{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:23:56Z","timestamp":1791386636035,"version":"4.3.3"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,10,15]],"date-time":"2011-10-15T00:00:00Z","timestamp":1318636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.0\/"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s12350-011-9460-2","type":"journal-article","created":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T16:16:08Z","timestamp":1318608968000},"page":"1066-1075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["High-resolution imaging of human atherosclerotic carotid plaques with micro18F-FDG PET scanning exploring plaque vulnerability"],"prefix":"10.1016","volume":"18","author":[{"given":"Marleen G.","family":"Masteling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark J.","family":"Zeebregts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 A.","family":"Tio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Cees","family":"Breek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe J.F.","family":"Tietge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Freark","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andor W.J.M.","family":"Glaudemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi A.J.O.","family":"Dierckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrikus H.","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riemer H.J.A.","family":"Slart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-011-9460-2_bib1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/STROKEAHA.108.521393","article-title":"Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: Reproducibility, partial volume correction, and correlation between methods","volume":"40","author":"Izquierdo-Garcia","year":"2009","journal-title":"Stroke"},{"key":"10.1007\/s12350-011-9460-2_bib2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1212\/01.wnl.0000176036.07558.82","article-title":"Carotid endarterectomy\u2014an evidence-based review: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology","volume":"65","author":"Chaturvedi","year":"2005","journal-title":"Neurology"},{"key":"10.1007\/s12350-011-9460-2_bib3","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.jvs.2008.07.011","article-title":"Current imaging modalities to visualize vulnerability within the atherosclerotic carotid plaque","volume":"48","author":"Wallis de Vries","year":"2008","journal-title":"J Vasc Surg"},{"key":"10.1007\/s12350-011-9460-2_bib4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00259-008-0947-2","article-title":"Emerging role of FDG-PET\/CT in assessing atherosclerosis in large arteries","volume":"36","author":"Chen","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-011-9460-2_bib5","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1161\/01.STR.29.8.1625","article-title":"Inflammation in high-grade carotid stenosis: A possible role for macrophages and T cells in plaque destabilization","volume":"29","author":"Jander","year":"1998","journal-title":"Stroke"},{"key":"10.1007\/s12350-011-9460-2_bib6","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jacc.2010.09.056","article-title":"Positron emission tomography measurement of periodontal (18)f-fluorodeoxyglucose uptake is associated with histologically determined carotid plaque inflammation","volume":"57","author":"Fifer","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-011-9460-2_bib7","first-page":"1245","article-title":"(18)F-FDG accumulation in atherosclerotic plaques: Immunohistochemical and PET imaging study","volume":"45","author":"Ogawa","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-011-9460-2_bib8","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1161\/01.CIR.0000020548.60110.76","article-title":"Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography","volume":"105","author":"Rudd","year":"2002","journal-title":"Circulation"},{"key":"10.1007\/s12350-011-9460-2_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCIMAGING.108.811752","article-title":"Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: A prospective fluorodeoxyglucose positron-emission tomography\/computed tomography imaging study","volume":"2","author":"Rudd","year":"2009","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-011-9460-2_bib10","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1148\/radiol.2293021168","article-title":"Fluorodeoxyglucose uptake in the aortic wall at PET\/CT: Possible finding for active atherosclerosis","volume":"229","author":"Tatsumi","year":"2003","journal-title":"Radiology"},{"key":"10.1007\/s12350-011-9460-2_bib11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.nuclcard.2005.03.002","article-title":"Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography","volume":"12","author":"Tawakol","year":"2005","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-011-9460-2_bib12","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/01.STR.0000190896.67743.b1","article-title":"Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging","volume":"36","author":"Davies","year":"2005","journal-title":"Stroke"},{"key":"10.1007\/s12350-011-9460-2_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejrad.2009.01.034","article-title":"PET\/SPECT imaging: From carotid vulnerability to brain viability","volume":"74","author":"Meerwaldt","year":"2010","journal-title":"Eur J Radiol"},{"key":"10.1007\/s12350-011-9460-2_bib14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00259-005-0005-2","article-title":"18F-FDG accumulation in atherosclerosis: Use of CT and MR co-registration of thoracic and carotid arteries","volume":"33","author":"Okane","year":"2006","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-011-9460-2_bib15","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2967\/jnumed.109.065151","article-title":"18F-FDG PET\/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease","volume":"50","author":"Rominger","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-011-9460-2_bib16","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.jacc.2006.11.046","article-title":"Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome","volume":"49","author":"Tahara","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-011-9460-2_bib17","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/eurheartj\/ehm245","article-title":"The prevalence of inflammation in carotid atherosclerosis: Analysis with fluorodeoxyglucose-positron emission tomography","volume":"28","author":"Tahara","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-011-9460-2_bib18","first-page":"455","article-title":"Performance evaluation of the microPET focus: A third-generation microPET scanner dedicated to animal imaging","volume":"46","author":"Tai","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-011-9460-2_bib19","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ejvs.2008.11.018","article-title":"Molecular pathology in vulnerable carotid plaques: Correlation with [18]-fluorodeoxyglucose positron emission tomography (FDG-PET)","volume":"37","author":"Graebe","year":"2009","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1007\/s12350-011-9460-2_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.atherosclerosis.2010.01.002","article-title":"FDG-PET imaging of atherosclerosis: Do we know what we see?","volume":"211","author":"Sheikine","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1007\/s12350-011-9460-2_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1056\/NEJM199108153250701","article-title":"Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis","volume":"325","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-011-9460-2_bib22","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(97)09292-1","article-title":"Randomised trial of endarterectomy for recently symptomatic carotid stenosis: Final results of the MRC European Carotid Surgery Trial (ECST)","volume":"351","year":"1998","journal-title":"Lancet"},{"key":"10.1007\/s12350-011-9460-2_bib23","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2214\/ajr.176.5.1761295","article-title":"Coronary artery calcium measurement: Agreement of multirow detector and electron beam CT","volume":"176","author":"Becker","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"10.1007\/s12350-011-9460-2_bib24","first-page":"235","article-title":"Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution","volume":"27","author":"Hamacher","year":"1986","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-011-9460-2_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jvs.2007.08.018","article-title":"Intraobserver and interobserver variability and spatial differences in histologic examination of carotid endarterectomy specimens","volume":"46","author":"Hellings","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.1007\/s12350-011-9460-2_bib26","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/j.jacc.2009.12.061","article-title":"Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: Ready for prime time?","volume":"55","author":"Rudd","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-011-9460-2_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jcmg.2010.01.001","article-title":"18FDG PET and ultrasound echolucency in carotid artery plaques","volume":"3","author":"Graebe","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-011-9460-2_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10554-009-9506-6","article-title":"FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis","volume":"26","author":"Davies","year":"2010","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1007\/s12350-011-9460-2_bib29","first-page":"531","article-title":"Glucose metabolism in lymphoid and inflammatory cells and tissues","volume":"10","author":"Calder","year":"2007","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1007\/s12350-011-9460-2_bib30","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1056\/NEJM200404013501425","article-title":"Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis","volume":"350","author":"Kietselaer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-011-9460-2_bib31","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.2741\/3457","article-title":"Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET","volume":"14","author":"Font","year":"2009","journal-title":"Front Biosci"},{"key":"10.1007\/s12350-011-9460-2_bib32","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.jacc.2006.05.076","article-title":"In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients","volume":"48","author":"Tawakol","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-011-9460-2_bib33","first-page":"1816","article-title":"Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET\/CT","volume":"45","author":"Ben-Haim","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-011-9460-2_bib34","first-page":"1278","article-title":"Association of vascular 18F-FDG uptake with vascular calcification","volume":"46","author":"Dunphy","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-011-9460-2_bib35","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1212\/01.wnl.0000314697.76580.cb","article-title":"Identifying vulnerable carotid plaques by noninvasive imaging","volume":"70","author":"Kwee","year":"2008","journal-title":"Neurology"},{"key":"10.1007\/s12350-011-9460-2_bib36","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00259-006-0159-6","article-title":"Non-specific binding of [18F]FDG to calcifications in atherosclerotic plaques: Experimental study of mouse and human arteries","volume":"33","author":"Laitinen","year":"2006","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-011-9460-2_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.atherosclerosis.2009.04.023","article-title":"Multimodality imaging of atherosclerotic plaque activity and composition using FDG-PET\/CT and MRI in carotid and femoral arteries","volume":"207","author":"Silvera","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1007\/s12350-011-9460-2_bib38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/MNM.0b013e328328bfc3","article-title":"Retrospective study of coronary uptake of 18F-fluorodeoxyglucose in association with calcification and coronary artery disease: A preliminary study","volume":"30","author":"Williams","year":"2009","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-011-9460-2_bib39","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.nuclcard.2006.07.008","article-title":"Changing patterns of abnormal vascular wall F-18 fluorodeoxyglucose uptake on follow-up PET\/CT studies","volume":"13","author":"Ben-Haim","year":"2006","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-011-9460-2_bib40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.nuclcard.2007.10.009","article-title":"Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events","volume":"15","author":"Paulmier","year":"2008","journal-title":"J Nucl Cardiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-011-9460-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-011-9460-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107135812304343X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107135812304343X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-011-9460-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-011-9460-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:52:30Z","timestamp":1761025950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107135812304343X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S107135812304343X"],"URL":"https:\/\/doi.org\/10.1007\/s12350-011-9460-2","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-resolution imaging of human atherosclerotic carotid plaques with micro18F-FDG PET scanning exploring plaque vulnerability","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-011-9460-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 THE AUTHORS. Published by ELSEVIER INC. on behalf of American Society of Nuclear Cardiology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}