{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:15:07Z","timestamp":1788869707205,"version":"build-2803163510"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s12350-013-9802-3","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T17:39:10Z","timestamp":1381945150000},"page":"1076-1085","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is regadenoson an appropriate stressor for MPI in patients with left bundle branch block or pacemakers?"],"prefix":"10.1016","volume":"20","author":[{"given":"Gregory S.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa R.","family":"Kinser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Kristy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Mahmarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-013-9802-3_bib1","unstructured":"Klocke FJ, Baird MG, Bateman TM, Messer JV, Berman DS, O'Gara PT, et al. 2003. ACC\/AHA\/ASNC guidelines for the clinical use of cardiac radionuclide imaging: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guideline (ACC\/AHA\/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Radionuclide Imaging). http:\/\/acc.org\/clinical\/guidelines\/radio\/rni_fulltext.pdf"},{"key":"10.1007\/s12350-013-9802-3_bib2","doi-asserted-by":"crossref","unstructured":"Henzlova MJ, Cerqueira MD, Mahmarian JJ, Yao SS. Stress protocols and tracers. J Nucl Cardiol 2009;16:63. www.asnc.org","DOI":"10.1007\/s12350-009-9062-4"},{"key":"10.1007\/s12350-013-9802-3_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.CIR.0000047041.66447.29","volume":"107","author":"Gibbons","year":"2003","journal-title":"Circulation"},{"key":"10.1007\/s12350-013-9802-3_bib4","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/0735-1097(93)90305-K","article-title":"Adenosine thallium-201 is superior to exercise thallium-201 for detecting coronary artery disease in patients with left bundle branch block","volume":"21","author":"O\u2019Keefe","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib5","first-page":"1479","article-title":"Thallium-201 SPECT in coronary artery disease patients with left bundle branch block","volume":"29","author":"Depuey","year":"1988","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-013-9802-3_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/00003072-200110000-00007","article-title":"Tc-99m sestamibi gated SPECT in patients with left bundle branch block","volume":"26","author":"Inanir","year":"2001","journal-title":"Clin Nucl Med"},{"key":"10.1007\/s12350-013-9802-3_bib7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0735-1097(97)82753-2","article-title":"Diagnosis of coronary artery disease by exercise thallium-201 tomography in patients with a right ventricular pacemaker","volume":"29","author":"Lakkis","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0735-1097(96)00586-4","article-title":"Long-term effect of right ventricular pacing on myocardial perfusion and function","volume":"29","author":"Tse","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib9","first-page":"424","article-title":"Dobutamine thallium-201 myocardial SPECT in patients with left bundle branch block and normal coronary arteries","volume":"38","author":"Caner","year":"1997","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-013-9802-3_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jcmg.2008.02.003","article-title":"Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective A2A agonist regadenoson versus adenosine in myocardial perfusion imaging","volume":"1","author":"Cerqueira","year":"2008","journal-title":"J Am Coll Cardiol Imaging"},{"key":"10.1007\/s12350-013-9802-3_bib11","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.nuclcard.2007.06.114","article-title":"Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: Results of the ADVANCE phase 3 multicenter international trial","volume":"14","author":"Iskandrian","year":"2007","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib12","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.jacc.2006.07.069","article-title":"A multinational study to establish the value of early adenosine technetium-99m sestamibi myocardial perfusion imaging in identifying a low-risk group for early hospital discharge after acute myocardial infarction","volume":"48","author":"Mahmarian","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib13","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jcmg.2009.04.011","article-title":"Regadenoson induces comparable left ventricular perfusion defects as adenosine: a quantitative analysis from the ADVANCE MPI 2 trial","volume":"2","author":"Mahmarian","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-013-9802-3_bib14","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0002-9149(99)80741-3","article-title":"High reproducibility of myocardial perfusion defects in patients undergoing serial exercise thallium-201 tomography","volume":"75","author":"Mahmarian","year":"1994","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib15","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1016\/j.jacc.2006.07.068","article-title":"An initial strategy of intensive medical therapy is comparable to that of coronary revascularization for suppression of scintigraphic ischemia in high risk but stable survivors of acute myocardial infarction","volume":"48","author":"Mahmarian","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s12350-011-9484-7","article-title":"Assessing risk in acute chest pain: The value of stress myocardial perfusion imaging in patients admitted through the emergency department","volume":"19","author":"Nabi","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0022-3565(24)29370-8","article-title":"Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: Inverse relationship between affinity and duration of action of A2A agonists","volume":"298","author":"Gao","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1007\/s12350-013-9802-3_bib18","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/S0960-894X(02)00609-1","article-title":"Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor","volume":"12","author":"Palle","year":"2002","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1007\/s12350-013-9802-3_bib19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/jpet.105.095323","article-title":"Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats","volume":"316","author":"Dhalla","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1007\/s12350-013-9802-3_bib20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.RES.61.6.779","article-title":"Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation","volume":"61","author":"Biaggioni","year":"1987","journal-title":"Circ Res"},{"key":"10.1007\/s12350-013-9802-3_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1476-5381.1986.tb10242.x","article-title":"Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine","volume":"88","author":"McQueen","year":"1986","journal-title":"Br J Pharmacol"},{"key":"10.1007\/s12350-013-9802-3_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(00)02314-3","article-title":"Differential expression of a(2a), A(1)-adenosine and D(2)-dopamine receptor genes in rat peripheral arterial chemoreceptors during postnatal development","volume":"872","author":"Gauda","year":"2000","journal-title":"Brain Res"},{"key":"10.1007\/s12350-013-9802-3_bib23","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4236\/wjcd.2013.32034","article-title":"Can regadenoson pharmacologic SPECT be performed effectively in patients with left bundle branch block or paced rhythm patients? A retrospective comparison to adenosine SPECT","volume":"3","author":"Palani","year":"2013","journal-title":"World J Cardiovasc Dis"},{"key":"10.1007\/s12350-013-9802-3_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1067\/mnc.2000.108030","article-title":"Treadmill exercise during adenosine infusion is safe, results in fewer adverse reactions, and improves myocardial perfusion image quality","volume":"7","author":"Thomas","year":"2000","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib25","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0002-9149(99)00323-9","article-title":"Impact of limited treadmill exercise on adenosine Tc-99m sestamibi single-photon emission computed tomographic myocardial perfusion imaging in coronary artery disease","volume":"84","author":"Jamil","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1071-3581(02)43236-9","article-title":"The impact of adjunctive adenosine infusion during exercise myocardial perfusion imaging: Results of the Both Exercise and Adenosine Stress Test (BEAST) trial","volume":"10","author":"Holly","year":"2003","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib27","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/0735-1097(95)00011-R","article-title":"Adenosine combined with dynamic exercise for myocardial perfusion imaging","volume":"25","author":"Pennell","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1067\/mnc.2002.119973","article-title":"Pharmacologic stress perfusion imaging with adenosine: role of simultaneous low-level treadmill exercise","volume":"9","author":"Samady","year":"2002","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12350-008-9001-9","article-title":"The RegEx trial: A randomized, double-blind, placebo- and active-controlled pilot study combining regadenoson, a selective A(2A) adenosine agonist, with low-level exercise, in patients undergoing myocardial perfusion imaging","volume":"16","author":"Thomas","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib30","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s12350-012-9562-5","article-title":"Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test","volume":"19","author":"Partington","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12350-012-9641-7","article-title":"A strategy of symptom-limited exercise with regadenoson-as-needed for stress myocardial perfusion imaging: A randomized controlled trial","volume":"20","author":"Parker","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12350-013-9679-1","article-title":"Safety and feasibility of adjunctive regadenoson injection at peak exercise during exercise myocardial perfusion imaging: The Both Exercise and Regadenoson Stress Test (BERST) trial","volume":"20","author":"Ross","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib33","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12350-013-9695-1","article-title":"Regadenoson and exercise myocardial perfusion imaging: The courtship continues","volume":"20","author":"Hundal","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s12350-012-9614-x","article-title":"Advanced hybrid stress testing: A potential new paradigm combining exercise and pharmacologic stress","volume":"19","author":"Thomas","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-013-9802-3_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ahj.2005.04.020","article-title":"Subgroup analyses in therapeutic cardiovascular clinical trials: Are most of them misleading?","volume":"151","author":"Hern\u00e1ndez","year":"2006","journal-title":"Am Heart J"},{"key":"10.1007\/s12350-013-9802-3_bib36","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0002-8703(98)70116-4","article-title":"Post hoc subgroup analysis and the truth of a clinical trial","volume":"136","author":"Adams","year":"1998","journal-title":"Am Heart J"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-013-9802-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-013-9802-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107135812303386X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107135812303386X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-013-9802-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:54:06Z","timestamp":1761026046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107135812303386X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S107135812303386X"],"URL":"https:\/\/doi.org\/10.1007\/s12350-013-9802-3","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is regadenoson an appropriate stressor for MPI in patients with left bundle branch block or pacemakers?","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-013-9802-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}