{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:49:41Z","timestamp":1792090181791,"version":"4.4.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin J Gastroenterol"],"DOI":"10.1007\/s12328-026-02466-2","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:03:27Z","timestamp":1792087407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colorectal neoplasia detected during colonoscopic surveillance in Li-Fraumeni syndrome: a retrospective case series"],"prefix":"10.1007","author":[{"given":"Akihiro","family":"Takagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-6971","authenticated-orcid":false,"given":"Masahiro","family":"Tajika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhito","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waki","family":"Hosoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Imoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"4","key":"2466_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1177\/1947601911413466","volume":"2","author":"D Malkin","year":"2011","unstructured":"Malkin D. Li-Fraumeni syndrome. Genes Cancer. 2011;2(4):475\u201384. https:\/\/doi.org\/10.1177\/1947601911413466.","journal-title":"Genes Cancer"},{"issue":"1","key":"2466_CR2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/CCO.0000000000000423","volume":"30","author":"A Amadou","year":"2018","unstructured":"Amadou A, Achatz MIW, Hainaut P. Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome. Curr Opin Oncol. 2018;30(1):23\u20139. https:\/\/doi.org\/10.1097\/CCO.0000000000000423.","journal-title":"Curr Opin Oncol"},{"issue":"1","key":"2466_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2023.100242","volume":"5","author":"KC de Andrade","year":"2024","unstructured":"de Andrade KC, Strande NT, Kim J, et al. Genome-first approach of the prevalence and cancer phenotypes of pathogenic or likely pathogenic germline TP53 variants. Hum Genet Genomics Adv. 2024;5(1):100242. https:\/\/doi.org\/10.1016\/j.xhgg.2023.100242.","journal-title":"Hum Genet Genomics Adv"},{"issue":"11","key":"2466_CR4","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1158\/1078-0432.CCR-17-0408","volume":"23","author":"CP Kratz","year":"2017","unstructured":"Kratz CP, Achatz MI, Brugieres L, et al. Cancer screening recommendations for individuals with Li-Fraumeni syndrome. Clin Cancer Res. 2017;23(11):e38\u201345. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-0408.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"2466_CR5","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1053\/j.gastro.2018.09.036","volume":"156","author":"SP MacFarland","year":"2019","unstructured":"MacFarland SP, Zelley K, Long JM, et al. Earlier colorectal cancer screening may be necessary in patients with Li-Fraumeni syndrome. Gastroenterology. 2019;156(1):273\u20134. https:\/\/doi.org\/10.1053\/j.gastro.2018.09.036.","journal-title":"Gastroenterology"},{"key":"2466_CR6","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1002\/cncr.30248","volume":"122","author":"PL Mai","year":"2016","unstructured":"Mai PL, Best AF, Peters JA, et al. Risks of first and subsequent cancers among TP53 mutation carriers in the NCI LFS cohort. Cancer. 2016;122:3673\u201381. https:\/\/doi.org\/10.1002\/cncr.30248.","journal-title":"Cancer"},{"issue":"1","key":"2466_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1053\/j.gastro.2005.10.014","volume":"130","author":"P Wong","year":"2006","unstructured":"Wong P, Verselis SJ, Garber JE, et al. Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome. Gastroenterol. 2006;130(1):73\u20139. https:\/\/doi.org\/10.1053\/j.gastro.2005.10.014.","journal-title":"Gastroenterol"},{"key":"2466_CR8","doi-asserted-by":"publisher","unstructured":"Daly MB, Pal T, Maxwell KN, Churpek J, Kohlmann W, AlHilli Z, Arun B, Buys SS, Cheng H, Domchek SM, Friedman S. 2023 NCCN Guidelines\u00ae insights: genetic\/familial high-risk assessment: breast, ovarian, and pancreatic, version 2.2024: featured updates to the NCCN guidelines. J National Comprehensive Cancer Net. 21(10):1000-10. https:\/\/doi.org\/10.6004\/jnccn.2023.0051","DOI":"10.6004\/jnccn.2023.0051"},{"key":"2466_CR9","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1038\/s41431-020-0638-4","volume":"28","author":"T Frebourg","year":"2020","unstructured":"Frebourg T, Bajalica Lagercrantz S, et al. Guidelines for the Li-Fraumeni and heritable TP53-related cancer syndromes. Eur J Hum Genet. 2020;28:1379\u201386. https:\/\/doi.org\/10.1038\/s41431-020-0638-4.","journal-title":"Eur J Hum Genet"},{"key":"2466_CR10","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S1470-2045(16)30249-2","volume":"17","author":"A Villani","year":"2016","unstructured":"Villani A, Shore A, Wasserman J, et al. Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 years follow-up of a prospective observational study. Lancet Oncol. 2016;17:1295\u2013305. https:\/\/doi.org\/10.1016\/S1470-2045(16)30249-2.","journal-title":"Lancet Oncol"},{"issue":"4","key":"2466_CR11","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1097\/CCO.0000000000000200","volume":"27","author":"ML Ballinger","year":"2015","unstructured":"Ballinger ML, Mitchell G, Thomas DM. Surveillance recommendations for patients with germline TP53 mutations. Curr Opin Oncol. 2015;27(4):332\u20137. https:\/\/doi.org\/10.1097\/CCO.0000000000000200.","journal-title":"Curr Opin Oncol"},{"issue":"10","key":"2466_CR12","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1158\/1078-0432.CCR-24-3301","volume":"31","author":"MI Achatz","year":"2025","unstructured":"Achatz MI, Villani A, Bertuch AA, et al. Update on cancer screening recommendations for individuals with Li-Fraumeni syndrome. Clin Cancer Res. 2025;31(10):1831\u201340.","journal-title":"Clin Cancer Res"},{"key":"2466_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2169\/internalmedicine.56.7274","volume":"56","author":"T Yoshida","year":"2017","unstructured":"Yoshida T, Tajika M, Tanaka T, et al. The features of colorectal tumors in a patient with Li-Fraumeni syndrome. Intern Med. 2017;56:295\u2013300. https:\/\/doi.org\/10.2169\/internalmedicine.56.7274.","journal-title":"Intern Med"},{"key":"2466_CR14","doi-asserted-by":"publisher","unstructured":"Spiegel SR, Orr C, Edgar NU, Cahill SR, Le AN, Good M, Lyman J, Feola S, Mehrhoff C, Naumer A, Vagher J. 2022 Colorectal neoplasia rates in Li Fraumeni syndrome. Official J American College Gastroenterol| ACG 10-4309 https:\/\/doi.org\/10.14309\/ajg.0000000000003976","DOI":"10.14309\/ajg.0000000000003976"},{"issue":"18","key":"2466_CR15","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1056\/NEJMoa054967","volume":"355","author":"J Regula","year":"2006","unstructured":"Regula J, Rupinski M, Kraszewska E, et al. Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med. 2006;355(18):1863\u201372. https:\/\/doi.org\/10.1056\/NEJMoa054967.","journal-title":"N Engl J Med"},{"issue":"1","key":"2466_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1470-2045(24)00600-4","volume":"26","author":"H Sung","year":"2025","unstructured":"Sung H, Siegel R, Laversanne M, et al. Colorectal cancer incidence trends in younger versus older adults: an analysis of population-based cancer registry data. Lancet Oncol. 2025;26(1):51\u201363. https:\/\/doi.org\/10.1016\/S1470-2045(24)00600-4.","journal-title":"Lancet Oncol"},{"issue":"12","key":"2466_CR17","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1136\/gutjnl-2019-319511","volume":"68","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Torre LA, Soerjomataram I, et al. Global patterns and trends in colorectal cancer incidence in young adults. Gut. 2019;68(12):2179\u201385. https:\/\/doi.org\/10.1136\/gutjnl-2019-319511.","journal-title":"Gut"},{"issue":"4","key":"2466_CR18","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1053\/j.gastro.2021.12.285","volume":"162","author":"PD Trivedi","year":"2022","unstructured":"Trivedi PD, Mohapatra A, Morris MK, et al. Prevalence and predictors of young-onset colorectal neoplasia: insights from a nationally representative colonoscopy registry. Gastroenterology. 2022;162(4):1136-46.e5. https:\/\/doi.org\/10.1053\/j.gastro.2021.12.285.","journal-title":"Gastroenterology"},{"key":"2466_CR19","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.2169\/internalmedicine.4945-24","volume":"64","author":"K Sekiguchi","year":"2025","unstructured":"Sekiguchi K, Motoo I, Ando T, et al. Early-onset colorectal cancer in a patient with Li-Fraumeni syndrome: a case series and literature review. Intern Med. 2025;64:3244\u201351. https:\/\/doi.org\/10.2169\/internalmedicine.4945-24.","journal-title":"Intern Med"},{"issue":"1","key":"2466_CR20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.cgh.2017.06.017","volume":"16","author":"W Rengifo-Cam","year":"2018","unstructured":"Rengifo-Cam W, Shepherd HM, Jasperson KW, et al. Colon pathology characteristics in Li-Fraumeni syndrome. Clin Gastroenterol Hepatol. 2018;16(1):140\u20131. https:\/\/doi.org\/10.1016\/j.cgh.2017.06.017.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2466_CR21","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1200\/JCO.2014.59.5728","volume":"33","author":"G Bougeard","year":"2015","unstructured":"Bougeard G, Renaux-Petel M, Flaman JM, et al. Revisiting Li-Fraumeni syndrome from TP53 mutation carriers. J Clin Oncol. 2015;33:2345\u201352. https:\/\/doi.org\/10.1200\/JCO.2014.59.5728.","journal-title":"J Clin Oncol"}],"container-title":["Clinical Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-026-02466-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-026-02466-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12328-026-02466-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:03:28Z","timestamp":1792087408000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12328-026-02466-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":21,"alternative-id":["2466"],"URL":"https:\/\/doi.org\/10.1007\/s12328-026-02466-2","relation":{},"ISSN":["1865-7257","1865-7265"],"issn-type":[{"value":"1865-7257","type":"print"},{"value":"1865-7265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]},"assertion":[{"value":"14 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).","order":2,"name":"Ethics","label":"Human rights","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The requirement for informed consent was waived due to the retrospective nature of the study and the use of anonymized clinical data. An opt-out procedure was provided for all eligible participants.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}]}}