{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:23:23Z","timestamp":1761092603816,"version":"build-2065373602"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s12350-018-1190-2","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T12:27:14Z","timestamp":1517488034000},"page":"1327-1344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Imaging doxorubicin and polymer-drug conjugates of doxorubicin-induced cardiotoxicity with bispecific anti-myosin-anti-DTPA antibody and Tc-99m-labeled polymers"],"prefix":"10.1016","volume":"26","author":[{"given":"Rajiv","family":"Panwar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Bhattarai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwesh","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyur","family":"Gada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ban An","family":"Khaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-018-1190-2_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/1097-0142(1967)20:3<333::AID-CNCR2820200302>3.0.CO;2-K","article-title":"Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Clinical evaluation with special reference to childhood leukemia","volume":"20","author":"Tan","year":"1967","journal-title":"Cancer"},{"key":"10.1007\/s12350-018-1190-2_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1136\/adc.71.5.457","article-title":"Anthracyclines; cardiotoxicity and its prevention","volume":"71","author":"Hale","year":"1994","journal-title":"Arch Dis Child"},{"key":"10.1007\/s12350-018-1190-2_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7748\/cnp2003.11.2.9.30.c98","article-title":"Cardiotoxicity associated with doxorubicin","volume":"2","author":"Mallison","year":"2003","journal-title":"Cancer Nurs Pract"},{"key":"10.1007\/s12350-018-1190-2_bib4","first-page":"23","article-title":"The cardiotoxicity of anticancer agents","volume":"9","author":"Von Hoff","year":"1982","journal-title":"Semin Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7326\/0003-4819-125-1-199607010-00008","article-title":"Anthracycline-induced cardiotoxicity","volume":"125","author":"Shan","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1007\/s12350-018-1190-2_bib6","first-page":"460","article-title":"Effect of anthracycline antibiotics on oxygen radical formation in rat heart","volume":"43","author":"Doroshow","year":"1983","journal-title":"Cancer Res"},{"key":"10.1007\/s12350-018-1190-2_bib7","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1172\/JCI72931","article-title":"Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation","volume":"124","author":"Ichikawa","year":"2014","journal-title":"J Clin Investig"},{"key":"10.1007\/s12350-018-1190-2_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12012-007-0023-3","article-title":"Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?","volume":"2","author":"Hasinoff","year":"2007","journal-title":"Cardiovasc Toxicol"},{"key":"10.1007\/s12350-018-1190-2_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00432-003-0498-7","article-title":"The current and future role of dexrazoxane as a cardioprotectant in anthracycline treatment: expert panel review","volume":"130","author":"Swain","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib10","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nm.2919","article-title":"Identification of the molecular basis of doxorubicin-induced cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat Med"},{"key":"10.1007\/s12350-018-1190-2_bib11","first-page":"71","article-title":"Evaluation of anthracycline cardiotoxicity: predictive ability and functional correlation of endomyocardial biopsy","volume":"3","author":"Bellingham","year":"1984","journal-title":"Cancer Treat Symp"},{"key":"10.1007\/s12350-018-1190-2_bib12","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.jacc.2014.06.1167","article-title":"Prevention of anthracycline-induced cardiotoxicity","volume":"64","author":"Vejpongsa","year":"2014","journal-title":"J Am Col Cardiol"},{"key":"10.1007\/s12350-018-1190-2_bib13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12350-013-9707-1","article-title":"Traditional and novel methods to assess and prevent chemotherapy-related cardiac dysfunction noninvasively","volume":"20","author":"Schwartz","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-018-1190-2_bib14","first-page":"59","article-title":"Chemotherapy-induced cardiotoxicity","volume":"8","author":"Florescu","year":"2013","journal-title":"Maeduca J Clin Med"},{"key":"10.1007\/s12350-018-1190-2_bib15","first-page":"842","article-title":"Annexin V imaging of acute doxorubicin cardiotoxicity (apoptosis) in rats","volume":"45","author":"Bennink","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib16","first-page":"1965","article-title":"Indium-111-antimyosin scintigraphy after doxorubicin therapy in patients with advanced breast cancer","volume":"31","author":"Estorch","year":"1990","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib17","first-page":"1503","article-title":"Detection of doxorubicin cardiotoxicity in patients with sarcomas by indium-111-antimyosin monoclonal antibody studies","volume":"34","author":"Carrio","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/oxfordjournals.annonc.a058933","article-title":"Usefulness of indium-111 antimyosin scintigraphy in confirming myocardial injury in patients with anthracycline-associated left ventricular dysfunction","volume":"5","author":"Vald\u00e9s Olmos","year":"1994","journal-title":"Ann Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/01.CIR.76.2.306","article-title":"Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis","volume":"76","author":"Yasuda","year":"1978","journal-title":"Circulation"},{"key":"10.1007\/s12350-018-1190-2_bib20","first-page":"1893","article-title":"Indium-111 antimyosin scintigraphy to assess myocardial damage in patients with suspected myocarditis and cardiac rejection","volume":"29","author":"Carrio","year":"1988","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib21","first-page":"1081","article-title":"Imaging apoptosis with Tc-99m-annexin-V in experiment subacute myocarditis","volume":"5","author":"Peker","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.addr.2012.10.014","article-title":"Polymer-drug conjugates: origins, progress to date and future directions","volume":"65","author":"Kopecek","year":"2013","journal-title":"Adv Drug Deliv"},{"key":"10.1007\/s12350-018-1190-2_bib23","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.addr.2007.11.009","article-title":"Polymer-drug conjugates: recent development in clinical oncology","volume":"60","author":"Li","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1007\/s12350-018-1190-2_bib24","first-page":"868","article-title":"Imaging experimental atherosclerotic lesions in ApoE knockout mice: enhanced targeting with Z2D3-anti-DTPA BISPECIfiC ANTIBODY and 99m Tc-labeled negatively charged polymers","volume":"47","author":"Khaw","year":"2006","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib25","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/MNM.0b013e32834af77b","article-title":"Pretargeted gamma imaging of murine metastatic melanoma lung lesions with bispecific antibody and radiolabeled polymer drug conjugates","volume":"32","author":"Gada","year":"2011","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-018-1190-2_bib26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1071-3581(99)90044-2","article-title":"Complementary roles of antibody affinity and specificity for in vivo diagnostic cardiovascular targeting: How specific is antimyosin for irreversible myocardial damage?","volume":"6","author":"Khaw","year":"1999","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-018-1190-2_bib27","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0003-2697(66)90275-2","article-title":"Determination of free amino groups in proteins by trinitrobenzenesulfonic acid","volume":"14","author":"Habeeb","year":"1966","journal-title":"Anal Biochem"},{"key":"10.1007\/s12350-018-1190-2_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.CIR.74.3.501","article-title":"Scintigraphic quantification of myocardial necrosis in patients after intravenous injection of myosin specific antibody","volume":"74","author":"Khaw","year":"1986","journal-title":"Circulation"},{"key":"10.1007\/s12350-018-1190-2_bib29","first-page":"824","article-title":"Imaging small human prostate cancer xenografts after pretargeting with bispecific bombesin-antibody complexes and targeting with high specific radioactivity labeled polymer-drug-conjugates","volume":"39","author":"Patil","year":"2012","journal-title":"EJNMMI"},{"key":"10.1007\/s12350-018-1190-2_bib30","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/bc050201y","article-title":"Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides","volume":"16","author":"Sun","year":"2005","journal-title":"Bioconjug Chem"},{"key":"10.1007\/s12350-018-1190-2_bib31","first-page":"1603","article-title":"Bispecific antibody complex pre-targeting and targeted delivery of polymer-drug-conjugates for imaging and therapy in dual-human mammary cancer xenografts","volume":"41","author":"Khaw","year":"2014","journal-title":"EJNMMI"},{"key":"10.1007\/s12350-018-1190-2_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s13346-011-0055-x","article-title":"Bispecific antibody complex pretargeted delivery of polymer-drug-conjugates for cancer","volume":"2","author":"Gada","year":"2012","journal-title":"Drug Deliv Trans Res"},{"key":"10.1007\/s12350-018-1190-2_bib33","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3109\/1061186X.2013.818675","article-title":"In vitro demonstration of enhanced prostate cancer toxicity: pretargeting with bombesin bispecific complexes and targeting with polymer-drug-conjugates","volume":"21","author":"Patil","year":"2013","journal-title":"J Drug Target"},{"key":"10.1007\/s12350-018-1190-2_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jchromb.2004.04.030","article-title":"Quantification of Doxorubicin and metabolites in rat plasma and small volume tissue samples by liquid chromatography\/electrospray tandem mass spectroscopy","volume":"808","author":"Arnold","year":"2004","journal-title":"J Chromatogr B"},{"key":"10.1007\/s12350-018-1190-2_bib35","unstructured":"Hammond W, Tekabe Y, Johnson L, Majewski S, Popov V, Kross B, et al. Development of high performance mini gamma cameras based on LaBr3scintillator and H8500 and H9500 PSPMTs and their use in small animal studies. Medical Imaging Conference. 2006."},{"key":"10.1007\/s12350-018-1190-2_bib36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/1061186X.2016.1271421","article-title":"An in vitro demonstration of overcoming drug resistance in SKOV3 TR and MCF7 ADR with targeted delivery of polymer pro-drug conjugates","volume":"25","author":"Bhattarai","year":"2017","journal-title":"J Drug Target"},{"key":"10.1007\/s12350-018-1190-2_bib37","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1096\/fasebj.11.12.9337145","article-title":"Adriamycin cardiomyopathy: pathophysiology and prevention","volume":"11","author":"Singal","year":"1997","journal-title":"FASEB J"},{"key":"10.1007\/s12350-018-1190-2_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000265166","article-title":"Doxorubicin cardiomyopathy","volume":"115","author":"Chatterjee","year":"2010","journal-title":"Cardiology"},{"key":"10.1007\/s12350-018-1190-2_bib39","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1161\/CIRCULATIONAHA.106.666248","article-title":"Prediction and prevention of chemotherapy-induced cardiomyopathy: can it be done?","volume":"114","author":"Granger","year":"2006","journal-title":"Circulation"},{"key":"10.1007\/s12350-018-1190-2_bib40","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1200\/JCO.2009.26.5751","article-title":"Cardiotoxicity after childhood cancer: beginning with the end in mind","volume":"28","author":"Lipshultz","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib41","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/annonc\/mdl477","article-title":"Pegylated liposomal doxorubicin-related palmar-plantar erythrodysesthesia (\u2018hand-foot\u2019 syndrome)","volume":"18","author":"Lorusso","year":"2007","journal-title":"Ann Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib42","first-page":"111","article-title":"Pegylated liposomal doxorubicin (PLD): enhanced skin toxicity in areas of vitiligo. Case report","volume":"2","author":"Yuan","year":"2008","journal-title":"Ecancermedicalscience"},{"key":"10.1007\/s12350-018-1190-2_bib43","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1200\/JCO.2004.10.093","article-title":"Liposome encapsulated doxorubicin in combination with standard agents cyclophosphamide, vincristine, prednisone) in patients with newly diagnosed AIDS-related non-Hodgkin\u2019s lymphoma: results of therapy and correlates of response","volume":"22","author":"Levine","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib44","unstructured":"U.S. Food and Drug Administration. Drug Safety and Availability. FDA statement on dexrazoxane. July 20, 2011. http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm263729.htm."},{"key":"10.1007\/s12350-018-1190-2_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJMoa035153","article-title":"The effect of dexrazoxane on myocardial injury in doxorubicin treated children with acute lymphoblastic leukemia","volume":"351","author":"Lipshultz","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1007\/s12350-018-1190-2_bib46","first-page":"1318","article-title":"Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer","volume":"15","author":"Swain","year":"1997","journal-title":"J Oncol"},{"key":"10.1007\/s12350-018-1190-2_bib47","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1124\/jpet.110.167965","article-title":"Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin 14-valerate (AD 198)","volume":"335","author":"Cai","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1007\/s12350-018-1190-2_bib48","first-page":"419","article-title":"Diagnosis of acute cardiac rejection with antimyosin monoclonal antibody, phosphorous nuclear magnetic resonance imaging, two-dimensional echocardiography, and endocardial biopsy","volume":"5","author":"Hall","year":"1986","journal-title":"J Heart Transplant"},{"key":"10.1007\/s12350-018-1190-2_bib49","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.2042-7158.1996.tb06007.x","article-title":"Protective effect of butylated hydroxyanisole on Adriamycin induced cardiotoxicity","volume":"48","author":"Vora","year":"1996","journal-title":"J Pharm Pharmacol"},{"key":"10.1007\/s12350-018-1190-2_bib50","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1161\/01.CIR.86.6.1965","article-title":"Myocardial uptake of 111In monoclonal antimyosin Fab in detecting doxorubicin cardiotoxicity in rats","volume":"86","author":"Hiroe","year":"1992","journal-title":"Circulation"},{"key":"10.1007\/s12350-018-1190-2_bib51","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.114.001952","article-title":"Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity","volume":"8","author":"Su","year":"2015","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1007\/s12350-018-1190-2_bib52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s12350-015-0274-5","article-title":"Imaging and chemotherapy cardiotoxicity: a long-playing story still seeking precision and improved outcome\/management data","volume":"23","author":"Van Decker","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-018-1190-2_bib53","first-page":"1507","article-title":"Antimyosin positivity in doxorubicin cardiotoxicity: earlier than the conventional evidence","volume":"34","author":"Narula","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-018-1190-2_bib54","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2967\/jnumed.110.082784","article-title":"Scintigraphic techniques for early detection of cancer-induced cardiotoxicity","volume":"52","author":"de Geus-Oei","year":"2011","journal-title":"J Nucl Med"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12350-018-1190-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-018-1190-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123062475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123062475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-018-1190-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:04:58Z","timestamp":1761026698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123062475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1071358123062475"],"URL":"https:\/\/doi.org\/10.1007\/s12350-018-1190-2","relation":{},"ISSN":["1071-3581"],"issn-type":[{"type":"print","value":"1071-3581"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging doxorubicin and polymer-drug conjugates of doxorubicin-induced cardiotoxicity with bispecific anti-myosin-anti-DTPA antibody and Tc-99m-labeled polymers","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-018-1190-2","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}