{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T19:33:57Z","timestamp":1768419237960,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12350-019-01887-6","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T16:02:45Z","timestamp":1568649765000},"page":"1692-1701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-4023","authenticated-orcid":false,"given":"G.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.M.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Durcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.S.","family":"Petrides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.T.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-019-01887-6_bib1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1017\/S0033291713000494","article-title":"The prevalence and incidence of dementia with Lewy bodies: A systematic review of population and clinical studies","volume":"44","author":"Vann","year":"2014","journal-title":"Psychol Med"},{"key":"10.1007\/s12350-019-01887-6_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13195-018-0350-6","article-title":"Clinical prevalence of Lewy body dementia","volume":"10","author":"Kane","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"10.1007\/s12350-019-01887-6_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1468-1331.2008.02388.x","article-title":"Differences in clinical course between dementia with Lewy bodies and Alzheimer\u2019s disease","volume":"16","author":"Hanyu","year":"2009","journal-title":"Eur J Neurol"},{"key":"10.1007\/s12350-019-01887-6_bib4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/gps.3799","article-title":"Examining carer stress in dementia: The role of subtype diagnosis and neuropsychiatric symptoms","volume":"28","author":"Lee","year":"2013","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1007\/s12350-019-01887-6_bib5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.parkreldis.2010.03.007","article-title":"Lewy body dementia: The caregiver experience of clinical care","volume":"16","author":"Galvin","year":"2010","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1007\/s12350-019-01887-6_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"10.1007\/s12350-019-01887-6_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/alzrt274","article-title":"The clinical characteristics of dementia with Lewy bodies and a consideration of prodromal diagnosis","volume":"6","author":"Donaghy","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1007\/s12350-019-01887-6_bib8","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/brain\/aws234","article-title":"Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies","volume":"135","author":"Schneider","year":"2012","journal-title":"Brain"},{"key":"10.1007\/s12350-019-01887-6_bib9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1097\/MNM.0000000000001024","article-title":"A comparison of visual and semiquantitative analysis methods for planar cardiac 123I-MIBG scintigraphy in dementia with Lewy bodies","volume":"40","author":"Roberts","year":"2019","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-019-01887-6_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.parkreldis.2019.01.024","article-title":"(123)I-MIBG scintigraphy utility and cut-off value in a clinically representative dementia cohort","volume":"62","author":"Kane","year":"2019","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1007\/s12350-019-01887-6_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s40336-017-0230-2","article-title":"Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: Phantom calibration and clinical applications","volume":"5","author":"Nakajima","year":"2017","journal-title":"Clin Transl Imaging"},{"key":"10.1007\/s12350-019-01887-6_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00259-011-1783-3","article-title":"Vascular time-activity variation in patients undergoing 123I-MIBG myocardial scintigraphy: Implications for quantification of cardiac and mediastinal uptake","volume":"38","author":"Verberne","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-019-01887-6_bib13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/MNM.0000000000000238","article-title":"123I-MIBG heart-to-mediastinum ratio is influenced by high-energy photon penetration of collimator septa from liver and lung activity","volume":"36","author":"Verschure","year":"2015","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-019-01887-6_bib14","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s12350-017-0782-6","article-title":"A European myocardial 123I-mIBG cross-calibration phantom study","volume":"25","author":"Verschure","year":"2017","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib15","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s12350-014-9943-z","article-title":"Quantification of I-123-meta-iodobenzylguanidine Heart-to-Mediastinum Ratios: Not So Simple After All","volume":"21","author":"Slomka","year":"2014","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12350-016-0708-8","article-title":"Influence of ROI definition on the heart-to-mediastinum ratio in planar 123I-MIBG imaging","volume":"25","author":"Klene","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib17","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00259-010-1491-4","article-title":"Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology","volume":"37","author":"Flotats","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-019-01887-6_bib18","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jacc.2010.01.014","article-title":"Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study","volume":"55","author":"Jacobson","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib19","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s12350-014-9916-2","article-title":"Multicenter cross-calibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator variations","volume":"21","author":"Nakajima","year":"2014","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00259-011-1963-1","article-title":"Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: Effects of correction on normal databases and a multicentre study","volume":"39","author":"Nakajima","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-019-01887-6_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120540","article-title":"Diagnostic accuracy of 123I-meta-iodobenzylguanidine myocardial scintigraphy in dementia with Lewy bodies: A multicenter study","volume":"10","author":"Yoshita","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1007\/s12350-019-01887-6_bib22","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1136\/jnnp-2017-317398","article-title":"(123)I-MIBG myocardial scintigraphy for the diagnosis of DLB: A multicentre 3-year follow-up study","volume":"89","author":"Komatsu","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1007\/s12350-019-01887-6_bib23","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s12350-015-0082-y","article-title":"Cardiac sympathetic imaging in the diagnosis of cardiac autonomic neuropathy in pre-diabetes","volume":"22","author":"Waqar","year":"2015","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib24","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1007\/s12350-015-0070-2","article-title":"Individuals with impaired glucose tolerance demonstrate normal cardiac sympathetic innervation using I-123 mIBG scintigraphy","volume":"22","author":"Asghar","year":"2015","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","article-title":"Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders","volume":"119","author":"Beach","year":"2010","journal-title":"Acta Neuropathol"},{"key":"10.1007\/s12350-019-01887-6_bib26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s12149-016-1065-z","article-title":"Normal values and standardization of parameters in nuclear cardiology: Japanese Society of Nuclear Medicine working group database","volume":"30","author":"Nakajima","year":"2016","journal-title":"Ann Nucl Med"},{"key":"10.1007\/s12350-019-01887-6_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/MNM.0000000000000608","article-title":"Iodine-123 metaiodobenzylguanidine scintigraphy for the assessment of cardiac sympathetic innervation and the relationship with cardiac autonomic function in healthy adults using standardized methods","volume":"38","author":"Asghar","year":"2017","journal-title":"Nucl Med Commun"},{"key":"10.1007\/s12350-019-01887-6_bib28","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1212\/01.wnl.0000219640.59984.a7","article-title":"Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD","volume":"66","author":"Yoshita","year":"2006","journal-title":"Neurology"},{"key":"10.1007\/s12350-019-01887-6_bib29","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160144","article-title":"123I-MIBG myocardial scintigraphy for the evaluation of Lewy body disease: Are delayed images essential? Is visual assessment useful?","volume":"89","author":"Sakamoto","year":"2016","journal-title":"Br J Radiol"},{"key":"10.1007\/s12350-019-01887-6_bib30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14802\/jmd.15015","article-title":"(123)I-metaiodobenzylguanidine myocardial scintigraphy in Lewy body-related disorders: A literature review","volume":"8","author":"Chung","year":"2015","journal-title":"J Mov Disord"},{"key":"10.1007\/s12350-019-01887-6_bib31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.arr.2016.01.001","article-title":"(123)I-meta-iodobenzylguanidine (MIBG) cardiac scintigraphy in alpha-synucleinopathies","volume":"30","author":"Orimo","year":"2016","journal-title":"Ageing Res Rev"},{"key":"10.1007\/s12350-019-01887-6_bib32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neurobiolaging.2016.04.026","volume":"52","author":"Sonni","year":"2017","journal-title":"Neurobiol Aging"},{"key":"10.1007\/s12350-019-01887-6_bib33","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/eurheartj\/ehn113","article-title":"Prognostic value of myocardial 123I-metaiodobenzylguanidine (MIBG) parameters in patients with heart failure: a systematic review","volume":"29","author":"Verberne","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1007\/s12350-019-01887-6_bib34","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s12350-018-1394-5","article-title":"How do we establish cardiac sympathetic nervous system imaging with (123)I-mIBG in clinical practice? Perspectives and lessons from Japan and the US","volume":"26","author":"Travin","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s12350-013-9701-7","article-title":"Impact of age on myocardial uptake of (1)(2)(3)I-mIBG in older adult subjects without coronary heart disease","volume":"20","author":"Jacobson","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s00259-015-3258-4","article-title":"The time has come to standardize (123)I-MIBG heart-to-mediastinum ratios including planar and SPECT methods","volume":"43","author":"Nakajima","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-019-01887-6_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12350-008-9008-2","article-title":"123I-mIBG scintigraphy to predict risk for adverse cardiac outcomes in heart failure patients: Design of two prospective multicenter international trials","volume":"16","author":"Jacobson","year":"2009","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib38","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12350-013-9701-7","article-title":"Impact of age on myocardial uptake of 123I-mIBG in older adult subjects without coronary heart disease","volume":"20","author":"Jacobson","year":"2013","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12149-018-1231-6","article-title":"Is (123)I-metaiodobenzylguanidine heart-to-mediastinum ratio dependent on age? From Japanese Society of Nuclear Medicine normal database","volume":"32","author":"Nakajima","year":"2018","journal-title":"Ann Nucl Med"},{"key":"10.1007\/s12350-019-01887-6_bib40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0002-9149(96)00280-9","article-title":"Regional cardiac sympathetic nerve dysfunction and the diagnostic efficacy of metaiodobenzylguanidine tomography in stable coronary artery disease","volume":"78","author":"Nakata","year":"1996","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib41","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12350-016-0675-0","article-title":"Potential for adrenergic imaging to serve as a unique tool for guidance of patient management during and after an acute ischemic event","volume":"25","author":"Travin","year":"2018","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib42","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/s12350-010-9292-5","article-title":"Dysinnervated but viable myocardium in ischemic heart disease","volume":"17","author":"Fallavollita","year":"2010","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib43","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-020282","article-title":"Incidence and prevalence of cardiovascular disease in English primary care: A cross-sectional and follow-up study of the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC)","volume":"8","author":"Hinton","year":"2018","journal-title":"BMJ Open"},{"key":"10.1007\/s12350-019-01887-6_bib44","unstructured":"Digital, N., Quality and outcomes framework, achievement, prevalence and exceptions data: 2017-2018. Quality and Outcomes Framework (QOF), 2018."},{"key":"10.1007\/s12350-019-01887-6_bib45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jacc.2008.02.075","article-title":"Trends in the incidence of coronary heart disease and stroke and their risk factors in Japan, 1964 to 2003: The Akita-Osaka study","volume":"52","author":"Kitamura","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-019-01887-6_bib46","first-page":"822","article-title":"Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation","volume":"5","author":"Pellegrino","year":"2015","journal-title":"Quant Imaging Med Surg"},{"key":"10.1007\/s12350-019-01887-6_bib47","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011843","article-title":"Association between physical activity and body fat percentage, with adjustment for BMI: A large cross-sectional analysis of UK Biobank","volume":"7","author":"Bradbury","year":"2017","journal-title":"BMJ Open"},{"key":"10.1007\/s12350-019-01887-6_bib48","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/01.STR.0000169925.57251.4e","article-title":"Body mass index and mortality from cardiovascular disease among Japanese men and women: The JACC study","volume":"36","author":"Cui","year":"2005","journal-title":"Stroke"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-019-01887-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12350-019-01887-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123009728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123009728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-019-01887-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T06:10:18Z","timestamp":1761027018000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123009728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1071358123009728"],"URL":"https:\/\/doi.org\/10.1007\/s12350-019-01887-6","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac 123I-MIBG normal uptake values are population-specific: Results from a cohort of controls over 60 years of age","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-019-01887-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}