{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T07:18:20Z","timestamp":1769930300641,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12328-025-02208-w","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:39:00Z","timestamp":1757687940000},"page":"1068-1073","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metachronous esophageal squamous cell carcinoma suspected as a second malignancy arising at the site of post-radiotherapy for esophageal adenocarcinoma"],"prefix":"10.1007","volume":"18","author":[{"given":"Hiroki","family":"Furusawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Nio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriho","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yamasita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"2208_CR1","unstructured":"The Global Cancer Observatory (GCO). Globocan 2022. https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/6-oesophagus-fact-sheet.pdf. Accessed 28 Apr 2024."},{"key":"2208_CR2","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1385\/IJGC:32:1:57","volume":"32","author":"S Dessureault","year":"2002","unstructured":"Dessureault S, Coppola D, Weitzner M, et al. Barrett\u2019s esophagus and squamous cell carcinoma in a patient with psychogenic vomiting. Int J Gastrointest Cancer. 2002;32:57\u201361.","journal-title":"Int J Gastrointest Cancer"},{"key":"2208_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s12328-010-0192-7","volume":"4","author":"Y Mishima","year":"2011","unstructured":"Mishima Y, Amano Y, Yuki T, et al. A rare case of Barrett\u2019s adenocarcinoma including squamous cell carcinoma component. Clin J Gastroenterol. 2011;4:5\u20139.","journal-title":"Clin J Gastroenterol"},{"key":"2208_CR4","first-page":"257","volume":"7","author":"I Maleki","year":"2015","unstructured":"Maleki I, Shekarriz R, Nosrati A, et al. Simultaneous esophageal squamous cell carcinoma and adenocarcinoma: a case report. Middle East J Dig Dis. 2015;7:257\u201360.","journal-title":"Middle East J Dig Dis"},{"key":"2208_CR5","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.2169\/internalmedicine.2722-19","volume":"58","author":"A Takeuchi","year":"2019","unstructured":"Takeuchi A, Hatta W, Koike T, et al. A primary Barrett\u2019s adenocarcinoma with a squamous cell carcinoma component. Intern Med. 2019;58:2467\u201372.","journal-title":"Intern Med"},{"key":"2208_CR6","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12328-016-0653-8","volume":"9","author":"T Yamazaki","year":"2016","unstructured":"Yamazaki T, Iwaya Y, Iwaya M, et al. A case of simultaneous esophageal squamous cell carcinoma and Barrett\u2019s adenocarcinoma. Clin J Gastroenterol. 2016;9:222\u20137.","journal-title":"Clin J Gastroenterol"},{"key":"2208_CR7","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1159\/000523774","volume":"30","author":"V Zimmer","year":"2022","unstructured":"Zimmer V, Bier B, Metzger M, et al. Two cancers in one Barrett\u2019s segment: first report of concurrent squamous cell carcinoma and adenocarcinoma. GE Port J Gastroenterol. 2022;30:316\u20138.","journal-title":"GE Port J Gastroenterol"},{"key":"2208_CR8","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1002\/cncr.29841","volume":"122","author":"SC Kamran","year":"2016","unstructured":"Kamran SC, de Gonzalez AB, Ng A, et al. Therapeutic radiation and the potential risk of second malignancies. Cancer. 2016;122:1809\u201321.","journal-title":"Cancer"},{"key":"2208_CR9","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/S0959-8049(97)00056-7","volume":"33","author":"R Epstein","year":"1997","unstructured":"Epstein R, Hanham I, Dale R. Radiotherapy-induced second cancers: are we doing enough to protect young patients? Eur J Cancer. 1997;33:526\u201330.","journal-title":"Eur J Cancer"},{"key":"2208_CR10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1046\/j.1442-2050.2000.00123.x","volume":"13","author":"F Wright","year":"2000","unstructured":"Wright F, Wasan S, Mercer CD. Radiation-induced esophageal squamous cell carcinoma in situ. Dis Esophagus. 2000;13:255\u20138.","journal-title":"Dis Esophagus"},{"key":"2208_CR11","doi-asserted-by":"publisher","first-page":"827","DOI":"10.5858\/arpa.2014-0111-RS","volume":"139","author":"D Murro","year":"2015","unstructured":"Murro D, Jakate S. Radiation esophagitis. Arch Pathol Lab Med. 2015;139:827\u201330.","journal-title":"Arch Pathol Lab Med"},{"key":"2208_CR12","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0016-5107(02)70436-7","volume":"56","author":"M Muto","year":"2002","unstructured":"Muto M, Hironaka S, Nakane M, et al. Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer. Gastrointest Endosc. 2002;56:517\u201321.","journal-title":"Gastrointest Endosc"},{"key":"2208_CR13","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10238-014-0301-x","volume":"15","author":"E Ojima","year":"2015","unstructured":"Ojima E, Fujimura T, Oyama K, et al. Chemoprevention of esophageal adenocarcinoma in a rat model by ursodeoxycholic acid. Clin Exp Med. 2015;15:343\u201350.","journal-title":"Clin Exp Med"},{"key":"2208_CR14","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1111\/cas.14105","volume":"110","author":"M Munemoto","year":"2019","unstructured":"Munemoto M, Mukaisho KI, Miyashita T, et al. Roles of the hexosamine biosynthetic pathway and pentose phosphate pathway in bile acid-induced cancer development. Cancer Sci. 2019;110:2408\u201320.","journal-title":"Cancer Sci"},{"key":"2208_CR15","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","author":"DE Dolmans","year":"2003","unstructured":"Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3:380\u20137.","journal-title":"Nat Rev Cancer"},{"key":"2208_CR16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrc1894","volume":"6","author":"AP Castano","year":"2006","unstructured":"Castano AP, Mroz P, Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer. 2006;6:535\u201345.","journal-title":"Nat Rev Cancer"},{"key":"2208_CR17","doi-asserted-by":"publisher","first-page":"20569","DOI":"10.1007\/s11356-018-2426-z","volume":"25","author":"X Yu","year":"2018","unstructured":"Yu X, Zheng H, Chan MTV, et al. Immune consequences induced by photodynamic therapy in non-melanoma skin cancers: a review. Environ Sci Pollut Res Int. 2018;25:20569\u201374.","journal-title":"Environ Sci Pollut Res Int"},{"key":"2208_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000469675","volume":"32","author":"S Kaneko","year":"2018","unstructured":"Kaneko S, Fujimoto S, Yamaguchi H, et al. Photodynamic therapy of malignant gliomas. Prog Neurol Surg. 2018;32:1\u201313.","journal-title":"Prog Neurol Surg"},{"key":"2208_CR19","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/lsm.22802","volume":"50","author":"S Hosokawa","year":"2018","unstructured":"Hosokawa S, Takebayashi S, Takahashi G, et al. Photodynamic therapy in patients with head and neck squamous cell carcinoma. Lasers Surg Med. 2018;50:420\u20136.","journal-title":"Lasers Surg Med"},{"key":"2208_CR20","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.euf.2018.08.005","volume":"4","author":"R Railkar","year":"2018","unstructured":"Railkar R, Agarwal PK. Photodynamic therapy in the treatment of bladder cancer: past challenges and current innovations. Eur Urol Focus. 2018;4:509\u201311.","journal-title":"Eur Urol Focus"},{"key":"2208_CR21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.5978\/islsm.16-OR-06","volume":"25","author":"T Oinuma","year":"2016","unstructured":"Oinuma T, Nakamura T, Nishiwaki Y. Report on the national survey of photodynamic therapy (PDT) for gastric cancer in Japan (a secondary publication). Laser Ther. 2016;25:87\u201398.","journal-title":"Laser Ther"},{"key":"2208_CR22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.pdpdt.2018.08.014","volume":"24","author":"Y Matoba","year":"2018","unstructured":"Matoba Y, Banno K, Kisu I, et al. Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: a review. Photodiagnosis Photodyn Ther. 2018;24:52\u20137.","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"2208_CR23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0169-5002(03)00242-3","volume":"42","author":"H Kato","year":"2003","unstructured":"Kato H, Furukawa K, Sato M, et al. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer. 2003;42:103\u201311.","journal-title":"Lung Cancer"},{"key":"2208_CR24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3171\/2013.7.JNS13415","volume":"119","author":"Y Muragaki","year":"2013","unstructured":"Muragaki Y, Akimoto J, Maruyama T, et al. Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors. J Neurosurg. 2013;119:845\u201352.","journal-title":"J Neurosurg"},{"key":"2208_CR25","doi-asserted-by":"publisher","first-page":"22135","DOI":"10.18632\/oncotarget.14029","volume":"8","author":"T Yano","year":"2017","unstructured":"Yano T, Kasai H, Horimatsu T, et al. A multicenter phase II study of salvage photodynamic therapy using talaporfin sodium (ME2906) and a diode laser (PNL6405EPG) for local failure after chemoradiotherapy or radiotherapy for esophageal cancer. Oncotarget. 2017;8:22135\u201344.","journal-title":"Oncotarget"},{"key":"2208_CR26","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10388-020-00799-6","volume":"18","author":"T Hayashi","year":"2021","unstructured":"Hayashi T, Asahina Y, Nakanishi H, et al. Evaluation of the efficacy and safety of salvage photodynamic therapy by talaporfin sodium for cervical esophageal cancers and lesions larger than 3 cm. Esophagus. 2021;18:645\u201354.","journal-title":"Esophagus"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02208-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-025-02208-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02208-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:46:33Z","timestamp":1763559993000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-025-02208-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2208"],"URL":"https:\/\/doi.org\/10.1007\/s12328-025-02208-w","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"3 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}