{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:30:05Z","timestamp":1787772605247,"version":"build-2784847793"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["journals.elsevierhealth.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Nuclear Cardiology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s12350-020-02087-3","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T14:31:35Z","timestamp":1584541895000},"page":"2687-2696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["99mTc-3SPboroxime: A neutral 99mTc(III) radiotracer with high heart uptake and long myocardial retention"],"prefix":"10.1016","volume":"28","author":[{"given":"Xiao-Ying","family":"Xi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailing","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo-Quan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1007\/s12350-020-02087-3_bib1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/bmb\/ldl014","article-title":"Non-invasive anatomical and functional imaging for the detection of coronary artery disease","volume":"79\u201380","author":"Henneman","year":"2006","journal-title":"Br Med Bull"},{"key":"10.1007\/s12350-020-02087-3_bib2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1161\/CIRCULATIONAHA.106.629808","article-title":"New technology for noninvasive evaluation of coronary artery disease","volume":"115","author":"Di Carli","year":"2007","journal-title":"Circulation"},{"key":"10.1007\/s12350-020-02087-3_bib3","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/CIRCULATIONAHA.108.778860","article-title":"Radiopharmaceutical agents for myocardial perfusion imaging","volume":"118","author":"Baggish","year":"2008","journal-title":"Circulation"},{"key":"10.1007\/s12350-020-02087-3_bib4","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1007\/s12350-014-0002-6","article-title":"Absolute myocardial blood flow quantification with SPECT\/CT: Is it possible?","volume":"21","author":"Slomka","year":"2014","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s12350-014-9971-8","article-title":"Feasibility and operator variability of myocardial blood flow and reserve measurements with 99mTc-sestamibi quantitative dynamic SPECT\/CT imaging","volume":"21","author":"Klein","year":"2014","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib6","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s12350-014-9996-z","article-title":"Myocardial blood flow quantification with SPECT and conventional tracers: A critical appraisal","volume":"21","author":"Nekolla","year":"2014","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib7","first-page":"94","article-title":"Myocardial extraction of teboroxime: Effects of teboroxime interaction with blood","volume":"33","author":"Rumsey","year":"1992","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-020-02087-3_bib8","first-page":"1979","article-title":"The effect of flow on technetium-99m-teboroxime (SQ30217) and thallium-201 extraction and retention in rabbit heart","volume":"32","author":"Marshall","year":"1991","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-020-02087-3_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/0735-1097(92)90029-M","article-title":"The relationship between myocardial retention of technetium-99m teboroxime and myocardial blood flow","volume":"20","author":"Beanlands","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.nucmedbio.2014.07.009","article-title":"Effect of co-ligands on chemical and biological properties of 99mTc(III) complexes [99mTc(L)(CDO)(CDOH)2BMe] (L = Cl, F, SCN and N3; CDOH2 = cyclohexanedione dioxime)","volume":"41","author":"Zheng","year":"2014","journal-title":"Nucl Med Biol"},{"key":"10.1007\/s12350-020-02087-3_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1021\/bc500583k","article-title":"Impact of boronate capping groups on biological characteristics of novel 99mTc(III) complexes [99mTcCl(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime)","volume":"26","author":"Yang","year":"2015","journal-title":"Bioconjug Chem"},{"key":"10.1007\/s12350-020-02087-3_bib12","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.nucmedbio.2016.05.001","article-title":"Novel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) as potential radiotracers for heart imaging","volume":"43","author":"Liu","year":"2016","journal-title":"Nucl Med Biol"},{"key":"10.1007\/s12350-020-02087-3_bib13","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1021\/acs.bioconjchem.6b00552","article-title":"Novel 99mTc(III) complexes [99mTcCl(CDO)(CDOH)2B-R] (CDOH2 = cyclohexanedione dioxime) useful as radiotracers for heart imaging","volume":"27","author":"Liu","year":"2016","journal-title":"Bioconjug Chem"},{"key":"10.1007\/s12350-020-02087-3_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/acs.jmedchem.7b01412","article-title":"Sulfonyl-containing boronate caps for optimization of biological properties of 99mTc(III) radiotracers [99mTcCl(CDO)(CDOH)2B\u2013R](CDOH2 = cyclohexanedione dioxime)","volume":"61","author":"Zhao","year":"2018","journal-title":"J Med Chem"},{"key":"10.1007\/s12350-020-02087-3_bib15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12350-010-9256-9","article-title":"Quantification of myocardial blood flow and flow reserve: Technical aspects","volume":"17","author":"Klein","year":"2010","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib16","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.jacc.2014.05.069","article-title":"Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: Cutoff values and diagnostic accuracy of quantitative [15O]H2O PET Imaging","volume":"64","author":"Danad","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.pcad.2015.01.001","article-title":"Positron-emitting myocardial blood flow tracers and clinical potential","volume":"57","author":"Schindler","year":"2015","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1007\/s12350-020-02087-3_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jacc.2012.11.022","article-title":"Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: Flurpiridaz F 18 positron emission tomography","volume":"61","author":"Berman","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib19","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00259-018-3958-7","article-title":"First validation of myocardial flow reserve assessed by dynamic 99mTc-sestamibi CZT-SPECT camera: Head to head comparison with 15O-water PET and fractional flow reserve in patients with suspected coronary artery disease: The WATERDAY study","volume":"45","author":"Agostini","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1007\/s12350-020-02087-3_bib20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S1071-3581(96)90005-7","article-title":"Experimental verification of technetium 99m-labeled teboroxime kinetic parameters in the myocardium with dynamic single-photon emission computed tomography: Reproducibility, correlation to flow, and susceptibility to extravascular contamination","volume":"3","author":"Smith","year":"1996","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib21","doi-asserted-by":"crossref","first-page":"9E","DOI":"10.1016\/0002-9149(90)90606-2","article-title":"Experimental studies of the physiologic properties of technetium-99m agents: Myocardial transport of perfusion imaging agents","volume":"66","author":"Meerdink","year":"1990","journal-title":"Am J Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib22","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0002-8703(96)90019-8","article-title":"Dynamic planar myocardial perfusion imaging in patients with one-vessel disease with intracoronary injection of technetium 99m teboroxime during papaverine-induced coronary hyperemia","volume":"132","author":"Tartagni","year":"1996","journal-title":"Am Heart J"},{"key":"10.1007\/s12350-020-02087-3_bib23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1071-3581(95)80022-0","article-title":"The Canadian exercise technetium 99m-labeled teboroxime single-photon emission computed tomographic study","volume":"2","author":"Burns","year":"1995","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib24","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1053\/j.semnuclmed.2014.05.004","article-title":"Noninvasive imaging in coronary artery disease","volume":"44","author":"Heo","year":"2014","journal-title":"Semin Nucl Med"},{"key":"10.1007\/s12350-020-02087-3_bib25","doi-asserted-by":"crossref","first-page":"14509","DOI":"10.1039\/C7DT01292F","article-title":"99mTc-3Cboroxime: A novel 99mTc(iii) (III) complex[99mTcCl(CDO)(CDOH)2B-3C] (CDOH2 = cyclohexanedione dioxime; 3C-B(OH)2 = 3-(carbamoylphenyl)boronic acid) with high heart uptake and long myocardial retention","volume":"46","author":"Liu","year":"2017","journal-title":"Dalton Trans"},{"key":"10.1007\/s12350-020-02087-3_bib26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1071-3581(05)80077-7","article-title":"Mechanism of uptake of technetium-tetrofosmin. II: Uptake into isolated adult rat heart mitochondria","volume":"2","author":"Youn\u00e8s","year":"1995","journal-title":"J Nucl Cardiol"},{"key":"10.1007\/s12350-020-02087-3_bib27","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/bc200106p","article-title":"64Cu-Labeled phosphonium cation as PET radiotracers for tumor imaging","volume":"22","author":"Zhou","year":"2011","journal-title":"Bioconjug Chem"},{"key":"10.1007\/s12350-020-02087-3_bib28","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.2967\/jnumed.114.139782","article-title":"Dynamic SPECT measurement of absolute myocardial blood flow in a porcine model","volume":"55","author":"Wells","year":"2014","journal-title":"J Nucl Med"},{"key":"10.1007\/s12350-020-02087-3_bib29","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/s12350-016-0513-4","article-title":"Avoiding full corrections in dynamic SPECT images impacts the performance of SPECT myocardial blood flow quantitation","volume":"24","author":"Wang","year":"2017","journal-title":"J Nucl Cardiol"}],"container-title":["Journal of Nuclear Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-020-02087-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12350-020-02087-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123016562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1071358123016562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12350-020-02087-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T15:50:53Z","timestamp":1735573853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1071358123016562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1071358123016562"],"URL":"https:\/\/doi.org\/10.1007\/s12350-020-02087-3","relation":{},"ISSN":["1071-3581"],"issn-type":[{"value":"1071-3581","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"99mTc-3SPboroxime: A neutral 99mTc(III) radiotracer with high heart uptake and long myocardial retention","name":"articletitle","label":"Article Title"},{"value":"Journal of Nuclear Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1007\/s12350-020-02087-3","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 American Society of Nuclear Cardiology. Published by ELSEVIER INC. All rights reserved. Published by Mosby, Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}