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One less common, though significant, complication of Kayexalate use is the formation of a malignancy-mimicking mass or pseudotumor. This presentation has been reported several times both within and outside of the gastrointestinal tract. Here we describe the case of a 65-year-old female presenting with a mass medial to the ascending colon with extension to the abdominal wall and adjacent bowel concerning for metastatic malignancy. Additionally, we review the current literature on Kayexalate associated pseudotumors and malignancy-mimicking masses.<\/jats:p>","DOI":"10.1007\/s12328-026-02371-8","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:11:17Z","timestamp":1779797477000},"page":"744-750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Malignancy-mimicking Kayexalate-associated extraintestinal mass and literature review"],"prefix":"10.1007","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6031-9269","authenticated-orcid":false,"given":"Jenna","family":"Magri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadi","family":"Hajar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Curran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"2371_CR1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S278812","author":"YH Wu","year":"2021","unstructured":"Wu YH, Chou JW, Lai HC, Su GS, Cheng KS, Chen TW. Adverse gastrointestinal effects with Kayexalate or Kalimate: a comprehensive review. Clin Exp Gastroenterol. 2021. https:\/\/doi.org\/10.2147\/CEG.S278812.","journal-title":"Clin Exp Gastroenterol"},{"key":"2371_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.016","author":"Z Harel","year":"2013","unstructured":"Harel Z, Harel S, Shah PS, Wald R, Perl J, Bell CM. Gastrointestinal adverse events with sodium polystyrene sulfonate (Kayexalate) use: a systematic review. Am J Med. 2013. https:\/\/doi.org\/10.1016\/j.amjmed.2012.08.016.","journal-title":"Am J Med"},{"key":"2371_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/jpps.2023.11892","author":"J Gruver","year":"2023","unstructured":"Gruver J, Al-Makki A, Shepler B. Therapeutic update on oral potassium exchange resin use in chronic kidney disease patients: a systematic review of randomized controlled clinical trials. 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Turk Patoloji Derg. 2019. https:\/\/doi.org\/10.5146\/tjpath.2018.01458.","journal-title":"Turk Patoloji Derg"},{"key":"2371_CR8","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8831814","author":"K Kumar","year":"2021","unstructured":"Kumar K, Patel H, Saad M, Baiomi A, Dev A. Kayexalate-induced esophageal ulceration in a patient with decompensated cirrhosis: a review of the literature. Case Rep Gastrointest Med. 2021. https:\/\/doi.org\/10.1155\/2021\/8831814.","journal-title":"Case Rep Gastrointest Med"},{"key":"2371_CR9","doi-asserted-by":"publisher","DOI":"10.55729\/2000-9666.1264","author":"A Jaan","year":"2023","unstructured":"Jaan A, Sarfraz Z, Malik S, Olson E, Dunnigan K, Okolo P. Unveiling the hazards: a case report on Kayexalate-induced colonic necrosis. J Community Hosp Intern Med Perspect. 2023. https:\/\/doi.org\/10.55729\/2000-9666.1264.","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"2371_CR10","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2020.1801322","author":"V Garcia Rodriguez","year":"2020","unstructured":"Garcia Rodriguez V, Grami Z, Laney J, Cai Z, Larson S. Esophageal necrosis associated with sodium polystyrene sulfonate (Kayexalate) use. Proc (Bayl Univ Med Cent). 2020. https:\/\/doi.org\/10.1080\/08998280.2020.1801322.","journal-title":"Proc (Bayl Univ Med Cent"},{"key":"2371_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2018.02.003","author":"L Piron","year":"2018","unstructured":"Piron L, Ramos J, Taourel P. Colonic perforation associated with sodium polystyrene sulfonate (Kayexalate) use. 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