{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:13:09Z","timestamp":1768590789126,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HL105787"],"award-info":[{"award-number":["K23HL105787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1007\/s12350-014-9943-z","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T18:25:20Z","timestamp":1404843920000},"page":"979-983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Quantification of I-123-meta-iodobenzylguanidine Heart-to-Mediastinum Ratios: Not So Simple After All"],"prefix":"10.1016","volume":"21","author":[{"given":"Piotr J.","family":"Slomka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puja K.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Germano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Berman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-014-9943-z_bib1","first-page":"e28","article-title":"Heart disease and stroke statistics\u20142014 update: A report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1007\/s12350-014-9943-z_bib2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cardfail.2010.04.004","article-title":"HFSA 2010 Comprehensive Heart Failure Practice Guideline","volume":"16","author":"Lindenfeld","year":"2010","journal-title":"J Card Fail."},{"key":"10.1007\/s12350-014-9943-z_bib3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2008.11.013","volume":"53","author":"Hunt","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jacc.2008.05.058","article-title":"A critical appraisal of implantable cardioverter-defibrillator therapy for the prevention of sudden cardiac death","volume":"52","author":"Tung","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib5","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1161\/CIRCULATIONAHA.104.526673","article-title":"Appropriate and inappropriate ventricular therapies, quality of life, and mortality among primary and secondary prevention implantable cardioverter defibrillator patients: Results from the Pacing Fast VT REduces Shock ThErapies (PainFREE Rx II) trial","volume":"111","author":"Sweeney","year":"2005","journal-title":"Circulation"},{"key":"10.1007\/s12350-014-9943-z_bib6","first-page":"I103","article-title":"Role of the sympathetic nervous system in the genesis of ventricular arrhythmia","volume":"82","author":"Podrid","year":"1990","journal-title":"Circulation"},{"key":"10.1007\/s12350-014-9943-z_bib7","first-page":"129","article-title":"Myocardial imaging in man with I-123 meta-iodobenzylguanidine","volume":"22","author":"Kline","year":"1981","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-014-9943-z_bib8","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","article-title":"Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study","volume":"55","author":"Jacobson","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib9","doi-asserted-by":"crossref","unstructured":"Nakajima K, Nakata T, Yamada T, Yamashina S, Momose M, Kasama S, et al. A prediction model for 5-year cardiac mortality in patients with chronic heart failure using I-metaiodobenzylguanidine imaging. Eur J Nucl Med Mol Imaging 2014. doi:10.1007\/s00259-014-2759-x","DOI":"10.1007\/s00259-014-2759-x"},{"key":"10.1007\/s12350-014-9943-z_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1067\/mnc.2003.2","article-title":"I-123 MIBG imaging and heart rate variability analysis to predict the need for an implantable cardioverter defibrillator","volume":"10","author":"Arora","year":"2003","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib11","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/j.jacc.2009.12.066","article-title":"Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients","volume":"55","author":"Boogers","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib12","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s00259-005-1810-3","article-title":"Influence of collimator choice and simulated clinical conditions on 123I-MIBG heart\/mediastinum ratios: A phantom study","volume":"32","author":"Verberne","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib13","doi-asserted-by":"crossref","first-page":"N307","DOI":"10.1088\/0031-9155\/51\/17\/N03","article-title":"Downscatter correction and choice of collimator in 123I imaging","volume":"51","author":"Small","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1007\/s12350-014-9943-z_bib14","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.nuclcard.2007.08.002","article-title":"Correction of iodine-123-labeled meta-iodobenzylguanidine uptake with multi-window methods for standardization of the heart-to-mediastinum ratio","volume":"14","author":"Nakajima","year":"2007","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib15","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00259-004-1495-z","article-title":"Scatter modelling and compensation in emission tomography","volume":"31","author":"Zaidi","year":"2004","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib16","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00259-010-1491-4","article-title":"Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology","volume":"37","author":"Flotats","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/MNM.0b013e3283375639","article-title":"I-123 MIBG cardiac uptake measurements: Limitations of collimator choice and scatter correction in the clinical context","volume":"31","author":"Fletcher","year":"2010","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-014-9943-z_bib18","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00259-007-0611-2","article-title":"Variations in 123I-metaiodobenzylguanidine (MIBG) late heart mediastinal ratios in chronic heart failure: A need for standardisation and validation","volume":"35","author":"Verberne","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12350-008-9008-2","article-title":"123I-mIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: Design of two prospective multicenter international trials","volume":"16","author":"Jacobson","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib20","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1007\/s00259-013-2461-4","article-title":"Observer reproducibility of results from a low-dose 123I-metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure","volume":"40","author":"Pellegrino","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib21","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00259-012-2180-2","article-title":"Reproducibility of planar (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy in patients with heart failure","volume":"39","author":"Veltman","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib22","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00259-012-2336-0","article-title":"Influence of myocardial region of interest definition on quantitative analysis of planar 123I-mIBG images","volume":"40","author":"Jacobson","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib23","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jcmg.2013.02.007","article-title":"A pooled analysis of multicenter cohort studies of (123)I-mIBG imaging of sympathetic innervation for assessment of long-term prognosis in heart failure","volume":"6","author":"Nakata","year":"2013","journal-title":"JACC Cardiovasc Imaging."},{"key":"10.1007\/s12350-014-9943-z_bib24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12350-011-9438-0","article-title":"Quantitative I-123 mIBG SPECT in differentiating abnormal and normal mIBG myocardial uptake","volume":"19","author":"Chen","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s12350-012-9539-4","article-title":"Assessment of global cardiac I-123 MIBG uptake and washout using volumetric quantification of SPECT acquisitions","volume":"19","author":"van der Veen","year":"2012","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib26","doi-asserted-by":"crossref","unstructured":"Nakajima K, Okuda K, Yoshimura M, Matsuo S, Wakabayashi H, Imanishi Y, et al. Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations. J Nucl Cardiol 2014. doi:10.1007\/s12350-014-9916-2","DOI":"10.1007\/s12350-014-9916-2"},{"key":"10.1007\/s12350-014-9943-z_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00259-011-1963-1","article-title":"Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: Effects of correction on normal databases and a multicentre study","volume":"39","author":"Nakajima","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-014-9943-z_bib28","unstructured":"Nakajima K. Distributution of H\/M ratios in the multicenter trial of MIBG. (personal communication) 2014."},{"key":"10.1007\/s12350-014-9943-z_bib29","doi-asserted-by":"crossref","unstructured":"Petretta M, Pellegrino T, Cuocolo A. The \u201cgray zone\u201d for the heart to mediastinum MIBG uptake ratio. J Nucl Cardiol 2014. doi:10.1007\/s12350-014-9894-4","DOI":"10.1007\/s12350-014-9894-4"},{"key":"10.1007\/s12350-014-9943-z_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2006.03.026","article-title":"Clinical outcome in patients with intermediate or equivocal left main coronary artery disease after deferral of surgical revascularization on the basis of fractional flow reserve measurements","volume":"152","author":"Lindstaedt","year":"2006","journal-title":"Am Heart J"},{"key":"10.1007\/s12350-014-9943-z_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12350-009-9052-6","article-title":"Advances in technical aspects of myocardial perfusion SPECT imaging","volume":"16","author":"Slomka","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-014-9943-z_bib32","first-page":"1723","article-title":"Simultaneous dual-radionuclide imaging with 99mTechnetium-MIBI and 123I-mIBG in patients with ventricular arrhythmia\u2014Initial experience","volume":"55","author":"Ben-Haim","year":"2014","journal-title":"J Nucl Med"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-014-9943-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-014-9943-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123073464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123073464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-014-9943-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:56:03Z","timestamp":1761026163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123073464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1071358123073464"],"URL":"https:\/\/doi.org\/10.1007\/s12350-014-9943-z","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of I-123-meta-iodobenzylguanidine Heart-to-Mediastinum Ratios: Not So Simple After All","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-014-9943-z","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}