{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:50:37Z","timestamp":1763560237757,"version":"3.45.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s12328-025-02215-x","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T02:34:52Z","timestamp":1757385292000},"page":"1095-1100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of Crohn\u2019s-disease-associated anal canal cancer with p53-positive dysplasia: suggesting insights to stepwise carcinogenesis"],"prefix":"10.1007","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6420-1109","authenticated-orcid":false,"given":"Kosuke","family":"Yoshimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Ohge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinnosuke","family":"Uegami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Watadani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Shimbara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Doi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Kuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"2215_CR1","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/ecco-jcc\/jjv141","volume":"9","author":"V Annese","year":"2015","unstructured":"Annese V, Beaugerie L, Egan L, et al. European evidence-based consensus: inflammatory bowel disease and malignancies. J Crohns Colitis. 2015;9:945\u201365.","journal-title":"J Crohns Colitis"},{"key":"2215_CR2","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/ibd.20036","volume":"13","author":"T Jess","year":"2007","unstructured":"Jess T, Riis L, Vind I, et al. Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen. Denmark Inflamm Bowel Dis. 2007;13:481\u20139.","journal-title":"Denmark Inflamm Bowel Dis"},{"key":"2215_CR3","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1111\/j.1365-2036.2006.02854.x","volume":"23","author":"C Canavan","year":"2006","unstructured":"Canavan C, Abrams KR, Mayberry J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn\u2019s disease. Aliment Pharmacol Ther. 2006;23:1097\u2013104.","journal-title":"Aliment Pharmacol Ther"},{"key":"2215_CR4","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/jgh.12189","volume":"28","author":"Y Yano","year":"2013","unstructured":"Yano Y, Matsui T, Hirai F, et al. Cancer risk in Japanese Crohn\u2019s disease patients: investigation of the standardized incidence ratio. J Gastroenterol Hepatol. 2013;28:1300.","journal-title":"J Gastroenterol Hepatol"},{"key":"2215_CR5","first-page":"3761","volume":"36","author":"D Higashi","year":"2016","unstructured":"Higashi D, Katsuno H, Kimura H, et al. Current state of and problems related to cancer of the intestinal tract associated with Crohn\u2019s disease in Japan. Anticancer Res. 2016;36:3761\u20136.","journal-title":"Anticancer Res"},{"key":"2215_CR6","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/j.1365-2559.2007.02663.x","volume":"50","author":"M Svrcek","year":"2007","unstructured":"Svrcek M, Cosnes J, Beaugerie L, et al. Colorectal neoplasia in Crohn\u2019s colitis: a retrospective comparative study with ulcerative colitis. Histopathology. 2007;50:574\u201383.","journal-title":"Histopathology"},{"key":"2215_CR7","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1136\/gut.48.4.526","volume":"48","author":"JA Eaden","year":"2001","unstructured":"Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001;48:526\u201335.","journal-title":"Gut"},{"key":"2215_CR8","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000321808","volume":"83","author":"H Tanaka","year":"2011","unstructured":"Tanaka H, Fukui H, Fujii S, et al. Immunohistochemical analysis of REG I\u03b1 expression in ulcerative colitis-associated neoplastic lesions. Digestion. 2011;83:204\u20139.","journal-title":"Digestion"},{"key":"2215_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061284","author":"K Kobayashi","year":"2017","unstructured":"Kobayashi K, Tomita H, Shimizu M, et al. P53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer. Int J Mol Sci. 2017. https:\/\/doi.org\/10.3390\/ijms18061284.","journal-title":"Int J Mol Sci"},{"key":"2215_CR10","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s12328-021-01431-5","volume":"14","author":"K Yoshimura","year":"2021","unstructured":"Yoshimura K, Ohge H, Uegami S, et al. Ulcerative colitis-associated rectal cancer resected and diagnosed by rectovesical fistula: a case report. Clin J Gastroenterol. 2021;14:1163\u20138.","journal-title":"Clin J Gastroenterol"},{"key":"2215_CR11","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.3748\/wjg.14.2662","volume":"14","author":"TL Zisman","year":"2008","unstructured":"Zisman TL, Rubin DT. Colorectal cancer and dysplasia in inflammatory bowel disease. World J Gastroenterol. 2008;14:2662\u20139.","journal-title":"World J Gastroenterol"},{"key":"2215_CR12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","volume":"395","author":"O Ol\u00e9n","year":"2020","unstructured":"Ol\u00e9n O, Erichsen R, Sachs MC, et al. Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study. Lancet. 2020;395:123\u201331.","journal-title":"Lancet"},{"key":"2215_CR13","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/S2468-1253(20)30005-4","volume":"5","author":"O Ol\u00e9n","year":"2020","unstructured":"Ol\u00e9n O, Erichsen R, Sachs MC, et al. Colorectal cancer in Crohn\u2019s disease: a Scandinavian population-based cohort study. Lancet Gastroenterol Hepatol. 2020;5:475\u201384.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2215_CR14","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s10620-007-9886-1","volume":"53","author":"JW Nathanson","year":"2008","unstructured":"Nathanson JW, Yadron NE, Farnan J, et al. P53 mutations are associated with dysplasia and progression of dysplasia in patients with Crohn\u2019s disease. Dig Dis Sci. 2008;53:474\u201380.","journal-title":"Dig Dis Sci"},{"key":"2215_CR15","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/jgh.16496","volume":"39","author":"M Uchino","year":"2024","unstructured":"Uchino M, Ikeuchi H, Noguchi T, et al. Histological differentiation between sporadic and colitis-associated intestinal cancer in a nationwide study: a propensity-score-matched analysis. J Gastroenterol Hepatol. 2024;39:893\u2013901.","journal-title":"J Gastroenterol Hepatol"},{"key":"2215_CR16","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/BF02238010","volume":"43","author":"MH Whiteford","year":"2000","unstructured":"Whiteford MH, Whiteford HM, Yee LF, et al. Usefulness of FDG-PET scan in the assessment of suspected metastatic or recurrent adenocarcinoma of the colon and rectum. Dis Colon Rectum. 2000;43:759\u201367.","journal-title":"Dis Colon Rectum"},{"key":"2215_CR17","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/j.1463-1318.2010.02241.x","volume":"13","author":"M Oua\u00efssi","year":"2011","unstructured":"Oua\u00efssi M, Maggiori L, Alves A, et al. Colorectal cancer complicating inflammatory bowel disease: a comparative study of Crohn\u2019s disease vs ulcerative colitis in 34 patients. Colorectal Dis. 2011;13:684\u20138.","journal-title":"Colorectal Dis"},{"key":"2215_CR18","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.14309\/ajg.0000000000002269","volume":"118","author":"T Ogino","year":"2023","unstructured":"Ogino T, Mizushima T, Fujii M, et al. Crohn\u2019s disease-associated anorectal cancer has a poor prognosis with high local recurrence: a subanalysis of the nationwide Japanese study. Am J Gastroenterol. 2023;118:1626\u201337.","journal-title":"Am J Gastroenterol"},{"key":"2215_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00535-022-01927-y","volume":"58","author":"T Noguchi","year":"2023","unstructured":"Noguchi T, Ishihara S, Uchino M, et al. Clinical features and oncological outcomes of intestinal cancers associated with ulcerative colitis and Crohn\u2019s disease. J Gastroenterol. 2023;58:14\u201324.","journal-title":"J Gastroenterol"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02215-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-025-02215-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02215-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:46:35Z","timestamp":1763559995000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-025-02215-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2215"],"URL":"https:\/\/doi.org\/10.1007\/s12328-025-02215-x","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"type":"print","value":"1865-7257"},{"type":"electronic","value":"1865-7265"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"25 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human\/animal rights"}},{"value":"Oral informed consent was obtained from the patient for publication of this report and the accompanying images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}