{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:50:37Z","timestamp":1763560237741,"version":"3.45.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eosinophilic infiltration of the esophageal muscular layer, known as eosinophilic esophageal myositis (EoEM), is an exceptionally rare condition that can mimic primary motility disorders such as achalasia. We present the case of a 72-year-old male with progressive dysphagia and significant weight loss, whose high-resolution manometry revealed findings consistent with achalasia, but with unusually elevated lower esophageal sphincter pressures. Surgical myotomy was performed and histopathological analysis unexpectedly revealed intense eosinophilic infiltration of the muscularis propria. The patient was treated with systemic corticosteroids, followed by topical budesonide, leading to partial and temporary clinical improvement. This case highlights eosinophilic esophageal myositis as a potential, but underrecognized differential diagnosis in patients with atypical achalasia features and treatment-refractory dysphagia.<\/jats:p>","DOI":"10.1007\/s12328-025-02209-9","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T04:28:49Z","timestamp":1756528129000},"page":"1074-1082","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilic esophageal myositis mimicking achalasia: a rare case of dysphagia with extreme LES pressures and histologic clarity"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8443-3494","authenticated-orcid":false,"given":"Matthias","family":"Hess","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aart","family":"Mookhoek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Lenglinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Heimgartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Borbely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"issue":"1","key":"2209_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.14309\/ajg.0000000000003194","volume":"120","author":"ES Dellon","year":"2025","unstructured":"Dellon ES, Muir AB, Katzka DA, Shah SC, Sauer BG, Aceves SS, et al. ACG clinical guideline: diagnosis and management of eosinophilic esophagitis. Am J Gastroenterol. 2025;120(1):31\u201359.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"2209_CR2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/ajg.2017.433","volume":"113","author":"Y Tang","year":"2018","unstructured":"Tang Y, Xiong W, Yu T, Wang M, Zhang G, Lin L. Eosinophilic esophageal myositis a plausible cause of histological changes of primary jackhammer esophagus: a case report. Am J Gastroenterol. 2018;113(1):150\u20132.","journal-title":"Am J Gastroenterol"},{"issue":"01","key":"2209_CR3","first-page":"E805-e6","volume":"56","author":"L Wang","year":"2024","unstructured":"Wang L, Yang GD, Pu K, Tao LP, Wang XF, Lin XM, et al. Eosinophilic esophageal myositis: a rare cause of dysphagia. 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Dupilumab is efficacious for eosinophilic esophagitis irrespective of prior swallowed budesonide or fluticasone, or prior treatments used alongside swallowed topical corticosteroids: results from the phase 3, randomized, placebo-controlled, LIBERTY EoE TREET trial. Expert Rev Gastroenterol Hepatol. 2025;19(2):197\u2013209.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"1","key":"2209_CR12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1053\/j.gastro.2019.09.042","volume":"158","author":"I Hirano","year":"2020","unstructured":"Hirano I, Dellon ES, Hamilton JD, Collins MH, Peterson K, Chehade M, et al. Efficacy of dupilumab in a phase 2 randomized trial of adults with active eosinophilic esophagitis. 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