita K, Uehara R, Nakamura Y, et al. Familial Mediterranean fever in Japan. Medicine. 2012;91:337\u201343.","journal-title":"Medicine"},{"key":"2095_CR3","doi-asserted-by":"publisher","first-page":"9584","DOI":"10.3390\/ijms24119584","volume":"24","author":"M Lancieri","year":"2023","unstructured":"Lancieri M, Bustaffa M, Palmeri S, et al. An update on familial Mediterranean fever. Int J Mol Sci. 2023;24:9584.","journal-title":"Int J Mol Sci"},{"key":"2095_CR4","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1097\/00005792-200211000-00001","volume":"81","author":"HH Fidder","year":"2002","unstructured":"Fidder HH, Chowers Y, Lidar M, et al. Crohn disease in patients with familial Mediterranean fever. Medicine. 2002;81:411\u20136.","journal-title":"Medicine"},{"key":"2095_CR5","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/S0140-6736(99)02134-0","volume":"355","author":"D Cattan","year":"2000","unstructured":"Cattan D, Notarnicola C, Molinari N, et al. Inflammatory bowel disease in non-Ashkenazi Jews with familial Mediterranean fever. Lancet. 2000;355:378\u20139.","journal-title":"Lancet"},{"key":"2095_CR6","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1016\/S0140-6736(12)61377-4","volume":"380","author":"S Arasawa","year":"2012","unstructured":"Arasawa S, Nakase H, Ozaki Y, et al. Mediterranean mimicker. Lancet. 2012;380:2052.","journal-title":"Lancet"},{"key":"2095_CR7","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40:1879\u201385.","journal-title":"Arthritis Rheum"},{"key":"2095_CR8","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1053\/j.gastro.2017.11.276","volume":"154","author":"D Sharma","year":"2018","unstructured":"Sharma D, Malik A, Guy C, et al. Pyrin inflammasome regulates tight junction integrity to restrict colitis and tumorigenesis. Gastroenterology. 2018;154:948\u201364.","journal-title":"Gastroenterology"},{"key":"2095_CR9","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/sj.ejhg.5200776","volume":"10","author":"R Gershoni-Baruch","year":"2002","unstructured":"Gershoni-Baruch R, Brik R, Shinawi M, et al. The differential contribution of MEFV mutant alleles to the clinical profile of familial Mediterranean fever. Eur J Hum Genet. 2002;10:145\u20139.","journal-title":"Eur J Hum Genet"},{"key":"2095_CR10","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/humu.9182","volume":"22","author":"D Tchernitchko","year":"2003","unstructured":"Tchernitchko D, Legendre M, Cazeneuve C, et al. The E148Q MEFV allele is not implicated in the development of familial Mediterranean fever. Hum Mutat. 2003;22:339\u201340.","journal-title":"Hum Mutat"},{"key":"2095_CR11","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s12328-021-01426-2","volume":"14","author":"Y Yokoyama","year":"2021","unstructured":"Yokoyama Y, Yamakawa T, Ichimiya T, et al. Gastrointestinal involvement in a patient with familial Mediterranean fever mimicking Crohn\u2019s disease: a case report. Clin J Gastroenterol. 2021;14:1103\u20137.","journal-title":"Clin J Gastroenterol"},{"key":"2095_CR12","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1159\/000502640","volume":"101","author":"D Saito","year":"2020","unstructured":"Saito D, Hibi N, Ozaki R, et al. MEFV gene-related enterocolitis account for some cases diagnosed as inflammatory bowel disease unclassified. Digestion. 2020;101:785\u201393.","journal-title":"Digestion"},{"key":"2095_CR13","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/den.12843","volume":"29","author":"M Esaki","year":"2017","unstructured":"Esaki M, Kawano S, Matsumoto T. Rare cause of duodenojejunal pseudopolyposis: report of a case of adult-onset familial Mediterranean fever. Dig Endosc. 2017;29:394\u20135.","journal-title":"Dig Endosc"},{"key":"2095_CR14","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3109\/00365521.2014.976838","volume":"49","author":"A Demir","year":"2014","unstructured":"Demir A, Akyuz F, Gokturk S, et al. Small bowel mucosal damagein familial Mediterranean fever: results of capsule endoscopy screening. Scand J Gastroenterol. 2014;49:1414\u20138.","journal-title":"Scand J Gastroenterol"},{"key":"2095_CR15","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1007\/s12328-021-01497-1","volume":"14","author":"Y Shibata","year":"2021","unstructured":"Shibata Y, Ishigami K, Kazama T, et al. Mediterranean fever gene-associated enterocolitis in an elderly Japanese woman. Clin J Gastroenterol. 2021;14:1661\u20136.","journal-title":"Clin J Gastroenterol"},{"key":"2095_CR16","first-page":"495","volume":"37","author":"B Limberg","year":"1999","unstructured":"Limberg B. Diagnosis of chronic inflammatory bowel disease by ultrasonography. Z Gastroenterol. 1999;37:495\u2013508.","journal-title":"Z Gastroenterol"},{"key":"2095_CR17","first-page":"234","volume":"13","author":"M Agin","year":"2018","unstructured":"Agin M, Tumgor G, Kont A, et al. Endoscopic findings in patients with familial Mediterranean fever and dyspeptic symptoms. Prz Gastroenterol. 2018;13:234\u201341.","journal-title":"Prz Gastroenterol"},{"key":"2095_CR18","doi-asserted-by":"publisher","first-page":"1288523","DOI":"10.3389\/fped.2023.1288523","volume":"11","author":"A Gayane","year":"2024","unstructured":"Gayane A, Tamara S, Artashes T, et al. Familial Mediterranean fever in Armenian children with inflammatory bowel disease. Front Pediatr. 2024;11:1288523.","journal-title":"Front Pediatr"},{"key":"2095_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105454","volume":"110","author":"H Nakase","year":"2024","unstructured":"Nakase H, Wagatsuma K, Kobayashi T, et al. Involvement of Mediterranean fever gene mutations in colchicine-responsive enterocolitis: a retrospective cohort study. EBioMedicine. 2024;110: 105454.","journal-title":"EBioMedicine"},{"key":"2095_CR20","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1111\/1756-185X.13396","volume":"21","author":"OA Gucenmez","year":"2018","unstructured":"Gucenmez OA, Kume T, Makay B, et al. Role of fecal calprotectinin the assessment of intestinal inflammation in children with familial Mediterranean fever. Int J Rheum Dis. 2018;21:1844\u20138.","journal-title":"Int J Rheum Dis"},{"key":"2095_CR21","doi-asserted-by":"publisher","first-page":"9982","DOI":"10.1073\/pnas.0602081103","volume":"103","author":"JC Jae","year":"2006","unstructured":"Jae JC, Geryl W, Seth LM, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci USA. 2006;103:9982\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2095_CR22","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1136\/gutjnl-2020-321731","volume":"70","author":"A Dominik","year":"2021","unstructured":"Dominik A, Maria Q, Soumya B, et al. Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance. Gut. 2021;70:1023\u201336.","journal-title":"Gut"},{"key":"2095_CR23","first-page":"79","volume":"15","author":"Z Zhuobin","year":"2005","unstructured":"Zhuobin Z, Akira A, Hirofumi Y, et al. Interleukin-1beta and tumor necrosis factor-alpha upregulate interleukin-23 subunit p19 gene expression in human colonic subepithelial myofibroblasts. Int J Mol Med. 2005;15:79\u201383.","journal-title":"Int J Mol Med"},{"key":"2095_CR24","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1093\/ecco-jcc\/jjad164","volume":"18","author":"S Weber","year":"2024","unstructured":"Weber S, Sitte S, Voegele AL, et al. NLRP3 inhibition leads to impaired mucosal fibroblast function in patients with inflammatory bowel diseases. J Crohns Colitis. 2024;18:446\u201361.","journal-title":"J Crohns Colitis"},{"key":"2095_CR25","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, P\u00e9trilli V, Mayor A, et al. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237\u201341.","journal-title":"Nature"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02095-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-025-02095-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02095-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T15:44:32Z","timestamp":1742399072000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-025-02095-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2095"],"URL":"https:\/\/doi.org\/10.1007\/s12328-025-02095-1","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"type":"print","value":"1865-7257"},{"type":"electronic","value":"1865-7265"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964, as revised in 2013.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human\/animal rights"}},{"value":"This study does not contain identifying information of the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}