{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:05:59Z","timestamp":1791378359133,"version":"4.3.2"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s12328-026-02399-w","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:17:43Z","timestamp":1784002663000},"page":"1092-1098","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenocarcinoma with enteroblastic differentiation with choriocarcinoma components arising in long-segment Barrett\u2019s esophagus: a report of autopsy case"],"prefix":"10.1007","volume":"19","author":[{"given":"Yuki","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-6435","authenticated-orcid":false,"given":"Kazushi","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Horikoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Masatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Osumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shosuke","family":"Hosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Ishiwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2399_CR1","doi-asserted-by":"publisher","first-page":"8203","DOI":"10.3748\/wjg.v22.i36.8203","volume":"22","author":"K Matsumoto","year":"2016","unstructured":"Matsumoto K, Ueyama H, Matsumoto K, Akazawa Y, Komori H, et al. Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation. World J Gastroenterol. 2016;22:8203\u201310.","journal-title":"World J Gastroenterol"},{"key":"2399_CR2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1007\/s10120-015-0497-9","volume":"19","author":"T Murakami","year":"2016","unstructured":"Murakami T, Yao T, Mitomi H, Morimoto T, Ueyama H, et al. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric Cancer. 2016;19:498\u2013507.","journal-title":"Gastric Cancer"},{"key":"2399_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.humpath.2018.04.022","volume":"78","author":"Y Akazawa","year":"2018","unstructured":"Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, et al. Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. Hum Pathol. 2018;78:79\u201388.","journal-title":"Hum Pathol"},{"key":"2399_CR4","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/1097-0142(19940201)73:3<534::AID-CNCR2820730307>3.0.CO;2-X","volume":"73","author":"H Matsunou","year":"1994","unstructured":"Matsunou H, Konishi F, Jalal RE, Yamamichi N, Mukawa A. Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. Cancer. 1994;73:534\u201340.","journal-title":"Cancer"},{"key":"2399_CR5","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1097\/PAS.0b013e3181d1dcdd","volume":"34","author":"T Ushiku","year":"2010","unstructured":"Ushiku T, Shinozaki A, Shibahara J, Iwasaki Y, Tateishi Y, et al. SALL4 represents fetal gut differentiation of gastric cancer, and is diagnostically useful in distinguishing hepatoid gastric carcinoma from hepatocellular carcinoma. Am J Surg Pathol. 2010;34:533\u201340.","journal-title":"Am J Surg Pathol"},{"key":"2399_CR6","doi-asserted-by":"publisher","first-page":"678","DOI":"10.51821\/84.4.022","volume":"84","author":"E Dias","year":"2021","unstructured":"Dias E, Santos-Antunes J, Nunes AC, Rodrigues JA, Pinheiro J, et al. Gastric adenocarcinoma with enteroblastic differentiation: an unexpected cause of upper gastrointestinal bleeding. Acta Gastroenterol Belg. 2021;84:678\u20139.","journal-title":"Acta Gastroenterol Belg"},{"key":"2399_CR7","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s12328-020-01115-6","volume":"13","author":"N Ikezawa","year":"2020","unstructured":"Ikezawa N, Tanaka S, Kaku H, Takao T, Morita Y, et al. Early gastric cancer involving a pure enteroblastic differentiation component that was curatively resected via endoscopic submucosal dissection. Clin J Gastroenterol. 2020;13:512\u20136.","journal-title":"Clin J Gastroenterol"},{"key":"2399_CR8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.15403\/jgld.2014.1121.262.gus","volume":"26","author":"R Gushima","year":"2017","unstructured":"Gushima R, Narita R, Shono T, Naoe H, Yao T, et al. Esophageal adenocarcinoma with enteroblastic differentiation arising in ectopic gastric mucosa in the cervical esophagus: a case report and literature review. J Gastrointest Liver Dis. 2017;26:193\u20137.","journal-title":"J Gastrointestin Liver Dis"},{"key":"2399_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ijscr.2015.07.009","volume":"14","author":"VF Martins","year":"2015","unstructured":"Martins VF, Moreno F, Vizcaino JR, Santos J. Primary gastric choriocarcinoma: a rare case. Int J Surg Case Rep. 2015;14:44\u20137.","journal-title":"Int J Surg Case Rep"},{"key":"2399_CR10","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1200\/JCO.2005.09.011","volume":"23","author":"DW Dye","year":"2005","unstructured":"Dye DW, Broadwater R, Lamps LW. Uncommon malignancies: case 2. Gastric choriocarcinoma. J Clin Oncol. 2005;23:6251\u20133.","journal-title":"J Clin Oncol"},{"key":"2399_CR11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1055\/a-1658-7554","volume":"54","author":"SN van Munster","year":"2022","unstructured":"van Munster SN, Verheij EPD, Nieuwenhuis EA, Offerhaus J, Meijer SL, et al. Extending treatment criteria for Barrett\u2019s neoplasia: results of a nationwide cohort of 138 endoscopic submucosal dissection procedures. Endoscopy. 2022;54:531\u201341.","journal-title":"Endoscopy"},{"key":"2399_CR12","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/BF00199396","volume":"427","author":"T Motoyama","year":"1995","unstructured":"Motoyama T, Higuchi M, Taguchi J. Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus. Virchows Arch. 1995;427:451\u20134.","journal-title":"Virchows Arch"},{"key":"2399_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s12328-023-01791-0","volume":"16","author":"K Sugawara","year":"2023","unstructured":"Sugawara K, Fukuda T, Kishimoto Y, Oka D, Kawashima Y, et al. Combined tubular adenocarcinoma, neuroendocrine carcinoma and adenocarcinoma with enteroblastic differentiation arising in Barrett esophagus. Clin J Gastroenterol. 2023;16:501\u20137.","journal-title":"Clin J Gastroenterol"},{"key":"2399_CR14","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/pin.12402","volume":"66","author":"K Mitsuma","year":"2016","unstructured":"Mitsuma K, Taniguchi H, Kishi Y, Hiraoka N. A case of adenocarcinoma with enteroblastic differentiation of the ampulla of Vater. Pathol Int. 2016;66:230\u20135.","journal-title":"Pathol Int"},{"key":"2399_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/his.13973","volume":"76","author":"T Murakami","year":"2020","unstructured":"Murakami T, Yao T, Yatagai N, Yamashiro Y, Saito T, et al. Colorectal adenocarcinoma with enteroblastic differentiation: a clinicopathological study of five cases. Histopathology. 2020;76:325\u201332.","journal-title":"Histopathology"},{"key":"2399_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4132\/jptm.2021.10.28","volume":"56","author":"E Abada","year":"2022","unstructured":"Abada E, Anaya IC, Abada O, Lebbos A, Beydoun R. Colorectal adenocarcinoma with enteroblastic differentiation: diagnostic challenges of a rare case encountered in clinical practice. J Pathol Transl Med. 2022;56:97\u2013102.","journal-title":"J Pathol Transl Med"},{"key":"2399_CR17","doi-asserted-by":"publisher","first-page":"926","DOI":"10.2169\/internalmedicine.43.926","volume":"43","author":"S Hirasaki","year":"2004","unstructured":"Hirasaki S, Tanimizu M, Tsuzuki T, Tsubouchi E, Hidaka S, et al. Seronegative alpha-fetoprotein-producing early gastric cancer treated with endoscopic mucosal resection and additional surgery. Intern Med. 2004;43:926\u201330.","journal-title":"Intern Med"},{"key":"2399_CR18","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.gie.2008.09.050","volume":"69","author":"T Horimatsu","year":"2009","unstructured":"Horimatsu T, Yano T, Doi T, Fujii S, Kaneko K. Complete resection of alpha-fetoprotein-producing early gastric cancer by using endoscopic submucosal dissection. Gastrointest Endosc. 2009;69:565\u20136.","journal-title":"Gastrointest Endosc"},{"key":"2399_CR19","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s12328-021-01356-z","volume":"14","author":"T Kato","year":"2021","unstructured":"Kato T, Hikichi T, Nakamura J, Takasumi M, Hashimoto M, et al. Two cases of gastric adenocarcinoma with enteroblastic differentiation resected by endoscopic submucosal dissection. Clin J Gastroenterol. 2021;14:736\u201344.","journal-title":"Clin J Gastroenterol"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-026-02399-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-026-02399-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-026-02399-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:43:19Z","timestamp":1791376999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12328-026-02399-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2399"],"URL":"https:\/\/doi.org\/10.1007\/s12328-026-02399-w","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"21 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"As this study is a single-case report, it was not approved by the Ethics Committee. Written informed consent was obtained from the family of deceased patient for the publication of this case report and any accompanying images. This study complied with the guidelines for human studies and was conducted in accordance with the World Medical Association Declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from the family member of deceased patient for the publication of this article.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}