{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T01:58:58Z","timestamp":1762999138056,"version":"build-2065373602"},"reference-count":116,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s12350-015-0344-8","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T17:39:40Z","timestamp":1450114780000},"page":"218-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Principles and techniques of imaging in identifying the substrate of ventricular arrhythmia"],"prefix":"10.1016","volume":"23","author":[{"given":"Mischa T.","family":"Rijnierse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis P.","family":"Allaart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Knaapen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-015-0344-8_bib1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCULATIONAHA.111.023838","article-title":"Epidemiology and genetics of sudden cardiac death","volume":"125","author":"Deo","year":"2012","journal-title":"Circulation"},{"issue":"4","key":"10.1007\/s12350-015-0344-8_bib2","first-page":"e29","article-title":"Heart disease and stroke statistics-2015 update: A report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"issue":"3","key":"10.1007\/s12350-015-0344-8_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1056\/NEJMoa043399","article-title":"Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure","volume":"352","author":"Bardy","year":"2005","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1007\/s12350-015-0344-8_bib4","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa013474","article-title":"Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction","volume":"346","author":"Moss","year":"2002","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1007\/s12350-015-0344-8_bib5","doi-asserted-by":"crossref","first-page":"e385","DOI":"10.1161\/CIRCULATIONAHA.106.178233","volume":"114","author":"Zipes","year":"2006","journal-title":"Circulation"},{"issue":"6","key":"10.1007\/s12350-015-0344-8_bib6","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/CIRCEP.113.001705","article-title":"Protein biomarkers identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillators: Findings from the Prospective Observational Study of Implantable Cardioverter Defibrillators (PROSE-ICD)","volume":"7","author":"Cheng","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"25","key":"10.1007\/s12350-015-0344-8_bib7","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1161\/01.CIR.0000150390.04704.B7","article-title":"Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator","volume":"110","author":"Moss","year":"2004","journal-title":"Circulation"},{"issue":"24","key":"10.1007\/s12350-015-0344-8_bib8","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1056\/NEJMoa1211107","article-title":"Reduction in inappropriate therapy and mortality through ICD programming","volume":"367","author":"Moss","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-015-0344-8_bib9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/CIRCIMAGING.110.961532","article-title":"Emerging role of multimodality imaging to evaluate patients at risk for sudden cardiac death","volume":"5","author":"Bertini","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/europace\/euq064","article-title":"Risk stratification for ventricular arrhythmias in ischaemic cardiomyopathy: The value of non-invasive imaging","volume":"12","author":"de Haan","year":"2010","journal-title":"Europace"},{"key":"10.1007\/s12350-015-0344-8_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jcmg.2009.07.013","article-title":"Will imaging assist in the selection of patients with heart failure for an ICD?","volume":"3","author":"Gerson","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib12","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jcmg.2014.03.013","article-title":"CMR-based identification of critical isthmus sites of ischemic and nonischemic ventricular tachycardia","volume":"7","author":"Piers","year":"2014","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1161\/CIRCEP.111.961946","article-title":"Integration of 3D electroanatomic maps and magnetic resonance scar characterization into the navigation system to guide ventricular tachycardia ablation","volume":"4","author":"Andreu","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib14","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/CIRCEP.109.889311","article-title":"Three-dimensional contrast-enhanced multidetector CT for anatomic, dynamic, and perfusion characterization of abnormal myocardium to guide ventricular tachycardia ablations","volume":"3","author":"Tian","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2967\/jnumed.111.094904","article-title":"Integration of 3-dimensional scar models from SPECT to guide ventricular tachycardia ablation","volume":"53","author":"Tian","year":"2012","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcmg.2007.10.001","article-title":"Integration of three-dimensional scar maps for ventricular tachycardia ablation with positron emission tomography-computed tomography","volume":"1","author":"Dickfeld","year":"2008","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/CIRCEP.114.002105","article-title":"Three-dimensional 123I-meta-iodobenzylguanidine cardiac innervation maps to assess substrate and successful ablation sites for ventricular tachycardia: Feasibility study for a novel paradigm of innervation imaging","volume":"8","author":"Klein","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib18","series-title":"Ventricular arrhythmias and sudden cardiac death","first-page":"18","article-title":"Mechanisms of ventricular tachycardia: Underlying pathological and physiological abnormalities","author":"de Bakker","year":"2008"},{"key":"10.1007\/s12350-015-0344-8_bib19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/CIRCULATIONAHA.111.023846","article-title":"Sudden cardiac death caused by coronary heart disease","volume":"125","author":"Myerburg","year":"2012","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib20","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1172\/JCI116358","article-title":"The ionic mechanism of reperfusion-induced early afterdepolarizations in feline left ventricular hypertrophy","volume":"91","author":"Furukawa","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1007\/s12350-015-0344-8_bib21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijcard.2006.09.016","article-title":"Myocardial ischemia and ventricular fibrillation: Pathophysiology and clinical implications","volume":"119","author":"Luqman","year":"2007","journal-title":"Int J Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0002-9149(00)01070-5","article-title":"Relation among exercise-induced ventricular arrhythmias, myocardial ischemia, and viability late after acute myocardial infarction","volume":"86","author":"Elhendy","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0735-1097(95)00491-2","article-title":"Exercise-induced ischemic arrhythmias in patients with previous myocardial infarction: Role of perfusion and tissue viability","volume":"27","author":"Margonato","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib24","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0002-8703(89)90792-8","article-title":"Slow conduction in the infarct scar: Relevance to the occurrence, detection, and ablation of ventricular reentry circuits resulting from myocardial infarction","volume":"117","author":"Stevenson","year":"1989","journal-title":"Am Heart J"},{"key":"10.1007\/s12350-015-0344-8_bib25","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.113.007497","article-title":"Sudden cardiac death early after myocardial infarction: Pathogenesis, risk stratification, and primary prevention","volume":"129","author":"Zaman","year":"2014","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib26","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.jacc.2004.12.057","article-title":"Infarct morphology identifies patients with substrate for sustained ventricular tachycardia","volume":"45","author":"Bello","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/CIRCRESAHA.107.158980","article-title":"Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: Implications for catheter ablation","volume":"101","author":"Ashikaga","year":"2007","journal-title":"Circ Res"},{"key":"10.1007\/s12350-015-0344-8_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/CIRCIMAGING.113.001158","article-title":"Impaired hyperemic myocardial blood flow is associated with inducibility of ventricular arrhythmia in ischemic cardiomyopathy","volume":"7","author":"Rijnierse","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib29","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/01.CIR.82.4.1095","article-title":"Influence of myocardial ischemia and infarction on autonomic innervation of heart","volume":"82","author":"Zipes","year":"1990","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib30","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/01.CIR.88.1.172","article-title":"Correlation between scintigraphic evidence of regional sympathetic neuronal dysfunction and ventricular refractoriness in the human heart","volume":"88","author":"Calkins","year":"1993","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib31","first-page":"103","article-title":"Role of the sympathetic nervous system in the genesis of ventricular arrhythmia","volume":"82","author":"Podrid","year":"1990","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib32","doi-asserted-by":"crossref","first-page":"H1838","DOI":"10.1152\/ajpheart.01106.2011","article-title":"Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction","volume":"302","author":"Vaseghi","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1007\/s12350-015-0344-8_bib33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/01.CIR.76.2.383","article-title":"Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmural myocardial infarction","volume":"76","author":"Kammerling","year":"1987","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib34","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0008-6363(00)00308-4","article-title":"Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death","volume":"50","author":"Chen","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1007\/s12350-015-0344-8_bib36","first-page":"H80","article-title":"Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure","volume":"277","author":"Nuss","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1007\/s12350-015-0344-8_bib37","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.RES.0000145047.14691.db","article-title":"What causes sudden death in heart failure?","volume":"95","author":"Tomaselli","year":"2004","journal-title":"Circ Res"},{"key":"10.1007\/s12350-015-0344-8_bib38","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10741-010-9201-7","article-title":"Multimodality imaging in the assessment of myocardial viability","volume":"16","author":"Partington","year":"2011","journal-title":"Heart Fail Rev"},{"key":"10.1007\/s12350-015-0344-8_bib39","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s00259-008-1001-0","article-title":"Agreement and disagreement between contrast-enhanced magnetic resonance imaging and nuclear imaging for assessment of myocardial viability","volume":"36","author":"Roes","year":"2009","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S1071-3581(97)90029-5","article-title":"Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease","volume":"4","author":"Gradel","year":"1997","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib41","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/0002-9149(87)91100-3","article-title":"Prevalence of ischemia by quantitative thallium-201 scintigraphy in patients with ventricular tachycardia or fibrillation inducible by programmed stimulation","volume":"59","author":"Sellers","year":"1987","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib42","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/0002-9149(83)90307-7","article-title":"Relation between site of origin of ventricular tachycardia and relative left ventricular myocardial perfusion and wall motion","volume":"51","author":"McFarland","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib43","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s12350-014-9911-7","article-title":"I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: A retrospective analysis","volume":"21","author":"Zhou","year":"2014","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib44","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1053\/euhj.2001.2628","article-title":"Influence of residual myocardial ischaemia on induced ventricular arrhythmias following a first acute myocardial infarction","volume":"22","author":"Paganelli","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-015-0344-8_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF03091744","article-title":"Cardiac PET-CT: Advanced hybrid imaging for the detection of coronary artery disease","volume":"18","author":"Knaapen","year":"2010","journal-title":"Neth Heart J"},{"key":"10.1007\/s12350-015-0344-8_bib46","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s12350-013-9753-8","article-title":"Diagnosing coronary artery disease with hybrid PET\/CT: It takes two to tango","volume":"20","author":"Danad","year":"2013","journal-title":"J Nucl Cardiol"},{"issue":"2","key":"10.1007\/s12350-015-0344-8_bib47","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.CIR.87.2.512","article-title":"Direct comparison of [13N]ammonia and [15O]water estimates of perfusion with quantification of regional myocardial blood flow by microspheres","volume":"87","author":"Bol","year":"1993","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib48","first-page":"1737","article-title":"Histochemical correlates of (15)O-water-perfusable tissue fraction in experimental canine studies of old myocardial infarction","volume":"41","author":"Iida","year":"2000","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib49","first-page":"75","article-title":"Myocardial blood flow measurement by PET: Technical aspects and clinical applications","volume":"46","author":"Kaufmann","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib50","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2967\/jnumed.106.038851","article-title":"Assessment of myocardial viability in patients with heart failure","volume":"48","author":"Schinkel","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib51","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/01.CIR.73.5.951","article-title":"Regional perfusion, glucose metabolism, and wall motion in patients with chronic electrocardiographic Q wave infarctions: Evidence for persistence of viable tissue in some infarct regions by positron emission tomography","volume":"73","author":"Brunken","year":"1986","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/01.CIR.90.2.735","article-title":"Histological alterations in chronically hypoperfused myocardium. Correlation with PET findings","volume":"90","author":"Maes","year":"1994","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib53","first-page":"1341","article-title":"Myocardial viability in chronic ischemic heart disease: Comparison of contrast-enhanced magnetic resonance imaging with (18)F-fluorodeoxyglucose positron emission tomography","volume":"41","author":"Kuhl","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib54","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1161\/hc0202.102123","article-title":"Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: Comparison with positron emission tomography","volume":"105","author":"Klein","year":"2002","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib55","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1540-8167.2008.01377.x","article-title":"Clinical application of PET\/CT fusion imaging for three-dimensional myocardial scar and left ventricular anatomy during ventricular tachycardia ablation","volume":"20","author":"Tian","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib56","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.hrthm.2008.08.020","article-title":"Integration of positron emission tomography\/computed tomography with electroanatomical mapping: A novel approach for ablation of scar-related ventricular tachycardia","volume":"5","author":"Fahmy","year":"2008","journal-title":"Heart Rhythm"},{"key":"10.1007\/s12350-015-0344-8_bib57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/01.CIR.74.1.81","article-title":"Increased uptake of 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina","volume":"74","author":"Camici","year":"1986","journal-title":"Circulation"},{"issue":"8","key":"10.1007\/s12350-015-0344-8_bib58","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/01.RES.0000125628.57672.CF","article-title":"Hibernating myocardium: Chronically adapted to ischemia but vulnerable to sudden death","volume":"94","author":"Canty","year":"2004","journal-title":"Circ Res"},{"key":"10.1007\/s12350-015-0344-8_bib59","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.nuclcard.2004.11.003","article-title":"Hibernating myocardium","volume":"12","author":"Canty","year":"2005","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib60","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1161\/01.RES.0000124934.84048.DF","article-title":"Cellular mechanisms of contractile dysfunction in hibernating myocardium","volume":"94","author":"Bito","year":"2004","journal-title":"Circ Res"},{"key":"10.1007\/s12350-015-0344-8_bib61","first-page":"H1418","article-title":"Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium","volume":"277","author":"Fallavollita","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1007\/s12350-015-0344-8_bib62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1055\/s-0038-1625688","article-title":"Myocardial perfusion\/metabolism mismatch and ventricular arrhythmias in the chronic post infarction state","volume":"44","author":"Krause","year":"2005","journal-title":"Nuklearmedizin"},{"key":"10.1007\/s12350-015-0344-8_bib63","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jacc.2013.07.096","article-title":"Regional myocardial sympathetic denervation predicts the risk of sudden cardiac arrest in ischemic cardiomyopathy","volume":"63","author":"Fallavollita","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib64","first-page":"1368","article-title":"Regional 11C-hydroxyephedrine retention in hibernating myocardium: Chronic inhomogeneity of sympathetic innervation in the absence of infarction","volume":"46","author":"Luisi","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12350-012-9644-4","article-title":"Assessment of cardiac autonomic neuronal function using PET imaging","volume":"20","author":"Thackeray","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib66","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/cs0800257","article-title":"Neuronal re-uptake of noradrenaline by sympathetic nerves in humans","volume":"80","author":"Eisenhofer","year":"1991","journal-title":"Clin Sci (Lond)"},{"key":"10.1007\/s12350-015-0344-8_bib67","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0163-7258(01)00144-9","article-title":"The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines","volume":"91","author":"Eisenhofer","year":"2001","journal-title":"Pharmacol Ther"},{"key":"10.1007\/s12350-015-0344-8_bib68","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12350-012-9655-1","article-title":"Cardiac autonomic imaging with SPECT tracers","volume":"20","author":"Travin","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib69","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.2967\/jnumed.115.158493","article-title":"Retention Kinetics of the 18F-labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-HED and 123I-MIBG","volume":"56","author":"Werner","year":"2015","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib70","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jcmg.2009.07.014","article-title":"Cardiac sympathetic imaging with mIBG in heart failure","volume":"3","author":"Carrio","year":"2010","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib71","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ehj.2004.02.016","article-title":"Presence of sympathetically denervated but viable myocardium and its electrophysiologic correlates after early revascularised, acute myocardial infarction","volume":"25","author":"Simoes","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-015-0344-8_bib72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/CIRCIMAGING.108.782433","article-title":"123 I-mIBG scintigraphy to predict inducibility of ventricular arrhythmias on cardiac electrophysiology testing: A prospective multicenter pilot study","volume":"1","author":"Bax","year":"2008","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib73","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13550-014-0052-4","article-title":"Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium","volume":"4","author":"Harms","year":"2014","journal-title":"EJNMMI Res"},{"key":"10.1007\/s12350-015-0344-8_bib74","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2967\/jnumed.110.084228","article-title":"Imaging targets of the sympathetic nervous system of the heart: Translational considerations","volume":"52","author":"Bengel","year":"2011","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib75","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.CIR.101.5.516","article-title":"Evaluation of sympathetic nerve terminals with [(11)C]epinephrine and [(11)C]hydroxyephedrine and positron emission tomography","volume":"101","author":"Munch","year":"2000","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib76","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCIMAGING.109.920538","article-title":"Iodine-123 metaiodobenzylguanidine imaging and carbon-11 hydroxyephedrine positron emission tomography compared in patients with left ventricular dysfunction","volume":"3","author":"Matsunari","year":"2010","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib77","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.2967\/jnumed.115.154377","article-title":"Use of a single 11C-meta-hydroxyephedrine scan protocol for assessing flow-innervation mismatches in patients with ischemic cardiomyopathy","volume":"56","author":"Harms","year":"2015","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib78","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1016\/j.jacc.2008.02.062","article-title":"Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction","volume":"51","author":"Sasano","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib79","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2967\/jnumed.114.149971","article-title":"Multiparametric molecular imaging provides mechanistic insights into sympathetic innervation impairment in the viable infarct border zone","volume":"56","author":"Lautamaki","year":"2015","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib80","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2967\/jnumed.107.044339","article-title":"Evidence for pre- to postsynaptic mismatch of the cardiac sympathetic nervous system in ischemic congestive heart failure","volume":"49","author":"Caldwell","year":"2008","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-015-0344-8_bib81","doi-asserted-by":"crossref","unstructured":"Rijnierse MT, Allaart CP, de Haan S, Harms HJ, Huisman MC, Wu L et al Sympathetic denervation is associated with microvascular dysfunction in non-infarcted myocardium in patients with cardiomyopathy. Eur Heart J Cardiovasc Imaging 2015.","DOI":"10.1016\/S0735-1097(15)61252-9"},{"key":"10.1007\/s12350-015-0344-8_bib82","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/hrt.81.3.262","article-title":"Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: An analysis using carbon-11 hydroxyephedrine and positron emission tomography","volume":"81","author":"Hartmann","year":"1999","journal-title":"Heart"},{"key":"10.1007\/s12350-015-0344-8_bib83","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1053\/euhj.2000.2556","article-title":"Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart; a non-invasive study using positron emission tomography","volume":"22","author":"Bengel","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-015-0344-8_bib84","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0735-1097(98)00213-7","article-title":"Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia","volume":"32","author":"Schafers","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib85","doi-asserted-by":"crossref","first-page":"H1286","DOI":"10.1152\/ajpheart.00276.2003","article-title":"Cardiac retention of [11C]HED in genotyped long QT patients: A potential amplifier role for severity of the disease","volume":"285","author":"Mazzadi","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1007\/s12350-015-0344-8_bib86","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1161\/01.CIR.0000146920.35020.44","article-title":"Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome","volume":"110","author":"Kies","year":"2004","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib87","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0002-9149(02)02381-0","article-title":"Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy","volume":"90","author":"Grothues","year":"2002","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib88","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.hrthm.2014.05.018","article-title":"Image-based left ventricular shape analysis for sudden cardiac death risk stratification","volume":"11","author":"Vadakkumpadan","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1007\/s12350-015-0344-8_bib89","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jacc.2010.11.013","article-title":"Assessment of myocardial fibrosis with cardiovascular magnetic resonance","volume":"57","author":"Mewton","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"19","key":"10.1007\/s12350-015-0344-8_bib90","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1161\/01.CIR.100.19.1992","article-title":"Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function","volume":"100","author":"Kim","year":"1999","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib91","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCIMAGING.108.835793","article-title":"Late gadolinium-enhancement cardiac magnetic resonance identifies postinfarction myocardial fibrosis and the border zone at the near cellular level in ex vivo rat heart","volume":"3","author":"Schelbert","year":"2010","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib92","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jcmg.2010.11.015","article-title":"Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance","volume":"4","author":"Flett","year":"2011","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib93","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCULATIONAHA.106.613414","article-title":"Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality","volume":"114","author":"Yan","year":"2006","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib94","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1136\/heartjnl-2011-300060","article-title":"Scar size and characteristics assessed by CMR predict ventricular arrhythmias in ischaemic cardiomyopathy: Comparison of previously validated models","volume":"97","author":"de Haan","year":"2011","journal-title":"Heart"},{"key":"10.1007\/s12350-015-0344-8_bib95","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/eurjhf\/hft053","article-title":"Late gadolinium enhancement cardiac magnetic resonance imaging for the prediction of ventricular tachyarrhythmic events: A meta-analysis","volume":"15","author":"Scott","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1007\/s12350-015-0344-8_bib96","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/CIRCULATIONAHA.106.653568","article-title":"Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction","volume":"115","author":"Schmidt","year":"2007","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib97","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1161\/CIRCULATIONAHA.105.549659","article-title":"Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy","volume":"112","author":"Nazarian","year":"2005","journal-title":"Circulation"},{"key":"10.1007\/s12350-015-0344-8_bib98","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1161\/CIRCEP.113.000264","article-title":"Three-dimensional architecture of scar and conducting channels based on high resolution ce-CMR: Insights for ventricular tachycardia ablation","volume":"6","author":"Fernandez-Armenta","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib99","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/CIRCEP.110.958744","article-title":"MRI-guided ventricular tachycardia ablation: Integration of late gadolinium-enhanced 3D scar in patients with implantable cardioverter-defibrillators","volume":"4","author":"Dickfeld","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib100","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/CIRCEP.112.970699","article-title":"Myocardial structural associations with local electrograms: A study of postinfarct ventricular tachycardia pathophysiology and magnetic resonance-based noninvasive mapping","volume":"5","author":"Sasaki","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib101","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.hrthm.2009.02.018","article-title":"Infarct architecture and characteristics on delayed enhanced magnetic resonance imaging and electroanatomic mapping in patients with postinfarction ventricular arrhythmia","volume":"6","author":"Desjardins","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1007\/s12350-015-0344-8_bib102","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jacc.2010.07.043","article-title":"Noninvasive identification of ventricular tachycardia-related conducting channels using contrast-enhanced magnetic resonance imaging in patients with chronic myocardial infarction: Comparison of signal intensity scar mapping and endocardial voltage mapping","volume":"57","author":"Perez-David","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib103","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jcmg.2011.08.021","article-title":"Delayed-enhanced MR scar imaging and intraprocedural registration into an electroanatomical mapping system in post-infarction patients","volume":"5","author":"Gupta","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib104","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/eurheartj\/eht510","article-title":"Usefulness of contrast-enhanced cardiac magnetic resonance in identifying the ventricular arrhythmia substrate and the approach needed for ablation","volume":"35","author":"Andreu","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-015-0344-8_bib105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jacc.2012.03.029","article-title":"Virtual electrophysiological study in a 3-dimensional cardiac magnetic resonance imaging model of porcine myocardial infarction","volume":"60","author":"Ng","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1007\/s12350-015-0344-8_bib106","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/ehjci\/jeu183","article-title":"T1 mapping in dilated cardiomyopathy with cardiac magnetic resonance: Quantification of diffuse myocardial fibrosis and comparison with endomyocardial biopsy","volume":"16","author":"Aus dem","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib107","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1161\/CIRCIMAGING.112.976738","article-title":"Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy","volume":"5","author":"Dass","year":"2012","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib108","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.jacc.2008.06.049","article-title":"Evaluation of diffuse myocardial fibrosis in heart failure with cardiac magnetic resonance contrast-enhanced T1 mapping","volume":"52","author":"Iles","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-015-0344-8_bib109","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jcmg.2012.03.015","article-title":"Acute left ventricular remodeling following myocardial infarction: Coupling of regional healing with remote extracellular matrix expansion","volume":"5","author":"Chan","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1007\/s12350-015-0344-8_bib110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1540-8159.1997.tb06199.x","article-title":"Microfibrosis produces electrical load variations due to loss of side-to-side cell connections: A major mechanism of structural heart disease arrhythmias","volume":"20","author":"Spach","year":"1997","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1007\/s12350-015-0344-8_bib111","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.hrthm.2014.12.020","article-title":"Myocardial tissue characterization by cardiac magnetic resonance imaging using T1 mapping predicts ventricular arrhythmia in ischemic and non-ischemic cardiomyopathy patients with implantable cardioverter-defibrillators","volume":"12","author":"Chen","year":"2015","journal-title":"Heart Rhythm"},{"key":"10.1007\/s12350-015-0344-8_bib112","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jcct.2015.03.003","article-title":"Myocardial scar imaging by standard single-energy and dual-energy late enhancement CT: Comparison with pathology and electroanatomic map in an experimental chronic infarct porcine model","volume":"9","author":"Truong","year":"2015","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"10.1007\/s12350-015-0344-8_bib113","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1161\/CIRCULATIONAHA.104.529511","article-title":"Characterization of acute and chronic myocardial infarcts by multidetector computed tomography: Comparison with contrast-enhanced magnetic resonance","volume":"113","author":"Gerber","year":"2006","journal-title":"Circulation"},{"issue":"7","key":"10.1007\/s12350-015-0344-8_bib114","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/RLI.0b013e3182145b4f","article-title":"Dual-energy computed tomography for the detection of late enhancement in reperfused chronic infarction: A comparison to magnetic resonance imaging and histopathology in a porcine model","volume":"46","author":"Deseive","year":"2011","journal-title":"Invest Radiol"},{"key":"10.1007\/s12350-015-0344-8_bib115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejrad.2006.11.031","article-title":"Sixty-four-MSCT in the characterization of porcine acute and subacute myocardial infarction: Determination of transmurality in comparison to magnetic resonance imaging and histopathology","volume":"62","author":"Brodoefel","year":"2007","journal-title":"Eur J Radiol"},{"key":"10.1007\/s12350-015-0344-8_bib116","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/01.rli.0000179524.58411.a2","article-title":"A feasibility study of contrast enhancement of acute myocardial infarction in multislice computed tomography: Comparison with magnetic resonance imaging and gross morphology in pigs","volume":"40","author":"Buecker","year":"2005","journal-title":"Invest Radiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-015-0344-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-015-0344-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123068162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123068162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-015-0344-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:57:57Z","timestamp":1761026277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123068162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":116,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1071358123068162"],"URL":"https:\/\/doi.org\/10.1007\/s12350-015-0344-8","relation":{},"ISSN":["1071-3581"],"issn-type":[{"type":"print","value":"1071-3581"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Principles and techniques of imaging in identifying the substrate of ventricular arrhythmia","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-015-0344-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 THE AUTHORS. Published by ELSEVIER INC. on behalf of American Society of Nuclear Cardiology. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}