{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:21:43Z","timestamp":1761092503374,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s12350-014-9894-4","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T17:56:12Z","timestamp":1399571772000},"page":"921-924","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The \u201cgray zone\u201d for the heart to mediastinum MIBG uptake ratio"],"prefix":"10.1016","volume":"21","author":[{"given":"Mario","family":"Petretta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cuocolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-014-9894-4_bib1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/CIRCRESAHA.113.300308","article-title":"Adrenergic nervous system in heart failure: Pathophysiology and therapy","volume":"113","author":"Lymperopoulos","year":"2013","journal-title":"Circ Res"},{"key":"10.1007\/s12350-014-9894-4_bib2","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.jacc.2009.05.015","article-title":"The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications","volume":"54","author":"Triposkiadis","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-014-9894-4_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1152\/physrev.00007.2009","article-title":"Sympathetic nervous system overactivity and its role in the development of cardiovascular disease","volume":"90","author":"Malpas","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1007\/s12350-014-9894-4_bib4","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","article-title":"Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView myocardial imaging for risk evaluation in heart failure) study","volume":"55","author":"Jacobson","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-014-9894-4_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12350-008-9008-2","article-title":"123I-mIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: Design of two prospective multicenter international trials","volume":"16","author":"Jacobson","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9894-4_bib6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/jnci\/86.11.829","article-title":"Dangers of using \u201coptimal\u201d cutpoints in the evaluation of prognostic factors","volume":"86","author":"Altman","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1007\/s12350-014-9894-4_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/sim.2331","article-title":"Dichotomizing continuous predictors in multiple regression: A bad idea","volume":"25","author":"Royston","year":"2006","journal-title":"Stat Med"},{"key":"10.1007\/s12350-014-9894-4_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jacr.2006.02.021","article-title":"Receiver operating characteristic analysis: A tool for the quantitative evaluation of observer performance and imaging systems","volume":"3","author":"Metz","year":"2006","journal-title":"J Am Coll Radiol"},{"key":"10.1007\/s12350-014-9894-4_bib9","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/bimj.200410135","article-title":"Estimation of the Youden Index and its associated cutoff point","volume":"47","author":"Fluss","year":"2005","journal-title":"Biom J"},{"key":"10.1007\/s12350-014-9894-4_bib10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/0272989X12470757","article-title":"Evaluation of markers and risk prediction models: Overview of relationships between NRI and decision-analytic measures","volume":"33","author":"Van Calster","year":"2013","journal-title":"Med Decis Making"},{"key":"10.1007\/s12350-014-9894-4_bib11","doi-asserted-by":"crossref","unstructured":"Van Calster B, Steyerberg EW, D\u2019Agostino RB Sr., Pencina MJ. Sensitivity and specificity can change in opposite directions when new predictive markers are added to risk models. Med Decis Making. 2014;34:513-22.","DOI":"10.1177\/0272989X13513654"},{"key":"10.1007\/s12350-014-9894-4_bib12","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jcmg.2013.02.007","article-title":"A pooled analysis of multicenter cohort studies of (123)I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure","volume":"6","author":"Nakata","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-014-9894-4_bib13","first-page":"471","article-title":"Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure","volume":"33","author":"Merlet","year":"1992","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-014-9894-4_bib14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12350-012-9518-9","article-title":"Tracking a therapeutic response: How reliable are serial measurements of LV perfusion and function?","volume":"19","author":"Germano","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9894-4_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jcmg.2013.05.022","article-title":"Serial myocardial perfusion imaging: Defining a significant change and targeting management decisions","volume":"7","author":"Iskandrian","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-014-9894-4_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00007256-200030010-00001","article-title":"Measures of reliability in sports medicine and science","volume":"30","author":"Hopkins","year":"2000","journal-title":"Sports Med"},{"key":"10.1007\/s12350-014-9894-4_bib17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/uog.122","article-title":"Applying the right statistics: Analyses of measurement studies","volume":"22","author":"Bland","year":"2003","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1007\/s12350-014-9894-4_bib18","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1469-185X.2010.00141.x","article-title":"Repeatability for Gaussian and non-Gaussian data: A practical guide for biologists","volume":"85","author":"Nakagawa","year":"2010","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10.1007\/s12350-014-9894-4_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jclinepi.2010.03.002","article-title":"Guidelines for reporting reliability and agreement studies (GRRAS) were proposed","volume":"64","author":"Kottner","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"10.1007\/s12350-014-9894-4_bib20","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.theriogenology.2010.01.003","article-title":"Method agreement analysis: A review of correct methodology","volume":"73","author":"Watson","year":"2010","journal-title":"Theriogenology"},{"key":"10.1007\/s12350-014-9894-4_bib21","unstructured":"ClinicalTrials.gov Identifier: NCT01936649. A Phase 4, Open-label test-retest study to assess the reproducibility of quantitative measurements of myocardial uptake of AdreView\u2122 (Iobenguane I 123 Injection). http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01936649. Accessed February 26, 2014."},{"key":"10.1007\/s12350-014-9894-4_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1253\/circj.66.537","article-title":"Prognostic value of repeated 123I-metaiodobenzylguanidine imaging in patients with dilated cardiomyopathy with congestive heart failure before and after optimized treatments: Comparison with neurohumoral factors","volume":"66","author":"Matsui","year":"2002","journal-title":"Circ J"},{"key":"10.1007\/s12350-014-9894-4_bib23","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2967\/jnumed.107.047548","article-title":"Prognostic value of serial cardiac 123I-MIBG imaging in patients with stabilized chronic heart failure and reduced left ventricular ejection fraction","volume":"49","author":"Kasama","year":"2008","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-014-9894-4_bib24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jcmg.2009.10.008","article-title":"Myocardial sympathetic innervation and long-term left ventricular mechanical unloading","volume":"3","author":"Drakos","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-014-9894-4_bib25","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00259-012-2180-2","article-title":"Reproducibility of planar 123I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure","volume":"39","author":"Veltman","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9894-4_bib26","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00259-013-2461-4","article-title":"Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure","volume":"40","author":"Pellegrino","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9894-4_bib27","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jclinepi.2005.10.015","article-title":"When to use agreement versus reliability measures","volume":"59","author":"de Vet","year":"2006","journal-title":"J Clin Epidemiol"},{"key":"10.1007\/s12350-014-9894-4_bib28","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jcin.2012.10.014","article-title":"Fractional flow reserve-guided revascularization: Practical implications of a diagnostic gray zone and measurement variability on clinical decisions","volume":"6","author":"Petraco","year":"2013","journal-title":"JACC Cardiovasc Intervent"},{"key":"10.1007\/s12350-014-9894-4_bib29","doi-asserted-by":"crossref","unstructured":"Zhou Y, Zhou W, Folks RD, Manatunga DN, Jacobson AF, Bax JJ, et al. I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on eectrophysiology testing: A retrospective analysis. J Nucl Cardiol. doi:10.1007\/s12350-014-9911-7.","DOI":"10.1007\/s12350-014-9911-7"},{"key":"10.1007\/s12350-014-9894-4_bib30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1161\/CIRCHEARTFAILURE.112.000043","article-title":"Risk prediction models for mortality in ambulatory patients with heart failure: A systematic review","volume":"6","author":"Alba","year":"2013","journal-title":"Circ Heart Fail"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-014-9894-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-014-9894-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123073300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123073300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-014-9894-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:55:51Z","timestamp":1761026151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123073300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1071358123073300"],"URL":"https:\/\/doi.org\/10.1007\/s12350-014-9894-4","relation":{},"ISSN":["1071-3581"],"issn-type":[{"type":"print","value":"1071-3581"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The \u201cgray zone\u201d for the heart to mediastinum MIBG uptake ratio","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-014-9894-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}