{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:27:01Z","timestamp":1771666021997,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s12328-025-02262-4","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T07:34:54Z","timestamp":1765352094000},"page":"265-273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of dramatic response to pembrolizumab monotherapy in dMMR unresectable colorectal cancer diagnosed following abdominal hemorrhage due to segmental arterial mediolysis"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-6441","authenticated-orcid":false,"given":"Takashi","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsei","family":"Yumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ofuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rin","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Iwatsuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"2262_CR1","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1038\/nm.4191","volume":"22","author":"RJ Hause","year":"2016","unstructured":"Hause RJ, Pritchard CC, Shendure J, et al. Classification and characterization of microsatellite instability across 18 cancer types. Nat Med. 2016;22:1342\u201350.","journal-title":"Nat Med"},{"key":"2262_CR2","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1053\/j.gastro.2009.12.064","volume":"138","author":"CR Boland","year":"2010","unstructured":"Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology. 2010;138:2073\u2013e873.","journal-title":"Gastroenterology"},{"key":"2262_CR3","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","volume":"372","author":"DT Le","year":"2015","unstructured":"Le DT, Uram JN, Wang H, et al. PD-1 Blockade in tumors with Mismatch-Repair deficiency. N Engl J Med. 2015;372:2509\u201320.","journal-title":"N Engl J Med"},{"key":"2262_CR4","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1056\/NEJMoa2017699","volume":"383","author":"T Andre","year":"2020","unstructured":"Andre T, Shiu KK, Kim TW, et al. Pembrolizumab in Microsatellite-Instability-High advanced colorectal cancer. N Engl J Med. 2020;383:2207\u201318.","journal-title":"N Engl J Med"},{"key":"2262_CR5","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1200\/JCO.2017.76.9901","volume":"36","author":"MJ Overman","year":"2018","unstructured":"Overman MJ, Lonardi S, Wong KYM, et al. Durable clinical benefit with nivolumab plus ipilimumab in DNA mismatch Repair-Deficient\/Microsatellite Instability-High metastatic colorectal cancer. J Clin Oncol. 2018;36:773\u20139.","journal-title":"J Clin Oncol"},{"key":"2262_CR6","first-page":"14","volume":"4","author":"Y Schwitalle","year":"2004","unstructured":"Schwitalle Y, Linnebacher M, Ripberger E, et al. Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells. Cancer Immun. 2004;4:14.","journal-title":"Cancer Immun"},{"key":"2262_CR7","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.trecan.2018.01.001","volume":"4","author":"R Salgia","year":"2018","unstructured":"Salgia R, Kulkarni P. The Genetic\/Non-genetic duality of drug \u2018Resistance\u2019 in cancer. Trends Cancer. 2018;4:110\u20138.","journal-title":"Trends Cancer"},{"key":"2262_CR8","doi-asserted-by":"publisher","first-page":"7168","DOI":"10.1158\/0008-5472.CAN-14-2458","volume":"74","author":"CY Slaney","year":"2014","unstructured":"Slaney CY, Kershaw MH, Darcy PK. Trafficking of T cells into tumors. Cancer Res. 2014;74:7168\u201374.","journal-title":"Cancer Res"},{"key":"2262_CR9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.immuni.2013.07.005","volume":"39","author":"GT Motz","year":"2013","unstructured":"Motz GT, Coukos G. Deciphering and reversing tumor immune suppression. Immunity. 2013;39:61\u201373.","journal-title":"Immunity"},{"key":"2262_CR10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.immuni.2013.06.014","volume":"39","author":"L Zitvogel","year":"2013","unstructured":"Zitvogel L, Galluzzi L, Smyth MJ, et al. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39:74\u201388.","journal-title":"Immunity"},{"key":"2262_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1056\/NEJMoa1001294","volume":"363","author":"PW Kantoff","year":"2010","unstructured":"Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411\u201322.","journal-title":"N Engl J Med"},{"key":"2262_CR12","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1126\/science.aar4060","volume":"359","author":"A Ribas","year":"2018","unstructured":"Ribas A, Wolchok JD. Cancer immunotherapy using checkpoint Blockade. Science. 2018;359:1350\u20135.","journal-title":"Science"},{"key":"2262_CR13","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1126\/science.aaa8172","volume":"348","author":"P Sharma","year":"2015","unstructured":"Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348:56\u201361.","journal-title":"Science"},{"key":"2262_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","volume":"39","author":"DS Chen","year":"2013","unstructured":"Chen DS, Mellman I. Oncology Meets immunology: the cancer-immunity cycle. Immunity. 2013;39:1\u201310.","journal-title":"Immunity"},{"key":"2262_CR15","doi-asserted-by":"publisher","first-page":"385","DOI":"10.4049\/jimmunol.1701302","volume":"200","author":"OJ Finn","year":"2018","unstructured":"Finn OJ. A believer\u2019s overview of cancer immunosurveillance and immunotherapy. J Immunol. 2018;200:385\u201391.","journal-title":"J Immunol"},{"key":"2262_CR16","doi-asserted-by":"publisher","first-page":"12293","DOI":"10.1073\/pnas.192461099","volume":"99","author":"Y Iwai","year":"2002","unstructured":"Iwai Y, Ishida M, Tanaka Y, et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 Blockade. Proc Natl Acad Sci U S A. 2002;99:12293\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2262_CR17","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","volume":"366","author":"SL Topalian","year":"2012","unstructured":"Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443\u201354.","journal-title":"N Engl J Med"},{"key":"2262_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jns.2018.12.023","volume":"397","author":"E Delafosse","year":"2019","unstructured":"Delafosse E, Armengol G, Triquenot-Bagan A, et al. A case of segmental arterial mediolysis with widespread involvement of cranial and abdominal arteries. J Neurol Sci. 2019;397:81\u20133.","journal-title":"J Neurol Sci"},{"key":"2262_CR19","doi-asserted-by":"publisher","first-page":"e190035","DOI":"10.1148\/ryct.2019190035","volume":"1","author":"MA Winkler","year":"2019","unstructured":"Winkler MA, Kapoor H, Elashery AR, et al. Coronary artery involvement in segmental arterial mediolysis: A case report. Radiol Cardiothorac Imaging. 2019;1:e190035.","journal-title":"Radiol Cardiothorac Imaging"},{"key":"2262_CR20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1126\/science.aan6733","volume":"357","author":"DT Le","year":"2017","unstructured":"Le DT, Durham JN, Smith KN, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 Blockade. Science. 2017;357:409\u201313.","journal-title":"Science"},{"key":"2262_CR21","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S1470-2045(17)30422-9","volume":"18","author":"MJ Overman","year":"2017","unstructured":"Overman MJ, McDermott R, Leach JL, et al. Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study. Lancet Oncol. 2017;18:1182\u201391.","journal-title":"Lancet Oncol"},{"key":"2262_CR22","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/icvts\/ivx177","volume":"25","author":"J Lee","year":"2017","unstructured":"Lee J, Ahn HY. Spontaneous intra-abdominal haemorrhage due to segmental arterial mediolysis following oesophagocolojejunostomy. Interact Cardiovasc Thorac Surg. 2017;25:993\u20134.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2262_CR23","doi-asserted-by":"publisher","first-page":"109418","DOI":"10.1016\/j.ijscr.2024.109418","volume":"116","author":"T Hayama","year":"2024","unstructured":"Hayama T, Ochiai H, Nozawa K, et al. A case of rectal cancer complicated with segmental arterial mediolysis (SAM) safely treated with curative resection - A case report. Int J Surg Case Rep. 2024;116:109418.","journal-title":"Int J Surg Case Rep"},{"key":"2262_CR24","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.2147\/OTT.S298333","volume":"14","author":"J Yang","year":"2021","unstructured":"Yang J, Bi F, Gou H. Complete pathologic response after concurrent treatment with pembrolizumab and radiotherapy in metastatic colorectal cancer: A case report. Onco Targets Ther. 2021;14:2555\u201361.","journal-title":"Onco Targets Ther"},{"key":"2262_CR25","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.3390\/cancers17132233","volume":"17","author":"Y Shimada","year":"2025","unstructured":"Shimada Y, Nakano M, Matsumoto A et al. Discordance between radiological and pathological responses to pembrolizumab in mismatch Repair-Deficient metastatic colorectal cancer: implications for precision oncology. Cancers (Basel). 2025;17:2233.","journal-title":"Cancers (Basel)"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02262-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-025-02262-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-025-02262-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:45:05Z","timestamp":1771663505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-025-02262-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2262"],"URL":"https:\/\/doi.org\/10.1007\/s12328-025-02262-4","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,10]]},"assertion":[{"value":"30 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no competing financial interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Patient Consent\n                      : Written informed consent was obtained from the patient for publication of this.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal on request.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}