{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:24:37Z","timestamp":1784870677690,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s12350-016-0622-0","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T12:51:18Z","timestamp":1469796678000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Heart failure patients with prediabetes and newly diagnosed diabetes display abnormalities in myocardial metabolism"],"prefix":"10.1016","volume":"25","author":[{"given":"Roni","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Jorsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Tolbod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bouchelouche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik Johannes","family":"Harms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Flyvbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"B\u00f8tker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Wiggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-016-0622-0_bib1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1007\/s12350-016-0622-0_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/eurheartj\/ehi555","article-title":"Predictors of mortality and morbidity in patients with chronic heart failure","volume":"27","author":"Pocock","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-016-0622-0_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/14017430903312438","article-title":"Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure","volume":"44","author":"Andersson","year":"2010","journal-title":"Scand Cardiovasc J"},{"key":"10.1007\/s12350-016-0622-0_bib4","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/CIRCULATIONAHA.107.702795","article-title":"Metabolic mechanisms in heart failure","volume":"116","author":"Ashrafian","year":"2007","journal-title":"Circulation"},{"key":"10.1007\/s12350-016-0622-0_bib5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/eurjhf\/hfq216","article-title":"Oral glucose tolerance testing in an outpatient heart failure clinic reveals a high proportion of undiagnosed diabetic patients with an adverse prognosis","volume":"13","author":"Egstrup","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1007\/s12350-016-0622-0_bib6","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.jacc.2006.06.078","article-title":"Myocardial glucose transport and utilization in patients with type 2 diabetes mellitus, left ventricular dysfunction, and coronary artery disease","volume":"48","author":"Dutka","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/1471-2288-11-158","article-title":"Selection of the appropriate method for the assessment of insulin resistance","volume":"11","author":"Borai","year":"2011","journal-title":"BMC Med Res Methodol"},{"key":"10.1007\/s12350-016-0622-0_bib8","first-page":"1730","article-title":"Myocardial glucose utilization and optimization of 18F-FDG PET imaging in patients with non-insulin-dependent diabetes mellitus, coronary artery disease, and left ventricular dysfunction","volume":"42","author":"Vitale","year":"2001","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-016-0622-0_bib9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s12350-010-9228-0","article-title":"An abbreviated hyperinsulinemic-euglycemic clamp results in similar myocardial glucose utilization in both diabetic and non-diabetic patients with ischemic cardiomyopathy","volume":"17","author":"Fallavollita","year":"2010","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-004885","article-title":"A protocol for a randomised, double-blind, placebo-controlled study of the effect of liraglutide on left ventricular function in chronic heart failure patients with and without type 2 diabetes (The LIVE Study)","volume":"4","author":"Jorsal","year":"2014","journal-title":"BMJ Open"},{"key":"10.1007\/s12350-016-0622-0_bib11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/sj.ijo.0800864","article-title":"Assessment of insulin sensitivity from plasma insulin and glucose in the fasting or post oral glucose-load state","volume":"23","author":"Avignon","year":"1999","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1007\/s12350-016-0622-0_bib12","first-page":"1292","article-title":"Measurement of myocardial glucose uptake in patients with ischemic cardiomyopathy: Application of a new quantitative method using regional tracer kinetic information","volume":"40","author":"Wiggers","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-016-0622-0_bib13","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s00259-011-1730-3","article-title":"Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET\/CT scanner","volume":"38","author":"Harms","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-016-0622-0_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0735-1097(96)00106-4","article-title":"Predictive value of low dose dobutamine transesophageal echocardiography and fluorine-18 fluorodeoxyglucose positron emission tomography for recovery of regional left ventricular function after successful revascularization","volume":"28","author":"Baer","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib15","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/jeu317","article-title":"PET\/MRI early after myocardial infarction: Evaluation of viability with late gadolinium enhancement transmurality vs 18F-FDG uptake","author":"Rischpler","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1007\/s12350-016-0622-0_bib16","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jacc.2014.05.069","article-title":"Quantitative assessment of myocardial-\u00e1perfusion in the detection of significant coronary artery disease: Cutoff values and diagnostic accuracy of quantitative [15O]H2O PET imaging","volume":"64","author":"Danad","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib17","first-page":"1299","article-title":"Perfusable tissue index as a potential marker of fibrosis in patients with idiopathic dilated cardiomyopathy","volume":"45","author":"Knaapen","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-016-0622-0_bib18","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1161\/01.CIR.93.4.737","article-title":"Pathophysiology of chronic left ventricular dysfunction: New insights from the measurement of absolute myocardial blood flow and glucose utilization","volume":"93","author":"Marinho","year":"1996","journal-title":"Circulation"},{"key":"10.1007\/s12350-016-0622-0_bib19","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1210\/jc.2006-1416","article-title":"Impact of type 2 diabetes on myocardial insulin sensitivity to glucose uptake and perfusion in patients with coronary artery disease","volume":"91","author":"Sondergaard","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1007\/s12350-016-0622-0_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1071-3581(97)90061-1","article-title":"Glucose uptake and lumped constant variability in normal human hearts determined with [18F]fluorodeoxyglucose","volume":"4","author":"B\u00f8tker","year":"1997","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s001250050946","article-title":"Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM","volume":"41","author":"Utriainen","year":"1998","journal-title":"Diabetologia"},{"key":"10.1007\/s12350-016-0622-0_bib22","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00259-002-0827-0","article-title":"Low whole-body insulin sensitivity in patients with ischaemic heart disease is associated with impaired myocardial glucose uptake predictive of poor outcome after revascularisation","volume":"29","author":"Kofoed","year":"2002","journal-title":"Eur J Nucl Med"},{"key":"10.1007\/s12350-016-0622-0_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1152\/physrev.00015.2009","article-title":"Myocardial fatty acid metabolism in health and disease","volume":"90","author":"Lopaschuk","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1007\/s12350-016-0622-0_bib24","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1006\/jmcc.1995.0129","article-title":"The effect of insulin and FFA on myocardial glucose uptake","volume":"27","author":"Juhani Knuuti","year":"1995","journal-title":"J Mol Cell Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCHEARTFAILURE.113.000187","article-title":"Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity","volume":"6","author":"Nielsen","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1007\/s12350-016-0622-0_bib26","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.jacc.2009.07.024","article-title":"The adrenergic-fatty acid load in heart failure","volume":"54","author":"Opie","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-016-0622-0_bib27","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1161\/01.CIR.99.4.578","article-title":"Glucose for the heart","volume":"99","author":"Depre","year":"1999","journal-title":"Circulation"},{"key":"10.1007\/s12350-016-0622-0_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/01.CIR.95.2.313","article-title":"Glucose metabolism in the ischemic heart","volume":"95","author":"Lopaschuk","year":"1997","journal-title":"Circulation"},{"key":"10.1007\/s12350-016-0622-0_bib29","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.1999.277.2.H643","article-title":"Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR","volume":"277","author":"Russell","year":"1999","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1007\/s12350-016-0622-0_bib30","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.CIR.89.2.793","article-title":"Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes","volume":"89","author":"Sun","year":"1994","journal-title":"Circulation"},{"key":"10.1007\/s12350-016-0622-0_bib31","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc16-S005","article-title":"2. Classification and Diagnosis of Diabetes","volume":"39","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1007\/s12350-016-0622-0_bib32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10863-009-9207-9","article-title":"Hexokinase-mitochondrial interaction in cardiac tissue: Implications for cardiac glucose uptake, the 18FDG lumped constant and cardiac protection","volume":"41","author":"Southworth","year":"2009","journal-title":"J Bioenerg Biomembr"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-016-0622-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-016-0622-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123021505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123021505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-016-0622-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-016-0622-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:59:56Z","timestamp":1761026396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123021505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1071358123021505"],"URL":"https:\/\/doi.org\/10.1007\/s12350-016-0622-0","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heart failure patients with prediabetes and newly diagnosed diabetes display abnormalities in myocardial metabolism","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-016-0622-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}