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Among these subtypes, localized gastric AL amyloidosis is rare and associated with lymphoproliferative disorders. Here, we report a case of gastric mucosa-associated lymphoid tissue (MALT) lymphoma diagnosed during follow-up of localized gastric AL (\u03ba) amyloidosis. A 65-year-old woman who underwent periodic endoscopic screening was found to have a localized erythematous lesion with erosion in the lower gastric body. Histopathological examination revealed amyloid deposits. Although potassium permanganate treatment suggested AA amyloidosis, immunohistochemical analysis confirmed AL (\u03ba)-type amyloid. Systemic evaluation revealed no evidence of plasma cell dyscrasia, and localized gastric AL amyloidosis was diagnosed. After six months, the lesion regressed, but a newly identified discolored lesion was diagnosed as MALT lymphoma with plasmacytic differentiation. This case highlights the limitations of potassium permanganate-based amyloid typing and raises the possibility of an association between localized AL amyloidosis and lymphoproliferative disorders. These cases require careful endoscopic surveillance.<\/jats:p>","DOI":"10.1007\/s12328-026-02435-9","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:41:50Z","timestamp":1788529310000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric mucosa-associated lymphoid tissue lymphoma diagnosed following localized gastric AL amyloidosis"],"prefix":"10.1007","author":[{"given":"Mizuki","family":"Kameyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-5754","authenticated-orcid":false,"given":"Masaya","family":"Iwamuro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogen","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"2435_CR1","doi-asserted-by":"publisher","first-page":"917","DOI":"10.5858\/2007-131-917-TOAIRB","volume":"131","author":"AA Satoskar","year":"2007","unstructured":"Satoskar AA, Burdge K, Cowden DJ, Nadasdy GM, Hebert LA, Nadasdy T. 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