{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:58:12Z","timestamp":1785466692089,"version":"3.56.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fk0210149"],"award-info":[{"award-number":["JP24fk0210149"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fk0210154"],"award-info":[{"award-number":["JP24fk0210154"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fk0210141"],"award-info":[{"award-number":["JP24fk0210141"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K11119"],"award-info":[{"award-number":["JP24K11119"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH23HC2002"],"award-info":[{"award-number":["JPMH23HC2002"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019385","name":"Kurume University","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100019385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s12328-026-02356-7","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:24:54Z","timestamp":1778077494000},"page":"902-908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid regression of advanced hepatic fibrosis in a patient with metabolic dysfunction-associated steatotic liver disease and severe obesity: a case report highlighting lifestyle-induced NETosis activation through serum proteomic analysis"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-1191","authenticated-orcid":false,"given":"Toru","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigemune","family":"Bekki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsutaka","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Amano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"2356_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2023.101182","volume":"29","author":"ADC Maldonado-Rojas","year":"2024","unstructured":"Maldonado-Rojas ADC, Zuarth-Vazquez JM, Uribe M, et al. Insulin resistance and Metabolic dysfunction-associated steatotic liver disease (MASLD): pathways of action of hypoglycemic agents. Ann Hepatol. 2024;29:101182.","journal-title":"Ann Hepatol"},{"key":"2356_CR2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jhep.2024.04.031","volume":"81","author":"European Association for the Study of the L","year":"2024","unstructured":"European Association for the Study of the L, European Association for the Study of D, European Association for the Study of O. EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). J Hepatol. 2024;81:492\u2013542.","journal-title":"J Hepatol"},{"key":"2356_CR3","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-024-00597-6","volume":"14","author":"D Simancas-Racines","year":"2025","unstructured":"Simancas-Racines D, Annunziata G, Verde L, et al. Nutritional strategies for battling obesity-linked liver disease: the role of medical nutritional therapy in metabolic dysfunction-associated steatotic liver disease (MASLD) management. Curr Obes Rep. 2025;14:7.","journal-title":"Curr Obes Rep"},{"issue":"2","key":"2356_CR4","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1053\/j.gastro.2015.04.005","volume":"149","author":"E Vilar-Gomez","year":"2015","unstructured":"Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015;149(2):367\u201378.","journal-title":"Gastroenterology"},{"key":"2356_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Z Younossi","year":"2018","unstructured":"Younossi Z, Anstee QM, Marietti M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15:11\u201320.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2356_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cmet.2017.08.002","volume":"27","author":"VT Samuel","year":"2018","unstructured":"Samuel VT, Shulman GI. Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases. Cell Metab. 2018;27:22\u201341.","journal-title":"Cell Metab"},{"key":"2356_CR7","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2017.74","volume":"14","author":"JP Mann","year":"2017","unstructured":"Mann JP, Anstee QM. NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD. Nat Rev Gastroenterol Hepatol. 2017;14:506\u20137.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2356_CR8","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/hepr.13670","volume":"51","author":"R Hashida","year":"2021","unstructured":"Hashida R, Matsuse H, Kawaguchi T, et al. Effects of a low-intensity resistance exercise program on serum miR-630, miR-5703, and fractalkine\/CX3CL1 expressions in subjects with no exercise habits: a preliminary study. Hepatol Res. 2021;51:823\u201333.","journal-title":"Hepatol Res"},{"key":"2356_CR9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/jgh3.12876","volume":"7","author":"R Hashida","year":"2023","unstructured":"Hashida R, Nakano D, Matsuse H, et al. A low-intensity 10-min resistance exercise program that ameliorated hepatic fibrosis indices and altered G-CSF\/IP-10\/PDGF-BB in a patient with nonalcoholic fatty liver disease: a case report. JGH Open. 2023;7:231\u20134.","journal-title":"JGH Open"},{"key":"2356_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/hep.23276","volume":"51","author":"K Promrat","year":"2010","unstructured":"Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51:121\u20139.","journal-title":"Hepatology"},{"key":"2356_CR11","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.14309\/ajg.0000000000002098","volume":"118","author":"JG Stine","year":"2023","unstructured":"Stine JG, DiJoseph K, Pattison Z, et al. Exercise training is associated with treatment response in liver fat content by magnetic resonance imaging independent of clinically significant body weight loss in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. Am J Gastroenterol. 2023;118:1204\u201313.","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"2356_CR12","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1053\/j.gastro.2015.04.014","volume":"149","author":"G Lassailly","year":"2015","unstructured":"Lassailly G, Caiazzo R, Buob D, Pigeyre M, Verkindt H, Labreuche J, et al. Bariatric surgery reduces features of nonalcoholic steatohepatitis in morbidly obese patients. Gastroenterology. 2015;149(2):379\u201388.","journal-title":"Gastroenterology"},{"key":"2356_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-67415-w","volume":"14","author":"L Nixdorf","year":"2024","unstructured":"Nixdorf L, Hartl L, Strohl S, et al. Rapid improvement of hepatic steatosis and liver stiffness after metabolic\/bariatric surgery: a prospective study. Sci Rep. 2024;14:17558.","journal-title":"Sci Rep"},{"key":"2356_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83782-0","volume":"11","author":"SY Liu","year":"2021","unstructured":"Liu SY, Wong VW, Wong SK, et al. A prospective 5-year study on the use of transient elastography to monitor the improvement of non-alcoholic fatty liver disease following bariatric surgery. Sci Rep. 2021;11:5416.","journal-title":"Sci Rep"},{"key":"2356_CR15","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nm.3547","volume":"20","author":"C Schauer","year":"2014","unstructured":"Schauer C, Janko C, Munoz LE, et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat Med. 2014;20:511\u20137.","journal-title":"Nat Med"},{"key":"2356_CR16","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","volume":"371","author":"J Wang","year":"2018","unstructured":"Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res. 2018;371:531\u20139.","journal-title":"Cell Tissue Res"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-026-02356-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-026-02356-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-026-02356-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:03:11Z","timestamp":1785463391000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-026-02356-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["2356"],"URL":"https:\/\/doi.org\/10.1007\/s12328-026-02356-7","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"21 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Takumi Kawaguchi received lecture fees from ASKA Pharmaceutical Co., Ltd., Taisho Pharmaceutical Co., Ltd., Kowa Company, Ltd., AbbVie GK., Eisai Co., Ltd., EA Pharma Co., Ltd., Nippon Boehringer Ingelheim Co., Ltd., Sumitomo Pharma Co., Ltd., Novo Nordisk Pharma Ltd., Otsuka Pharmaceutical Co., Ltd., Janssen Pharmaceutical K.K. The other authors state that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval of the research protocol: N\/A. Registry and the Registration No. of the study\/trial:\u202fN\/A. Animal Studies:\u202fN\/A.","order":2,"name":"Ethics","label":"Human and animal rights","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}